Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver.
paper
Cited
Public
- Authors
- SchrΓΆder, A; Klein, K; Winter, S; Schwab, M; Bonin, M; Zell, A; Zanger, U M
- Year
- 2013
- Journal
- The pharmacogenomics journal
- PMID
- 22006096
- DOI
- 10.1038/tpj.2011.44
- PMCID
- PMC3564008
Expression quantitative trait loci (eQTL) analysis is a powerful approach toward identifying genetic loci associated with quantitative changes in gene expression. We applied genome-wide association analysis to a data set of >300β000 single-nucleotide polymorphisms and >48β000 mRNA expression phenotypes obtained by Illumina microarray profiling of 149 human surgical liver samples obtained from Caucasian donors with detailed medical documentation. Of 1226 significant associations, only 200 were validated when comparing with a previously published similar study. Potential explanations for low replication rate include differences in microarray platforms, statistical modeling, covariates considered and origin and collection procedures of tissues. Focused analysis revealed a subset of 95 associations related to absorption, distribution, metabolism and excretion of drugs. Of these, 21 were true replications and 74 were newly discovered associations in enzymes, transporters, transcriptional regulators and other genes. This study extends our knowledge about the genetics of inter-individual variability of gene expression with particular emphasis on pharmacogenomics.
Distribution of SNPs among different genotyping platforms used in the Seattle and Stuttgart study. SNP, single-nucleotide polymorphism.
Venn diagram of eQTL results in the Stuttgart and Seattle studies. Comparison of significant genetic associations detected in the two studies after Bonferroni's correction. Numbers in the upper box refer to genome-wide associations (GWAs), whereas numbers in the lower box refer to ADME genes. The number of associated expression traits is given in brackets. ADME, absorption, distribution, metabolism and excretion; eQTL, expression quantitative trait loci.
Box plots of validated ADME associations. Box and whisker diagrams include smallest gene expression values, lower quartiles, medians, upper quartiles, largest gene expression values and outliers of the 11 validated ADME associations. The size of each genotyping group is given in brackets along the x axis. ADME, absorption, distribution, metabolism and excretion.
Manhattan plot of novel trans-eQTL and related box-plots of cis/trans-associations. (a) Negative log-transformed P-values of all SNPs tested for association to the serine protease UNQ9391 (PRSS55), which is located on chromosome 8. A set of 6 trans-acting SNPs at the plasminogen (PLG) locus on chromosome 6 was identified to be significantly associated. The dashed line represents the P-value cutoff level for trans-associations. The three indicated SNPs are simultaneously locally associated with the expression of PLG itself. (b) Box plots showing cis (left) and trans (right) genotypeβphenotype relationships for one selected SNP. eQTL, expression quantitative trait loci; SNP, single-nucleotide polymorphism.
β Prev
21β29 of 29
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| AltmanRBPharmGKB: a logical home for knowledge relating genotype to drug response phenotypeNat Genet2007394261739279510.1038/ng0407-426PMC3203536 | β | β | β |
| AulchenkoYSRipkeSIsaacsAvan DuijnCMGenABEL: an R library for genome-wide association analysisBioinformatics200723129412961738401510.1093/bioinformatics/btm108 | β | β | β |
| Barbosa-MoraisNLDunningMJSamarajiwaSADarotJFJRitchieMELynchAGA re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression dataNucleic Acids Res201038e171992323210.1093/nar/gkp942PMC2817484 | β | β | β |
| BarrettJCHaploview: visualization and analysis of SNP genotype dataCold Spring Harb Protoc20092009pdb ip71.10.1101/pdb.ip7120147036 | β | β | β |
| BosmaPJvan der MeerIMBakkerCTHofmanAPaul-AbrahamseMWittemanJCUGT1A1*28 allele and coronary heart disease: the Rotterdam StudyClin Chem200349118011811281691610.1373/49.7.1180 | β | β | β |
| Bouatia-NajiNBonnefondACavalcanti-ProencaCSparsoTHolmkvistJMarchandMA variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes riskNat Genet20094189941906090910.1038/ng.277 | β | β | β |
| CauffiezCKlinzigFRatETournelGAllorgeDChevalierDHuman CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymesBiochem Pharmacol200468241724251554838810.1016/j.bcp.2004.08.025 | β | β | β |
