Estimating missing heritability for disease from genome-wide association studies.
paper
Cited
Public
Unavailable
- Authors
- Lee, Sang Hong; Wray, Naomi R; Goddard, Michael E; Visscher, Peter M
- Year
- 2011
- Journal
- American journal of human genetics
- PMID
- 21376301
- DOI
- 10.1016/j.ajhg.2011.02.002
- PMCID
- PMC3059431
Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. Employing strict significance thresholds when testing individual SNPs avoids false positives at the expense of increasing false negatives. Recently, we developed a method for quantitative traits that estimates the variation accounted for when fitting all SNPs simultaneously. Here we develop this method further for case-control studies. We use a linear mixed model for analysis of binary traits and transform the estimates to a liability scale by adjusting both for scale and for ascertainment of the case samples. We show by theory and simulation that the method is unbiased. We apply the method to data from the Wellcome Trust Case Control Consortium and show that a substantial proportion of variation in liability for Crohn disease, bipolar disorder, and type I diabetes is tagged by common SNPs.
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| How to approach understanding complex trait genetics - inflammatory bowel disease as a model complex trait. | Cleynen I et al. | β | 2019 | β |
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| A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans. | Xu H et al. | β | 2018 | β |
| A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes. | Meng W et al. | β | 2018 | β |
| A large electronic-health-record-based genome-wide study of serum lipids. | Hoffmann TJ et al. | β | 2018 | β |
| A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci. | Hoffmann TJ et al. | β | 2018 | β |
| An assessment of the performance of the logistic mixed model for analyzing binary traits in maize and sorghum diversity panels. | Shenstone E et al. | β | 2018 | β |
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| Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. | Evans LM et al. | β | 2018 | β |
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| Detecting significant genotype-phenotype association rules in bipolar disorder: market research meets complex genetics. | Breuer R et al. | β | 2018 | β |
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| Embracing polygenicity: a review of methods and tools for psychiatric genetics research. | Maier RM et al. | β | 2018 | β |
| Empirical Bayes Estimation of Semi-parametric Hierarchical Mixture Models for Unbiased Characterization of Polygenic Disease Architectures. | Nishino J et al. | β | 2018 | β |
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| Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics. | Weissbrod O et al. | β | 2018 | β |
| Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits. | Zhang Y et al. | β | 2018 | β |
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| Functional Partitioning of Genomic Variance and Genome-Wide Association Study for Carcass Traits in Korean Hanwoo Cattle Using Imputed Sequence Level SNP Data. | Bhuiyan MSA et al. | β | 2018 | β |
| Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability. | Hysi PG et al. | β | 2018 | β |
| Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. | Shah RL et al. | β | 2018 | β |
| Genome-wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogs. | Gallana M et al. | β | 2018 | β |
| Genome-wide association study and meta-analysis identify loci associated with ventricular and supraventricular ectopy. | Napier MD et al. | β | 2018 | β |
| Genome-wide association study for risk taking propensity indicates shared pathways with body mass index. | Clifton EAD et al. | β | 2018 | β |
| Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. | Vijayakrishnan J et al. | β | 2018 | β |
| Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways. | Howard DM et al. | β | 2018 | β |
| Genome-wide association study of developmental dysplasia of the hip identifies an association with <i>GDF5</i>. | Hatzikotoulas K et al. | β | 2018 | β |
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| IRE1Ξ± Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases. | Junjappa RP et al. | β | 2018 | β |
| Largest GWAS of PTSD (N=20β070) yields genetic overlap with schizophrenia and sex differences in heritability. | Duncan LE et al. | β | 2018 | β |
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| Modeling heterotic effects in beef cattle using genome-wide SNP-marker genotypes. | Akanno EC et al. | β | 2018 | β |
| Molecular genetic overlap between migraine and major depressive disorder. | Yang Y et al. | β | 2018 | β |
| Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans. | Khetarpal SA et al. | β | 2018 | β |
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| Sociogenomics in the 21<sup>st</sup> Century: An Introduction to the History and Potential of Genetically-informed Social Science. | Braudt DB | β | 2018 | β |
