Literature suggests there is a significant relationship between recent alcohol drinking history and SRE measures (Schuckit et al., 1997a; Schuckit et al., 2003; Schuckit and Smith, 2004; Schuckit et al., 2005b; Schuckit et al., 2006; Schuckit et al., 2007; Ray et al., 2011). Most of these studies have focused on cohorts of European descent. Although rates of alcohol dependence currently hold constant for all racial groups (SAMHSA, 2010), African Americans have in the past become more alcohol dependent, at faster rates, within the ages of 18–29 years (Grant et al., 2004; Breslau et al., 2006). The heritability of LR and its association with RDH may explain such trends in alcohol dependence among African Americans. There is limited data on the association of the SRE with alcohol-related problems in African Americans. To our knowledge there is only one study that related increased drinking, alcohol related problems, and DSMIV alcohol use disorders to SRE (Pedersen and McCarthy, 2009). One of their findings, that SRE and acute response were unrelated, differed from previous research on alcohol response. This present study examines (1) how