| CheungVGSpielmanRSGenetics of human gene expression: mapping DNA variants that influence gene expressionNat Rev Genet2009105956041963634210.1038/nrg2630PMC2989458 | β | β | β |
| DalyAKGenome-wide association studies in pharmacogenomicsNat Rev Genet2010112412462030008810.1038/nrg2751 | β | β | β |
| DixonALLiangLMoffattMFChenWHeathSWongKCCA genome-wide association study of global gene expressionNat Genet200739120212071787387710.1038/ng2109 | β | β | β |
| DunningMJCurtisCBarbosa-MoraisNLCaldasCTavareSLynchAGThe importance of platform annotation in interpreting microarray dataLancet Oncol2010117172068827310.1016/S1470-2045(10)70115-7 | β | β | β |
| EmilssonVThorleifssonGZhangBLeonardsonASZinkFZhuJGenetics of gene expression and its effect on diseaseNature20084524234281834498110.1038/nature06758 | β | β | β |
| FrankeLJansenRCeQTL analysis in humansMethods Mol Biol20095733113281976393510.1007/978-1-60761-247-6_17 | β | β | β |
| FransenKVisschedijkMCvan SommerenSFuJYFrankeLFestenEAMAnalysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's diseaseHum Mol Genet201019348234882060167610.1093/hmg/ddq264 | β | β | β |
| GentlemanRCCareyVJBatesDMBolstadBDettlingMDudoitSBioconductor: open software development for computational biology and bioinformaticsGenome Biol20045R801546179810.1186/gb-2004-5-10-r80PMC545600 | β | β | β |
| GibbsJRvan der BrugMPHernandezDGTraynorBJNallsMALaiS-LAbundant quantitative trait loci exist for DNA methylation and gene expression in human brainPLoS Genet20106e10009522048556810.1371/journal.pgen.1000952PMC2869317 | β | β | β |
| GiladYRifkinSAPritchardJKRevealing the architecture of gene regulation: the promise of eQTL studiesTrends Genet2008244084151859788510.1016/j.tig.2008.06.001PMC2583071 | β | β | β |
| GΓΆringHHHCurranJEJohnsonMPDyerTDCharlesworthJColeSADiscovery of expression QTLs using large-scale transcriptional profiling in human lymphocytesNat Genet200739120812161787387510.1038/ng2119 | β | β | β |
| HeinzenELGeDCroninKDMaiaJMShiannaKVGabrielWNTissue-specific genetic control of splicing: implications for the study of complex traitsPLoS Biol20086e11922230210.1371/journal.pbio.1000001PMC2605930 | β | β | β |
| HindorffLASethupathyPJunkinsHARamosEMMehtaJPCollinsFSPotential etiologic and functional implications of genome-wide association loci for human diseases and traitsProc Natl Acad Sci USA2009106936293671947429410.1073/pnas.0903103106PMC2687147 | β | β | β |
| HofmannMHBlievernichtJKKleinKSausseleTSchaeffelerESchwabMAberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liverJ Pharmacol Exp Ther20083252842921817190510.1124/jpet.107.133306 | β | β | β |
| HustertEHaberlMBurkOWolboldRHeYQKleinKThe genetic determinants of the CYP3A5 polymorphismPharmacogenetics2001117737791174034110.1097/00008571-200112000-00005 | β | β | β |
| InnocentiFCooperGMStanawayIBGamazonERSmithJDMirkovSIdentification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissuePLoS Genet20117e10020782163779410.1371/journal.pgen.1002078PMC3102751 | β | β | β |
| JohnsonADZhangYPappACPinsonneaultJKLimJ-ESaffenDPolymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissuesPharmacogenet Genomics2008187817911869823110.1097/FPC.0b013e3283050107PMC2779843 | β | β | β |
| KaracaorenBSilanderTAlvarez-CastroJHaleyCde KoningDJAssociation analyses of the MAS-QTL data set using grammar, principal components and Bayesian network methodologiesBMC Proceedings20115(Suppl 3S82162417810.1186/1753-6561-5-S3-S8PMC3103207 | β | β | β |
| KuehlPZhangJLinYLambaJAssemMSchuetzJSequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expressionNat Genet2001273833911127951910.1038/86882 | β | β | β |
| LanzRBJericevicZZuercherWJWatkinsCSteffenDLMargolisRNuclear receptor signaling atlas( www.nursa.org ): hyperlinking the nuclear receptor signaling community.Nucleic Acids Res200634(Database issueD221D2261638185110.1093/nar/gkj029PMC1347392 | β | β | β |
| LiYWillerCSannaSAbecasisGGenotype imputationAnnu Rev Genomics Hum Genet2009103874061971544010.1146/annurev.genom.9.081307.164242PMC2925172 | β | β | β |
| MackayTFStoneEAAyrolesJFThe genetics of quantitative traits: challenges and prospectsNat Rev Genet2009105655771958481010.1038/nrg2612 | β | β | β |
| McCarthyMIAbecasisGRCardonLRGoldsteinDBLittleJIoannidisJPAGenome-wide association studies for complex traits: consensus, uncertainty and challengesNat Rev Genet200893563691839841810.1038/nrg2344 | β | β | β |
