Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.
paper
Primary
Public
Unavailable
- Authors
- Wang, J C; Grucza, R; Cruchaga, C; Hinrichs, A L; Bertelsen, S; Budde, J P; Fox, L; Goldstein, E; Reyes, O; Saccone, N; Saccone, S; Xuei, X; Bucholz, K; Kuperman, S; Nurnberger, J; Rice, J P; Schuckit, M; Tischfield, J; Hesselbrock, V; Porjesz, B; Edenberg, H J; Bierut, L J; Goate, A M
- Year
- 2009
- Journal
- Molecular psychiatry
- PMID
- 18414406
- DOI
- 10.1038/mp.2008.42
- PMCID
- PMC4381434
Alcohol dependence frequently co-occurs with cigarette smoking, another common addictive behavior. Evidence from genetic studies demonstrates that alcohol dependence and smoking cluster in families and have shared genetic vulnerability. Recently a candidate gene study in nicotine dependent cases and nondependent smoking controls reported strong associations between a missense mutation (rs16969968) in exon 5 of the CHRNA5 gene and a variant in the 3'-UTR of the CHRNA3 gene and nicotine dependence. In this study we performed a comprehensive association analysis of the CHRNA5-CHRNA3-CHRNB4 gene cluster in the Collaborative Study on the Genetics of Alcoholism (COGA) families to investigate the role of genetic variants in risk for alcohol dependence. Using the family-based association test, we observed that a different group of polymorphisms, spanning CHRNA5-CHRNA3, demonstrate association with alcohol dependence defined by Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV) criteria. Using logistic regression we replicated this finding in an independent case-control series from the family study of cocaine dependence. These variants show low linkage disequilibrium with the SNPs previously reported to be associated with nicotine dependence and therefore represent an independent observation. Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Disruption of <i>chrna5</i> blunts aversion and adaptive transcriptomic responses to nicotine and alcohol. | Goel T et al. | β | 2026 | β |
| Ionotropic Glutamate Receptor Function in Interpeduncular Nucleus Is Modulated by Nicotine Exposure. | Yan Y et al. | β | 2025 | β |
| Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6. | Yang D et al. | β | 2025 | β |
| Multivariate Bayesian variable selection for multi-trait genetic fine mapping. | Canida T et al. | β | 2025 | β |
| The influence of CHRNA5 and D398N missense variation on social and emotional behaviors in rodents and humans. | de Chaumont F et al. | β | 2025 | β |
| Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons. | Tochon L et al. | β | 2024 | β |
| Evaluating the interaction between 3'aQTL and alcohol consumption/smoking on anxiety and depression: 3'aQTL-by-environment interaction study in UK Biobank cohort. | Yang X et al. | β | 2023 | β |
| Sex-dependent factors of alcohol and neuroimmune mechanisms. | Cruz B et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | β | 2023 | β |
| Depressive Symptoms Predict Clinical Recurrence of Inflammatory Bowel Disease. | Jordi SBU et al. | β | 2022 | β |
| Mutation of the Ξ±5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption. | Quijano CardΓ© NA et al. | β | 2022 | β |
| Risk of lower respiratory tract infections: a genome-wide association study with Mendelian randomization analysis in three independent European populations. | Flatby HM et al. | β | 2022 | β |
| Behavioral Economic Demand for Alcohol and Cigarettes in Heavy Drinking Smokers: Evidence of Asymmetric Cross-commodity Reinforcing Value. | Green R et al. | β | 2021 | β |
| Ethanol interaction with Ξ±3Ξ²4 nicotinic acetylcholine receptors in neurons of the laterodorsal tegmentum. | Abburi C et al. | β | 2021 | β |
| Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms. | Brynildsen JK et al. | β | 2021 | β |
| Depressive symptoms and single nucleotide polymorphisms predict clinical recurrence of inflammatory bowel disease | Ulrich Jordi SB et al. | β | 2020 | β |
| Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution. | Icick R et al. | β | 2020 | β |
| Neuronal nicotinic acetylcholine receptors mediate β<sup>9</sup> -THC dependence: Mouse and human studies. | Donvito G et al. | β | 2020 | β |
| Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models. | Gipson CD et al. | β | 2020 | β |
| Spontaneous Ultrasonic Vocalization Transmission in Adult, Male Long-Evans Rats Is Age-Dependent and Sensitive to EtOH Modulation. | Mittal N et al. | β | 2020 | β |
| The Impact of Electronic Nicotine Delivery System (ENDS) Flavors on Nicotinic Acetylcholine Receptors and Nicotine Addiction-Related Behaviors. | Cooper SY et al. | β | 2020 | β |
| The innate immunity protein IFITM3 modulates Ξ³-secretase in Alzheimer's disease. | Hur JY et al. | β | 2020 | β |
| Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and Ξ³-Hydroxybutyric Acid. | Singh AK | β | 2019 | β |
| Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior. | Besson M et al. | β | 2019 | β |
