Complement factor H polymorphism in age-related macular degeneration.
paper
Cited
Public
Unavailable
- Authors
- Klein, Robert J; Zeiss, Caroline; Chew, Emily Y; Tsai, Jen-Yue; Sackler, Richard S; Haynes, Chad; Henning, Alice K; SanGiovanni, John Paul; Mane, Shrikant M; Mayne, Susan T; Bracken, Michael B; Ferris, Frederick L; Ott, Jurg; Barnstable, Colin; Hoh, Josephine
- Year
- 2005
- Journal
- Science (New York, N.Y.)
- PMID
- 15761122
- DOI
- 10.1126/science.1109557
- PMCID
- PMC1512523
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204 single-nucleotide polymorphisms genotyped, an intronic and common variant in the complement factor H gene (CFH) is strongly associated with AMD (nominal P value <10(-7)). In individuals homozygous for the risk allele, the likelihood of AMD is increased by a factor of 7.4 (95% confidence interval 2.9 to 19). Resequencing revealed a polymorphism in linkage disequilibrium with the risk allele representing a tyrosine-histidine change at amino acid 402. This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies.
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| Thrombospondin-1, BIM and CFH polymorphisms and response to anti-VEGF treatment in neovascular age- related macular degeneration patients. | Sorenson CM et al. | — | 2024 | → |
| Unravelling the Genetic Landscape of Hemiplegic Migraine: Exploring Innovative Strategies and Emerging Approaches. | Alfayyadh MM et al. | — | 2024 | → |
| 10 Years of GWAS in intraocular pressure. | Gao XR et al. | — | 2023 | → |
| AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model. | Grigsby D et al. | — | 2023 | → |
| Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits. | de Hemptinne MC et al. | — | 2023 | → |
| Adverse COVID-19 outcomes in American Veterans with age-related macular degeneration: a case-control study. | Armbrust KR et al. | — | 2023 | → |
| Age-related macular degeneration. | Guymer RH et al. | — | 2023 | → |
| Age-related macular degeneration: A disease of extracellular complement amplification. | de Jong S et al. | — | 2023 | → |
| Age-Related Macular Degeneration: An Exponentially Emerging Imminent Threat of Visual Impairment and Irreversible Blindness. | Chaudhuri M et al. | — | 2023 | → |
| A Guide to Genome-Wide Association Study Design for Diabetic Retinopathy. | Gurung RL et al. | — | 2023 | → |
| Alternative pathway diagnostics. | Thurman JM et al. | — | 2023 | → |
| A multi-threaded approach to genotype pattern mining for detecting digenic disease genes. | Zhang Q et al. | — | 2023 | → |
| An in-depth association analysis of genetic variants within nicotine-related loci: Meeting in middle of GWAS and genetic fine-mapping. | Mo C et al. | — | 2023 | → |
| Associations Between Autoimmune Disease and the Development of Age-Related Macular Degeneration. | Moir J et al. | — | 2023 | → |
| Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults. | Singh S et al. | — | 2023 | → |
| Bruch's Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration. | Hammadi S et al. | — | 2023 | → |
| CD11c+ macrophages are proangiogenic and necessary for experimental choroidal neovascularization. | Droho S et al. | — | 2023 | → |
| Complement factor H inhibits endothelial cell migration through suppression of STAT3 signaling. | Li J et al. | — | 2023 | → |
| COMPLEMENT INHIBITION FOR GEOGRAPHIC ATROPHY: Review of Salient Functional Outcomes and Perspective. | Spaide RF et al. | — | 2023 | → |
| Complement Inhibitors for Advanced Dry Age-Related Macular Degeneration (Geographic Atrophy): Some Light at the End of the Tunnel? | Cruz-Pimentel M et al. | — | 2023 | → |
| Complement inhibitors for age-related macular degeneration. | Tzoumas N et al. | — | 2023 | → |
| Contribution of animal models to the mechanistic understanding of Alternative Pathway and Amplification Loop (AP/AL)-driven Complement-mediated Diseases. | Gibson BG et al. | — | 2023 | → |
| Controversies and Disparities in the Management of Age-Related Macular Degeneration. | Fairbanks AM et al. | — | 2023 | → |
| Co-occurrence of chronic kidney disease and glaucoma: Epidemiology and etiological mechanisms. | Liu W et al. | — | 2023 | → |
| Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration. | Gogna N et al. | — | 2023 | → |
| Detecting patterns of accessory genome coevolution in Staphylococcus aureus using data from thousands of genomes. | Mehta RS et al. | — | 2023 | → |
| Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex. | Gytz Olesen H et al. | — | 2023 | → |
| Digenic Analysis Finds Highly Interactive Genetic Variants Underlying Polygenic Traits. | Wang G et al. | — | 2023 | → |
| Dysfunctional Autophagy, Proteostasis, and Mitochondria as a Prelude to Age-Related Macular Degeneration. | Lenin RR et al. | — | 2023 | → |
| Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life. | Hata M et al. | — | 2023 | → |
| Editorial: Genetics of inflammatory and immune diseases. | Wang T et al. | — | 2023 | → |
| Editorial: Statistical methods for genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) and their applications. | Shao M et al. | — | 2023 | → |
| Effect of case and control definitions on genome-wide association study (GWAS) findings. | Isgut M et al. | — | 2023 | → |
| Emerging synovial cell states in rheumatoid arthritis as potential therapeutic targets. | Mantel I et al. | — | 2023 | → |
| Emerging therapeutic strategies for unmet need in neovascular age-related macular degeneration. | Khachigian LM et al. | — | 2023 | → |
| Evolution of the spinach sex-linked region within a rarely recombining pericentromeric region. | She H et al. | — | 2023 | → |
| Examining the shared etiology of psychopathology with genome-wide association studies. | Mallard TT et al. | — | 2023 | → |
| Exogenous CFH Modulates Levels of Pro-Inflammatory Mediators to Prevent Oxidative Damage of Retinal Pigment Epithelial Cells with the At-Risk CFH Y402H Variant. | Velazquez-Soto H et al. | — | 2023 | → |
| Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration. | Pan Y et al. | — | 2023 | → |
| Exploring the Research Landscape of High Myopia: Trends, Contributors, and Key Areas of Focus. | Chi K et al. | — | 2023 | → |
| Family History of Age-Related Macular Degeneration and Genetics Predict Progression to Advanced Age-Related Macular Degeneration Adjusting for Macular Status, Demographic, and Lifestyle Factors. | Seddon JM et al. | — | 2023 | → |
| From genetic variation to precision medicine. | Sergouniotis PI et al. | — | 2023 | → |
| Future prospects for human genetics and genomics in drug discovery. | Ghoussaini M et al. | — | 2023 | → |
| Gene Association Analysis of Quantitative Trait Based on Functional Linear Regression Model with Local Sparse Estimator. | Wang J et al. | — | 2023 | → |
| Genetic and molecular biomarkers for geographic atrophy. | Riley-Gillis B et al. | — | 2023 | → |
| Genetic Variability of Complement Factor H Has Ethnicity-Specific Associations With Choroidal Thickness. | Fenner BJ et al. | — | 2023 | → |
| Genetic variability shapes the alternative pathway complement activity and predisposition to complement-related diseases. | Rodríguez de Córdoba S | — | 2023 | → |
| Genome-wide association analysis identified molecular markers and candidate genes for flower traits in Chinese orchid (<i>Cymbidium sinense</i>). | Yang F et al. | — | 2023 | → |
| Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs. | Zhou F et al. | — | 2023 | → |
| Genome-wide association studies: utility and limitations for research in physiology. | Pereira Ciochetti N et al. | — | 2023 | → |
| Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway. | Mori Y et al. | — | 2023 | → |
| Genome-wide association study on abdomen depth, head width, hip width, and withers height in native cattle of Guilan (Bos indicus). | Jourshari MG et al. | — | 2023 | → |
| Genome-wide association testing in malaria studies in the presence of overdominance. | Akoth M et al. | — | 2023 | → |
| Geographic atrophy: pathophysiology and current therapeutic strategies. | Rajanala K et al. | — | 2023 | → |
| Human height: a model common complex trait. | Conery M et al. | — | 2023 | → |
| Identification and validation of lactate metabolism-related genes in oxygen-induced retinopathy. | Xu J et al. | — | 2023 | → |
| Identifying Novel Genes and Variants in Immune and Coagulation Pathways Associated with Macular Degeneration. | Huan T et al. | — | 2023 | → |
| Importance of Diversity in Precision Medicine: Generalizability of Genetic Associations Across Ancestry Groups Toward Better Identification of Disease Susceptibility Variants. | Cruz LA et al. | — | 2023 | → |
| Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up. | Jung W et al. | — | 2023 | → |
| Inflammation and retinal degenerative diseases. | Kaur G et al. | — | 2023 | → |
| Intracellular complement: Evidence, definitions, controversies, and solutions. | King BC et al. | — | 2023 | → |
| Knockout of AMD-associated gene <i>POLDIP2</i> reduces mitochondrial superoxide in human retinal pigment epithelial cells. | Nguyen T et al. | — | 2023 | → |
| Latest Development on Genetics of Common Retinal Diseases. | Chen LJ et al. | — | 2023 | → |
| Leveraging Single-Cell Populations to Uncover the Genetic Basis of Complex Traits. | Minow MAA et al. | — | 2023 | → |
| Local complement synthesis-A process with near and far consequences for ischemia reperfusion injury and transplantation. | Nauser CL et al. | — | 2023 | → |
| Mechanistic Insight into Age-Related Macular Degeneration (AMD): Anatomy, Epidemiology, Genetics, Pathogenesis, Prevention, Implications, and Treatment Strategies to Pace AMD Management. | Amini MA et al. | — | 2023 | → |
| MicroRNAs as potential biomarkers and therapeutic targets in age-related macular degeneration. | Cruz-Aguilar M et al. | — | 2023 | → |
| Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. | Shrine N et al. | — | 2023 | → |
| Natural variation of respiration-related traits in plants. | Bulut M et al. | — | 2023 | → |
| New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications. | Andreassen OA et al. | — | 2023 | → |
| NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration. | Droho S et al. | — | 2023 | → |
| NSPA: characterizing the disease association of multiple genetic interactions at single-subject resolution. | Sha Z et al. | — | 2023 | → |
| Ocular manifestations in renal diseases. | Goyal JL et al. | — | 2023 | → |
| Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation. | Wang X et al. | — | 2023 | → |
| Oxidative stress in retinal pigment epithelium degeneration: from pathogenesis to therapeutic targets in dry age-related macular degeneration. | Maurya M et al. | — | 2023 | → |
| PENTOSAN POLYSULFATE SODIUM (ELMIRON) MACULOPATHY: A Genetic Perspective. | Kalaw FGP et al. | — | 2023 | → |
| Physiology and pathology of the C3 amplification cycle: A retrospective. | Peters K | — | 2023 | → |
| Polypoidal Choroidal Vasculopathy: Updates on Risk Factors, Diagnosis, and Treatments. | Ruamviboonsuk P et al. | — | 2023 | → |
| Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease. | Yeyeodu S et al. | — | 2023 | → |
| Potential therapeutic targets for age-related macular degeneration: The nuclear option. | Choudhary M et al. | — | 2023 | → |
| Progress in genetics of type 2 diabetes and diabetic complications. | Shojima N et al. | — | 2023 | → |
| Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration. | Molcak H et al. | — | 2023 | → |
