The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods.
paper
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- Authors
- Penninx, Brenda W J H; Beekman, Aartjan T F; Smit, Johannes H; Zitman, Frans G; Nolen, Willem A; Spinhoven, Philip; Cuijpers, Pim; De Jong, Peter J; Van Marwijk, Harm W J; Assendelft, Willem J J; Van Der Meer, Klaas; Verhaak, Peter; Wensing, Michel; De Graaf, Ron; Hoogendijk, Witte J; Ormel, Johan; Van Dyck, Richard; NESDA Research Consortium
- Year
- 2008
- Journal
- International journal of methods in psychiatric research
- PMID
- 18763692
- DOI
- 10.1002/mpr.256
- PMCID
- PMC6878352
The Netherlands Study of Depression and Anxiety (NESDA) is a multi-site naturalistic cohort study to: (1) describe the long-term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and psychosocial research paradigms within an epidemiological approach in order to examine (interaction between) predictors of the long-term course and consequences. Its design is an eight-year longitudinal cohort study among 2981 participants aged 18 through 65 years. The sample consists of 1701 persons with a current (six-month recency) diagnosis of depression and/or anxiety disorder, 907 persons with life-time diagnoses or at risk because of a family history or subthreshold depressive or anxiety symptoms, and 373 healthy controls. Recruitment took place in the general population, in general practices (through a three-stage screening procedure), and in mental health organizations in order to recruit persons reflecting various settings and developmental stages of psychopathology. During a four-hour baseline assessment including written questionnaires, interviews, a medical examination, a cognitive computer task and collection of blood and saliva samples, extensive information was gathered about key (mental) health outcomes and demographic, psychosocial, clinical, biological and genetic determinants. Detailed assessments will be repeated after one, two, four and eight years of follow-up. The findings of NESDA are expected to provide more detailed insight into (predictors of) the long-term course of depressive and anxiety disorders in adults. Besides its scientific relevance, this may contribute to more effective prevention and treatment of depressive and anxiety disorders.
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| Associations of financial strain and income with depressive and anxiety disorders. | Dijkstra-Kersten SM et al. | β | 2015 | β |
| Childhood maltreatment modifies the relationship of depression with hippocampal volume. | Gerritsen L et al. | β | 2015 | β |
| Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time. | Bus BA et al. | β | 2015 | β |
| Cognitive reactivity, self-depressed associations, and the recurrence of depression. | Elgersma HJ et al. | β | 2015 | β |
| Cognitive vulnerability and implicit emotional processing: imbalance in frontolimbic brain areas? | Groenewold NA et al. | β | 2015 | β |
| Common rather than unique aspects of repetitive negative thinking are related to depressive and anxiety disorders and symptoms. | Spinhoven P et al. | β | 2015 | β |
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| Depression and anxiety in patients with and without same-sex attraction: differences in clinical expression, lifestyle factors, and vulnerability indicators. | Bos HM et al. | β | 2015 | β |
| Depression, anxiety and 6-year risk of cardiovascular disease. | Seldenrijk A et al. | β | 2015 | β |
| Depressive and anxiety disorders: Associated with losing or gaining weight over 2 years? | de Wit LM et al. | β | 2015 | β |
| Determinants of hair cortisol and hair cortisone concentrations in adults. | Staufenbiel SM et al. | β | 2015 | β |
| Differential associations of specific depressive and anxiety disorders with somatic symptoms. | Bekhuis E et al. | β | 2015 | β |
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| Discovery of serum biomarkers predicting development of a subsequent depressive episode in social anxiety disorder. | Gottschalk MG et al. | β | 2015 | β |
| Disturbances in Hypothalamic-Pituitary-Adrenal Axis and Immunological Activity Differentiating between Unipolar and Bipolar Depressive Episodes. | Becking K et al. | β | 2015 | β |
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| Effectiveness of the implementation of guidelines for anxiety disorders in specialized mental health care. | van Dijk MK et al. | β | 2015 | β |
