Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.
- Authors
- Johnson, Eric O; Chen, Li-Shiun; Breslau, Naomi; Hatsukami, Dorothy; Robbins, Tania; Saccone, Nancy L; Grucza, Richard A; Bierut, Laura J
- Year
- 2010
- Journal
- Addiction (Abingdon, England)
- PMID
- 20840187
- DOI
- 10.1111/j.1360-0443.2010.03074.x
- PMCID
- PMC2970633
BACKGROUND: Peer smoking provides a socially reinforcing context of friends' encouragement and approval that contributes to smoking behavior. Twin studies show correlations and interactions between peer substance use and genetic liability for substance use. However, none examined specific genes. Here we test the hypothesis that the nicotinic receptor genes CHRNA5 (rs16969968), CHRNA3 (rs578776), CHRNB3 (rs13277254) and CHRND (rs12466358) modify the risk for nicotine dependence associated with peer smoking. METHODS: Cases of current nicotine dependence [Fagerström Test for Nicotine Dependence (FTND)≥ 4] and smoking-exposed (smoked 100+ cigarettes life-time), but non-dependent controls (life-time FTND= 0) came from the Collaborative Genetic Study of Nicotine Dependence (n=2038). Peer smoking was assessed retrospectively for grades 9-12. RESULTS: Peer smoking and the four single nucleotide polymorphisms (SNPs) were associated with nicotine dependence. A statistically significant interaction was found between peer smoking and rs16969968 (P=0.0077). Overall risk of nicotine dependence was highest for the rs16969968 AA genotype. However, variance in nicotine dependence attributable to peer smoking was substantially lower among those with the AA genotype at rs16969968 than the lower-risk genotypes: AA=2.5%, GA/AG=11.2%, GG=14.2%; P≤ 0.004. CONCLUSIONS: Peer smoking had a substantially lower effect on nicotine dependence among those with the high-risk AA genotype at the functional SNP rs16969968 (CHRNA5) than among those with lower-risk genotypes. Such results highlight the possibility that given drug exposure those with specific genetic risks may be less affected by social contexts and intervention strategies focused upon social factors could have less influence on those at highest genetic risk.
No figures extracted from this document.
No entities extracted from this document yet.
No uploaded files.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Discovery and characterization of gene-by-environment and epistatic genetic effects in a vertebrate model. | Welz B et al. | — | 2026 | → |
| Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer. | Peng T et al. | — | 2026 | → |
| Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model | Welz B et al. | — | 2025 | — |
| Adverse physiological effects of smoking cessation on the gastrointestinal tract: A review. | Mahyoub MA et al. | — | 2023 | → |
| Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies. | Goldberg LR et al. | — | 2022 | → |
| Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia. | Shi J et al. | — | 2021 | → |
| The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico. | Martínez-Magaña JJ et al. | — | 2020 | → |
| Determining population stratification and subgroup effects in association studies of rare genetic variants for nicotine dependence. | Hsieh AR et al. | — | 2019 | → |
| Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function. | Goldberg LR et al. | — | 2019 | → |
| Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence. | Garcia-Rivas V et al. | — | 2019 | → |
| Tobacco Smoking: Risk to Develop Addiction, Chronic Obstructive Pulmonary Disease, and Lung Cancer. | Santoro A et al. | — | 2019 | → |
| Testing Familial Transmission of Smoking With Two Different Research Designs. | Treur JL et al. | — | 2018 | → |
| Developmentally Specific Associations Between CNR1 Genotype and Cannabis Use Across Emerging Adulthood. | Ashenhurst JR et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | Wen L et al. | — | 2016 | → |
| Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions. | Yang J et al. | — | 2016 | → |
| Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. | Wen L et al. | — | 2016 | → |
| Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. | Zuo L et al. | — | 2016 | → |
| A preliminary exploration of college smokers' reactions to nicotine dependence genetic susceptibility feedback. | Lipkus IM et al. | — | 2015 | → |
| Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study. | Buczkowski K et al. | — | 2015 | → |
| CHRNA5 polymorphisms and risk of lung cancer in Chinese Han smokers. | Huang CY et al. | — | 2015 | → |
| Exon sequencing identifies a novel CHRNA3-CHRNA5-CHRNB4 variant that increases the risk for chronic obstructive pulmonary disease. | Zhao Z et al. | — | 2015 | → |
| Risky Business: Pathways to Progress in Biologically Informed Studies of Psychopathology. | Agrawal A et al. | — | 2015 | → |
| A glimpse into the future - Personalized medicine for smoking cessation. | Bierut LJ et al. | — | 2014 | → |
| Genetics and smoking. | Loukola A et al. | — | 2014 | → |
| Initial responses to the first dose of nicotine in novel smokers: the role of exposure to environmental smoking and genetic predisposition. | Schuck K et al. | — | 2014 | → |
| The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | — | 2014 | → |
| Variation in the α 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content. | Macqueen DA et al. | — | 2014 | → |
| A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. | Zayats T et al. | — | 2013 | → |
| Adolescent peer choice and cigarette smoking: evidence of active gene-environment correlation? | Wills AG et al. | — | 2013 | → |
| Genetics in population health science: strategies and opportunities. | Belsky DW et al. | — | 2013 | → |
| Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. | Belsky DW et al. | — | 2013 | → |
| Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. | Broms U et al. | — | 2012 | → |
| Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males. | Xie P et al. | — | 2012 | → |
| Effects of cumulative stress and impulsivity on smoking status. | Ansell EB et al. | — | 2012 | → |
| From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. | Ware JJ et al. | — | 2012 | → |
| Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors. | Tammimäki A et al. | — | 2012 | → |
| Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. | Hartz SM et al. | — | 2012 | → |
| Social determinants of smoking behavior: the Healthy Twin Study, Korea. | Kim YS et al. | — | 2012 | → |
| Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation. | Chassin L et al. | — | 2012 | → |
| The genetics of addiction-a translational perspective. | Agrawal A et al. | — | 2012 | → |
| Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. | Kapoor M et al. | — | 2012 | → |
| Genome-wide association study of smoking behaviours in patients with COPD. | Siedlinski M et al. | — | 2011 | → |