Chunk #36 — Findings — Improvements in PLINK 1.9 — Other noteworthy algorithms — Hardy-Weinberg equilibrium and Fisher’s exact tests

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Second-generation PLINK: rising to the challenge of larger and richer datasets.

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We note that, while the Hardy-Weinberg equilibrium exact test is only of interest to geneticists, Fisher’s exact test has wider application. Thus, we are preparing another paper which discusses these algorithms in more detail, with proofs of numerical error bounds and a full explanation of how the Fisher’s exact test algorithm extends to larger tables.