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| Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. | Walters RK et al. | β | 2018 | β |
| Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for WaldenstrΓΆm macroglobulinemia. | McMaster ML et al. | β | 2018 | β |
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| A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis. | Ng M et al. | β | 2017 | β |
| A Systems Genetics Approach Identified GPD1L and its Molecular Mechanism for Obesity in Human Adipose Tissue. | He H et al. | β | 2017 | β |
| A UNIFIED FRAMEWORK FOR VARIANCE COMPONENT ESTIMATION WITH SUMMARY STATISTICS IN GENOME-WIDE ASSOCIATION STUDIES. | Zhou X | β | 2017 | β |
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| Estimation of genomic prediction accuracy from reference populations with varying degrees of relationship. | Lee SH et al. | β | 2017 | β |
| Estimation of heritability for nine common cancers using data from genome-wide association studies in Chinese population. | Dai J et al. | β | 2017 | β |
| Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. | Charney AW et al. | β | 2017 | β |
| Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. | Melroy-Greif WE et al. | β | 2017 | β |
| Familial Aggregation and Heritability of Schizophrenia and Co-aggregation of Psychiatric Illnesses in Affected Families. | Chou IJ et al. | β | 2017 | β |
| Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. | Klarin D et al. | β | 2017 | β |
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| Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex. | Clay-Gilmour AI et al. | β | 2017 | β |
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| Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis. | Redondo MJ et al. | β | 2017 | β |
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| Genome-wide association study identifies multiple risk loci for renal cell carcinoma. | Scelo G et al. | β | 2017 | β |
| Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. | Ji SG et al. | β | 2017 | β |
| Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration. | Lees JA et al. | β | 2017 | β |
| Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth. | Lee SH et al. | β | 2017 | β |
| GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk. | Pirastu N et al. | β | 2017 | β |
| Heritability Estimation using a Regularized Regression Approach (HERRA): Applicable to continuous, dichotomous or age-at-onset outcome. | Gorfine M et al. | β | 2017 | β |
| Heritability of Atrial Fibrillation. | Weng LC et al. | β | 2017 | β |
| Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure. | Verweij N et al. | β | 2017 | β |
| Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. | Merkel PA et al. | β | 2017 | β |
| Integration of expression quantitative trait loci and pleiotropy identifies a novel psoriasis susceptibility gene, PTPN1. | Yin X et al. | β | 2017 | β |
| Integrative genetic analysis suggests that skin color modifies the genetic architecture of melanoma. | Hulur I et al. | β | 2017 | β |
| Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction. | Hu Y et al. | β | 2017 | β |
| LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. | Zheng J et al. | β | 2017 | β |
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| Mitochondrial-nuclear co-evolution leads to hybrid incompatibility through pentatricopeptide repeat proteins. | Jhuang HY et al. | β | 2017 | β |
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| Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students. | Webb BT et al. | β | 2017 | β |
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| The pharmacogenetics of metformin. | Florez JC | β | 2017 | β |
| Transcriptome sequencing implicates dorsal striatum-specific gene network, immune response and energy metabolism pathways in bipolar disorder. | Pacifico R et al. | β | 2017 | β |
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| A genome-wide association study of congenital cardiovascular left-sided lesions shows association with a locus on chromosome 20. | Hanchard NA et al. | β | 2016 | β |
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| A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. | Fritsche LG et al. | β | 2016 | β |
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| Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics. | Holland D et al. | β | 2016 | β |
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| Genetic Correlation Analysis Suggests Association between Increased Self-Reported Sleep Duration in Adults and Schizophrenia and Type 2 Diabetes. | Byrne EM et al. | β | 2016 | β |
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| Genome-wide association study of sporadic brain arteriovenous malformations. | Weinsheimer S et al. | β | 2016 | β |
| Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. | Bigdeli TB et al. | β | 2016 | β |
| Genome-wide estimate of the heritability of Multiple System Atrophy. | Federoff M et al. | β | 2016 | β |
