In a biobank research system, the biobank should work with the primary researchers (or collection sites) and secondary researchers involved in the biobank system to clarify the criteria for evaluating findings (such as analytic validity, established and substantial risk of a serious health condition, and actionability) and roster of returnable IFs and IRRs. This roster should be reviewed and updated regularly in light of the literature, to incorporate new genetic and genomic findings. The biobank should consider the recommendations of a Central Advisory Body, if any. Creation of a Central Advisory Body to recommend a core roster would promote consistency among biobank research systems. However, biobanks will commonly need to consider whether the nature of their contributor population, their research collection, and the research facilitated suggests adjustments to the recommended roster. We recommend that researchers in the biobank research system should offer to return IFs and IRRs that meet all of the following criteria: The findings are analytically valid;Returning them to the contributor comports with applicable law, including CLIA (which may require ascertaining or verifying results in a CLIA-certified lab);The
