Chunk #23 — 3. Results — 3.5. Pretreatment with PPARα activators attenuates microglial/macrophage activation, leukocyte recruitment, and neuronal injury after LPS

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Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.

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Fluoro-Jade B positive cells were clearly detected in the LPS injected brains (Fig. 7A). Wy-14643 and fenofibrate dramatically decreased the number of Fluoro-Jade B positive cells (Figs. 7A and B). Cortical lesion volume determined by cresyl violet staining at 3 days was also profoundly reduced by these drugs (Fig. 7C).