Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions.
paper
Cited
Public
Unavailable
- Authors
- Kimpel, Mark W; Strother, Wendy N; McClintick, Jeanette N; Carr, Lucinda G; Liang, Tiebing; Edenberg, Howard J; McBride, William J
- Year
- 2007
- Journal
- Alcohol (Fayetteville, N.Y.)
- PMID
- 17517326
- DOI
- 10.1016/j.alcohol.2007.03.003
- PMCID
- PMC1976291
The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naΓ―ve adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. When examining the main effect of strain across regions, 296 genes were differentially expressed. Although the relatively small number of genes found significant within individual regions precluded a powerful analysis for over-represented Gene Ontology categories, the much larger list resulting from the main effect of strain analysis produced 17 over-represented categories (P < .05), including axon guidance, gliogenesis, negative regulation of programmed cell death, regulation of programmed cell death, regulation of synapse structure function, and transmission of nerve impulse. Co-citation analysis and graphing of significant genes revealed a network involved in the neuropeptide Y (NPY) transmitter system. Correlation of all significant genes with those located within previously established rat alcohol QTLs revealed that of the total of 313 significant genes, 71 are located within such QTLs. The many regional and overall gene expression differences between the iP and iNP rat lines may contribute to the divergent alcohol drinking phenotypes of these rats.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Chronic alcohol consumption sex-dependently affects IL-6 modulation of GABAergic synapses in the central amygdala of rhesus macaques. | Bajo M et al. | β | 2026 | β |
| Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice. | Mignogna KM et al. | β | 2024 | β |
| Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment. | Yao Z et al. | β | 2023 | β |
| IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder. | Borgonetti V et al. | β | 2023 | β |
| IL-6, but not TNF-Ξ±, response to alcohol cues and acute consumption associated with neural cue reactivity, craving, and future drinking in binge drinkers. | Blaine SK et al. | β | 2023 | β |
| Sex-dependent factors of alcohol and neuroimmune mechanisms. | Cruz B et al. | β | 2023 | β |
| Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel. | Lusk R et al. | β | 2022 | β |
| Genetic Mapping of Progressive Ethanol Consumption in the Diversity Outbred Mouse | Tatom Z et al. | β | 2022 | β |
| Changes in the Gene Expression Profiles of the Inferior Colliculus Following Unilateral Cochlear Ablation in Adult Rats. | Kil HK et al. | β | 2021 | β |
| Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways. | Johnstone AL et al. | β | 2021 | β |
| Effect of oral alcohol administration on plasma cytokine concentrations in heavy drinking individuals. | Lee MR et al. | β | 2021 | β |
| Genetically selected alcohol-preferring msP rats to study alcohol use disorder: Anything lost in translation? | Borruto AM et al. | β | 2021 | β |
| Constraining classifiers in molecular analysis: invariance and robustness. | Lausser L et al. | β | 2020 | β |
| Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders. | Duveau A et al. | β | 2020 | β |
| Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naΓ―ve rat offspring. | Mierzejewski P et al. | β | 2020 | β |
| Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity. | Popova M et al. | β | 2020 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Role of MyD88 in IL-1Ξ² and Ethanol Modulation of GABAergic Transmission in the Central Amygdala. | Bajo M et al. | β | 2019 | β |
| Advancing Pharmacotherapy Development from Preclinical Animal Studies. | Egli M | β | 2018 | β |
| A molecular mechanism for choosing alcohol over an alternative reward. | Augier E et al. | β | 2018 | β |
| Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders. | Khoja S et al. | β | 2018 | β |
| Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice. | Khoja S et al. | β | 2018 | β |
| Regional Differences and Similarities in the Brain Transcriptome for Mice Selected for Ethanol Preference From HS-CC Founders. | Colville AM et al. | β | 2018 | β |
| The Intertwined Roles of Circadian Rhythms and Neuronal Metabolism Fueling Drug Reward and Addiction. | Freyberg Z et al. | β | 2018 | β |
| Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. | Kalinin S et al. | β | 2018 | β |
| Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice. | Baker JA et al. | β | 2017 | β |
| Ethanol Consumption in Mice Lacking CD14, TLR2, TLR4, or MyD88. | Blednov YA et al. | β | 2017 | β |
| Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse. | Lacagnina MJ et al. | β | 2017 | β |
| Neuropeptide Y in Alcohol Addiction and Affective Disorders. | Thorsell A et al. | β | 2017 | β |
| P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology. | Stokes L et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder. | Roche DJ et al. | β | 2016 | β |
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | Bell RL et al. | β | 2016 | β |
| Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research. | Fritz BM et al. | β | 2016 | β |
| The neuroimmune transcriptome and alcohol dependence: potential for targeted therapies. | Warden A et al. | β | 2016 | β |
| Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks. | Osterndorff-Kahanek EA et al. | β | 2015 | β |
| Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking. | McClintick JN et al. | β | 2015 | β |
| Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. | Stankiewicz AM et al. | β | 2015 | β |
| XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. | Juraeva D et al. | β | 2015 | β |
| Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice. | Wyatt LR et al. | β | 2014 | β |
| Differential patterns of expression of neuropeptide Y throughout abstinence in outbred Swiss mice classified as susceptible or resistant to ethanol-induced locomotor sensitization. | de Pauli RF et al. | β | 2014 | β |
| Effects of Acute Prenatal Exposure to Ethanol on microRNA Expression are Ameliorated by Social Enrichment. | Ignacio C et al. | β | 2014 | β |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Genetic risk prediction and neurobiological understanding of alcoholism. | Levey DF et al. | β | 2014 | β |
| Genetics and genomics of alcohol sensitivity. | Morozova TV et al. | β | 2014 | β |
| Genetics of gene expression characterizes response to selective breeding for alcohol preference. | Hoffman PL et al. | β | 2014 | β |
| Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. | Blednov YA et al. | β | 2014 | β |
| P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. | Franklin KM et al. | β | 2014 | β |
| Performing integrative functional genomics analysis in GeneWeaver.org. | Jay JJ et al. | β | 2014 | β |
| Perspectives on the neuroscience of alcohol from the National Institute on Alcohol Abuse and Alcoholism. | Reilly MT et al. | β | 2014 | β |
| Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats. | McBride WJ et al. | β | 2013 | β |
| Chromatin remodeling--a novel strategy to control excessive alcohol drinking. | Warnault V et al. | β | 2013 | β |
| Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption. | McBride WJ et al. | β | 2013 | β |
| Genetically selected alcohol preferring rats to model human alcoholism. | Ciccocioppo R | β | 2013 | β |
| Neurobiological signatures of alcohol dependence revealed by protein profiling. | Gorini G et al. | β | 2013 | β |
| Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin. | Bortolato M et al. | β | 2013 | β |
| Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. | Davies DL et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors. | Popova M et al. | β | 2013 | β |
| Analysis of functional and pathway association of differential co-expressed genes: a case study in drug addiction. | Li ZH et al. | β | 2012 | β |
| Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice. | Melendez RI et al. | β | 2012 | β |
| Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption. | McBride WJ et al. | β | 2012 | β |
| Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain. | Contet C | β | 2012 | β |
| Ivermectin reduces alcohol intake and preference in mice. | Yardley MM et al. | β | 2012 | β |
| Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study. | Zhao Z et al. | β | 2012 | β |
| Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. | Blednov YA et al. | β | 2012 | β |
| The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. | Morozova TV et al. | β | 2012 | β |
| Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats. | Sari Y et al. | β | 2011 | β |
| Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference. | Landgren S et al. | β | 2011 | β |
| Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. | Mulligan MK et al. | β | 2011 | β |
| Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening. | Gorini G et al. | β | 2011 | β |
| Pharmacologically targeting the P2rx4 gene on maintenance and reinstatement of alcohol self-administration in rats. | Kosten TA | β | 2011 | β |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | β | 2010 | β |
| Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking. | McBride WJ et al. | β | 2010 | β |
| Fine mapping and expression of candidate genes within the chromosome 10 QTL region of the high and low alcohol-drinking rats. | Bice PJ et al. | β | 2010 | β |
| Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. | BjΓΆrk K et al. | β | 2010 | β |
| Rat genomics applied to psychiatric research. | Moisan MP et al. | β | 2010 | β |
| What aspects of human alcohol use disorders can be modeled using selectively bred rat lines? | Froehlich JC | β | 2010 | β |
| Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. | Hurley JH et al. | β | 2009 | β |
| Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study. | McBride WJ et al. | β | 2009 | β |
| Excitatory and inhibitory synapses in neuropeptide Y-expressing striatal interneurons. | Partridge JG et al. | β | 2009 | β |
| From QTL to candidate gene: a genetic approach to alcoholism research. | Spence JP et al. | β | 2009 | β |
| Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption. | Bell RL et al. | β | 2009 | β |
| The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. | Walker MW et al. | β | 2009 | β |
| Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. | Rodd ZA et al. | β | 2008 | β |
| Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice. | Bice PJ et al. | β | 2008 | β |
| Genetic factors influencing alcohol dependence. | Mayfield RD et al. | β | 2008 | β |
| Neuropeptide Y activates a G-protein-coupled inwardly rectifying potassium current and dampens excitability in the lateral amygdala. | Sosulina L et al. | β | 2008 | β |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | β | 2008 | β |