| Genome-Wide Estimates of Heritability for Social Demographic Outcomes. | Domingue BW et al. | β | 2016 | β |
| Genotypic Context and Epistasis in Individuals and Populations. | Sackton TB et al. | β | 2016 | β |
| Heritability of Recurrent Exertional Rhabdomyolysis in Standardbred and Thoroughbred Racehorses Derived From SNP Genotyping Data. | Norton EM et al. | β | 2016 | β |
| Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. | Figueroa JD et al. | β | 2016 | β |
| Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans. | Ye BD et al. | β | 2016 | β |
| Identifying genetically driven clinical phenotypes using linear mixed models. | Mosley JD et al. | β | 2016 | β |
| Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis. | Wei WH et al. | β | 2016 | β |
| Morphometricity as a measure of the neuroanatomical signature of a trait. | Sabuncu MR et al. | β | 2016 | β |
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| Pleiotropic Mechanisms Indicated for Sex Differences in Autism. | Mitra I et al. | β | 2016 | β |
| RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders. | Montalvo-Ortiz JL et al. | β | 2016 | β |
| Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. | Pigeyre M et al. | β | 2016 | β |
| Smooth-Threshold Multivariate Genetic Prediction with Unbiased Model Selection. | Ueki M et al. | β | 2016 | β |
| SNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE. | Docherty AR et al. | β | 2016 | β |
| Structural Variant Detection by Large-scale Sequencing Reveals New Evolutionary Evidence on Breed Divergence between Chinese and European Pigs. | Zhao P et al. | β | 2016 | β |
| Systematic identification of genetic influences on methylation across the human life course. | Gaunt TR et al. | β | 2016 | β |
| The Genetic Epidemiological Landscape of Hip and Knee Osteoarthritis: Where Are We Now and Where Are We Going? | Zengini E et al. | β | 2016 | β |
| Transethnic Genetic-Correlation Estimates from Summary Statistics. | Brown BC et al. | β | 2016 | β |
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| Uncovering the Genetic Architectures of Quantitative Traits. | Lee JJ et al. | β | 2016 | β |
| Validity of using ad hoc methods to analyze secondary traits in case-control association studies. | Yung G et al. | β | 2016 | β |
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| Accuracy of Gene Scores when Pruning Markers by Linkage Disequilibrium. | Dudbridge F et al. | β | 2015 | β |
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| Advances in risk prediction of type 2 diabetes: integrating genetic scores with Framingham risk models. | Keating BJ | β | 2015 | β |
| A genome-wide association study of myasthenia gravis. | Renton AE et al. | β | 2015 | β |
| A Genome-wide Association Study Provides Evidence of Sex-specific Involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) With Diabetic Neuropathic Pain. | Meng W et al. | β | 2015 | β |
| A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain. | Meng W et al. | β | 2015 | β |
| A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences. | Hoffmann TJ et al. | β | 2015 | β |
| Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types. | Sampson JN et al. | β | 2015 | β |
| Analysis of the genetic architecture of susceptibility to cervical cancer indicates that common SNPs explain a large proportion of the heritability. | Chen D et al. | β | 2015 | β |
| An Empirical Bayes Mixture Model for Effect Size Distributions in Genome-Wide Association Studies. | Thompson WK et al. | β | 2015 | β |
| An Empirical Bayes risk prediction model using multiple traits for sequencing data. | Li G et al. | β | 2015 | β |
| A Rosetta stone for epidemiology: genomic risk profile scores contain clues related to modifiable risk factors. | McGrath JJ | β | 2015 | β |
| Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals. | Fullerton JM et al. | β | 2015 | β |
| Characteristics of Bipolar I patients grouped by externalizing disorders. | Swaminathan S et al. | β | 2015 | β |
| Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. | Childs EJ et al. | β | 2015 | β |
| Concepts and Misconceptions about the Polygenic Additive Model Applied to Disease. | Visscher PM et al. | β | 2015 | β |
| Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. | Loh PR et al. | β | 2015 | β |
| Converging evidence implicates the abnormal microRNA system in schizophrenia. | Zhang F et al. | β | 2015 | β |
| Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes. | Shen L et al. | β | 2015 | β |
| Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease. | Won HH et al. | β | 2015 | β |
| Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning. | Levine ME et al. | β | 2015 | β |
| Estimates of genetic parameters for breech strike and potential indirect indicators in sheep. | Pickering NK et al. | β | 2015 | β |
| Evaluation of Penalized and Nonpenalized Methods for Disease Prediction with Large-Scale Genetic Data. | Won S et al. | β | 2015 | β |
