whether some genes had a disproportionately high number of changing edges. For the latter, the binomial test was used with the following parameters. The average incidence of changing edges (the rate of the binomial test) was computed by dividing the number of changing edges (p < 0.01) by the total number of network edges. The number of trials (for each gene) was equal to the number of edges. The number of “successes” was equal to the number of changing edges.
