Chunk #25 — RESULTS — I. Family-based SNP panel — ROC curve analysis

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Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence.

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The distribution of genetic sum scores was similar in cases and controls in COGA and SAGE (Fig. 2). Neither of the genetic sum scores had an AUC estimate that reached statistical significance at p < 0.05 for COGA or SAGE. Because of the lack of replication for individual SNPs and sum score associations with AD, AUC estimates were not significant. Family history, however, did produce a statistically significant AUC. ROC curve analysis results for family history compared with the sum scores are summarized in Table 5.