There are a few limitations to consider. First, the mean AUDIT score in drinkers is lower than the range that suggests hazardous drinking. Thus, although the current results may reflect drinking problems as captured by the AUDIT score, their clinical significance remains to be clarified. Our ongoing work to follow these individuals and characterize potential changes in drinking trajectory would help in resolving this issue. Second, we attempted to distinguish the neural correlates of duration of alcohol use and age, but it is impossible to isolate one effect from the other in alcohol drinkers. Although the neural correlates of years of drinking was obtained by masking of age-related changes in non-drinkers, our best interpretation of the results would have to be considered with any confounding, interaction effects of age and alcohol use. Third, inhibitory control is a multidimensional construct that cannot be fully characterized by behavioral tasks that solely address motor response inhibition. Thus, paradigms that examine delay discounting, risky decision making, reward responsivity would need to be considered to understand the multifaceted etiologies of alcohol misuse (Moreno et al.,