| Effect of variation in BDNF Val(66)Met polymorphism, smoking, and nicotine dependence on symptom severity of depressive and anxiety disorders. | Jamal M et al. | β | 2015 | β |
| Glucocorticoid and mineralocorticoid receptor polymorphisms and recurrence of major depressive disorder. | Hardeveld F et al. | β | 2015 | β |
| Heritability of liver enzyme levels estimated from genome-wide SNP data. | van Beek JH et al. | β | 2015 | β |
| IDENTIFYING PANIC DISORDER SUBTYPES USING FACTOR MIXTURE MODELING. | Pattyn T et al. | β | 2015 | β |
| Increased prevalence of ECG markers for sudden cardiac arrest in refractory epilepsy. | Lamberts RJ et al. | β | 2015 | β |
| In Silico Post Genome-Wide Association Studies Analysis of C-Reactive Protein Loci Suggests an Important Role for Interferons. | Vaez A et al. | β | 2015 | β |
| Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study. | Vimaleswaran KS et al. | β | 2015 | β |
| Investigating distinct and common abnormalities of resting-state functional connectivity in depression, anxiety, and their comorbid states. | Pannekoek JN et al. | β | 2015 | β |
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| Long-lasting effects of affective disorders and childhood trauma on dispositional optimism. | Broekhof R et al. | β | 2015 | β |
| Long-term work disability and absenteeism in anxiety and depressive disorders. | Hendriks SM et al. | β | 2015 | β |
| Metabolic syndrome in patients with bipolar disorder: comparison with major depressive disorder and non-psychiatric controls. | Silarova B et al. | β | 2015 | β |
| Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment. | Vinkers CH et al. | β | 2015 | β |
| Neurophysiological effects of sleep deprivation in healthy adults, a pilot study. | Klumpers UM et al. | β | 2015 | β |
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| Pathophysiology of major depressive disorder: mechanisms involved in etiology are not associated with clinical progression. | Verduijn J et al. | β | 2015 | β |
| Salivary Testosterone Is Consistently and Positively Associated with Extraversion: Results from The Netherlands Study of Depression and Anxiety. | Smeets-Janssen MM et al. | β | 2015 | β |
| Serum proteomic profiling of major depressive disorder. | Bot M et al. | β | 2015 | β |
| Sleep duration, insomnia, and markers of systemic inflammation: results from the Netherlands Study of Depression and Anxiety (NESDA). | Prather AA et al. | β | 2015 | β |
| Somatisation as a risk factor for incident depression and anxiety. | Dijkstra-Kersten SM et al. | β | 2015 | β |
| Symptom dimensions of affective disorders in migraine patients. | Louter MA et al. | β | 2015 | β |
| Taking Personalized Medicine Seriously: Biomarker Approaches in Phase IIb/III Studies in Major Depression and Schizophrenia. | Murck H et al. | β | 2015 | β |
| The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects. | Peyrot WJ et al. | β | 2015 | β |
| The association between somatization and disability in primary care patients. | van der Leeuw G et al. | β | 2015 | β |
| The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length. | Verhoeven JE et al. | β | 2015 | β |
| The associations of depression and hypertension with brain volumes: Independent or interactive? | Meurs M et al. | β | 2015 | β |
| The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores. | Mbarek H et al. | β | 2015 | β |
| The longitudinal joint effect of obesity and major depression on work performance impairment. | Nigatu YT et al. | β | 2015 | β |
| The role of frailty in the association between depression and somatic comorbidity: results from baseline data of an ongoing prospective cohort study. | Collard RM et al. | β | 2015 | β |
| The similarity of the structure of DSM-IV criteria for major depression in depressed women from China, the United States and Europe. | Kendler KS et al. | β | 2015 | β |
| Trait rumination predicts onset of Post-Traumatic Stress Disorder through trauma-related cognitive appraisals: A 4-year longitudinal study. | Spinhoven P et al. | β | 2015 | β |
| Watchful waiting for subthreshold depression and anxiety in visually impaired older adults. | van der Aa HP et al. | β | 2015 | β |
| Where You Live May Make You Old: The Association between Perceived Poor Neighborhood Quality and Leukocyte Telomere Length. | Park M et al. | β | 2015 | β |
