Figure 3). In addition, age was negatively correlated with AUDIT scores (β = −0.02, p < 2 × 10−6; Supplementary Table 8). Therefore, both sex and age were used as covariates in the GWAS analyses. The mean AUDIT-C score was 4.24 (S.D. = 2.83) and the mean AUDIT-P score was 0.75 (S.D. = 2.0). As expected, there was a moderate positive phenotypic correlation between AUDIT-C and AUDIT-P (r = 0.478, 95% C.I. = 0.473–0.481, p < 2 × 10−16; Supplementary Table 8).
