The present study is a crucial direct extension of our prior work with these 17 endophenotypes. Here, the question is not whether psychophysiological endophenotypes can aid in initial discovery of disorderrelevant genes, but whether such endophenotypes can inform us about the role and mechanisms of action of genes already known to be associated with a major neurodevelopmental mental disorder. To answer this question, we took the results from a recent schizophrenia genetic association meta-analysis by the Psychiatric Genomics Consortium (PGC), which discovered 128 independent genetic variants in 108 genomic loci associated with schizophrenia (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014), and tested them for association with the same 17 endophenotypes described above. Many of these endophenotypes have demonstrated substantial construct validity as endophenotypes for schizophrenia (Iacono et al. 2016); others less so, but nevertheless have been associated with schizophrenia, found to be heritable in twin studies, and show deviation in schizophrenia patient first-degree relatives (Fukushima et al. 1988; Braff et al. 1992; Iacono et al. 1999; Hong et al. 2012; Kam et al. 2013; Chen et al. 2014;