| Relationship of common variants in CHRNA5 with early-onset schizophrenia and executive function. | Han W et al. | β | 2019 | β |
| Sex, ADHD symptoms, and CHRNA5 genotype influence reaction time but not response inhibition. | Schote AB et al. | β | 2019 | β |
| The Role of the Medial Habenula Cholinergic System in Addiction and Emotion-Associated Behaviors. | Lee HW et al. | β | 2019 | β |
| The Ξ±3Ξ²4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice. | Miller CN et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice. | Dawson A et al. | β | 2018 | β |
| Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions. | Klenowski PM et al. | β | 2018 | β |
| Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use. | Brown-Rice KA et al. | β | 2018 | β |
| Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells. | Qian J et al. | β | 2018 | β |
| The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. | Saccone NL et al. | β | 2018 | β |
| Ξ±5 nAChR modulation of the prefrontal cortex makes attention resilient. | Howe WM et al. | β | 2018 | β |
| Increased habenular connectivity in opioid users is associated with an Ξ±5 subunit nicotinic receptor genetic variant. | Curtis K et al. | β | 2017 | β |
| Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse. | Cross SJ et al. | β | 2017 | β |
| Pharmacogenetic study of seven polymorphisms in three nicotinic acetylcholine receptor subunits in smoking-cessation therapies. | Pintarelli G et al. | β | 2017 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. | Barrie ES et al. | β | 2017 | β |
| African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction. | Levran O et al. | β | 2016 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Association between variants in nicotinic acetylcholine receptor genes and smoking cessation in a Chinese rural population. | Wang Q et al. | β | 2016 | β |
| Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. | Zuo L et al. | β | 2016 | β |
| Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | Wen L et al. | β | 2016 | β |
| Electrophysiology-Based Assays to Detect Subtype-Selective Modulation of Human Nicotinic Acetylcholine Receptors. | Kirsch GE et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| Pleiotropic effects of Chr15q25 nicotinic gene cluster and the relationship between smoking, cognition and ADHD. | Schuch JB et al. | β | 2016 | β |
| Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. | Olfson E et al. | β | 2016 | β |
| Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan. | Joshi PK et al. | β | 2016 | β |
| A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. | Hancock DB et al. | β | 2015 | β |
| A powerful nonparametric statistical framework for family-based association analyses. | Li M et al. | β | 2015 | β |
| Checks and balances on cholinergic signaling in brain and body function. | Soreq H | β | 2015 | β |
| Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. | Manzardo AM et al. | β | 2015 | β |
| CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. | Chen J et al. | β | 2015 | β |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | β | 2015 | β |
| Examining gene-environment interactions in comorbid depressive and disruptive behavior disorders using a Bayesian approach. | Adrian M et al. | β | 2015 | β |
| Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. | Reyes-Gibby CC et al. | β | 2015 | β |
| Genetic influences on nicotinic Ξ±5 receptor (CHRNA5) CpG methylation and mRNA expression in brain and adipose tissue. | Ramsay JE et al. | β | 2015 | β |
| Nicotine administration in the wake-promoting basal forebrain attenuates sleep-promoting effects of alcohol. | Sharma R et al. | β | 2015 | β |
| Nicotinic Mechanisms Modulate Ethanol Withdrawal and Modify Time Course and Symptoms Severity of Simultaneous Withdrawal from Alcohol and Nicotine. | Perez E et al. | β | 2015 | β |
| Pharmacological stress is required for the anti-alcohol effect of the Ξ±3Ξ²4* nAChR partial agonist AT-1001. | Cippitelli A et al. | β | 2015 | β |
| Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed. | Schneider KK et al. | β | 2015 | β |
| The Role of Nicotine in Schizophrenia. | Featherstone RE et al. | β | 2015 | β |
| ADHD diagnosis may influence the association between polymorphisms in nicotinic acetylcholine receptor genes and tobacco smoking. | Polina ER et al. | β | 2014 | β |
| A glimpse into the future - Personalized medicine for smoking cessation. | Bierut LJ et al. | β | 2014 | β |
| ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. | Quillen EE et al. | β | 2014 | β |
| Association of the CHRNA4 neuronal nicotinic receptor subunit gene with frequency of binge drinking in young adults. | Coon H et al. | β | 2014 | β |
| CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women. | Criado JR et al. | β | 2014 | β |
| CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control. | Evans DE et al. | β | 2014 | β |
| Curious cases: Altered dose-response relationships in addiction genetics. | Uhl GR et al. | β | 2014 | β |
| Family-based association analysis of alcohol dependence criteria and severity. | Wetherill L et al. | β | 2014 | β |
| Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. | Haller G et al. | β | 2014 | β |
| Genetics and genomics of alcohol sensitivity. | Morozova TV et al. | β | 2014 | β |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| Identification of CHRNA5 rare variants in African-American heavy smokers. | Doyle GA et al. | β | 2014 | β |
| Nicotine administration in the cholinergic basal forebrain increases alcohol consumption in C57BL/6J mice. | Sharma R et al. | β | 2014 | β |
| Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. | Haller G et al. | β | 2014 | β |
| Scientific overview: 2013 BBC plenary symposium on tobacco addiction. | De Biasi M et al. | β | 2014 | β |
| Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung. | Nguyen JD et al. | β | 2014 | β |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | β | 2014 | β |
| The role of the habenula in drug addiction. | Velasquez KM et al. | β | 2014 | β |
| Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. | Yan J et al. | β | 2014 | β |
| Variation in the Ξ± 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content. | Macqueen DA et al. | β | 2014 | β |
| A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity. | Wen Y et al. | β | 2013 | β |
| Abnormal social behavior in nicotinic acetylcholine receptor Ξ²4 subunit-null mice. | Salas R et al. | β | 2013 | β |
| A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. | Zayats T et al. | β | 2013 | β |
| Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression. | Gallego X et al. | β | 2013 | β |
| Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction. | Greenbaum L et al. | β | 2013 | β |
| Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry. | Wang JC et al. | β | 2013 | β |
| Examination of rare missense variants in the CHRNA5-A3-B4 gene cluster to level of response to alcohol in the San Diego Sibling Pair study. | Choquet H et al. | β | 2013 | β |
| Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. | Dani JA et al. | β | 2013 | β |
| Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. | Hendrickson LM et al. | β | 2013 | β |
| Nicotinic acetylcholine receptors containing Ξ±6 subunits contribute to alcohol reward-related behaviours. | Powers MS et al. | β | 2013 | β |
| Nominal association with CHRNA4 variants and nicotine dependence. | Kamens HM et al. | β | 2013 | β |
| Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. | Zhang H et al. | β | 2013 | β |
| Role of Ξ±5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice. | Fowler CD et al. | β | 2013 | β |
| Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study. | HΓ€llfors J et al. | β | 2013 | β |
| The Ξ±5 neuronal nicotinic acetylcholine receptor subunit plays an important role in the sedative effects of ethanol but does not modulate consumption in mice. | Santos N et al. | β | 2013 | β |
| The Ξ±5 subunit regulates the expression and function of Ξ±4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. | Chatterjee S et al. | β | 2013 | β |
| ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. | Bierut LJ et al. | β | 2012 | β |
| Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. | Broms U et al. | β | 2012 | β |
| Chronic alcohol exposure alters gene expression in HepG2 cells. | Pochareddy S et al. | β | 2012 | β |
| Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. | Stephens SH et al. | β | 2012 | β |
| From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. | Ware JJ et al. | β | 2012 | β |
| Function of human Ξ±3Ξ²4Ξ±5 nicotinic acetylcholine receptors is reduced by the Ξ±5(D398N) variant. | George AA et al. | β | 2012 | β |
| Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review. | Hurley LL et al. | β | 2012 | β |
| Prevalence and correlates of alcohol use disorders in the Singapore Mental Health Survey. | Subramaniam M et al. | β | 2012 | β |
| Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. | Haller G et al. | β | 2012 | β |
| The CHRNA5-A3-B4 gene cluster in nicotine addiction. | Berrettini WH et al. | β | 2012 | β |
| The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. | Morozova TV et al. | β | 2012 | β |
| The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: an ordinal bivariate genetic analysis. | Zhang T et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. | Gallego X et al. | β | 2012 | β |
| Updates on the COPD gene list. | BossΓ© Y | β | 2012 | β |
| Utility of genetically modified mice for understanding the neurobiology of substance use disorders. | Fowler CD et al. | β | 2012 | β |
| A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. | Wei C et al. | β | 2011 | β |
