of 13 phenotypesPreviously associated to neuroticism sum-score3. D2-receptors are thought to be involved in reward processing. GRM8 7126,078,6528 items + sum-scoreNot associated to neuroticism before. Has been associated to the response to selective serotonin reuptake inhibitors (SSRI) in depressed individuals52. SORCS3 10106,400,859Items in the depressed affect cluster and sum-score, but not items in the worry clusterSignal is driven primarily by 3 items (MIS, MOOD, FED-UP), all part of the depressed affect cluster. SORCS3 has been associated to depression3, and is involved in neuropeptide receptor activity. CADM2 385,008,133Items in the worry cluster and sum-score, but not items in the depressed affect clusterMost strongly associated gene for the worry cluster (P = 2.24 × 10−23), and GWS for all items in this cluster. Linked to BMI in multiple studies53,54 (see genetic correlations between both clusters and BMI in Fig. 3).Region A349.215–50.226 MbDepressed affect itemsGenes in this region (e.g., C3orf84, RHOA, MST1, APEH) were previously linked to e.g. Crohn’s disease55 and blood protein levels56. A subset of the genes in this region (e.g. IP6K1, CAMKV, SEMA3F) have been associated with educational attainment57.Region B350.264–53.080 MbWorry itemsGenes in this region (e.g. ALAS1, STAB1, GNL3, ITIH4, TMEM110) have been linked to schizophrenia and autism spectrum disorder