| MeyerUAPharmacogenetics and adverse drug reactionsLancet2000356166716711108983810.1016/S0140-6736(00)03167-6 | β | β | β |
| MichaelsonJJLoguercioSBeyerADetection and interpretation of expression quantitative trait loci (eQTL)Methods2009482652761930304910.1016/j.ymeth.2009.03.004 | β | β | β |
| MorleyMMolonyCMWeberTMDevlinJLEwensKGSpielmanRSGenetic analysis of genome-wide variation in human gene expressionNature20044307437471526978210.1038/nature02797PMC2966974 | β | β | β |
| Motsinger-ReifAAJorgensonERellingMVKroetzDLWeinshilboumRCoxNJGenome-wide association studies in pharmacogenomics: successes and lessonsPharmacogenet Genomics2012doi: 10.1097/FPC.0b013e32833d7b45(in press).PMC300394020639796 | β | β | β |
| MyersAJGibbsJRWebsterJARohrerKZhaoAMarloweLA survey of genetic human cortical gene expressionNat Genet200739149414991798245710.1038/ng.2007.16 | β | β | β |
| NiesAKKoepsellHWinterSBurkOKleinKKerbRExpression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liverHepatology200950122712401959119610.1002/hep.23103 | β | β | β |
| PriceALPattersonNJPlengeRMWeinblattMEShadickNAReichDPrincipal components analysis corrects for stratification in genome-wide association studiesNat Genet2006389049091686216110.1038/ng1847 | β | β | β |
| RockmanMVKruglyakLGenetics of global gene expressionNat Rev Genet200678628721704768510.1038/nrg1964 | β | β | β |
| SchadtEEMolonyCChudinEHaoKYangXLumPYMapping the genetic architecture of gene expression in human liverPLoS Biol20086e1071846201710.1371/journal.pbio.0060107PMC2365981 | β | β | β |
| ShinkaTNarodaTTamuraTSasaharaKNakahoriYA rapid and simple method for sex identification by heteroduplex analysis, using denaturing high-performance liquid chromatography (DHPLC)J Hum Genet2001462632661135501610.1007/s100380170076 | β | β | β |
| SimΓ²n-SΓ nchezJSchulteCBrasJMSharmaMGibbsJRBergDGenome-wide association study reveals genetic risk underlying Parkinsons diseaseNat Genet200941130813121991557510.1038/ng.487PMC2787725 | β | β | β |
| SmigielskiEMSirotkinKWardMSherrySTdbSNP: a database of single nucleotide polymorphismsNucleic Acids Res2000283523551059227210.1093/nar/28.1.352PMC102496 | β | β | β |
| SmythGLimma: Linear models for microarray dataIn: Gentleman R, Carey VJ, Huber W, Irizarry RA, Dudoit S (eds).Bioinformatics and Computational Biology Solutions Using R and BioconductorSpringer: New York2005397420 | β | β | β |
| StrangerBENicaACForrestMSDimasABirdCPBeazleyCPopulation genomics of human gene expressionNat Genet200739121712241787387410.1038/ng2142PMC2683249 | β | β | β |
| TianCGregersenPKSeldinMFAccounting for ancestry: population substructure and genome-wide association studiesHum Mol Genet200817(R2R143R1501885220310.1093/hmg/ddn268PMC2782357 | β | β | β |
| TroyanskayaOCantorMSherlockGBrownPHastieTTibshiraniRMissing value estimation methods for DNA microarraysBioinformatics2001175205251139542810.1093/bioinformatics/17.6.520 | β | β | β |
| VeyrierasJ-BKudaravalliSKimSYDermitzakisETGiladYStephensMHigh-resolution mapping of expression-QTLs yields insight into human gene regulationPLoS Genet20084e10002141884621010.1371/journal.pgen.1000214PMC2556086 | β | β | β |
| WebsterJAGibbsJRClarkeJRayMZhangWHolmansPGenetic control of human brain transcript expression in Alzheimer diseaseAm J Hum Genet2009844454581936161310.1016/j.ajhg.2009.03.011PMC2667989 | β | β | β |
| WillerCJSpeliotesEKLoosRJLiSLindgrenCMHeidIMSix new loci associated with body mass index highlight a neuronal influence on body weight regulationNat Genet20094125341907926110.1038/ng.287PMC2695662 | β | β | β |
| ZangerUMTurpeinenMKleinKSchwabMFunctional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformationAnal Bioanal Chem2008392109311081869597810.1007/s00216-008-2291-6 | β | β | β |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | 2014 | 25231870 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| [Androgen receptor-targeted therapies - avoid clinically relevant interactions]. | Lipp HP et al. | β | 2025 | β |
| A Patient-Derived 3D Cyst Model of Polycystic Kidney Disease That Mimics Disease Development and Responds to Repurposing Candidates. | Meyer A et al. | β | 2025 | β |
| From molecular mechanisms of prostate cancer to translational applications: based on multi-omics fusion analysis and intelligent medicine. | Ren S et al. | β | 2024 | β |