| Qihuang Granule protects the retinal pigment epithelium from oxidative stress via regulation of the alternative complement pathway. | Wang Y et al. | — | 2023 | → |
| Recent Developments in Gene Therapy for Neovascular Age-Related Macular Degeneration: A Review. | Finocchio L et al. | — | 2023 | → |
| Regulatable Complement Inhibition of the Alternative Pathway Mitigates Wet Age-Related Macular Degeneration Pathology in a Mouse Model. | Parsons NB et al. | — | 2023 | → |
| Risk and protection of different rare protein-coding variants of complement component C4A in age-related macular degeneration. | Seddon JM et al. | — | 2023 | → |
| Role of Adrenomedullin 2/Intermedin in the Pathogenesis of Neovascular Age-Related Macular Degeneration. | Kakihara S et al. | — | 2023 | → |
| RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models. | Millington-Ward S et al. | — | 2023 | → |
| Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration. | Shome I et al. | — | 2023 | → |
| Tear fluid and complement activation products in tears after ocular surgery. | Maehara H et al. | — | 2023 | → |
| The Activation of JAK/STAT3 Signaling and the Complement System Modulate Inflammation in the Primary Human Dermal Fibroblasts of PXE Patients. | Lindenkamp C et al. | — | 2023 | → |
| The complement alternative pathway in health and disease-activation or amplification? | Harrison RA et al. | — | 2023 | → |
| The complement system: a novel therapeutic target for age-related macular degeneration. | Shughoury A et al. | — | 2023 | → |
| The Factor H protein family: The switchers of the complement alternative pathway. | Lucientes-Continente L et al. | — | 2023 | → |
| The growth curve determination and economic trait correlation for Qinchuan bull population. | Hengwei Y et al. | — | 2023 | → |
| The Hoof Color of Australian White Sheep Is Associated with Genetic Variation of the <i>MITF</i> Gene. | Su P et al. | — | 2023 | → |
| The Noncanonical Role of Complement Factor H in Retinal Pigment Epithelium (RPE) Cells and Implications for Age-Related Macular Degeneration (AMD). | Armento A et al. | — | 2023 | → |
| The Role of Inflammation in Age-Related Macular Degeneration: Updates and Possible Therapeutic Approaches. | Arrigo A et al. | — | 2023 | → |
| The role of the gut microbiome in eye diseases. | Zysset-Burri DC et al. | — | 2023 | → |
| The susceptibility of the kidney to alternative pathway activation-A hypothesis. | Thurman JM et al. | — | 2023 | → |
| Voluntary exercise modulates pathways associated with amelioration of retinal degenerative diseases. | Chu-Tan JA et al. | — | 2023 | → |
| Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration. | Acar IE et al. | — | 2023 | → |
| WITHDRAWN: Pegcetacoplan in the treatment of geographic atrophy. | Kumar M et al. | — | 2023 | → |
| Wrestling with Social and Behavioral Genomics: Risks, Potential Benefits, and Ethical Responsibility. | Meyer MN et al. | — | 2023 | → |
| 3D genome organization links non-coding disease-associated variants to genes. | Orozco G et al. | — | 2022 | → |
| A Clinical and Preclinical Assessment of Clinical Trials for Dry Age-Related Macular Degeneration. | Abidi M et al. | — | 2022 | → |
| Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy. | Deng Y et al. | — | 2022 | → |
| Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration. | Kato Y et al. | — | 2022 | → |
| AMD Genomics: Non-Coding RNAs as Biomarkers and Therapeutic Targets. | Zhang C et al. | — | 2022 | → |
| An Approach of Epistasis Detection Using Integer Linear Programming Optimizing Bayesian Network. | Yang X et al. | — | 2022 | → |
| An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration. | Biggs RM et al. | — | 2022 | → |
| A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative <i>CFI</i> variants in age-related macular degeneration. | Hallam TM et al. | — | 2022 | → |
| A Novel Multitasking Ant Colony Optimization Method for Detecting Multiorder SNP Interactions. | Tuo S et al. | — | 2022 | → |
| A proteogenomic signature of age-related macular degeneration in blood. | Emilsson V et al. | — | 2022 | → |
| A Secure High-Order Gene Interaction Detecting Method for Infectious Diseases. | Wang H et al. | — | 2022 | → |
| Association of Age-Related Macular Degeneration with Prior Hyperthyroidism and Hypothyroidism: A Case-Control Study. | Hung SH et al. | — | 2022 | → |
| Association of <i>CFH</i> and <i>MAP1LC3B</i> gene polymorphisms with age-related macular degeneration in a high-altitude population. | Guan RJ et al. | — | 2022 | → |
| Bioengineering approaches for modelling retinal pathologies of the outer blood-retinal barrier. | Molins B et al. | — | 2022 | → |
| Biomarkers as Predictive Factors of Anti-VEGF Response. | Bobadilla M et al. | — | 2022 | → |
| Breeding of African sheep reared under low-input/output smallholder production systems for trypanotolerance. | Malatji DP | — | 2022 | → |
| C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex. | Cong Q et al. | — | 2022 | → |
| C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration. | Yednock T et al. | — | 2022 | → |
| Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration. | Bharti K et al. | — | 2022 | → |
| Challenges and future directions for studying effects of host genetics on the gut microbiome. | Sanna S et al. | — | 2022 | → |
| Circulating complement factor H levels are associated with disease severity and relapse in autoimmune hepatitis. | Hayashi M et al. | — | 2022 | → |
| CNest: A novel copy number association discovery method uncovers 862 new associations from 200,629 whole-exome sequence datasets in the UK Biobank. | Fitzgerald T et al. | — | 2022 | → |
| Cognitive neuroscience at the crossroads. | — | — | 2022 | → |
| Complement cascade functions during brain development and neurodegeneration. | Fatoba O et al. | — | 2022 | → |
| Computational Genomics in the Era of Precision Medicine: Applications to Variant Analysis and Gene Therapy. | Wang YC et al. | — | 2022 | → |
| Concurrent outcomes from multiple approaches of epistasis analysis for human body mass index associated loci provide insights into obesity biology. | D'Silva S et al. | — | 2022 | → |
| Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish. | Waksmunski AR et al. | — | 2022 | → |
| Elastin turnover in ocular diseases: A special focus on age-related macular degeneration. | Navneet S et al. | — | 2022 | → |
| ELSSI: parallel SNP-SNP interactions detection by ensemble multi-type detectors. | Wang X et al. | — | 2022 | → |
| Epigenetics and Degenerative Retinal Diseases: Prospects for New Therapeutic Approaches. | Barnstable CJ | — | 2022 | → |
| Epigenetics and genetics of hepatoblastoma: Linkage and treatment. | Zhu LR et al. | — | 2022 | → |
| Evaluating the clinical utility of measuring levels of factor H and the related proteins. | Banerjee P et al. | — | 2022 | → |
| Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options. | Fernandes AR et al. | — | 2022 | → |
| Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain. | Parker A et al. | — | 2022 | → |
| From Genes, Proteins, and Clinical Manifestation: Why Do We Need to Better Understand Age-Related Macular Degeneration? | Schmitz-Valckenberg S et al. | — | 2022 | → |
| From Genome-Wide to Environment-Wide: Capturing the Environome. | von Stumm S et al. | — | 2022 | → |
| Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies. | Camilleri M et al. | — | 2022 | → |
| Genetic susceptibility to autoimmunity-Current status and challenges. | Huang M et al. | — | 2022 | → |
| Genetic Variants of Complement Factor H Y402H (rs1061170), C2 R102G (rs2230199), and C3 E318D (rs9332739) and Response to Intravitreal Anti-VEGF Treatment in Patients with Exudative Age-Related Macular Degeneration. | Kubicka-Trząska A et al. | — | 2022 | → |
| Genome-Wide Association Studies and Haplotype-Sharing Analysis Targeting the Egg Production Traits in Shaoxing Duck. | Xu W et al. | — | 2022 | → |
| Genome-Wide Association Study Identifies a Rice Panicle Blast Resistance Gene <i>Pb3</i> Encoding NLR Protein. | Ma L et al. | — | 2022 | → |
| Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration. | Osterman MD et al. | — | 2022 | → |
| Gut Microbes and Eye Disease. | Donabedian P et al. | — | 2022 | → |
| Heritability of retinal drusen in the Copenhagen Twin Cohort Eye Study. | Belmouhand M et al. | — | 2022 | → |
| High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota. | Xiao J et al. | — | 2022 | → |
| Human pluripotent stem cells for the modelling of retinal pigment epithelium homeostasis and disease: A review. | Hall JC et al. | — | 2022 | → |
| Identification of Genomic Regions and Candidate Genes Associated with Body Weight and Body Conformation Traits in Karachai Goats. | Easa AA et al. | — | 2022 | → |
| <i>IGF1R</i> and <i>LOX</i> Modules Are Related to Antler Growth Rate Revealed by Integrated Analyses of Genomics and Transcriptomics. | Hu P et al. | — | 2022 | → |
| Incorporating regulatory interactions into gene-set analyses for GWAS data: A controlled analysis with the MAGMA tool. | Groenewoud D et al. | — | 2022 | → |
| Inhibition of Complement Factor 3 in Geographic Atrophy with NGM621: Phase 1 Dose-Escalation Study Results. | Wykoff CC et al. | — | 2022 | → |
| Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis. | Slenders L et al. | — | 2022 | → |
| Leveraging the local genetic structure for trans-ancestry association mapping. | Xiao J et al. | — | 2022 | → |
| Lipid profile and future risk of exudative age-related macular degeneration development: a nationwide cohort study from South Korea. | Hwang S et al. | — | 2022 | → |
| Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration. | Mulfaul K et al. | — | 2022 | → |
| Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization. | Trivizki O et al. | — | 2022 | → |
| Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26. | Mcharg S et al. | — | 2022 | → |
| Maximal Information Coefficient-Based Testing to Identify Epistasis in Case-Control Association Studies. | Guo Y et al. | — | 2022 | → |
| MDSN: A Module Detection Method for Identifying High-Order Epistatic Interactions. | Sun Y et al. | — | 2022 | → |
| Missing heritability found for height. | Kuchenbaecker K | — | 2022 | → |
| Molecular Genetic Mechanisms in Age-Related Macular Degeneration. | Shughoury A et al. | — | 2022 | → |
| Multi-Objective Artificial Bee Colony Algorithm Based on Scale-Free Network for Epistasis Detection. | Gu Y et al. | — | 2022 | → |
| Patients with MPNs and retinal drusen show signs of complement system dysregulation and a high degree of chronic low-grade inflammation. | Liisborg C et al. | — | 2022 | → |
| Performing Genome-Wide Association Studies Using rMVP. | Liu X et al. | — | 2022 | → |
| Photoreceptor Layer Thinning Is an Early Biomarker for Age-Related Macular Degeneration: Epidemiologic and Genetic Evidence from UK Biobank OCT Data. | Zekavat SM et al. | — | 2022 | → |
| Potential participation of CTRP6, a complement regulator, in the pathology of age related macular degeneration. | Shinomiya K et al. | — | 2022 | → |
| Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge. | Wainberg M et al. | — | 2022 | → |
| Progression of Age-Related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5) or Chromosome 10 (ARMS2/HTRA1) or Both. | Schmitz-Valckenberg S et al. | — | 2022 | → |
| Regenerative Medicine, Advanced Stem Cell, and Gene Therapies for Eye Diseases. | Barnstable CJ et al. | — | 2022 | → |