| Why visually impaired older adults often do not receive mental health services: the patient's perspective. | van der Aa HP et al. | β | 2015 | β |
| A comprehensive assessment protocol including patient reported outcomes, physical tests, and biological sampling in newly diagnosed patients with head and neck cancer: is it feasible? | van Nieuwenhuizen AJ et al. | β | 2014 | β |
| A longitudinal study of experiential avoidance in emotional disorders. | Spinhoven P et al. | β | 2014 | β |
| A new method for constructing networks from binary data. | van Borkulo CD et al. | β | 2014 | β |
| An examination of generalized anxiety disorder and dysthymic disorder by latent class analysis. | Rhebergen D et al. | β | 2014 | β |
| Antidepressants differentially related to 1,25-(OH)β vitamin Dβ and 25-(OH) vitamin Dβ in late-life depression. | Oude Voshaar RC et al. | β | 2014 | β |
| Anxiety disorders and onset of cardiovascular disease: the differential impact of panic, phobias and worry. | Batelaan NM et al. | β | 2014 | β |
| Applying polygenic risk scores to postpartum depression. | Byrne EM et al. | β | 2014 | β |
| Basal inflammation and innate immune response in chronic multisite musculoskeletal pain. | Generaal E et al. | β | 2014 | β |
| BDNF in late-life depression: effect of SSRI usage and interaction with childhood abuse. | van der Meij A et al. | β | 2014 | β |
| Bipolar polygenic loading and bipolar spectrum features in major depressive disorder. | Wiste A et al. | β | 2014 | β |
| Brugada syndrome ECG is highly prevalent in schizophrenia. | Blom MT et al. | β | 2014 | β |
| Comorbidity of PTSD in anxiety and depressive disorders: prevalence and shared risk factors. | Spinhoven P et al. | β | 2014 | β |
| Cue reactivity is associated with duration and severity of alcohol dependence: an FMRI study. | Sjoerds Z et al. | β | 2014 | β |
| Disability in anxiety disorders. | Hendriks SM et al. | β | 2014 | β |
| Disorder-specific cognitive profiles in major depressive disorder and generalized anxiety disorder. | Hendriks SM et al. | β | 2014 | β |
| Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? | Quak J et al. | β | 2014 | β |
| Dysregulated physiological stress systems and accelerated cellular aging. | RΓ©vΓ©sz D et al. | β | 2014 | β |
| Effect of polygenic risk scores on depression in childhood trauma. | Peyrot WJ et al. | β | 2014 | β |
| Further confirmation of the association between anxiety and CTNND2: replication in humans. | Nivard MG et al. | β | 2014 | β |
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| Genome-wide analyses of borderline personality features. | Lubke GH et al. | β | 2014 | β |
| Hemoglobin levels in persons with depressive and/or anxiety disorders. | Lever-van Milligen BA et al. | β | 2014 | β |
| Heritability and genomics of gene expression in peripheral blood. | Wright FA et al. | β | 2014 | β |
| High dose benzodiazepines prolong reaction times in chronic users who have major depressive and/or anxiety disorders. | Manthey L et al. | β | 2014 | β |
| Hypoactive medial prefrontal cortex functioning in adults reporting childhood emotional maltreatment. | van Harmelen AL et al. | β | 2014 | β |
| Identifying genetic variants for heart rate variability in the acetylcholine pathway. | Riese H et al. | β | 2014 | β |
| Implicit and explicit self-associations in bipolar disorder: a comparison with healthy controls and unipolar depressive disorder. | Jabben N et al. | β | 2014 | β |
| Implicit associations in social anxiety disorder: the effects of comorbid depression. | Wong J et al. | β | 2014 | β |
| Increased cortisol awakening response was associated with time to recurrence of major depressive disorder. | Hardeveld F et al. | β | 2014 | β |
| Inflammatory and metabolic dysregulation and the 2-year course of depressive disorders in antidepressant users. | Vogelzangs N et al. | β | 2014 | β |
| Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing. | Opmeer EM et al. | β | 2014 | β |
| Low serum BDNF levels in depressed patients cannot be attributed to individual depressive symptoms or symptom cluster. | Bus BA et al. | β | 2014 | β |
| Maintenance use of antidepressants in Dutch general practice: non-guideline concordant. | Piek E et al. | β | 2014 | β |
| Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. | Verhoeven JE et al. | β | 2014 | β |
| Major depressive disorder subtypes to predict long-term course. | van Loo HM et al. | β | 2014 | β |