| KAT8 beyond Acetylation: A Survey of Its Epigenetic Regulation, Genetic Variability, and Implications for Human Health. | Yoo L et al. | β | 2024 | β |
| OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids. | Mickols E et al. | β | 2024 | β |
| Plasminogen missense variants and their involvement in cardiovascular and inflammatory disease. | Brito-Robinson T et al. | β | 2024 | β |
| Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations. | Khor CC et al. | β | 2023 | β |
| Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans. | Nieschalke K et al. | β | 2023 | β |
| Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity. | Wegler C et al. | β | 2022 | β |
| Hepatic Expression of the Na<sup>+</sup>-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation. | Tremmel R et al. | β | 2022 | β |
| High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development. | Krumm J et al. | β | 2022 | β |
| How paediatric drug development and use could benefit from OMICs: A c4c expert group white paper. | Neumann E et al. | β | 2022 | β |
| Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes. | Wang X et al. | β | 2022 | β |
| Integrating pharmacogenomics into clinical trials of hearing disorders. | Brutnell TP et al. | β | 2022 | β |
| Pharmacogenomics deliberations of 2-deoxy-d-glucose in the treatment of COVID-19 disease: an in silico approach. | Prabhu NB et al. | β | 2022 | β |
| Comprehensive Assessment of Smoking and Sex Related Effects in Publicly Available Gene Expression Data | Flynn E et al. | β | 2021 | β |
| Comprehensive Transcriptome Analyses in Sea Louse Reveal Novel Delousing Drug Responses Through MicroRNA regulation. | NΓΊΓ±ez-AcuΓ±a G et al. | β | 2021 | β |
| Conditions for maintenance of hepatocyte differentiation and function in 3D cultures. | Handin N et al. | β | 2021 | β |
| Epistatic interactions of genetic loci associated with age-related macular degeneration. | Kiel C et al. | β | 2021 | β |
| Expanding the Efflux InΒ Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1. | Wegler C et al. | β | 2021 | β |
| Trypsin Genes Are Regulated through the miRNA Bantam and Associated with Drug Sensitivity in the Sea Louse <i>Caligus rogercresseyi</i>. | NΓΊΓ±ez-AcuΓ±a G et al. | β | 2021 | β |
| A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes. | Etheridge AS et al. | β | 2020 | β |
| Cell-type-resolved proteomic analysis of the human liver. | Γlander M et al. | β | 2020 | β |
| Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression. | Tremmel R et al. | β | 2020 | β |
| Genome-wide pQTL analysis of protein expression regulatory networks in the human liver. | He B et al. | β | 2020 | β |
| The drug likeness analysis of anti-inflammatory clerodane diterpenoids. | Feng Z et al. | β | 2020 | β |
| A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort. | Klein K et al. | β | 2019 | β |
| A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver. | Strunz T et al. | β | 2018 | β |
| Ξ²-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids <i>via</i> Farnesoid X Receptor and Constitutive Androstane Receptor. | Klag T et al. | β | 2018 | β |
| Database of Optimized Proteomic Quantitative Methods for Human Drug Disposition-Related Proteins for Applications in Physiologically Based Pharmacokinetic Modeling. | Vrana M et al. | β | 2017 | β |
| Effect of Genetic Variability in the <i>CYP4F2</i>, <i>CYP4F11</i>, and <i>CYP4F12</i> Genes on Liver mRNA Levels and Warfarin Response. | Zhang JE et al. | β | 2017 | β |
| Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. | Howson JMM et al. | β | 2017 | β |
| <i>ATP2C2</i> and <i>DYX1C1</i> are putative modulators of dyslexia-related MMR. | MΓΌller B et al. | β | 2017 | β |
| Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels. | Tremmel R et al. | β | 2017 | β |
| Molecular Signatures of Primary Human Spermatogonial Progenitors and Its Neighboring Peritubular Stromal Compartment. | Harichandan A et al. | β | 2017 | β |
| Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies. | Tamm R et al. | β | 2017 | β |
| Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21<sup>st</sup> International Symposium on Microsomes and Drug Oxidations (MDO). | Yu AM et al. | β | 2017 | β |
| Relation of Transcriptional Factors to the Expression and Activity of Cytochrome P450 and UDP-Glucuronosyltransferases 1A in Human Liver: Co-Expression Network Analysis. | Zhong S et al. | β | 2017 | β |