| Relative Telomere Length Is Associated With Age-Related Macular Degeneration in Women. | Koller A et al. | — | 2022 | → |
| rs10737680 polymorphism in complement factor H and neovascular age-related macular degeneration in Yogyakarta, Indonesia. | Sigalingging T et al. | — | 2022 | → |
| Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration. | Marin AI et al. | — | 2022 | → |
| Sex-Differences and Associations Between Complement Activation and Synovial Vascularization in Patients with Late-Stage Knee Osteoarthritis. | Sodhi EU et al. | — | 2022 | → |
| Single-cell omics: A new direction for functional genetic research in human diseases and animal models. | Kong S et al. | — | 2022 | → |
| Statistical methods for Mendelian randomization in genome-wide association studies: A review. | Boehm FJ et al. | — | 2022 | → |
| Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration: A Systematic Review. | Lin JB et al. | — | 2022 | → |
| Systems genomics in age-related macular degeneration. | den Hollander AI et al. | — | 2022 | → |
| Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy. | Yang S et al. | — | 2022 | → |
| Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models. | Landowski M et al. | — | 2022 | → |
| The Genetic Architecture of Non-Syndromic Rhegmatogenous Retinal Detachment. | Moledina M et al. | — | 2022 | → |
| The Importance of a Genome-Wide Association Analysis in the Study of Alternative Splicing Mutations in Plants with a Special Focus on Maize. | Jia ZC et al. | — | 2022 | → |
| The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases. | Alsheikh AJ et al. | — | 2022 | → |
| The potential of marine resources for retinal diseases: a systematic review of the molecular mechanisms. | Krueger K et al. | — | 2022 | → |
| The role of dual antiplatelets in geographic atrophy secondary to non-neovascular aged-related macular degeneration. | Chantarasorn Y et al. | — | 2022 | → |
| The role of properdin and Factor H in disease. | Cortes C et al. | — | 2022 | → |
| The Role of Sulfation in Nematode Development and Phenotypic Plasticity. | Igreja C et al. | — | 2022 | → |
| Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration. | Senabouth A et al. | — | 2022 | → |
| Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases. | Barnstable CJ et al. | — | 2022 | → |
| Variants in PRKCE and KLC1, Potential Regulators of Type I Psoriasis. | Xing J et al. | — | 2022 | → |
| What have we learned from genome-wide association studies (GWAS) in Parkinson's disease? | Fernández-Santiago R et al. | — | 2022 | → |
| A comparative study on the unified model based multifactor dimensionality reduction methods for identifying gene-gene interactions associated with the survival phenotype. | Lee JW et al. | — | 2021 | → |
| A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in <i>C. elegans</i> cilia. | Acker N et al. | — | 2021 | → |
| Age-related macular degeneration. | Fleckenstein M et al. | — | 2021 | → |
| Age-related macular degeneration and premorbid allergic diseases: a population-based case-control study. | Shen YC et al. | — | 2021 | → |
| Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration. | Hirai H et al. | — | 2021 | → |
| Anti-inflammatory Effects of GTE in Eye Diseases. | Li J et al. | — | 2021 | → |
| A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration. | Halawa OA et al. | — | 2021 | → |
| A Single-Step Genome Wide Association Study on Body Size Traits Using Imputation-Based Whole-Genome Sequence Data in Yorkshire Pigs. | Liu H et al. | — | 2021 | → |
| A Splice Variant in <i>SLC16A8</i> Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells. | Klipfel L et al. | — | 2021 | → |
| Association of Dietary Nutrient Intake with Early Age-Related Macular Degeneration in Japanese-Americans. | Edo A et al. | — | 2021 | → |
| Association of genetic variants rs641153 (<i>CFB</i>), rs2230199 (<i>C3</i>), and rs1410996 (<i>CFH</i>) with age-related macular degeneration in a Brazilian population. | Neto JM et al. | — | 2021 | → |
| Associations of <i>ARMS2</i> and <i>CFH</i> Gene Polymorphisms with Neovascular Age-Related Macular Degeneration. | Supanji S et al. | — | 2021 | → |
| Average semivariance yields accurate estimates of the fraction of marker-associated genetic variance and heritability in complex trait analyses. | Feldmann MJ et al. | — | 2021 | → |
| Bench Research Informed by GWAS Results. | Kondratyev NV et al. | — | 2021 | → |
| Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations. | Cipriani V et al. | — | 2021 | → |
| Beyond the Liver: Liver-Eye Communication in Clinical and Experimental Aspects. | Yuan TH et al. | — | 2021 | → |
| Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci. | Hammond RK et al. | — | 2021 | → |
| C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. | Jaffe GJ et al. | — | 2021 | → |
| Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease. | Tanaka K et al. | — | 2021 | → |
| Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration. | Lorés-Motta L et al. | — | 2021 | → |
| Complement as a powerful "influencer" in the brain during development, adulthood and neurological disorders. | Petrisko TJ et al. | — | 2021 | → |
| Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway. | Murray H et al. | — | 2021 | → |
| Complement Factor H Gene Variant in a Patient with Thrombotic Microangiopathy on a Mixed Clinical Background. | Iwafuchi Y et al. | — | 2021 | → |
| Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model. | Armento A et al. | — | 2021 | → |
| Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells. | Schäfer N et al. | — | 2021 | → |
| Complement Inhibition for Geographic Atrophy: A Tempting Target with Mixed Results. | Lin JB et al. | — | 2021 | → |
| Complement Inhibitors in Age-Related Macular Degeneration: A Potential Therapeutic Option. | Qin S et al. | — | 2021 | → |
| Complement in metabolic disease: metaflammation and a two-edged sword. | King BC et al. | — | 2021 | → |
| Deficits in Monocyte Function in Age Related Macular Degeneration: A Novel Systemic Change Associated With the Disease. | Gu BJ et al. | — | 2021 | → |
| Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina. | Farhan F et al. | — | 2021 | → |
| Dendritic cells play no significant role in the laser-induced choroidal neovascularization model. | Droho S et al. | — | 2021 | → |
| Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration. | Demirs JT et al. | — | 2021 | → |
| Dissecting polygenic signals from genome-wide association studies on human behaviour. | Abdellaoui A et al. | — | 2021 | → |
| Editorial: Advances in Genomics of Crossbred Farm Animals. | Wu XL et al. | — | 2021 | → |
| Epistatic interactions of genetic loci associated with age-related macular degeneration. | Kiel C et al. | — | 2021 | → |
| EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases. | Yuan J et al. | — | 2021 | → |
| Functional Mapping of Phenotypic Plasticity of <i>Staphylococcus aureus</i> Under Vancomycin Pressure. | Yang D et al. | — | 2021 | → |
| Functional microRNA targetome undergoes degeneration-induced shift in the retina. | Chu-Tan JA et al. | — | 2021 | → |
| Functional Screenings Identify Regulatory Variants Associated with Breast Cancer Susceptibility. | Ren N et al. | — | 2021 | → |
| Gene Therapy in the Treatment of Geographic Atrophy. | Csaky KG | — | 2021 | → |
| Genetic Association between <i>MMP9</i> and Choroidal Neovascularization in Age-Related Macular Degeneration. | Sohn EH et al. | — | 2021 | → |
| Genetic Basis of Dual Diagnosis: A Review of Genome-Wide Association Studies (GWAS) Focusing on Patients with Mood or Anxiety Disorders and Co-Occurring Alcohol-Use Disorders. | Stoychev K et al. | — | 2021 | → |
| Genetic factors associated with age-related macular degeneration: identification of a novel PRPH2 single nucleotide polymorphism associated with increased risk of the disease. | Ulańczyk Z et al. | — | 2021 | → |
| Genetic loci associated with winter survivorship in diverse lowland switchgrass populations. | Poudel HP et al. | — | 2021 | → |
| Genetic Parameters and Genome-Wide Association Studies of Eight Longevity Traits Representing Either Full or Partial Lifespan in Chinese Holsteins. | Zhang H et al. | — | 2021 | → |
| Genetic polymorphisms of the HLA-DP and HLA-DQ genes could influence Hepatitis B virus infection in Yunnan population. | Song Y et al. | — | 2021 | → |
| Genetic predisposition to tinnitus in the UK Biobank population. | Urbanek ME et al. | — | 2021 | → |
| Genetic Risk Stratification: A Paradigm Shift in Prevention of Coronary Artery Disease. | Roberts R et al. | — | 2021 | → |
| Genetics of Progressive Supranuclear Palsy: A Review. | Wen Y et al. | — | 2021 | → |
| Genome-wide association analysis identified molecular markers associated with important tea flavor-related metabolites. | Fang K et al. | — | 2021 | → |
| Genome-wide association mapping in maize: status and prospects. | Shikha K et al. | — | 2021 | → |
| Genome-wide association studies: assessing trait characteristics in model and crop plants. | Alseekh S et al. | — | 2021 | → |
| Genomewide Association Studies in Pharmacogenomics. | McInnes G et al. | — | 2021 | → |
| Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats. | Zhang L et al. | — | 2021 | → |
| Genotype Pattern Mining for Pairs of Interacting Variants Underlying Digenic Traits. | Okazaki A et al. | — | 2021 | → |
| Genotype-phenotype correlation and interaction of 4q25, 15q14 and <i>MIPEP</i> variants with myopia in southern Chinese population. | Liu J et al. | — | 2021 | → |
| Glycoprotein 2 in health and disease: lifting the veil. | Lin Y et al. | — | 2021 | → |
| GWAS for genetics of complex quantitative traits: Genome to pangenome and SNPs to SVs and k-mers. | Gupta PK | — | 2021 | → |
| HDL Cholesterol and Non-Cardiovascular Disease: A Narrative Review. | Kjeldsen EW et al. | — | 2021 | → |
| High Myopia and the Complement System: Factor H in Myopic Maculopathy. | García-Gen E et al. | — | 2021 | → |
| Hijacking Factor H for Complement Immune Evasion. | Moore SR et al. | — | 2021 | → |
| IL-1/IL-1R signaling induced by all-trans-retinal contributes to complement alternative pathway activation in retinal pigment epithelium. | Cheng X et al. | — | 2021 | → |
| Impacts of high fat diet on ocular outcomes in rodent models of visual disease. | Clarkson-Townsend DA et al. | — | 2021 | → |
| Implications of genetic variation in the complement system in age-related macular degeneration. | de Jong S et al. | — | 2021 | → |
| Increasing calling accuracy, coverage, and read-depth in sequence data by the use of haplotype blocks. | Pook T et al. | — | 2021 | → |
| Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor H. | Romero-Vazquez S et al. | — | 2021 | → |
| Interpretable artificial neural networks incorporating Bayesian alphabet models for genome-wide prediction and association studies. | Zhao T et al. | — | 2021 | → |
| Low-Reflectivity Drusen With Overlying RPE Damage Revealed by Spectral-Domain OCT: Hint for the Development of Age-Related Macular Degeneration. | Yang S et al. | — | 2021 | → |
| MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy. | Hyttinen JMT et al. | — | 2021 | → |
| MoBPSweb: A web-based framework to simulate and compare breeding programs. | Pook T et al. | — | 2021 | → |
| Morphologic Predictors and Temporal Characteristics of Conversion from Nonexudative to Exudative Age-Related Macular Degeneration in the Fellow Eye. | Teo KYC et al. | — | 2021 | → |
| mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells. | Merle DA et al. | — | 2021 | → |
| Novel EDGE encoding method enhances ability to identify genetic interactions. | Hall MA et al. | — | 2021 | → |
| Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration. | Narendran S et al. | — | 2021 | → |
| Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration. | May A et al. | — | 2021 | → |
| Pathway analysis for genome-wide genetic variation data: Analytic principles, latest developments, and new opportunities. | Silberstein M et al. | — | 2021 | → |
| Photobiomodulation therapy in age-related macular degeneration. | Muste JC et al. | — | 2021 | → |
| Photoreceptor layer thinning is an early biomarker for age-related macular degeneration development: Epidemiological and genetic evidence from UK Biobank optical coherence tomography data | Zekavat SM et al. | — | 2021 | — |
| Power analysis of transcriptome-wide association study: Implications for practical protocol choice. | Cao C et al. | — | 2021 | → |
| Progress in developing rodent models of age-related macular degeneration (AMD). | Soundara Pandi SP et al. | — | 2021 | → |
| Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci. | Pappas CM et al. | — | 2021 | → |
| Recessive/dominant model: Alternative choice in case-control-based genome-wide association studies. | Liu HM et al. | — | 2021 | → |
| Recombinant sulfated CCR2 peptide trap reduces retinal degeneration in mice. | Jung SA et al. | — | 2021 | → |
| Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants. | Tzoumas N et al. | — | 2021 | → |
| Risk Mitigation of Immunogenicity: A Key to Personalized Retinal Gene Therapy. | Varin J et al. | — | 2021 | → |
| Role of retinal pigment epithelium in age-related macular disease: a systematic review. | Bird A | — | 2021 | → |
| Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration. | Acar IE et al. | — | 2021 | → |
| Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. | Voigt AP et al. | — | 2021 | → |
| SNP- and Haplotype-Based GWAS of Flowering-Related Traits in <i>Brassica napus</i>. | Helal M et al. | — | 2021 | → |
| Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases. | Campochiaro PA et al. | — | 2021 | → |
| Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions. | Kim BJ et al. | — | 2021 | → |
| The 100 most-cited papers on age-related macular degeneration: a bibliographic perspective. | Grzybowski A et al. | — | 2021 | → |
| The 2021 National Eye Institute Strategic Plan: Fostering Collaboration in Vision Research and Clinical Care. | Chiang MF | — | 2021 | → |
| The complement system in age-related macular degeneration. | Armento A et al. | — | 2021 | → |
| The current review of adolescent obesity: the role of genetic factors. | Yılmaz B et al. | — | 2021 | → |
| The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case-Control Study. | Hamel T et al. | — | 2021 | → |
| The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD. | Lu ZG et al. | — | 2021 | → |
| The molecular pathology of pathogenic mitochondrial tRNA variants. | Richter U et al. | — | 2021 | → |
| The pathogenesis of age-related macular degeneration is not inflammatory mediated but is instead due to immunosenescence-related failure of tissue repair. | Kent D | — | 2021 | → |
| Therapeutic Options Under Development for Nonneovascular Age-Related Macular Degeneration and Geographic Atrophy. | Kim JB et al. | — | 2021 | → |
| The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade. | McMahon O et al. | — | 2021 | → |
| The Role of Electronic Health Records in Advancing Genomic Medicine. | Linder JE et al. | — | 2021 | → |
| Translating genetic association of lipid levels for biological and clinical application. | Crone B et al. | — | 2021 | → |
| Translational biomarkers in the era of precision medicine. | Bravo-Merodio L et al. | — | 2021 | → |
| Uncoupling proteins in the mitochondrial defense against oxidative stress. | Hass DT et al. | — | 2021 | → |
| Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration. | Deng Y et al. | — | 2021 | → |
| Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration. | Kaynezhad P et al. | — | 2021 | → |
| Whole-genome re-sequencing association study on yearling wool traits in Chinese fine-wool sheep. | Zhao H et al. | — | 2021 | → |
| Workshop proceedings: GWAS summary statistics standards and sharing. | MacArthur JAL et al. | — | 2021 | → |
| 15 years of genome-wide association studies and no signs of slowing down. | Loos RJF | — | 2020 | → |
| 2018 Langley Award for Basic Research on Nicotine and Tobacco: Bringing Precision Medicine to Smoking Cessation. | Bierut LJ | — | 2020 | → |
| A brief history of human disease genetics. | Claussnitzer M et al. | — | 2020 | → |
| Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. | Efstathiou NE et al. | — | 2020 | → |
| A family-based genome-wide association study of recurrent aphthous stomatitis. | Bankvall M et al. | — | 2020 | → |
| A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes. | Alic L et al. | — | 2020 | → |
| Age-related Macular Degeneration: Nutrition, Genes and Deep Learning-The LXXVI Edward Jackson Memorial Lecture. | Chew EY | — | 2020 | → |
| Age-Related Macular Degeneration Preferred Practice Pattern®. | Flaxel CJ et al. | — | 2020 | → |
| Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies. | Hadziahmetovic M et al. | — | 2020 | → |
| An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration. | Dabouz R et al. | — | 2020 | → |
| Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities. | Oguchi Y et al. | — | 2020 | → |
| An exploratory study to evaluate visual function endpoints in non-advanced age-related macular degeneration. | Narayanan D et al. | — | 2020 | → |
| A Novel Antitumor Strategy: Simultaneously Inhibiting Angiogenesis and Complement by Targeting VEGFA/PIGF and C3b/C4b. | Wang H et al. | — | 2020 | → |
| Anti-VEGF Treatment and Response in Age-related Macular Degeneration: Disease's Susceptibility, Pharmacogenetics and Pharmacokinetics. | Maroñas O et al. | — | 2020 | → |
| Associations between the Complement System and Choroidal Neovascularization in Wet Age-Related Macular Degeneration. | Jensen EG et al. | — | 2020 | → |
| Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration. | Zysset-Burri DC et al. | — | 2020 | → |
| Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors. | Camelo S et al. | — | 2020 | → |
| Biotechnology and Biomaterial-Based Therapeutic Strategies for Age-Related Macular Degeneration. Part I: Biomaterials-Based Drug Delivery Devices. | Jemni-Damer N et al. | — | 2020 | → |
| Canalization and Robustness in Human Genetics and Disease. | Gibson G et al. | — | 2020 | → |
| Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks. | Fritsche LG et al. | — | 2020 | → |
| Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models. | Abokyi S et al. | — | 2020 | → |
| Characteristics of Pachychoroid Diseases and Age-Related Macular Degeneration: Multimodal Imaging and Genetic Backgrounds. | Yamashiro K et al. | — | 2020 | → |
| Characterization of Binding Properties of Individual Functional Sites of Human Complement Factor H. | Haque A et al. | — | 2020 | → |
| Clinical implications of recent advances in primary open-angle glaucoma genetics. | Choquet H et al. | — | 2020 | → |
| Coculture techniques for modeling retinal development and disease, and enabling regenerative medicine. | Ghareeb AE et al. | — | 2020 | → |
| Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infection. | van den Broek B et al. | — | 2020 | → |
| Complement Activation Levels Are Related to Disease Stage in AMD. | Heesterbeek TJ et al. | — | 2020 | → |
| Complement Activation Products and Cytokines in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular Degeneration. | Kato Y et al. | — | 2020 | → |
| Complement family member CFI polymorphisms and AMD susceptibility from a comprehensive analysis. | Yu Q et al. | — | 2020 | → |
| Complement Receptor 1 (CR1/CD35)-expressing retinal pigment epithelial cells as a potential therapy for age-related macular degeneration. | Simmons KT et al. | — | 2020 | → |
| coPLINK: A complementary tool to PLINK. | Liu HM et al. | — | 2020 | → |
| CXCR5/NRF2 double knockout mice develop retinal degeneration phenotype at early adult age. | Huang H et al. | — | 2020 | → |
| Dengue virus and the complement alternative pathway. | Carr JM et al. | — | 2020 | → |
| Dietary and Lifestyle Factors Modulate the Activity of the Endogenous Antioxidant System in Patients with Age-Related Macular Degeneration: Correlations with Disease Severity. | Ulańczyk Z et al. | — | 2020 | → |
| Do Genomic Factors Play a Role in Diabetic Retinopathy? | Cabrera AP et al. | — | 2020 | → |
| DualWMDR: Detecting epistatic interaction with dual screening and multifactor dimensionality reduction. | Cao X et al. | — | 2020 | → |
| EFEMP1 Overexpression Contributes to Neovascularization in Age-Related Macular Degeneration. | Cheng L et al. | — | 2020 | → |
| Epigenetics in age-related macular degeneration: new discoveries and future perspectives. | Gemenetzi M et al. | — | 2020 | → |
| Evidence for Activation of Lectin and Classical Pathway Complement Components in Aqueous Humor of Neovascular Age-Related Macular Degeneration. | Omori T et al. | — | 2020 | → |
| Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes. | Hu J et al. | — | 2020 | → |
| Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein. | Harrison RES et al. | — | 2020 | → |
| Family-based exome sequencing identifies rare coding variants in age-related macular degeneration. | Ratnapriya R et al. | — | 2020 | → |
| Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on. | Miller SM | — | 2020 | → |
| Functional Characterization of Rare Genetic Variants in the N-Terminus of Complement Factor H in aHUS, C3G, and AMD. | Wong EKS et al. | — | 2020 | → |
| Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (<i>SLCO</i>2<i>B</i>1). | Yang J et al. | — | 2020 | → |
| Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits. | Meri S et al. | — | 2020 | → |
| Gene, Cell and Antibody-Based Therapies for the Treatment of Age-Related Macular Degeneration. | Akyol E et al. | — | 2020 | → |
| GenEpi: gene-based epistasis discovery using machine learning. | Chang YC et al. | — | 2020 | → |
| Genetic Architecture of Early Vigor Traits in Wild Soybean. | Kofsky J et al. | — | 2020 | → |
| Genetic Association of Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. | Chen LJ | — | 2020 | → |
| Genetic Variants Detection Based on Weighted Sparse Group Lasso. | Che K et al. | — | 2020 | → |
| Genotypes and Phenotypes: A Search for Influential Genes in Diabetic Retinopathy. | Cabrera AP et al. | — | 2020 | → |
| Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions. | Bonilha VL et al. | — | 2020 | → |
| GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals. | Tian D et al. | — | 2020 | → |
| Heritability of Inner Retinal Layer and Outer Retinal Layer Thickness: The Healthy Twin Study. | Kong M et al. | — | 2020 | → |
| High-density lipoproteins are a potential therapeutic target for age-related macular degeneration. | Kelly UL et al. | — | 2020 | → |
| HTRA1 rs11200638 variant and AMD risk from a comprehensive analysis about 15,316 subjects. | Liu Y et al. | — | 2020 | → |
| Hypothetical pathogenesis of age-related macular degeneration and pachychoroid diseases derived from their genetic characteristics. | Yamashiro K et al. | — | 2020 | → |
