Chunk #43 — Results — RYR3: Regulation of initial sensitivity to ethanol in C. elegans, rapid tolerance to ethanol in Drosophila, and motivation to self administer alcohol in rats
The availability of dantrolene, a pharmacological antagonist of ryanodine receptors, allowed us to assess the effect of antagonism of RyRs on the complex behavior of ethanol self administration in rats. We found that in rats, dantrolene dose-dependently reduced motivation to self-administer ethanol after 50 contiguous days of chronic ethanol self-administration (Supplementary Materials and Methods, Supplementary Results and Supplementary Figure S9).