| gammaMAXT: a fast multiple-testing correction algorithm. | Lishout FV et al. | β | 2015 | β |
| Gene by Social-Environment Interaction for Youth Delinquency and Violence: Thirty-Nine Aggression-related Genes. | Liu H et al. | β | 2015 | β |
| Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality. | Larkin EK et al. | β | 2015 | β |
| Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis. | Anand A et al. | β | 2015 | β |
| Genetic and environmental components of family history in type 2 diabetes. | Cornelis MC et al. | β | 2015 | β |
| Genetic and molecular aspects of hypertension. | Padmanabhan S et al. | β | 2015 | β |
| Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke. | Adib-Samii P et al. | β | 2015 | β |
| Genetic overlap between diagnostic subtypes of ischemic stroke. | Holliday EG et al. | β | 2015 | β |
| Genetic sharing and heritability of paediatric age of onset autoimmune diseases. | Li YR et al. | β | 2015 | β |
| Genetics of type 2 diabetes-pitfalls and possibilities. | Prasad RB et al. | β | 2015 | β |
| Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. | Yang J et al. | β | 2015 | β |
| Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample. | Derringer J et al. | β | 2015 | β |
| Heritability estimates on Hodgkin's lymphoma: a genomic- versus population-based approach. | Thomsen H et al. | β | 2015 | β |
| Heritability in inflammatory bowel disease: from the first twin study to genome-wide association studies. | Gordon H et al. | β | 2015 | β |
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| Human fertility, molecular genetics, and natural selection in modern societies. | Tropf FC et al. | β | 2015 | β |
| Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways. | Bossini-Castillo L et al. | β | 2015 | β |
| Implications of simplified linkage equilibrium SNP simulation. | Lee SH | β | 2015 | β |
| Kernel Approach for Modeling Interaction Effects in Genetic Association Studies of Complex Quantitative Traits. | Broadaway KA et al. | β | 2015 | β |
| Letter by Mosley Regarding Article, "Iron Homeostasis and Pulmonary Hypertension: Iron Deficiency Leads to Pulmonary Vascular Remodeling in the Rat". | Mosley JD et al. | β | 2015 | β |
| MAGMA: generalized gene-set analysis of GWAS data. | de Leeuw CA et al. | β | 2015 | β |
| Marker-based estimation of heritability in immortal populations. | Kruijer W et al. | β | 2015 | β |
| Massively expedited genome-wide heritability analysis (MEGHA). | Ge T et al. | β | 2015 | β |
| Mixed model with correction for case-control ascertainment increases association power. | Hayeck TJ et al. | β | 2015 | β |
| Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. | VilhjΓ‘lmsson BJ et al. | β | 2015 | β |
| New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. | Lee SH et al. | β | 2015 | β |
| Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk. | SegrΓ¨ AV et al. | β | 2015 | β |
| Prediction of complex human diseases from pathway-focused candidate markers by joint estimation of marker effects: case of chronic fatigue syndrome. | Bhattacharjee M et al. | β | 2015 | β |
| Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. | Look AHEAD Research Group | β | 2015 | β |
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| Quantitative genetics of disease traits. | Wray NR et al. | β | 2015 | β |
| Recent genetic findings in schizophrenia and their therapeutic relevance. | Harrison PJ | β | 2015 | β |
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| Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry. | Palmer RH et al. | β | 2015 | β |
| Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. | Lu Y et al. | β | 2015 | β |
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| The genetic basis of eosinophilic esophagitis. | Sleiman PMA et al. | β | 2015 | β |
| The genome as pharmacopeia: association of genetic dose with phenotypic response. | Wadhawan S et al. | β | 2015 | β |
| The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses. | Caballero A et al. | β | 2015 | β |
| The Red Queen in mitochondria: cyto-nuclear co-evolution, hybrid breakdown and human disease. | Chou JY et al. | β | 2015 | β |
| The Use of the Linear Mixed Model in Human Genetics. | Dandine-Roulland C et al. | β | 2015 | β |
| Tourette Syndrome: Bridging the Gap between Genetics and Biology. | Richer P et al. | β | 2015 | β |
| Toward stratified treatments for bipolar disorders. | Hasler G et al. | β | 2015 | β |
| Using Network Methodology to Infer Population Substructure. | Prokopenko D et al. | β | 2015 | β |
| Weighted Score Tests Implementing Model-Averaging Schemes in Detection of Rare Variants in Case-Control Studies. | Coombes B et al. | β | 2015 | β |
| Accurate and robust genomic prediction of celiac disease using statistical learning. | Abraham G et al. | β | 2014 | β |
| Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene. | Levin AM et al. | β | 2014 | β |
| Advantages and pitfalls in the application of mixed-model association methods. | Yang J et al. | β | 2014 | β |