| Identifying novel associations in GWAS by hierarchical Bayesian latent variable detection of differentially misclassified phenotypes. | Shafquat A et al. | — | 2020 | → |
| IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration. | Behnke V et al. | — | 2020 | → |
| Immunization Against Oxidized Elastin Exacerbates Structural and Functional Damage in Mouse Model of Smoke-Induced Ocular Injury. | Annamalai B et al. | — | 2020 | → |
| Incidence and Risk Factors of Reticular Pseudodrusen Using Multimodal Imaging. | Dutheil C et al. | — | 2020 | → |
| Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration. | Cipriani V et al. | — | 2020 | → |
| Insights into the multifactorial causation of obesity by integrated genetic and epigenetic analysis. | Diels S et al. | — | 2020 | → |
| Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration. | Shen Y et al. | — | 2020 | → |
| Introducing <i>Complex Psychiatry</i>. | Gelernter J et al. | — | 2020 | → |
| Investigation of genetic base in the treatment of age-related macular degeneration. | Gourgouli K et al. | — | 2020 | → |
| Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity? | Lawson DJ et al. | — | 2020 | → |
| Learning from Fifteen Years of Genome-Wide Association Studies in Age-Related Macular Degeneration. | Strunz T et al. | — | 2020 | → |
| Local oral and nasal microbiome diversity in age-related macular degeneration. | Rullo J et al. | — | 2020 | → |
| Macular retinal thickness differs markedly in age-related macular degeneration driven by risk polymorphisms on chromosomes 1 and 10. | Zouache MA et al. | — | 2020 | → |
| Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease. | Caruso A et al. | — | 2020 | → |
| NEI-Supported Age-Related Macular Degeneration Research: Past, Present, and Future. | Wright C et al. | — | 2020 | → |
| Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches. | Ricci F et al. | — | 2020 | → |
| New Technologies to Study Functional Genomics of Age-Related Macular Degeneration. | Nguyen T et al. | — | 2020 | → |
| Next generation sequencing using phenotype-based panels for genetic testing in inherited retinal diseases. | Shah M et al. | — | 2020 | → |
| Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration. | Tong Y et al. | — | 2020 | → |
| Ocular genetics in the genomics age. | Walter MA et al. | — | 2020 | → |
| Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization. | Droho S et al. | — | 2020 | → |
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| Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration. | Lynch AM et al. | — | 2020 | → |
| Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD). | Kiel C et al. | — | 2020 | → |
| Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants. | Crouch DJM et al. | — | 2020 | → |
| Predictive genetics for AMD: Hype and hopes for genetics-based strategies for treatment and prevention. | Gorin MB et al. | — | 2020 | → |
| PREIMPLANTATION GENETIC TESTING: Preimplantation genetic testing for polygenic disease risk. | Treff NR et al. | — | 2020 | → |
| Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways. | Wang L et al. | — | 2020 | → |
| Review of Preferential Suspicious Genes in Microtia Patients Through Various Approaches. | Lu M et al. | — | 2020 | → |
| Robustness during Aging-Molecular Biological and Physiological Aspects. | Barth E et al. | — | 2020 | → |
| SAMA: A Fast Self-Adaptive Memetic Algorithm for Detecting SNP-SNP Interactions Associated with Disease. | Yin Y et al. | — | 2020 | → |
| STEPS: an efficient prospective likelihood approach to genetic association analyses of secondary traits in extreme phenotype sequencing. | Bi W et al. | — | 2020 | → |
| Systemic activation of the complement system in patients with advanced age-related macular degeneration. | Lynch AM et al. | — | 2020 | → |
| Systemic Inflammation by Collagen-Induced Arthritis Affects the Progression of Age-Related Macular Degeneration Differently in Two Mouse Models of the Disease. | Schnabolk G et al. | — | 2020 | → |
| The Diagnosis and Treatment of Age-Related Macular Degeneration. | Stahl A | — | 2020 | → |
| The Genetic Control of Stoichiometry Underlying Autism. | Darnell RB | — | 2020 | → |
| The genetic map of diabetic nephropathy: evidence from a systematic review and meta-analysis of genetic association studies. | Tziastoudi M et al. | — | 2020 | → |
| The Relationship Between Cognitive Status and Known Single Nucleotide Polymorphisms in Age-Related Macular Degeneration. | Murphy C et al. | — | 2020 | → |
| The Role of Complement in Angiogenesis. | Markiewski MM et al. | — | 2020 | → |
| Title: Pachydrusen in Fellow Eyes Predict Response to Aflibercept Monotherapy in Patients with Polypoidal Choroidal Vasculopathy. | Fukuda Y et al. | — | 2020 | → |
| Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration. | Mulfaul K et al. | — | 2020 | → |
| Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions. | Mannes M et al. | — | 2020 | → |
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| Adaptive and Maladaptive Complement Activation in the Retina. | Silverman SM et al. | — | 2019 | → |
| A genome-wide association study on photic sneeze reflex in the Chinese population. | Wang M et al. | — | 2019 | → |
| Age-Related Hearing Loss. | Bowl MR et al. | — | 2019 | → |
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| Assessing the performance of genome-wide association studies for predicting disease risk. | Patron J et al. | — | 2019 | → |
| ASSOCIATION BETWEEN ORAL IRON SUPPLEMENTATION AND RETINAL OR SUBRETINAL HEMORRHAGE IN THE COMPARISON OF AGE-RELATED MACULAR DEGENERATION TREATMENT TRIALS. | Song D et al. | — | 2019 | → |
| Association Between Perifoveal Drusen Burden Determined by OCT and Genetic Risk in Early and Intermediate Age-Related Macular Degeneration. | Seddon JM et al. | — | 2019 | → |
| Association of rs10490924 in ARMS2/HTRA1 with age-related macular degeneration in the Pakistani population. | Ayub H et al. | — | 2019 | → |
| A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. | Handa JT et al. | — | 2019 | → |
| Atypical haemolytic uremic syndrome from multiple missenses to a full-blown disease. | Mira FS et al. | — | 2019 | → |
| Benefits and limitations of genome-wide association studies. | Tam V et al. | — | 2019 | → |
| CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex. | Borras C et al. | — | 2019 | → |
| Characterization of Retinal Pigment Epithelial Melanin and Degraded Synthetic Melanin Using Mass Spectrometry and In Vitro Biochemical Diagnostics. | Yacout SM et al. | — | 2019 | → |
| Clinical promise of next-generation complement therapeutics. | Mastellos DC et al. | — | 2019 | → |
| Compendium of current complement therapeutics. | Zelek WM et al. | — | 2019 | → |
| Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration. | Sivapathasuntharam C et al. | — | 2019 | → |
| Complement inhibition as a therapeutic strategy in retinal disorders. | Kassa E et al. | — | 2019 | → |
| Complement system and age-related macular degeneration: drugs and challenges. | Wu J et al. | — | 2019 | → |
| Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation. | Zeng B et al. | — | 2019 | → |
| Deconstructing the sources of genotype-phenotype associations in humans. | Young AI et al. | — | 2019 | → |
| Development and characterization of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. | Zelek WM et al. | — | 2019 | → |
| Development and evaluation of a transfusion medicine genome wide genotyping array. | Guo Y et al. | — | 2019 | → |
| Dysregulations of follicular helper T cells through IL-21 pathway in age-related macular degeneration. | Wu Q et al. | — | 2019 | → |
| Epi-GTBN: an approach of epistasis mining based on genetic Tabu algorithm and Bayesian network. | Guo Y et al. | — | 2019 | → |
| Evaluation of the association of <i>C5</i> with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. | Liu K et al. | — | 2019 | → |
| Fellow Eye Status Is a Biomarker for the Progression Rate of Geographic Atrophy: A Systematic Review and Meta-analysis. | Shen LL et al. | — | 2019 | → |
| Fluorescent silver nanoclusters as antibody label in a competitive immunoassay for the complement factor H. | Valencia E et al. | — | 2019 | → |
| Functional Genomics of the Retina to Elucidate its Construction and Deconstruction. | Blond F et al. | — | 2019 | → |
| Gene and Induced Pluripotent Stem Cell Therapy for Retinal Diseases. | Maeda A et al. | — | 2019 | → |
| Gene therapy for visual loss: Opportunities and concerns. | Lee JH et al. | — | 2019 | → |
| Genetically-guided algorithm development and sample size optimization for age-related macular degeneration cases and controls in electronic health records from the VA Million Veteran Program. | Halladay CW et al. | — | 2019 | → |
| Genetic risk factors for eating disorders: an update and insights into pathophysiology. | Himmerich H et al. | — | 2019 | → |
| Genetics of psoriasis: a basis for precision medicine. | Ran D et al. | — | 2019 | → |
| Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy. | Hosoda Y et al. | — | 2019 | → |
| Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs. | Tang Z et al. | — | 2019 | → |
| Genomic and Phenomic Research in the 21st Century. | Hebbring S | — | 2019 | → |
| Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice. | Landowski M et al. | — | 2019 | → |
| Identification and characterization of a novel promoter variant in placental growth factor for neovascular age-related macular degeneration. | Ma L et al. | — | 2019 | → |
| Identification of Key Long Non-Coding RNAs in the Pathology of Alzheimer's Disease and their Functions Based on Genome-Wide Associations Study, Microarray, and RNA-seq Data. | Han Z et al. | — | 2019 | → |
| Identifying Multi-Omics Causers and Causal Pathways for Complex Traits. | Qin H et al. | — | 2019 | → |
| INCREASED COMPLEMENT LEVELS IN HUMAN VITREOUS ASPIRATES OF PROLIFERATIVE DIABETIC RETINOPATHY AND RETINAL DETACHMENT EYES. | Manoharan N et al. | — | 2019 | → |
| Increased Nonexudative Age-Related Macular Degeneration Diagnosis Among Medicare Beneficiaries With Rheumatoid Arthritis. | Schnabolk G et al. | — | 2019 | → |
| Integration of target discovery, drug discovery and drug delivery: A review on computational strategies. | Duarte Y et al. | — | 2019 | → |
| Metabolic GWAS-based dissection of genetic bases underlying the diversity of plant metabolism. | Fang C et al. | — | 2019 | → |
| Microvascular contributions to age-related macular degeneration (AMD): from mechanisms of choriocapillaris aging to novel interventions. | Lipecz A et al. | — | 2019 | → |
| Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration. | Mansoor N et al. | — | 2019 | → |
| Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17. | Yu JJ et al. | — | 2019 | → |
| On entropy and information in gene interaction networks. | Wallace ZS et al. | — | 2019 | → |
| On the origin of proteins in human drusen: The meet, greet and stick hypothesis. | Bergen AA et al. | — | 2019 | → |
| Oxidative stress in patients with neovascular macular degeneration. | Cinq Frais C et al. | — | 2019 | → |
| Phenotypic Plasticity of <i>Staphylococcus aureus</i> in Liquid Medium Containing Vancomycin. | Rong M et al. | — | 2019 | → |
| Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective. | Dalvi S et al. | — | 2019 | → |
| Predictive Genes for the Prognosis of Central Serous Chorioretinopathy. | Hosoda Y et al. | — | 2019 | → |
