Multiple genes, all but one of which were in the region around the top SNP (rs4622308), reached gene-based significance (reflecting the high LD in the region). The remaining significant gene was FAM19A2, a putative chemokine/cytokine, and the 4th best locus in our SNP based analyses. No pathways were significant (see Supplementary Table S3 for the complete gene-based and pathway analysis results). As has typically been reported for other psychiatric disorders, candidate genes from previous studies did not reach gene-based significance [or in our other analyses; for a detailed review of the candidate gene literature see (5)].