| A genome-wide association meta-analysis of preschool internalizing problems. | Benke KS et al. | β | 2014 | β |
| A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses. | Blott SC et al. | β | 2014 | β |
| Assessment of Parkinson's disease risk loci in Greece. | Kara E et al. | β | 2014 | β |
| Chemotherapy-induced peripheral neurotoxicity and ototoxicity: new paradigms for translational genomics. | Travis LB et al. | β | 2014 | β |
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| Comparison of Multi-Sample Variant Calling Methods for Whole Genome Sequencing. | Nho K et al. | β | 2014 | β |
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| Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait. | Torres JM et al. | β | 2014 | β |
| Dissection of additive genetic variability for quantitative traits in chickens using SNP markers. | Abdollahi-Arpanahi R et al. | β | 2014 | β |
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| Entropy-based selection for maternal-fetal genotype incompatibility with application to preterm prelabor rupture of membranes. | Li S et al. | β | 2014 | β |
| Estimating heritability of complex traits from genome-wide association studies using IBS-based Haseman-Elston regression. | Chen GB | β | 2014 | β |
| Estimating heritability of drug-induced liver injury from common variants and implications for future study designs. | Overby CL et al. | β | 2014 | β |
| Estimating the heritability of colorectal cancer. | Jiao S et al. | β | 2014 | β |
| Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data. | Chen GB et al. | β | 2014 | β |
| Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. | Yang C et al. | β | 2014 | β |
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| Genetic analysis of resistance to Pseudomonas syringae pv. actinidiae (Psa) in a kiwifruit progeny test: an application of generalised linear mixed models (GLMMs). | De Silva NH et al. | β | 2014 | β |
| Genetic-based prediction of disease traits: prediction is very difficult, especially about the future. | Schrodi SJ et al. | β | 2014 | β |
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| Genetics of Guillain-BarrΓ© syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): current knowledge and future directions. | Blum S et al. | β | 2014 | β |
| Genetics of ischemic stroke in young adults. | Cheng YC et al. | β | 2014 | β |
| Genetics of obsessive-compulsive disorder and related disorders. | Browne HA et al. | β | 2014 | β |
| Genetic studies of Crohn's disease: past, present and future. | Liu JZ et al. | β | 2014 | β |
| Genome-wide association analyses identify variants in developmental genes associated with hypospadias. | Geller F et al. | β | 2014 | β |
| Genome-wide association analysis of radiation resistance in Drosophila melanogaster. | Vaisnav M et al. | β | 2014 | β |
| Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. | Cerhan JR et al. | β | 2014 | β |
| Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. | Wolpin BM et al. | β | 2014 | β |
| Genome-wide association study of lung function phenotypes in a founder population. | Yao TC et al. | β | 2014 | β |
| Genomic architecture of pharmacological efficacy and adverse events. | Chhibber A et al. | β | 2014 | β |
| Genomic heritability estimation for the early life-history transition related to propensity to migrate in wild rainbow and steelhead trout populations. | Hu G et al. | β | 2014 | β |
| Genotype-environment correlation in the era of DNA. | Plomin R | β | 2014 | β |
| GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. | Chung D et al. | β | 2014 | β |
| Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions. | Li X et al. | β | 2014 | β |
| Identification of pathways for bipolar disorder: a meta-analysis. | Nurnberger JI et al. | β | 2014 | β |
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| Integrating genetics and social science: genetic risk scores. | Belsky DW et al. | β | 2014 | β |
| Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index. | Boardman JD et al. | β | 2014 | β |
| Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study. | Chen Z et al. | β | 2014 | β |
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| Measuring missing heritability: inferring the contribution of common variants. | Golan D et al. | β | 2014 | β |
| Modelling the genetic contribution to mental illness: a timely end for the psychiatric rodent? | Davis BA et al. | β | 2014 | β |
| Most common 'sporadic' cancers have a significant germline genetic component. | Lu Y et al. | β | 2014 | β |
| Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data. | Lange K et al. | β | 2014 | β |
| Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. | Jiang L et al. | β | 2014 | β |
| Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. | Gusev A et al. | β | 2014 | β |
| Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). | Chhibber A et al. | β | 2014 | β |
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| Practitioner review: A critical perspective on gene-environment interaction models--what impact should they have on clinical perceptions and practice? | MunafΓ² MR et al. | β | 2014 | β |
