The total additive genetic variance (heritability, h2) and its standard error were estimated for the SHAS-E phenotypes using SOLAR [85]. A genetic association analyses was conducted where the number of copies of the minor allele of each individual was used as a covariate in a variance component analysis as implemented in SOLAR v2.0.4 [86], and the statistical significance of the ability of the covariate to explain phenotypic variance was determined. Age and sex were also accounted for in the analyses. To account for multiple comparisons, in these exploratory analyses, nominal significance was set at the p < 0.01 level.