| Ranking Cancer Proteins by Integrating PPI Network and Protein Expression Profiles. | Ren J et al. | — | 2019 | → |
| Rare variants and loci for age-related macular degeneration in the Ohio and Indiana Amish. | Waksmunski AR et al. | — | 2019 | → |
| Rediscover and Refine QTLs for Pig Scrotal Hernia by Increasing a Specially Designed F<sub>3</sub> Population and Using Whole-Genome Sequence Imputation Technology. | Xu W et al. | — | 2019 | → |
| Regulation of regulators: Role of the complement factor H-related proteins. | Cserhalmi M et al. | — | 2019 | → |
| Regulation of the Complement System by Pentraxins. | Haapasalo K et al. | — | 2019 | → |
| Replicability analysis in genome-wide association studies via Cartesian hidden Markov models. | Wang P et al. | — | 2019 | → |
| Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (<i>Ovies aries</i>). | Gebreselassie G et al. | — | 2019 | → |
| Role of the Choroid in Age-related Macular Degeneration: A Current Review. | Farazdaghi MK et al. | — | 2019 | → |
| Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant. | Tran MTN et al. | — | 2019 | → |
| Self-Adjusting Ant Colony Optimization Based on Information Entropy for Detecting Epistatic Interactions. | Guan B et al. | — | 2019 | → |
| Sexually dimorphic leanness and hypermobility in p16<sup>Ink4a</sup>/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum. | Kim KH et al. | — | 2019 | → |
| Stemming retinal regeneration with pluripotent stem cells. | Jin ZB et al. | — | 2019 | → |
| Susceptible loci associated with autoimmune disease as potential biomarkers for checkpoint inhibitor-induced immune-related adverse events. | Hoefsmit EP et al. | — | 2019 | → |
| Systematic assessment of prescribed medications and short-term risk of myocardial infarction - a pharmacopeia-wide association study from Norway and Sweden. | Sen A et al. | — | 2019 | → |
| Systemic expression of Alu RNA in patients with geographic atrophy secondary to age-related macular degeneration. | Yoshida H et al. | — | 2019 | → |
| Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration. | Krogh Nielsen M et al. | — | 2019 | → |
| Systems biology in inflammatory bowel diseases: on the way to precision medicine. | Dovrolis N et al. | — | 2019 | → |
| The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration. | Mullins RF et al. | — | 2019 | → |
| The association between complement factor H rs1061170 polymorphism and age-related macular degeneration: a comprehensive meta-analysis stratified by stage of disease and ethnicity. | Maugeri A et al. | — | 2019 | → |
| The Challenges and Promise of Complement Therapeutics for Ocular Diseases. | Park DH et al. | — | 2019 | → |
| The impact of lipids, lipid oxidation, and inflammation on AMD, and the potential role of miRNAs on lipid metabolism in the RPE. | Jun S et al. | — | 2019 | → |
| The Potential Role of Genomic Medicine in the Therapeutic Management of Rheumatoid Arthritis. | Acosta-Herrera M et al. | — | 2019 | → |
| Time trends, disease patterns and gender imbalance in the top 100 most cited articles in ophthalmology. | Heng Wong MY et al. | — | 2019 | → |
| Validated Prediction Models for Macular Degeneration Progression and Predictors of Visual Acuity Loss Identify High-Risk Individuals. | Seddon JM et al. | — | 2019 | → |
| Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention. | Nusinovici S et al. | — | 2019 | → |
| Zinc Nutrition and Inflammation in the Aging Retina. | Gilbert R et al. | — | 2019 | → |
| 4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells. | Linetsky M et al. | — | 2018 | → |
| A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells. | Parmar VM et al. | — | 2018 | → |
| Activation of the ERK1/2-MAPK Signaling Pathway by Complement Serum in UV-POS-Pretreated ARPE-19 Cells. | Busch M et al. | — | 2018 | → |
| A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 (AREDS2) Report No. 14. | van Asten F et al. | — | 2018 | → |
| A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver. | Strunz T et al. | — | 2018 | → |
| Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. | Gharahkhani P et al. | — | 2018 | → |
| Analysis of the association between CFH Y402H polymorphism and response to intravitreal ranibizumab in patients with neovascular age-related macular degeneration (nAMD). | Mohamad NA et al. | — | 2018 | → |
| A Perspective of AMD Through the Eyes of Immunology. | Copland DA et al. | — | 2018 | → |
| A phylogenetic method to perform genome-wide association studies in microbes that accounts for population structure and recombination. | Collins C et al. | — | 2018 | → |
| Applied Human Genetic Epidemiology. | Chan BKC | — | 2018 | → |
| A Review on Methods for Detecting SNP Interactions in High-Dimensional Genomic Data. | Uppu S et al. | — | 2018 | → |
| Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration. | Cobos E et al. | — | 2018 | → |
| Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis. | Zhang J et al. | — | 2018 | → |
| Association of CDKAL1 nucleotide variants with the risk of non-syndromic cleft lip with or without cleft palate. | Gaczkowska A et al. | — | 2018 | → |
| Association of coding and UTR variants in the known regions with wet age-related macular degeneration in Han Chinese population. | Huang L et al. | — | 2018 | → |
| Association of genetic polymorphism of interleukin-17A & interleukin-17F with susceptibility of psoriasis. | Kaur R et al. | — | 2018 | → |
| Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients. | Lana TP et al. | — | 2018 | → |
| Association of Rare Predicted Loss-of-Function Variants in Cellular Pathways with Sub-Phenotypes in Age-Related Macular Degeneration. | Pietraszkiewicz A et al. | — | 2018 | → |
| A survey of high dimension low sample size asymptotics. | Aoshima M et al. | — | 2018 | → |
| Beyond genomics: understanding exposotypes through metabolomics. | Rattray NJW et al. | — | 2018 | → |
| Blue-light filtering intraocular lenses (IOLs) for protecting macular health. | Downie LE et al. | — | 2018 | → |
| Calf melanin immunomodulates RPE cell attachment to extracellular matrix protein. | Yacout SM et al. | — | 2018 | → |
| Changing vision: a review of pharmacogenetic studies for treatment response in age-related macular degeneration patients. | Arslan J et al. | — | 2018 | → |
| Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships. | Low YS et al. | — | 2018 | → |
| Coding and Noncoding Variants in CFH Act Synergistically for Complement Activation in Immunoglobulin A Nephropathy. | Guo WY et al. | — | 2018 | → |
| Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects. | Kim Y et al. | — | 2018 | → |
| Complement factor H in AMD: Bridging genetic associations and pathobiology. | Toomey CB et al. | — | 2018 | → |
| Complement Factor H Inhibits Anti-Neutrophil Cytoplasmic Autoantibody-Induced Neutrophil Activation by Interacting With Neutrophils. | Chen SF et al. | — | 2018 | → |
| Complement in cancer: untangling an intricate relationship. | Reis ES et al. | — | 2018 | → |
| Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine. | Maugeri A et al. | — | 2018 | → |
| Complete Transcriptome Profiling of Normal and Age-Related Macular Degeneration Eye Tissues Reveals Dysregulation of Anti-Sense Transcription. | Kim EJ et al. | — | 2018 | → |
| Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer. | Wittkowski KM et al. | — | 2018 | → |
| Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy. | Wu X et al. | — | 2018 | → |
| C-Reactive Protein As a Mediator of Complement Activation and Inflammatory Signaling in Age-Related Macular Degeneration. | Chirco KR et al. | — | 2018 | → |
| C-Reactive Protein as a Therapeutic Target in Age-Related Macular Degeneration. | Molins B et al. | — | 2018 | → |
| Developments in anti-complement therapy; from disease to clinical trial. | Harris CL et al. | — | 2018 | → |
| Dissecting microRNA dysregulation in age-related macular degeneration: new targets for eye gene therapy. | Askou AL et al. | — | 2018 | → |
| DNA Nanotweezers and Graphene Transistor Enable Label-Free Genotyping. | Hwang MT et al. | — | 2018 | → |
| Dynamic Interplay of Innate and Adaptive Immunity During Sterile Retinal Inflammation: Insights From the Transcriptome. | Natoli R et al. | — | 2018 | → |
| Empirical Comparisons of Different Statistical Models To Identify and Validate Kernel Row Number-Associated Variants from Structured Multi-parent Mapping Populations of Maize. | Yang J et al. | — | 2018 | → |
| [Epigenetics in age-related macular degeneration (AMD) - French translation of the article]. | Desmettre T | — | 2018 | → |
| Epigenome-based cancer risk prediction: rationale, opportunities and challenges. | Widschwendter M et al. | — | 2018 | → |
| Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors. | Chirco KR et al. | — | 2018 | → |
| Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration. | Pujol-Lereis LM et al. | — | 2018 | → |
| Examining the current standards for genetic discovery and replication in the era of mega-biobanks. | Huffman JE | — | 2018 | → |
| Exploring the association of rs10490924 polymorphism with age-related macular degeneration: An in silico approach. | Jahanfar F et al. | — | 2018 | → |
| Exploring the pathogenesis of canine epilepsy using a systems genetics method and implications for anti-epilepsy drug discovery. | Cui ZJ et al. | — | 2018 | → |
| Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration. | Lorés-Motta L et al. | — | 2018 | → |
| Extracting Complementary Insights from Molecular Phenotypes for Prioritization of Disease-Associated Mutations. | Wierbowski SD et al. | — | 2018 | → |
| FDHE-IW: A Fast Approach for Detecting High-Order Epistasis in Genome-Wide Case-Control Studies. | Tuo S | — | 2018 | → |
| Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population. | Sasaki M et al. | — | 2018 | → |
| Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders. | Singh M et al. | — | 2018 | → |
| Genetic analysis of the complement pathway in C3 glomerulopathy. | Zhao W et al. | — | 2018 | → |
| Genetics and genetic testing for age-related macular degeneration. | Warwick A et al. | — | 2018 | → |
| Genetics of Alzheimer's Disease. | Kim JH | — | 2018 | → |
| Genetics of Exfoliation Syndrome. | Aung T et al. | — | 2018 | → |
| Genetics of human autoimmunity: From genetic information to functional insights. | Ishigaki K et al. | — | 2018 | → |
| Genetics of membranous nephropathy. | Gupta S et al. | — | 2018 | → |
| Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches. | Mozzi A et al. | — | 2018 | → |
| Genetic variants in mRNA untranslated regions. | Steri M et al. | — | 2018 | → |
| Genome sequencing in the clinic: the past, present, and future of genomic medicine. | Prokop JW et al. | — | 2018 | → |
| Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records. | Robinson JR et al. | — | 2018 | → |
| Genotype Imputation from Large Reference Panels. | Das S et al. | — | 2018 | → |
| Genotype-phenotype correlations of low-frequency variants in the complement system in renal disease and age-related macular degeneration. | Geerlings MJ et al. | — | 2018 | → |
| Host-parasite interactions and ecology of the malaria parasite-a bioinformatics approach. | Izak D et al. | — | 2018 | → |
| How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration? | McCarty CA et al. | — | 2018 | → |
| HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1. | Lin MK et al. | — | 2018 | → |