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| Regulatory genomic regions active in immune cell types explain a large proportion of the genetic risk of multiple sclerosis. | Elangovan RI et al. | β | 2014 | β |
| Research review: Polygenic methods and their application to psychiatric traits. | Wray NR et al. | β | 2014 | β |
| Statistical power to detect genetic (co)variance of complex traits using SNP data in unrelated samples. | Visscher PM et al. | β | 2014 | β |
| The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. | Thompson PM et al. | β | 2014 | β |
| The Inheritance of Tourette Disorder: A review. | Pauls DL et al. | β | 2014 | β |
| Underestimation of heritability using a mixed model with a polygenic covariance structure in a genome-wide association study for complex traits. | Ryoo H et al. | β | 2014 | β |
| Warped linear mixed models for the genetic analysis of transformed phenotypes. | Fusi N et al. | β | 2014 | β |
| Whole-genome analyses of lung function, height and smoking. | Janss L et al. | β | 2014 | β |
| Whole-genome pathway analysis on 132,497 individuals identifies novel gene-sets associated with body mass index. | Simonson MA et al. | β | 2014 | β |
| Why do we differ in number sense? Evidence from a genetically sensitive investigation. | Tosto MG et al. | β | 2014 | β |
| Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. | de Candia TR et al. | β | 2013 | β |
| A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. | Lane J et al. | β | 2013 | β |
| Alzheimer's disease: analyzing the missing heritability. | Ridge PG et al. | β | 2013 | β |
| A sequence of methodological changes due to sequencing. | Burkett K et al. | β | 2013 | β |
| Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits. | Stringer S et al. | β | 2013 | β |
| Behavior genetics: past, present, future. | Jaffee SR et al. | β | 2013 | β |
| Characterization and correction of error in genome-wide IBD estimation for samples with population structure. | Morrison J | β | 2013 | β |
| Child development and molecular genetics: 14 years later. | Plomin R | β | 2013 | β |
| Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. | Kos MZ et al. | β | 2013 | β |
| Common DNA markers can account for more than half of the genetic influence on cognitive abilities. | Plomin R et al. | β | 2013 | β |
| Common genetic variation contributes significantly to the risk of developing chronic lymphocytic leukemia. | Di Bernardo MC et al. | β | 2013 | β |
| Complex variation in measures of general intelligence and cognitive change. | Rowe SJ et al. | β | 2013 | β |
| Current evidence for an inherited genetic basis of childhood acute lymphoblastic leukemia. | Urayama KY et al. | β | 2013 | β |
| Dense mapping of IL2RA shows no association with Graves' disease in Chinese Han population. | Song ZY et al. | β | 2013 | β |
| DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities. | Trzaskowski M et al. | β | 2013 | β |
| Estimating heritability in pharmacogenetic studies. | Marshall SL et al. | β | 2013 | β |
| Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. | Lee SH et al. | β | 2013 | β |
| Estimation and partition of heritability in human populations using whole-genome analysis methods. | Vinkhuyzen AA et al. | β | 2013 | β |
| Evaluating empirical bounds on complex disease genetic architecture. | Agarwala V et al. | β | 2013 | β |
| Finding the sources of missing heritability in a yeast cross. | Bloom JS et al. | β | 2013 | β |
| Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. | Cross-Disorder Group of the Psychiatric Genomics Consortium et al. | β | 2013 | β |
| Genetics of bipolar disorder. | Craddock N et al. | β | 2013 | β |
| Genetics of callous-unemotional behavior in children. | Viding E et al. | β | 2013 | β |
| Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. | Kirin M et al. | β | 2013 | β |
| Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. | Berndt SI et al. | β | 2013 | β |
| Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. | Chen DT et al. | β | 2013 | β |
| Genome-wide complex trait analysis (GCTA): methods, data analyses, and interpretations. | Yang J et al. | β | 2013 | β |
| Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. | Berndt SI et al. | β | 2013 | β |
| Genomic prediction of dichotomous traits with Bayesian logistic models. | Technow F et al. | β | 2013 | β |
| Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux. | Ek WE et al. | β | 2013 | β |
| Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage. | Devan WJ et al. | β | 2013 | β |
| Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. | Zhou JJ et al. | β | 2013 | β |
| How meaningful are heritability estimates of liability? | Benchek PH et al. | β | 2013 | β |
| Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort. | Browning SR et al. | β | 2013 | β |
| Identity by descent: variation in meiosis, across genomes, and in populations. | Thompson EA | β | 2013 | β |
