Detecting gene-environment interactions in genome-wide association data.
- Authors
- Engelman, Corinne D; Baurley, James W; Chiu, Yen-Feng; Joubert, Bonnie R; Lewinger, Juan P; Maenner, Matthew J; Murcray, Cassandra E; Shi, Gang; Gauderman, W James
- Year
- 2009
- Journal
- Genetic epidemiology
- PMID
- 19924704
- DOI
- 10.1002/gepi.20475
- PMCID
- PMC2924567
Despite the importance of gene-environment (GxE) interactions in the etiology of common diseases, little work has been done to develop methods for detecting these types of interactions in genome-wide association study data. This was the focus of Genetic Analysis Workshop 16 Group 10 contributions, which introduced a variety of new methods for the detection of GxE interactions in both case-control and family-based data using both cross-sectional and longitudinal study designs. Many of these contributions detected significant GxE interactions. Although these interactions have not yet been confirmed, the results suggest the importance of testing for interactions. Issues of sample size, quantifying the environmental exposure, longitudinal data analysis, family-based analysis, selection of the most powerful analysis method, population stratification, and computational expense with respect to testing GxE interactions are discussed.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Gene-environment interaction in psychological traits and disorders. | 2011 | 21219196 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in <i>Camelus bactrianus</i>. | Guo F et al. | — | 2020 | → |
| Effect of population stratification on SNP-by-environment interaction. | An J et al. | — | 2019 | → |
| Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next? | Esposito G et al. | — | 2018 | → |
| A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions. | Waken RJ et al. | — | 2017 | → |
| Association of single nucleotide polymorphism rs2076185 in chromosome 6P24.1 with premature coronary artery diseases in Chinese Han population. | Liu X et al. | — | 2016 | → |
| Gene-by-Environment Interactions in Pancreatic Cancer: Implications for Prevention. | Jansen RJ et al. | — | 2015 | → |
| The differential view of genotype-phenotype relationships. | Orgogozo V et al. | — | 2015 | → |
| Molecular genetic gene-environment studies using candidate genes in schizophrenia: a systematic review. | Modinos G et al. | — | 2013 | → |
| Challenges and opportunities in genome-wide environmental interaction (GWEI) studies. | Aschard H et al. | — | 2012 | → |
| Frontiers in occupational and environmental lung disease research. | Muzaffar SAF et al. | — | 2012 | → |
| Genetics of nonsyndromic orofacial clefts. | Rahimov F et al. | — | 2012 | → |
| Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. | Wei S et al. | — | 2012 | → |
| Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2. | Pinelli M et al. | — | 2012 | → |
| An Interdisciplinary Approach to Studying Gene-Environment Interactions: From Twin Studies to Gene Identification and Back. | Dick DM | — | 2011 | → |
| Gene-environment interaction in psychological traits and disorders. | Dick DM | — | 2011 | → |