of linkage to this region on 7q has been made by the Nicotine Addiction Genetics project for alcohol consumption phenotypes [Agrawal et al., 2008a], and for alcohol dependence in a sample of multiplex families ascertained at Pittsburgh [Hill et al., 2004]. A systematic SNP screen to fine map this region on chromosome 7 using the COGA dataset identified an association with ACN9 a gene involved in gluconeogenesis and the assimilation of ethanol or acetate into carbohydrate [Dick et al., 2008].
