The aim of this study was to examine the intersection of stress and gender in association with transitions in DSM-5 SUD diagnoses (AUD, TUD, CUD, and OUD), across all major classes of substances, using newly available data from a nationally representative sample of adults living in the United States (National Epidemiologic Survey on Alcohol and Related Conditions (NESARC); Wave 3). We first examined whether stressful life events in the past 12 months and gender were related to (1) new vs. absent cases of AUD, TUD, CUD, and OUD in the past 12 months and (2) ongoing vs. remitted cases of AUD, TUD, CUD, and OUD in the past 12 months. We then examined two-way interactions in relation to AUD, TUD, CUD, and OUD diagnoses (new vs. absent; ongoing vs. remitted) between stressful life events and gender. We predicted that individuals who experienced stressful life events in the past 12 months would be more likely to also have new or ongoing SUD in the past 12 months, and that this effect would be stronger for women compared to men. It is
