The FinnGen diagnosis is defined by the F5 Mood category and was downloaded from Freeze 2 of the database (http://r2.finngen.fi/pheno/F5_MOOD). This phenotype is broad and contains manic episodes, bipolar disorders, depression, persistent mood disorders, and other unspecified mood [affective] disorders. Data from UKB8 is a broad depression phenotype based on affirmative responses to either of the questions: “Have you ever seen a general practitioner for nerves, anxiety, tension or depression?”, and “Have you ever seen a psychiatrist for nerves, anxiety, tension or depression?”. PGC data also has been previously reported,7 and come from meta-analysis of 35 cohorts with a spectrum of depression phenotypes, including some with clinical diagnosis from structured interviews and others with broader definitions. LD-intercept (1.03, SE 0.011) and attenuation ratio (0.0297, SE 0.011) of the LD score regression revealed minimal evidence for inflation or confounding, with 97% of inflation observed due to high polygenicity of depression (Figure S4). Data distribution was assumed to be normal but this was not formally tested.