| Methylenetetrahydrofolate reductase (MTHFR) genetic variation and major depressive disorder prognosis: A five-year prospective cohort study of primary care attendees. | Bousman CA et al. | β | 2014 | β |
| Neuroticism and extraversion are associated with amygdala resting-state functional connectivity. | Aghajani M et al. | β | 2014 | β |
| On the connection between level of education and the neural circuitry of emotion perception. | Demenescu LR et al. | β | 2014 | β |
| Pain and the onset of depressive and anxiety disorders. | Gerrits MMJG et al. | β | 2014 | β |
| Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders. | Gerrits MM et al. | β | 2014 | β |
| Physical frailty: vulnerability of patients suffering from late-life depression. | Collard RM et al. | β | 2014 | β |
| Plasma cotinine levels in cigarette smokers: impact of mental health and other correlates. | Bot M et al. | β | 2014 | β |
| Predictors of the onset of manic symptoms and a (hypo)manic episode in patients with major depressive disorder. | Boschloo L et al. | β | 2014 | β |
| Reciprocal effects of stable and temporary components of neuroticism and affective disorders: results of a longitudinal cohort study. | Spinhoven P et al. | β | 2014 | β |
| Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders. | Generaal E et al. | β | 2014 | β |
| Repetitive negative thinking as a transdiagnostic factor in depression and anxiety: A conceptual replication. | Drost J et al. | β | 2014 | β |
| Reporting suicide attempts: consistency and its determinants in a large mental health study. | Eikelenboom M et al. | β | 2014 | β |
| Response inhibition in alcohol-dependent patients and patients with depression/anxiety: a functional magnetic resonance imaging study. | Sjoerds Z et al. | β | 2014 | β |
| Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. | Korhonen T et al. | β | 2014 | β |
| Self-attributed seasonality of mood and behavior: a report from the Netherlands study of depression and anxiety. | Winthorst WH et al. | β | 2014 | β |
| Sex differences in the human peripheral blood transcriptome. | Jansen R et al. | β | 2014 | β |
| Stress exposure across the life span cumulatively increases depression risk and is moderated by neuroticism. | Vinkers CH et al. | β | 2014 | β |
| The association between low vitamin D and depressive disorders. | Milaneschi Y et al. | β | 2014 | β |
| The association of depression and anxiety with pain: a study from NESDA. | de Heer EW et al. | β | 2014 | β |
| The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels. | van Dongen J et al. | β | 2014 | β |
| The effect of FTO rs9939609 on major depression differs across MDD subtypes. | Milaneschi Y et al. | β | 2014 | β |
| The effects of co-morbidity in defining major depression subtypes associated with long-term course and severity. | Wardenaar KJ et al. | β | 2014 | β |
| The four-year course of major depressive disorder: the role of staging and risk factor determination. | Boschloo L et al. | β | 2014 | β |
| The impact of lifestyle factors on the 2-year course of depressive and/or anxiety disorders. | Boschloo L et al. | β | 2014 | β |
| The metabolic syndrome and related characteristics in major depression: inpatients and outpatients compared: metabolic differences across treatment settings. | Luppino FS et al. | β | 2014 | β |
| The use of symptom dimensions to investigate the longitudinal effects of life events on depressive and anxiety symptomatology. | Wardenaar KJ et al. | β | 2014 | β |
| Trajectories of functioning after remission from anxiety disorders: 2-year course and outcome predictors. | Iancu SC et al. | β | 2014 | β |
| ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder. | de Klerk OL et al. | β | 2013 | β |
| Aberrant limbic and salience network resting-state functional connectivity in panic disorder without comorbidity. | Pannekoek JN et al. | β | 2013 | β |
| Amygdala activation and its functional connectivity during perception of emotional faces in social phobia and panic disorder. | Demenescu LR et al. | β | 2013 | β |
| Anxiety and depression are associated with migraine and pain in general: an investigation of the interrelationships. | Ligthart L et al. | β | 2013 | β |
| Anxiety disorders and inflammation in a large adult cohort. | Vogelzangs N et al. | β | 2013 | β |