| Combined analysis of CHRNA5, CHRNA3 and CYP2A6 in relation to adolescent smoking behaviour. | Rodriguez S et al. | β | 2011 | β |
| Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. | Le-Niculescu H et al. | β | 2011 | β |
| Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain. | McGeary JE et al. | β | 2011 | β |
| Examining naltrexone and alcohol effects in a minority population: results from an initial human laboratory study. | Plebani JG et al. | β | 2011 | β |
| GABRB3 gene expression increases upon ethanol exposure in human embryonic stem cells. | Krishnamoorthy M et al. | β | 2011 | β |
| Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. | Sarginson JE et al. | β | 2011 | β |
| Nicotinic Ξ±5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms. | Smith RM et al. | β | 2011 | β |
| Partial agonists of the Ξ±3Ξ²4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. | Chatterjee S et al. | β | 2011 | β |
| Pharmacological aspects of the acetylcholinesterase inhibitor galantamine. | Ago Y et al. | β | 2011 | β |
| Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior. | Tuesta LM et al. | β | 2011 | β |
| Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population. | Jaworowska E et al. | β | 2011 | β |
| Stigmatizing Clients with Mental Health Conditions: An Assessment of Social Work Student Attitudes. | Kubiak SP et al. | β | 2011 | β |
| The Role of the Habenula in Nicotine Addiction. | Baldwin PR et al. | β | 2011 | β |
| BOLD Responses to Negative Reward Prediction Errors in Human Habenula. | Salas R et al. | β | 2010 | β |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | β | 2010 | β |
| Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking. | McBride WJ et al. | β | 2010 | β |
| Cigarette smoking and depression: a question of causation. | MunafΓ² MR et al. | β | 2010 | β |
| Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice. | Symons MN et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| Human variation in alcohol response is influenced by variation in neuronal signaling genes. | Joslyn G et al. | β | 2010 | β |
| Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. | Pillai SG et al. | β | 2010 | β |
| Meta-analysis and imputation refines the association of 15q25 with smoking quantity. | Liu JZ et al. | β | 2010 | β |
| Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. | Kamens HM et al. | β | 2010 | β |
| Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. | Saccone NL et al. | β | 2010 | β |
| Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. | Chatterjee S et al. | β | 2010 | β |
| Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. | Erlich PM et al. | β | 2010 | β |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | β | 2010 | β |
| Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the FagerstrΓΆm test for nicotine dependence. | Wessel J et al. | β | 2010 | β |
| Risk gene variants for nicotine dependence: a success story in neuropsychiatric genetics with possible applications to drug development. | Winterer G | β | 2010 | β |
| The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. | Improgo MR et al. | β | 2010 | β |
| Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. | Sherva R et al. | β | 2010 | β |
| Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. | Zhang H et al. | β | 2010 | β |
| A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. | Yuferov V et al. | β | 2009 | β |
| Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. | Greenbaum L et al. | β | 2009 | β |
| Genetics of alcohol dependence. | Gelernter J et al. | β | 2009 | β |
| New insights into the genetics of addiction. | Li MD et al. | β | 2009 | β |
| Nicotine dependence and genetic variation in the nicotinic receptors. | Bierut LJ | β | 2009 | β |
| Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. | Lester HA et al. | β | 2009 | β |
| Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. | Wang JC et al. | β | 2009 | β |
| Role of genetic variants in the CHRNA5-CHRNA3-CHRNB4 cluster in nicotine dependence risk: importance of gene-environment interplay. | Greenbaum L et al. | β | 2009 | β |
| SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. | Hoft NR et al. | β | 2009 | β |
| The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation. | Kamens HM et al. | β | 2009 | β |
| The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. | Saccone NL et al. | β | 2009 | β |
| Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. | Chen X et al. | β | 2009 | β |
| Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. | Joslyn G et al. | β | 2008 | β |
| Genetics of smoking behavior and its consequences: the role of nicotinic acetylcholine receptors. | Thorgeirsson TE et al. | β | 2008 | β |
| Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer. | Wacholder S et al. | β | 2008 | β |
| Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. | Fowler CD et al. | β | 2008 | β |