Ultimately we would like to combine imaging data with genetic information. ENIGMA has developed pipelines for integrated analyses of both neuroimaging and genetic data. Some of this work has focused on common variants: Satizabal et al. (2019), for example, investigated nearly 40,000 individuals, and found that more than 45 genetic loci were significantly associated with subcortical volumes. Analyses indicated that associated genes are implicated in neurodevelopment, synaptic signaling, axonal transport, and other key processes. Other work has focused on CNVs: in the largest CNV neuroimaging study to date, for example, 15q11.2 BP1‐BP2 structural variation was found associated with brain morphology and cognition, with deletion carriers being particularly affected (Writing Committee for the ENIGMA‐CNV Working Group., 2019). There is a clear potential to extend such work to specific disorders such as OCD. In a proof of principle investigation, ENIGMA‐OCD has explored the overlap in genetic contributions to subcortical volumes and OCD (Hibar et al., 2018); significant positive concordance was found between OCD risk variants and variants associated with greater nucleus accumbens and putamen volumes. Further work is needed to expand on
