In our study a signal is declared validated if it satisfies ALL of the following three criteria: (i)the sentinel SNV is genome-wide significant (P < 5×10-8) in the combined meta-analysis for any of the three BP traits;(ii)the sentinel SNV shows evidence of support (P < 0.01) in the replication meta-analysis alone for association with the most significantly associated BP trait from the combined meta-analysis (NB: P < 0.01 is more stringent than a range of thresholds calculated according to False Discovery Rate (FDR), see Supplementary Methods);(iii)the sentinel SNV has concordant direction of effect between the UKB discovery and the replication meta-analysis for the most significantly associated BP trait from the combined meta-analysis.