| Are childhood and adult life adversities differentially associated with specific symptom dimensions of depression and anxiety? Testing the tripartite model. | van Veen T et al. | β | 2013 | β |
| Association between autozygosity and major depression: stratification due to religious assortment. | Abdellaoui A et al. | β | 2013 | β |
| Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients. | Sjoerds Z et al. | β | 2013 | β |
| Big Five personality and depression diagnosis, severity and age of onset in older adults. | Koorevaar AM et al. | β | 2013 | β |
| Challenges in drug target discovery in bipolar disorder. | Alsaif M et al. | β | 2013 | β |
| Childhood abuse in late-life depression. | Comijs HC et al. | β | 2013 | β |
| Cognitive reactivity, implicit associations, and the incidence of depression: a two-year prospective study. | Kruijt AW et al. | β | 2013 | β |
| Cognitive vulnerability differentially predicts symptom dimensions of depression. | Struijs SY et al. | β | 2013 | β |
| Comparing cognitive and somatic symptoms of depression in myocardial infarction patients and depressed patients in primary and mental health care. | Groenewold NA et al. | β | 2013 | β |
| Course and risk factors of functional impairment in subthreshold depression and anxiety. | Karsten J et al. | β | 2013 | β |
| DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts. | Zhernakova DV et al. | β | 2013 | β |
| Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety (NESDA). | Duivis HE et al. | β | 2013 | β |
| Dysregulation of the autonomic nervous system predicts the development of the metabolic syndrome. | Licht CM et al. | β | 2013 | β |
| Enhanced amygdala reactivity to emotional faces in adults reporting childhood emotional maltreatment. | van Harmelen AL et al. | β | 2013 | β |
| Evening salivary alpha-amylase, major depressive disorder, and antidepressant use in the Netherlands Study of Depression and Anxiety (NESDA). | Veen G et al. | β | 2013 | β |
| Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. | Lamers F et al. | β | 2013 | β |
| Examining determinants of early and late age at onset in panic disorder: an admixture analysis. | Tibi L et al. | β | 2013 | β |
| Exposure to secondhand smoke and depression and anxiety: a report from two studies in the Netherlands. | Bot M et al. | β | 2013 | β |
| Family history of alcohol dependence and gray matter abnormalities in non-alcoholic adults. | Sjoerds Z et al. | β | 2013 | β |
| Family history of alcohol dependence modulates functional neurophysiology in mood/anxiety disorders. | Sjoerds Z et al. | β | 2013 | β |
| GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. | Rietveld CA et al. | β | 2013 | β |
| HIV-infected mental health patients: characteristics and comparison with HIV-infected patients from the general population and non-infected mental health patients. | SchadΓ© A et al. | β | 2013 | β |
| Influence of COMT val158met genotype on the depressed brain during emotional processing and working memory. | Opmeer EM et al. | β | 2013 | β |
| Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity. | van Reedt Dortland AK et al. | β | 2013 | β |
| Long-term stability of the cortisol awakening response over adolescence. | Platje E et al. | β | 2013 | β |
| Measuring automatic associations: validation of algorithms for the Implicit Association Test (IAT) in a laboratory setting. | Glashouwer KA et al. | β | 2013 | β |
| Modulatory effects of the piccolo genotype on emotional memory in health and depression. | Woudstra S et al. | β | 2013 | β |
| Negative and positive life events are associated with small but lasting change in neuroticism. | Jeronimus BF et al. | β | 2013 | β |
| Neutrophil gelatinase-associated lipocalin: a novel inflammatory marker associated with late-life depression. | NaudΓ© PJ et al. | β | 2013 | β |
| Perceived need for care and health care utilization among depressed and anxious patients with and without suicidal ideation. | Stringer B et al. | β | 2013 | β |
| Population structure, migration, and diversifying selection in the Netherlands. | Abdellaoui A et al. | β | 2013 | β |
| Prevalence of vitamin D deficiency and consequences for PTH reference values. | Deckers MM et al. | β | 2013 | β |
| Psychiatric co-morbidities in patients with chronic peripheral neuropathic pain: a multicentre cohort study. | Radat F et al. | β | 2013 | β |
| Recurrence of anxiety disorders and its predictors. | Scholten WD et al. | β | 2013 | β |