| The Genetic Heterogeneity among Different Mouse Strains Impacts the Lung Injury Potential of Multiwalled Carbon Nanotubes. | Wang X et al. | β | 2017 | β |
| The impact of ABCC11 polymorphisms on the risk of early-onset fluoropyrimidine toxicity. | Hamzic S et al. | β | 2017 | β |
| The Promises of Quantitative Proteomics in Precision Medicine. | Prasad B et al. | β | 2017 | β |
| Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach. | Vatakuti S et al. | β | 2017 | β |
| Association between CYP2E1 polymorphisms and risk of differentiated thyroid carcinoma. | PellΓ© L et al. | β | 2016 | β |
| Association, characterisation and meta-analysis of SNPs linked to general reading ability in a German dyslexia case-control cohort. | MΓΌller B et al. | β | 2016 | β |
| Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain. | Guan L et al. | β | 2016 | β |
| Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1. | Tremmel R et al. | β | 2016 | β |
| Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. | Hartiala JA et al. | β | 2016 | β |
| Genomic Characterization of Metformin Hepatic Response. | Luizon MR et al. | β | 2016 | β |
| Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. | Jiang M et al. | β | 2016 | β |
| The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition. | Γlander M et al. | β | 2016 | β |
| Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. | Zhou K et al. | β | 2016 | β |
| Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure. | Vildhede A et al. | β | 2015 | β |
| Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding lociβ . | Kirsten H et al. | β | 2015 | β |
| Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children. | Breitling C et al. | β | 2015 | β |
| Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort. | Vandenberghe F et al. | β | 2015 | β |
| Peroxisome proliferator-activated receptor alpha, PPARΞ±, directly regulates transcription of cytochrome P450 CYP2C8. | Thomas M et al. | β | 2015 | β |
| The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARΞ±-tr, autonomously regulates proliferative and pro-inflammatory genes. | Thomas M et al. | β | 2015 | β |
| Uncovering RNA binding proteins associated with age and gender during liver maturation. | Chaturvedi P et al. | β | 2015 | β |
| Development of a broad-based ADME panel for use in pharmacogenomic studies. | Brown AM et al. | β | 2014 | β |
| Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. | Ganesh SK et al. | β | 2014 | β |
| Genetic and epigenetic regulation of gene expression in fetal and adult human livers. | Bonder MJ et al. | β | 2014 | β |
| Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population. | Wang X et al. | β | 2014 | β |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. | Perry JR et al. | β | 2014 | β |
| Promise of pharmacogenomics for drug discovery, treatment and prevention of Parkinson's disease. A perspective. | Payami H et al. | β | 2014 | β |
| Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs. | Zhang X et al. | β | 2014 | β |
| ABCC11/MRP8 polymorphisms affect 5-fluorouracil-induced severe toxicity and hepatic expression. | Magdy T et al. | β | 2013 | β |
| Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Zanger UM et al. | β | 2013 | β |
| Developmental changes in the expression and function of cytochrome P450 3A isoforms: evidence from in vitro and in vivo investigations. | Ince I et al. | β | 2013 | β |
| Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression. | Rieger JK et al. | β | 2013 | β |
| Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1. | Nies AT et al. | β | 2013 | β |
| Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel. | Kim S et al. | β | 2013 | β |
| Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. | Sabater-Lleal M et al. | β | 2013 | β |
| Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem. | Klein K et al. | β | 2013 | β |
| A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT. | Brown CC et al. | β | 2012 | β |
| DMET-analyzer: automatic analysis of Affymetrix DMET data. | Guzzi PH et al. | β | 2012 | β |
| Genetic polymorphisms affecting drug metabolism: recent advances and clinical aspects. | Daly AK | β | 2012 | β |
| Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project. | Auer PL et al. | β | 2012 | β |
| Liver expression quantitative trait loci: a foundation for pharmacogenomic research. | Glubb DM et al. | β | 2012 | β |