| Intelligence indexes generalist genes for cognitive abilities. | Trzaskowski M et al. | β | 2013 | β |
| Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease. | Wei Z et al. | β | 2013 | β |
| Mapping the genetic variation of regional brain volumes as explained by all common SNPs from the ADNI study. | Bryant C et al. | β | 2013 | β |
| Meta-analysis methods for genome-wide association studies and beyond. | Evangelou E et al. | β | 2013 | β |
| Molecular genetics and subjective well-being. | Rietveld CA et al. | β | 2013 | β |
| Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies. | McManus IC et al. | β | 2013 | β |
| No genetic influence for childhood behavior problems from DNA analysis. | Trzaskowski M et al. | β | 2013 | β |
| Novel genetic analysis for case-control genome-wide association studies: quantification of power and genomic prediction accuracy. | Lee SH et al. | β | 2013 | β |
| Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. | Davis LK et al. | β | 2013 | β |
| Patterns of methylation heritability in a genome-wide analysis of four brain regions. | Quon G et al. | β | 2013 | β |
| Performance and robustness of penalized and unpenalized methods for genetic prediction of complex human disease. | Abraham G et al. | β | 2013 | β |
| Pitfalls of predicting complex traits from SNPs. | Wray NR et al. | β | 2013 | β |
| Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. | McGeachie MJ et al. | β | 2013 | β |
| Polygenic modeling with bayesian sparse linear mixed models. | Zhou X et al. | β | 2013 | β |
| Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. | Yang L et al. | β | 2013 | β |
| Power and predictive accuracy of polygenic risk scores. | Dudbridge F | β | 2013 | β |
| Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. | Chatterjee N et al. | β | 2013 | β |
| Quantifying missing heritability at known GWAS loci. | Gusev A et al. | β | 2013 | β |
| Response to Lee et al.: SNP-based heritability analysis with dense data. | Speed D et al. | β | 2013 | β |
| Strategies for developing prediction models from genome-wide association studies. | Wu J et al. | β | 2013 | β |
| The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants. | Mowry BJ et al. | β | 2013 | β |
| The evolutionary paradox and the missing heritability of schizophrenia. | van Dongen J et al. | β | 2013 | β |
| The future of genomics for developmentalists. | Plomin R et al. | β | 2013 | β |
| The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases. | Manchia M et al. | β | 2013 | β |
| The molecular genetic architecture of self-employment. | van der Loos MJ et al. | β | 2013 | β |
| Toward a systems biology of mood disorder. | McIntosh AM | β | 2013 | β |
| Transcriptomics of cortical gray matter thickness decline during normal aging. | Kochunov P et al. | β | 2013 | β |
| Translating genome wide association study results to associations among common diseases: in silico study with an electronic medical record. | Anand V et al. | β | 2013 | β |
| Unraveling genetic origin of aging-related traits: evolving concepts. | Kulminski AM | β | 2013 | β |
| Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. | Zaitlen N et al. | β | 2013 | β |
| Utilizing twins as controls for non-twin case-materials in genome wide association studies. | Ganna A et al. | β | 2013 | β |
| What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. | Kendler KS | β | 2013 | β |
| Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia. | McGrath JJ et al. | β | 2013 | β |
| A better coefficient of determination for genetic profile analysis. | Lee SH et al. | β | 2012 | β |
| A general framework for two-stage analysis of genome-wide association studies and its application to case-control studies. | Wason JM et al. | β | 2012 | β |
| A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. | Pajewski NM et al. | β | 2012 | β |
| Alternative glycosylation modulates function of IgG and other proteins - implications on evolution and disease. | Gornik O et al. | β | 2012 | β |
| A mixed-model approach for genome-wide association studies of correlated traits in structured populations. | Korte A et al. | β | 2012 | β |
| Commentary: Discussion of βThe history of twins, as a criterion of the relative powers of nature and nurture' by Francis Galton (1875). | Martin NG | β | 2012 | β |
| Common genetic variants, acting additively, are a major source of risk for autism. | Klei L et al. | β | 2012 | β |
| Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia. | Enciso-Mora V et al. | β | 2012 | β |
| Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. | Vinkhuyzen AA et al. | β | 2012 | β |
| Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. | Holliday EG et al. | β | 2012 | β |
| Epistasis network centrality analysis yields pathway replication across two GWAS cohorts for bipolar disorder. | Pandey A et al. | β | 2012 | β |
| Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. | Lubke GH et al. | β | 2012 | β |