| Human pharyngeal microbiota in age-related macular degeneration. | Ho EXP et al. | — | 2018 | → |
| <i>CFH</i> and <i>VIPR2</i> as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy. | Hosoda Y et al. | — | 2018 | → |
| Identification of complement inhibitory activities of two chemotherapeutic agents using a high-throughput cell imaging-based screening assay. | Zhang L et al. | — | 2018 | → |
| Imputation from SNP chip to sequence: a case study in a Chinese indigenous chicken population. | Ye S et al. | — | 2018 | → |
| Increased levels of circulating CD34+ cells in neovascular age-related macular degeneration: relation with clinical and OCT features. | Kara C et al. | — | 2018 | → |
| Indirect effect inference and application to GAW20 data. | Li L et al. | — | 2018 | → |
| Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures. | Everson TM et al. | — | 2018 | → |
| Interactions among different genetic loci in age-related macular degeneration. | Bonyadi M et al. | — | 2018 | → |
| Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association. | Musunuru K et al. | — | 2018 | → |
| Intravitreal injection of aflibercept, an anti-VEGF antagonist, down-regulates plasma von Willebrand factor in patients with age-related macular degeneration. | Yamashita M et al. | — | 2018 | → |
| Lessons from CKD-Related Genetic Association Studies-Moving Forward. | Limou S et al. | — | 2018 | → |
| LSMM: a statistical approach to integrating functional annotations with genome-wide association studies. | Ming J et al. | — | 2018 | → |
| Mass spectrometry identification of potential biomarker proteins in the 150-kD electrophoretic band in patients with schizophrenia. | Xu R et al. | — | 2018 | → |
| Microglia in Alzheimer's disease. | Hansen DV et al. | — | 2018 | → |
| MicroRNA-124 Dysregulation is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina. | Chu-Tan JA et al. | — | 2018 | → |
| Models of retinal diseases and their applicability in drug discovery. | Malek G et al. | — | 2018 | → |
| Multivariate Methods for Meta-Analysis of Genetic Association Studies. | Dimou NL et al. | — | 2018 | → |
| Myopia in Chinese families shows linkage to 10q26.13. | Musolf AM et al. | — | 2018 | → |
| [Next generation biobanking: the challenge of data]. | Dagher G et al. | — | 2018 | → |
| Next-generation sequencing in drug development: target identification and genetically stratified clinical trials. | Doostparast Torshizi A et al. | — | 2018 | → |
| Nitrite ion modifies tyrosine and lysine residues of extracellular matrix proteins. | Thao MT et al. | — | 2018 | → |
| Novel Association of High C-Reactive Protein Levels and A69S at Risk Alleles in Wet Age-Related Macular Degeneration Women. | Fernandez-Robredo P et al. | — | 2018 | → |
| Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium. | Ebrahimi KB et al. | — | 2018 | → |
| Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors. | Pickett SJ et al. | — | 2018 | → |
| Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism. | Hummert S et al. | — | 2018 | → |
| Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population. | Connolly E et al. | — | 2018 | → |
| Proteomic-genomic adjustments and their confluence for elucidation of pathways and networks during liver fibrosis. | Husain H et al. | — | 2018 | → |
| Psychiatric Genomics: An Update and an Agenda. | Sullivan PF et al. | — | 2018 | → |
| Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration. | Arya S et al. | — | 2018 | → |
| Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (<i>CFH</i>) gene family. | Cantsilieris S et al. | — | 2018 | → |
| Replicability and Prediction: Lessons and Challenges from GWAS. | Marigorta UM et al. | — | 2018 | → |
| Retinal pigment epithelium in the pathogenesis of age-related macular degeneration and photobiomodulation as a potential therapy? | Ao J et al. | — | 2018 | → |
| Selection of growth-related genes and dominant genotypes in transgenic Yellow River carp Cyprinus carpio L. | Luo L et al. | — | 2018 | → |
| Selective permeability of mouse blood-aqueous barrier as determined by <sup>15</sup>N-heavy isotope tracing and mass spectrometry. | Liu P et al. | — | 2018 | → |
| Shared mechanisms among neurodegenerative diseases: from genetic factors to gene networks. | Arneson D et al. | — | 2018 | → |
| Spontaneous preterm birth: advances toward the discovery of genetic predisposition. | Strauss JF et al. | — | 2018 | → |
| Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration. | Kersten E et al. | — | 2018 | → |
| The effects of zinc supplementation on primary human retinal pigment epithelium. | Pao PJ et al. | — | 2018 | → |
| The eye as a complement dysregulation hotspot. | Clark SJ et al. | — | 2018 | → |
| The impact of genome-wide association studies on biomedical research publications. | Struck TJ et al. | — | 2018 | → |
| The importance of cohort studies in the post-GWAS era. | Wijmenga C et al. | — | 2018 | → |
| The Post-GWAS Era: From Association to Function. | Gallagher MD et al. | — | 2018 | → |
| The use of the vaccinia virus complement control protein (VCP) in the rat retina. | Fernando N et al. | — | 2018 | → |
| Treatment of Geographic Atrophy with Intravitreal Sirolimus: The Age-Related Eye Disease Study 2 Ancillary Study. | Gensler G et al. | — | 2018 | → |
| Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces. | Osborne AJ et al. | — | 2018 | → |
| Unified Cox model based multifactor dimensionality reduction method for gene-gene interaction analysis of the survival phenotype. | Lee S et al. | — | 2018 | → |
| Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. | Lusk R et al. | — | 2018 | → |
| Variations on a Chip: Technologies of Difference in Human Genetics Research. | Rajagopalan RM et al. | — | 2018 | → |
| Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1, a Component of Bruch's Membrane. | Corominas J et al. | — | 2018 | → |
| Abnormal Complement Activation and Inflammation in the Pathogenesis of Retinopathy of Prematurity. | Rathi S et al. | — | 2017 | → |
| A comparison of graph- and kernel-based -omics data integration algorithms for classifying complex traits. | Yan KK et al. | — | 2017 | → |
| A decade of age-related macular degeneration risk models: What have we learned from them and where are we going? | Zhang M et al. | — | 2017 | → |
| Advances in Age-related Macular Degeneration Understanding and Therapy. | Miller JW et al. | — | 2017 | → |
| Advances in the genome-wide association study of chronic hepatitis B susceptibility in Asian population. | Qiu B et al. | — | 2017 | → |
| Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation? | Fierz W | — | 2017 | → |
| Age-related macular degeneration and mortality: the Melbourne Collaborative Cohort Study. | McGuinness MB et al. | — | 2017 | → |
| Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. | Huang H et al. | — | 2017 | → |
| AICAR suppresses TNF-α-induced complement factor B in RPE cells. | Chung EJ et al. | — | 2017 | → |
| An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology. | Berber P et al. | — | 2017 | → |
| An Illustration of Errors in Using the P Value to Indicate Clinical Significance or Epidemiological Importance of a Study Finding. | Kang J et al. | — | 2017 | → |
| A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma. | Zhang P et al. | — | 2017 | → |
| Anti-complement component 5 antibody targeting MG4 domain inhibits choroidal neovascularization. | Jo DH et al. | — | 2017 | → |
| A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility. | Uren C et al. | — | 2017 | → |
| A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration. | Feng L et al. | — | 2017 | → |
| Association between Decreased Renal Function and Reticular Macular Disease in Age-Related Macular Degeneration. | Leisy HB et al. | — | 2017 | → |
| Association Genetics in Plant Pathogens: Minding the Gap between the Natural Variation and the Molecular Function. | Genissel A et al. | — | 2017 | → |
| Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis. | Jabbarpoor Bonyadi MH et al. | — | 2017 | → |
| Association of copy number variations in complement factor H-Related genes among age-related macular degenerative subjects. | Bakri NM et al. | — | 2017 | → |
| Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration. | Cipriani V et al. | — | 2017 | → |
| Association of DNA repair gene polymorphisms with genotoxic stress in underground coal miners. | Sinitsky MY et al. | — | 2017 | → |
| A targeted approach to genome-wide studies reveals new genetic associations with central corneal thickness. | Benson MD et al. | — | 2017 | → |
| Bacterial Genetic Architecture of Ecological Interactions in Co-culture by GWAS-Taking <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> as an Example. | He X et al. | — | 2017 | → |
| Bioinformatics in translational drug discovery. | Wooller SK et al. | — | 2017 | → |
| Can innate and autoimmune reactivity forecast early and advance stages of age-related macular degeneration? | Adamus G | — | 2017 | → |
| Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases. | Jones MK et al. | — | 2017 | → |
| Cis-SNPs Set Testing and PrediXcan Analysis for Gene Expression Data using Linear Mixed Models. | Zeng P et al. | — | 2017 | → |
| Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration. | Song D et al. | — | 2017 | → |
| Complement Dysregulation and Disease: Insights from Contemporary Genetics. | Liszewski MK et al. | — | 2017 | → |
| Compliments of Factor H: What's in it for AMD? | Mattapallil MJ et al. | — | 2017 | → |
| Controlling the joint local false discovery rate is more powerful than meta-analysis methods in joint analysis of summary statistics from multiple genome-wide association studies. | Jiang W et al. | — | 2017 | → |
| C-reactive protein and complement factor H polymorphism interaction in advanced exudative age-related macular degeneration. | Soheilian R et al. | — | 2017 | → |
| Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development. | Li H et al. | — | 2017 | → |
| Current Progress of Virus-mimicking Nanocarriers for Drug Delivery. | Somiya M et al. | — | 2017 | → |
| Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation. | Kerr H et al. | — | 2017 | → |
| Doyne lecture 2016: intraocular health and the many faces of inflammation. | Dick AD | — | 2017 | → |
| Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis. | Park SW et al. | — | 2017 | → |
| Dry Age-Related Macular Degeneration Pharmacology. | Wright CB et al. | — | 2017 | → |
| Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with <i>Lactobacillus rhamnosus</i> GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Elderly (Saimes Study). | Costabile A et al. | — | 2017 | → |
| Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis). | van Kuijk FJGM et al. | — | 2017 | → |
| Enhancing the efficacy of AREDS antioxidants in light-induced retinal degeneration. | Wong P et al. | — | 2017 | → |
| Equipoise on the Use of Steroids in Systemic Inflammatory Response Syndrome? | Jardine D | — | 2017 | → |
| Exploring the association of rs10490924 polymorphism with age-related macular degeneration: An in silico approach. | Jahanfar F et al. | — | 2017 | → |
| Fine mapping by composite genome-wide association analysis. | Casellas J et al. | — | 2017 | → |
| From compliment to insult: genetics of the complement system in physiology and disease in the human retina. | Mullins RF et al. | — | 2017 | → |
| Gene therapy for age-related macular degeneration. | Moore NA et al. | — | 2017 | → |
