combined in order to calculate the overall efficacy effect-size. In comparisons of efficacy in blind versus open-label, the control arms were analyzed separately. In addition, for comparisons of cocaine versus non cocaine trials, supervised versus non supervised conditions, and across the various control conditions, only the no disulfiram arm was analyzed to determine disulfiram efficacy and this part of both trials was open-label. When appropriate, arms were combined according to Higgins and Green [29].
