Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients.
paper
Cited
Public
- Authors
- Nemoda, Zsofia; Lyons-Ruth, Karlen; Szekely, Anna; Bertha, Eszter; Faludi, Gabor; Sasvari-Szekely, Maria
- Year
- 2010
- Journal
- Behavioral and brain functions : BBF
- PMID
- 20205808
- DOI
- 10.1186/1744-9081-6-4
- PMCID
- PMC2823641
BACKGROUND: In the development of borderline personality disorder (BPD) both genetic and environmental factors have important roles. The characteristic affective disturbance and impulsive aggression are linked to imbalances in the central serotonin system, and most of the genetic association studies focused on serotonergic candidate genes. However, the efficacy of dopamine D2 receptor (DRD2) blocking antipsychotic drugs in BPD treatment also suggests involvement of the dopamine system in the neurobiology of BPD. METHODS: In the present study we tested the dopamine dysfunction hypothesis of impulsive self- and other-damaging behaviors: borderline and antisocial traits were assessed by Structured Clinical Interview for Diagnosis (SCID) for DSM-IV in a community-based US sample of 99 young adults from low-to-moderate income families. For the BPD trait analyses a second, independent group was used consisting of 136 Hungarian patients with bipolar or major depressive disorder filling out self-report SCID-II Screen questionnaire. In the genetic association analyses the previously indicated polymorphisms of the catechol-O-methyl-transferase (COMT Val158Met) and dopamine transporter (DAT1 40 bp VNTR) were studied. In addition, candidate polymorphisms of the DRD2 and DRD4 dopamine receptor genes were selected from the impulsive behavior literature. RESULTS: The DRD2 TaqI B1-allele and A1-allele were associated with borderline traits in the young adult sample (p = 0.001, and p = 0.005, respectively). Also, the DRD4 -616 CC genotype appeared as a risk factor (p = 0.02). With severity of abuse accounted for in the model, genetic effects of the DRD2 and DRD4 polymorphisms were still significant (DRD2 TaqIB: p = 0.001, DRD2 TaqIA: p = 0.008, DRD4 -616 C/G: p = 0.002). Only the DRD4 promoter finding was replicated in the independent sample of psychiatric inpatients (p = 0.007). No association was found with the COMT and DAT1 polymorphisms. CONCLUSIONS: Our results of the two independent samples suggest a possible involvement of the DRD4 -616 C/G promoter variant in the development of BPD traits. In addition, an association of the DRD2 genetic polymorphisms with impulsive self-damaging behaviors was also demonstrated.
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21–36 of 36
| Name | Type |
|---|---|
| 120 bp duplication in 5' UTR local | variant |
| 48 bp VNTR in exon III local | variant |
| -521 C/T SNP local | variant |
| -616 CC genotype local | variant |
| -616 C/G SNP local | variant |
| A~C~T haplotype local | variant |
| addiction | phenotype |
| ADHD | phenotype |
| African American | cohort |
| Alcohol and substance misuse local | phenotype |
| alcoholism | phenotype |
| ANKK1 | gene |
| Antipsychotic drugs local | drug |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| APD traits local | phenotype |
| At-risk sample local | cohort |
| At-risk US young adults local | cohort |
| at-risk young adults local | cohort |
| B1~A1 haplotype local | variant |
| behavioral inhibition | phenotype |
| borderline personality disorder | phenotype |
| Borderline personality disorder traits local | phenotype |
| BPD | phenotype |
| BPD traits local | phenotype |
| brain | anatomy |
| C957T local | variant |
| Caucasian subgroup local | cohort |
| child externalizing behavior local | phenotype |
| childhood conduct disorder | phenotype |
| COMT | gene |
| COMT Met/Met genotype local | variant |
| COMT polymorphism | gene |
| COMT Val158Met | gene |
| COMT Val158Met (rs4680) local | variant |
| conduct disorder | phenotype |
| Crossectional families local | cohort |
| D2 receptor density | drug |
| DAT1 10-repeat allele local | variant |
| DAT1 11-repeat allele local | variant |
| DAT1 12-repeat allele local | variant |
| DAT1 3-repeat allele local | variant |
| DAT1 40 bp VNTR local | variant |
| DAT1 40bp VNTR local | variant |
| DAT1 6-repeat allele local | variant |
| DAT1 8-repeat allele local | variant |
| DAT1 9 local | variant |
| DAT1 9+ local | variant |
| DAT1 9-absent group local | cohort |
| DAT1 9-present group local | cohort |
| DAT1 9-repeat allele local | variant |
| DAT1 9-repeat VNTR allele local | variant |
| DAT1 polymorphism local | variant |
| DAT1 VNTR | variant |
| decreased postsynaptic dopamine receptor density local | phenotype |
| depression | phenotype |
| dopamine | drug |
| Dopaminergic polymorphisms local | variant |