| Estimating the proportion of variation in susceptibility to multiple sclerosis captured by common SNPs. | Watson CT et al. | β | 2012 | β |
| Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. | Lee SH et al. | β | 2012 | β |
| Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood. | Lee SH et al. | β | 2012 | β |
| Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. | Visscher PM et al. | β | 2012 | β |
| Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetes. | Howson JM et al. | β | 2012 | β |
| Genetic contributions to stability and change in intelligence from childhood to old age. | Deary IJ et al. | β | 2012 | β |
| Genetic predisposition to radiation-related cancer and potential implications for risk assessment. | Sigurdson AJ et al. | β | 2012 | β |
| Genetics: How intelligence changes with age. | Plomin R | β | 2012 | β |
| Genetics of bipolar disorder: where we are and where we are going. | Nurnberger JI | β | 2012 | β |
| Genetics of coronary artery disease: genome-wide association studies and beyond. | Prins BP et al. | β | 2012 | β |
| Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. | Thompson SD et al. | β | 2012 | β |
| Heritability and genetic correlations explained by common SNPs for metabolic syndrome traits. | Vattikuti S et al. | β | 2012 | β |
| Heritability in the genome-wide association era. | Zaitlen N et al. | β | 2012 | β |
| Hierarchical Naive Bayes for genetic association studies. | Malovini A et al. | β | 2012 | β |
| Identifying plausible genetic models based on association and linkage results: application to type 2 diabetes. | Guan W et al. | β | 2012 | β |
| Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes. | Wray NR et al. | β | 2012 | β |
| Improved heritability estimation from genome-wide SNPs. | Speed D et al. | β | 2012 | β |
| Informed conditioning on clinical covariates increases power in case-control association studies. | Zaitlen N et al. | β | 2012 | β |
| Insights into type 1 diabetes provided by genetic analyses. | Morahan G | β | 2012 | β |
| Integrating genomic and epigenomic information: a promising strategy for identifying functional DNA variants of human disease. | Zaina S et al. | β | 2012 | β |
| Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. | Morris AP et al. | β | 2012 | β |
| Linkage-disequilibrium-based binning affects the interpretation of GWASs. | Christoforou A et al. | β | 2012 | β |
| Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways. | Harari O et al. | β | 2012 | β |
| Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. | Moskvina V et al. | β | 2012 | β |
| Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality. | Yashin AI et al. | β | 2012 | β |
| Prediction of expected years of life using whole-genome markers. | de los Campos G et al. | β | 2012 | β |
| Presence of multiple independent effects in risk loci of common complex human diseases. | Ke X | β | 2012 | β |
| Risk in complex genetics: "all models are wrong but some are useful". | Sawcer S et al. | β | 2012 | β |
| The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. | Cusanovich DA et al. | β | 2012 | β |
| The genetic architecture of economic and political preferences. | Benjamin DJ et al. | β | 2012 | β |
| The genetics of alcohol dependence: advancing towards systems-based approaches. | Palmer RH et al. | β | 2012 | β |
| The implications of inheritance for clinical management. | Sen-Chowdhry S et al. | β | 2012 | β |
| Unidentified genetic variants influence pancreatic cancer risk: an analysis of polygenic susceptibility in the PanScan study. | Pierce BL et al. | β | 2012 | β |
| Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. | Keller MF et al. | β | 2012 | β |
| Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. | Wray NR et al. | β | 2012 | β |
| Current status of genome-wide association studies in cancer. | Chung CC et al. | β | 2011 | β |
| Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population. | Ceulemans S et al. | β | 2011 | β |
| Genetic risk prediction in complex disease. | Jostins L et al. | β | 2011 | β |
| Genome-wide association study identifies five new schizophrenia loci. | Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium | β | 2011 | β |
| Integrating genomic data and social science: challenges and opportunities. | Freese J | β | 2011 | β |
| Modelling the effects of penetrance and family size on rates of sporadic and familial disease. | Al-Chalabi A et al. | β | 2011 | β |
| Population structure can inflate SNP-based heritability estimates. | Browning SR et al. | β | 2011 | β |
| Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss. | Bennett MR | β | 2011 | β |
| Six Degrees of Epistasis: Statistical Network Models for GWAS. | McKinney BA et al. | β | 2011 | β |
| The genetics of asthma and allergic disease: a 21st century perspective. | Ober C et al. | β | 2011 | β |
| Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes. | Stringer S et al. | β | 2011 | β |
| Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. | Do CB et al. | β | 2011 | β |