Chunk #22 — RESULTS — Matching hallmark enrichment scores to protein level phenotypes — BCL2 and Apoptosis (Figure 3D)

Source

The Molecular Signatures Database (MSigDB) hallmark gene set collection.

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yes

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BCL2 blocks apoptosis and consequently its protein levels display strong association (IC = 0.476, p < 4.8×10−7) with a proliferation signature represented by the E2F hallmark (Topham and Taylor, 2013). The BCL2 profile has also a strong negative association with the apoptosis hallmark (IC = −0.588, p < 4.8×10−7).