To reduce the stress associated with IP drug administration, all rats were handled as if they were going to receive an IP injection for 5 consecutive days prior to initial drug treatment. Clonidine (40 µg/kg BW; n = 10) or an equivalent volume (1 mL) of saline vehicle (n = 10) was administered 30 min prior to the daily 2-h saccharin vs. water access period on each of 3 consecutive days.
