The region of the genome that provided the best evidence for linkage in the UCSF family study was on chromosome 7q (LOD = 5.6) for the cannabis craving phenotype. This region has consistently emerged with significant evidence of linkage in the COGA project. In the initial COGA sample this region on chromosome 7q provided the strongest evidence of linkage to alcohol dependence with a multipoint LOD score of 3.49 [Reich et al., 1998]. An additional linkage analysis with expanded microsatellite markers in the full COGA sample revealed a LOD score of 2.9 [Wang et al., 2004], and a set of SNPs genotyped in the region that were not in linkage disequilibrium with adjacent markers generated a LOD score at the peak of 4.1 [Dunn et al., 2005]. Other population samples have also found evidence for linkage on 7q. A report of linkage to this region on 7q has been made by the Nicotine Addiction Genetics project for alcohol consumption phenotypes [Agrawal et al., 2008a], and for alcohol dependence in a sample of multiplex families ascertained at Pittsburgh [Hill et al.,
