Credible set annotations at the remaining loci are more diverse (Supplementary Data 3). The most strongly associated locus on chromosome 1 (index variant rs112984125) covers a gene-rich 250kb region of strong LD. The index variant is intronic to ST3GAL3, and most SNPs in the credible set are strongly associated with expression of ST3GAL3 in whole blood79 (Supplementary Data 3). Missense mutations in ST3GAL3 have been shown to cause autosomal recessive intellectual disability80. Hi-C and eQTL annotations suggest multiple alternative genes however, including PTPRF (Supplementary Data 4). The locus also includes an intergenic variant, rs11210892, that has previously been associated with schizophrenia33.