| Recurrence of major depressive disorder across different treatment settings: results from the NESDA study. | Hardeveld F et al. | β | 2013 | β |
| Recurrent suicide attempts in patients with depressive and anxiety disorders: the role of borderline personality traits. | Stringer B et al. | β | 2013 | β |
| Reference values for mental health assessment instruments: objectives and methods of the Leiden Routine Outcome Monitoring Study. | Schulte-van Maaren YW et al. | β | 2013 | β |
| Resequencing three candidate genes for major depressive disorder in a Dutch cohort. | Verbeek EC et al. | β | 2013 | β |
| Resilience to childhood maltreatment is associated with increased resting-state functional connectivity of the salience network with the lingual gyrus. | van der Werff SJ et al. | β | 2013 | β |
| Resting-state functional connectivity abnormalities in limbic and salience networks in social anxiety disorder without comorbidity. | Pannekoek JN et al. | β | 2013 | β |
| Resting-state functional connectivity in adults with childhood emotional maltreatment. | van der Werff SJ et al. | β | 2013 | β |
| Risk factors for onset of multiple or long major depressive episodes versus single and short episodes. | Stegenga BT et al. | β | 2013 | β |
| Salivary cortisol levels and the 2-year course of depressive and anxiety disorders. | Vreeburg SA et al. | β | 2013 | β |
| Sensitivity to depression or anxiety and subclinical cardiovascular disease. | Seldenrijk A et al. | β | 2013 | β |
| Side effects of antidepressants during long-term use in a naturalistic setting. | Bet PM et al. | β | 2013 | β |
| Sleep disturbances and reduced work functioning in depressive or anxiety disorders. | van Mill JG et al. | β | 2013 | β |
| Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. | Peyrot WJ et al. | β | 2013 | β |
| The association between immune activation and manic symptoms in patients with a depressive disorder. | Becking K et al. | β | 2013 | β |
| The associations between personality characteristics and absenteeism: a cross-sectional study in workers with and without depressive and anxiety disorders. | Vlasveld MC et al. | β | 2013 | β |
| The EPDS-Lifetime: assessment of lifetime prevalence and risk factors for perinatal depression in a large cohort of depressed women. | Meltzer-Brody S et al. | β | 2013 | β |
| The impact of chronic somatic diseases on the course of depressive and anxiety disorders. | Gerrits MM et al. | β | 2013 | β |
| The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression. | van Reedt Dortland AK et al. | β | 2013 | β |
| The Mood Disorder Questionnaire (MDQ) for detecting (hypo)manic episodes: its validity and impact of recall bias. | Boschloo L et al. | β | 2013 | β |
| The role of negative emotionality and impulsivity in depressive/anxiety disorders and alcohol dependence. | Boschloo L et al. | β | 2013 | β |
| The role of somatic health problems in the recognition of depressive and anxiety disorders by general practitioners. | Gerrits MM et al. | β | 2013 | β |
| Treatment inadequacy in primary and specialized care patients with depressive and/or anxiety disorders. | Bet PM et al. | β | 2013 | β |
| Two-year course of anxiety disorders: different across disorders or dimensions? | Hendriks SM et al. | β | 2013 | β |
| Two-year stability and change of neuroticism and extraversion in treated and untreated persons with depression: findings from the Netherlands Study of Depression and Anxiety (NESDA). | Renner F et al. | β | 2013 | β |
| Whole-brain functional connectivity during emotional word classification in medication-free Major Depressive Disorder: Abnormal salience circuitry and relations to positive emotionality. | van Tol MJ et al. | β | 2013 | β |
| Alcohol use disorders and the course of depressive and anxiety disorders. | Boschloo L et al. | β | 2012 | β |
| Association of depressive disorders, depression characteristics and antidepressant medication with inflammation. | Vogelzangs N et al. | β | 2012 | β |
| Association of smoking and nicotine dependence with severity and course of symptoms in patients with depressive or anxiety disorder. | Jamal M et al. | β | 2012 | β |
| BDNF val66met affects hippocampal volume and emotion-related hippocampal memory activity. | Molendijk ML et al. | β | 2012 | β |
| Clinical relevance of comorbidity in anxiety disorders: a report from the Netherlands Study of Depression and Anxiety (NESDA). | Hofmeijer-Sevink MK et al. | β | 2012 | β |