| DRD2 | gene |
| DRD2 -141C Del local | variant |
| DRD2 A1+ local | variant |
| DRD2 A1-allele local | variant |
| DRD2 A1+ group local | cohort |
| DRD2 A2 allele local | variant |
| DRD2/ANKK1 A1-allele local | variant |
| DRD2 antagonist local | drug |
| DRD2 availability local | phenotype |
| DRD2 B1 allele local | variant |
| DRD2 B1-allele local | variant |
| DRD2 B2 allele local | variant |
| DRD2 B+ group local | cohort |
| DRD2 density local | phenotype |
| DRD2 TaqIA | variant |
| DRD2 TaqIA (rs1800497) local | variant |
| DRD2 TaqIB local | variant |
| DRD2 TaqI B1 allele local | variant |
| DRD2 TaqIB (rs1079597) local | variant |
| DRD2 TaqIB SNP local | variant |
| DRD2 TaqID local | variant |
| DRD2 TaqID (rs1800498) local | variant |
| DRD4 | gene |
| DRD4 120bp duplication local | variant |
| DRD4 48bp VNTR local | variant |
| DRD4 -521 CC+CT group local | cohort |
| DRD4 -521 C>T promoter SNP local | variant |
| DRD4 -521 C/T (rs1800955) local | variant |
| DRD4 -521 C/T SNP local | variant |
| DRD4 -521 C>T SNP local | variant |
| DRD4 -521 T allele local | variant |
| DRD4 -521 TT group local | cohort |
| DRD4 -616 C local | variant |
| DRD4 -616C~-521T haplotype local | variant |
| DRD4 -616 C allele local | variant |
| DRD4 -616 CC group local | cohort |
| DRD4 -616 C/G local | variant |
| DRD4 -616 CG+GG group local | cohort |
| DRD4 -616 C>G promoter SNP local | variant |
| DRD4 -616 C/G (rs747302) local | variant |
| DRD4 -616 C/G SNP local | variant |
| DRD4 -616 C>G SNP local | variant |
| DRD4 7-absent group local | cohort |
| DRD4 7-present group local | cohort |
| DRD4 7-repeat allele | variant |
| DRD4 7-repeat VNTR allele local | variant |
| DRD4 promoter -521 C/T SNP local | variant |
| DRD4 promoter -616 C/G SNP local | variant |
| DRD4 VNTR | variant |
| Emotional disturbance | phenotype |
| healthy controls | cohort |
| higher striatal dopamine receptor density local | phenotype |
| Hispanic | phenotype |
| Hungarian clinical sample local | cohort |
| Hungarian control sample local | cohort |
| Hungarian depressive patients local | cohort |
| Hungarian inpatient psychiatric sample local | cohort |
| Hungarian patient sample local | cohort |
| Hungarian patients with mood disorder local | cohort |
| Hungarian population local | cohort |
| Hungarian psychiatric patient population local | cohort |
| Hungarian psychiatric patients local | cohort |
| Hungarian psychiatric sample local | cohort |
| impulsive phenotype | phenotype |
| Impulsive self- and other-damaging behaviors local | phenotype |
| Impulsive self-damaging behaviors local | phenotype |
| impulsivity | phenotype |
| Independent Caucasian population local | cohort |
| Independent replication sample local | cohort |
| Intense and unstable relationships local | phenotype |
| Longitudinal attachment study local | cohort |
| Low educational or occupational status local | phenotype |
| Low family socioeconomic status local | phenotype |
| low-income young adults local | cohort |
| Low-to-moderate income families local | phenotype |
| maternal insensitivity local | phenotype |
| Mesolimbic dopamine reward system local | anatomy |
| mood disorders | phenotype |
| mothers | cohort |
| non-clinical Hungarian sample local | cohort |
| non-Hispanic Caucasian subgroup local | cohort |
| norepinephrine | drug |
| novelty seeking | phenotype |
| nucleus accumbens | anatomy |
| Other Personality Disorder local | phenotype |
| pair bonding | phenotype |
| personality disorders | phenotype |
| positive parenting | phenotype |
| prefrontal cortex | anatomy |
| psychiatric disorder(s) local | phenotype |
| psychiatric patients local | cohort |
| reward-related impulsivity endophenotype local | phenotype |
| reward-related ventral striatum reactivity local | phenotype |
| rs273849 local | variant |
| self-reported impulsivity | phenotype |
| serotonin | drug |
| severity of abuse local | phenotype |
| SLC6A3 | gene |
| striatum | anatomy |
| substance abuse | phenotype |
| Suicidal or self-mutilating behavior local | phenotype |
| suicide | phenotype |
| TaqI A1 allele local | variant |
| TaqIA polymorphism local | variant |
| TaqIB local | variant |
| TaqIB polymorphism local | variant |
| TaqID local | variant |
| two samples local | cohort |
| US at-risk young adults local | cohort |
| US community-based sample of 99 young adults local | cohort |
| US sample local | cohort |
| US young adult sample local | cohort |
| ventral striatum | anatomy |
| White | phenotype |
| Young adult cohort | cohort |
| Young adult follow-up study local | cohort |
| young adults | cohort |
| young adults of low socioeconomic status local | cohort |
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