AA populations. Top SNPs from both populations were then successfully replicated in independent samples. Results from this GWAS suggested population specific SNPs related to alcohol dependence (AD). However, although the individual SNPs differed across populations, many were located in similar risk loci for AD, such as SNPs in the ADH cluster responsible for alcohol metabolism.47 These results support previous GWAS studies that suggested common biological pathways across ancestral populations,15,48 though more work is still needed to understand the extent to which there are common biological and population-specific risks.
