By conditional analysis within UKB data we assess all validated secondary signals from our validated and previously reported loci at the time of analysis for independence from the sentinel or previously reported SNV, respectively (Supplementary Note). We declare a secondary signal to be independent of the previously reported SNV if there is less than a 1.5 fold difference between the main association and conditional association P-values on a –log10 scale, i.e. if –log10(P) / -log10(P_cond) < 1.5. Note that the lookup criteria already ensure that the secondary variant is not in LD (r2 < 0.2) with the previously reported SNV. If more than one SNV in a region is found to be independent we undertake further rounds of iterative conditional analysis.
