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Chunk #14 — METHODS — Cross comparison with GWAS and human gene expression results

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Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
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We compared the LCL results with results from 14 recent genome wide association studies (GWAS) for alcohol dependence or related phenotypes (Bierut et al., 2010; Edenberg et al., 2010; Foroud et al., 2007; Gelernter et al., 2013; Hack et al., 2011; Johnson et al., 2011; Kapoor et al., 2013; Kendler et al., 2011; Lind et al., 2010; Treutlein et al., 2009; Wang et al., 2012; Xuei et al., 2006; Zlojutro et al., 2011; Zuo et al., 2012a). These studies used alcohol dependence and/or one or more related phenotypes: age of onset of DSM4 alcohol dependence, DSM4 symptom count, initial sensitivity to alcohol, alcohol tolerance, withdrawal, craving and maximum number of drinks within a 24 hour period (maxdrinks). Gene symbols were matched to gene names reported by the various groups, which frequently represented genes within a given distance from the SNP.