| Common mental disorders associated with 2-year diabetes incidence: the Netherlands Study of Depression and Anxiety (NESDA). | Atlantis E et al. | β | 2012 | β |
| Co-occurrence of social anxiety and depression symptoms in adolescence: differential links with implicit and explicit self-esteem? | de Jong PJ et al. | β | 2012 | β |
| Correlates of benzodiazepine dependence in the Netherlands Study of Depression and Anxiety. | Manthey L et al. | β | 2012 | β |
| Course trajectories of unipolar depressive disorders identified by latent class growth analysis. | Rhebergen D et al. | β | 2012 | β |
| Depressive and anxiety disorders on-the-job: the importance of job characteristics for good work functioning in persons with depressive and anxiety disorders. | Plaisier I et al. | β | 2012 | β |
| Determinants of (non-)recognition of depression by general practitioners: results of the Netherlands Study of Depression and Anxiety. | Piek E et al. | β | 2012 | β |
| Different gene sets contribute to different symptom dimensions of depression and anxiety. | van Veen T et al. | β | 2012 | β |
| Dimensions of the inventory of depressive symptomatology as predictors of the course of depressive and anxiety disorders. | Wardenaar KJ et al. | β | 2012 | β |
| Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain. | Barakat A et al. | β | 2012 | β |
| Early and late onset depression in young and middle aged adults: differential symptomatology, characteristics and risk factors? | Korten NC et al. | β | 2012 | β |
| Effect of running therapy on depression (EFFORT-D). Design of a randomised controlled trial in adult patients [ISRCTN 1894]. | Kruisdijk FR et al. | β | 2012 | β |
| Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: a longitudinal study. | Licht CM et al. | β | 2012 | β |
| Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. | Lubke GH et al. | β | 2012 | β |
| Functional magnetic resonance imaging correlates of emotional word encoding and recognition in depression and anxiety disorders. | van Tol MJ et al. | β | 2012 | β |
| Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety. | Molendijk ML et al. | β | 2012 | β |
| General, Specific and Unique Cognitive Factors Involved in Anxiety and Depressive Disorders. | Drost J et al. | β | 2012 | β |
| Impact of childhood life events and trauma on the course of depressive and anxiety disorders. | Hovens JG et al. | β | 2012 | β |
| Impact of pain on the course of depressive and anxiety disorders. | Gerrits MMJG et al. | β | 2012 | β |
| Is alcohol consumption irrelevant to outcome in anxiety and depression? | Bailey J et al. | β | 2012 | β |
| Meta-analysis of genome-wide association studies for personality. | de Moor MH et al. | β | 2012 | β |
| Moderators of the synchrony of change between decreasing depression severity and disability. | Verboom CE et al. | β | 2012 | β |
| Orbitofrontal gray matter relates to early morning awakening: a neural correlate of insomnia complaints? | Stoffers D et al. | β | 2012 | β |
| Personality and perceived need for mental health care among primary care patients. | Seekles WM et al. | β | 2012 | β |
| Personality traits and childhood trauma as correlates of metabolic risk factors: the Netherlands Study of Depression and Anxiety (NESDA). | van Reedt Dortland AK et al. | β | 2012 | β |
| Physical function as predictor for the persistence of depressive and anxiety disorders. | van Milligen BA et al. | β | 2012 | β |
| Piccolo genotype modulates neural correlates of emotion processing but not executive functioning. | Woudstra S et al. | β | 2012 | β |
| Predictors of the 2-year recurrence and persistence of alcohol dependence. | Boschloo L et al. | β | 2012 | β |
| Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients. | Nauta MH et al. | β | 2012 | β |
| Prognostic value of implicit and explicit self-associations for the course of depressive and anxiety disorders. | Glashouwer KA et al. | β | 2012 | β |
| Salivary testosterone: associations with depression, anxiety disorders, and antidepressant use in a large cohort study. | Giltay EJ et al. | β | 2012 | β |
| Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight. | Molendijk ML et al. | β | 2012 | β |
| Sociodemographic and psychiatric determinants of attrition in the Netherlands Study of Depression and Anxiety (NESDA). | Lamers F et al. | β | 2012 | β |
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