| Genetic aetiology of glycaemic traits: approaches and insights. | Wheeler E et al. | — | 2017 | → |
| Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS. | Kalmbach DA et al. | — | 2017 | → |
| Genetics of age-related macular degeneration (AMD). | DeAngelis MM et al. | — | 2017 | → |
| Genetics of common complex diseases: a view from Iceland. | Arnar DO et al. | — | 2017 | → |
| Genetics of idiopathic pulmonary fibrosis: from mechanistic pathways to personalised medicine. | Spagnolo P et al. | — | 2017 | → |
| Genetics of primary sclerosing cholangitis and pathophysiological implications. | Jiang X et al. | — | 2017 | → |
| Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort. | Heckerman D et al. | — | 2017 | → |
| Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis. | Salminen A et al. | — | 2017 | → |
| Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins. | Liu A et al. | — | 2017 | → |
| Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes. | Zhu H et al. | — | 2017 | → |
| Genome-wide association study of neovascular age-related macular degeneration in the Thai population. | Ruamviboonsuk P et al. | — | 2017 | → |
| Genome-wide study of an elite rice pedigree reveals a complex history of genetic architecture for breeding improvement. | Chen S et al. | — | 2017 | → |
| HIF signalling: The eyes have it. | Peet DJ et al. | — | 2017 | → |
| Human induced pluripotent stem cells illuminate pathways and novel treatment targets for age-related macular degeneration. | Farrer LA et al. | — | 2017 | → |
| Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress. | Fanelli G et al. | — | 2017 | → |
| Identification of candidate protective variants for common diseases and evaluation of their protective potential. | Butler JM et al. | — | 2017 | → |
| Identification of genetic variants of Brucella spp. through genome-wide association studies. | Sankarasubramanian J et al. | — | 2017 | → |
| Identifying Pleiotropic Genes in Genome-Wide Association Studies for Multivariate Phenotypes with Mixed Measurement Scales. | Yang JJ et al. | — | 2017 | → |
| Identifying pleiotropic genes in genome-wide association studies from related subjects using the linear mixed model and Fisher combination function. | Yang JJ et al. | — | 2017 | → |
| Imputation-Based Whole-Genome Sequence Association Study Rediscovered the Missing QTL for Lumbar Number in Sutai Pigs. | Yan G et al. | — | 2017 | → |
| Induced pluripotent stem cell-based therapy for age-related macular degeneration. | Bracha P et al. | — | 2017 | → |
| Influence of <i>CFH</i> gene on symptom severity of schizophrenia. | Zhang C et al. | — | 2017 | → |
| In Retrospect: A decade of shared genomic associations. | Manolio TA | — | 2017 | → |
| Intergenic disease-associated regions are abundant in novel transcripts. | Bartonicek N et al. | — | 2017 | → |
| Investigation of associations of <i>ARMS2</i>, <i>CD14</i>, and <i>TLR4</i> gene polymorphisms with wet age-related macular degeneration in a Greek population. | Sarli A et al. | — | 2017 | → |
| Joint association of complement component 3 and CC-cytokine ligand2 (CCL2) or complement component 3 and CFH polymorphisms in age-related macular degeneration. | Bonyadi M et al. | — | 2017 | → |
| Lessons from ten years of genome-wide association studies of asthma. | Vicente CT et al. | — | 2017 | → |
| Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration. | Handa JT et al. | — | 2017 | → |
| Local complement activation in aqueous humor in patients with age-related macular degeneration. | Schick T et al. | — | 2017 | → |
| Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration. | Liu J et al. | — | 2017 | → |
| Macrophage physiology in the eye. | Chinnery HR et al. | — | 2017 | → |
| Macular Degeneration Epidemiology: Nature-Nurture, Lifestyle Factors, Genetic Risk, and Gene-Environment Interactions - The Weisenfeld Award Lecture. | Seddon JM | — | 2017 | → |
| Major review: Molecular genetics of primary open-angle glaucoma. | Liu Y et al. | — | 2017 | → |
| Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol-Associated Mechanisms in Etiology of Age-Related Macular Degeneration. | Burgess S et al. | — | 2017 | → |
| Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma. | Su M et al. | — | 2017 | → |
| Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration. | García M et al. | — | 2017 | → |
| Mitochondrial dysfunction in ocular disease: Focus on glaucoma. | Kamel K et al. | — | 2017 | → |
| Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation. | Ueda Y et al. | — | 2017 | → |
| New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement. | Schnabolk G et al. | — | 2017 | → |
| Niche harmony search algorithm for detecting complex disease associated high-order SNP combinations. | Tuo S et al. | — | 2017 | → |
| Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration. | Krilis M et al. | — | 2017 | → |
| No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration. | Popp NA et al. | — | 2017 | → |
| On phagocytes and macular degeneration. | Guillonneau X et al. | — | 2017 | → |
| Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL-8). | Lechner J et al. | — | 2017 | → |
| Personalized medicine: Genetic risk prediction of drug response. | Zhang G et al. | — | 2017 | → |
| Potential influences of complement factor H in autoimmune inflammatory and thrombotic disorders. | Ferluga J et al. | — | 2017 | → |
| Proangiogenic characteristics of activated macrophages from patients with age-related macular degeneration. | Hagbi-Levi S et al. | — | 2017 | → |
| Proteomic analysis of human lacrimal and tear fluid in dry eye disease. | Jung JH et al. | — | 2017 | → |
| Rapid identification of a new gene influencing low amylose content in rice landraces (Oryza sativa L.) using genome-wide association study with specific-locus amplified fragment sequencing. | Yang X et al. | — | 2017 | → |
| Rethinking ovarian cancer genomics: where genome-wide association studies stand? | Pinto R et al. | — | 2017 | → |
| Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration. | Iannaccone A et al. | — | 2017 | → |
| RNA expression in human retina. | Li M et al. | — | 2017 | → |
| Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases. | Sharma K et al. | — | 2017 | → |
| Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians. | Fan Q et al. | — | 2017 | → |
| Signature of genetic associations in oral cancer. | Sharma V et al. | — | 2017 | → |
| Spotlight on reticular pseudodrusen. | Rabiolo A et al. | — | 2017 | → |
| Statistical methods to detect pleiotropy in human complex traits. | Hackinger S et al. | — | 2017 | → |
| Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. | Fini ME et al. | — | 2017 | → |
| Structural and molecular changes in the aging choroid: implications for age-related macular degeneration. | Chirco KR et al. | — | 2017 | → |
| Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration. | Tan PL et al. | — | 2017 | → |
| Systemic complement activation in central serous chorioretinopathy. | van Dijk EHC et al. | — | 2017 | → |
| Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans. | Cheung CM et al. | — | 2017 | → |
| Systems biology in the central nervous system: a brief perspective on essential recent advancements. | Dougherty JD et al. | — | 2017 | → |
| The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration. | Gorusupudi A et al. | — | 2017 | → |
| The complement system: a gateway to gene-environment interactions in schizophrenia pathogenesis. | Nimgaonkar VL et al. | — | 2017 | → |
| The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment. | Geerlings MJ et al. | — | 2017 | → |
| The Finnish national guideline for diagnosis, treatment and follow-up of patients with wet age-related macular degeneration. | Tuuminen R et al. | — | 2017 | → |
| The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping. | Eyre S et al. | — | 2017 | → |
| The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. | Datta S et al. | — | 2017 | → |
| The link between morphology and complement in ocular disease. | Mohlin C et al. | — | 2017 | → |
| The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis. | Erreni M et al. | — | 2017 | → |
| The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation. | Manthiram K et al. | — | 2017 | → |
| The Necessity of Diploid Genome Sequencing to Unravel the Genetic Component of Complex Phenotypes. | Aleman F | — | 2017 | → |
| The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). | MacArthur J et al. | — | 2017 | → |
| THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET. | Boyer DS et al. | — | 2017 | → |
| Type 1 diabetes genome-wide association studies: not to be lost in translation. | Pociot F | — | 2017 | → |
| Using Population and Comparative Genomics to Understand the Genetic Basis of Effector-Driven Fungal Pathogen Evolution. | Plissonneau C et al. | — | 2017 | → |
| Visual function improvement using photocromic and selective blue-violet light filtering spectacle lenses in patients affected by retinal diseases. | Colombo L et al. | — | 2017 | → |
| What is the probability of replicating a statistically significant association in genome-wide association studies? | Jiang W et al. | — | 2017 | → |
| Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology. | Hoh Kam J et al. | — | 2016 | → |
| AMD and the alternative complement pathway: genetics and functional implications. | Tan PL et al. | — | 2016 | → |
| AMD-like retinopathy associated with intravenous iron. | Song D et al. | — | 2016 | → |
| Analysis of copy number variation at DMBT1 and age-related macular degeneration. | Polley S et al. | — | 2016 | → |
| Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis. | Nishiguchi KM et al. | — | 2016 | → |
| Analysis of Risk Alleles and Complement Activation Levels in Familial and Non-Familial Age-Related Macular Degeneration. | Saksens NT et al. | — | 2016 | → |
| A new structural approach to genomic discovery of disease: example of adult-onset diabetes. | Sirovich L | — | 2016 | → |
| Application of multiplex immunoassay technology to investigations of ocular disease. | Jones VS et al. | — | 2016 | → |
| Are Interactions between cis-Regulatory Variants Evidence for Biological Epistasis or Statistical Artifacts? | Fish AE et al. | — | 2016 | → |
| Association of Combined Complement Factor H Y402H and ARMS/LOC387715 A69S Polymorphisms with Age-related Macular Degeneration: A Meta-analysis. | Jabbarpoor Bonyadi MH et al. | — | 2016 | → |
| CFH Y402H and VEGF Polymorphisms and Anti-VEGF Treatment Response in Exudative Age-Related Macular Degeneration. | Kepez Yildiz B et al. | — | 2016 | → |
| Clinical Characteristics, Choroidal Neovascularization, and Predictors of Visual Outcomes in Acquired Vitelliform Lesions. | Balaratnasingam C et al. | — | 2016 | → |
| Combination analysis of genome-wide association and transcriptome sequencing of residual feed intake in quality chickens. | Xu Z et al. | — | 2016 | → |
| Complement Biomarkers as Predictors of Disease Progression in Alzheimer's Disease. | Hakobyan S et al. | — | 2016 | → |
| Complement in removal of the dead - balancing inflammation. | Martin M et al. | — | 2016 | → |
| Data analysis in the post-genome-wide association study era. | Wang QL et al. | — | 2016 | → |
| Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration. | McLeod DS et al. | — | 2016 | → |
| Does the use of acetylsalicylic acid have an influence on our vision? | Michalska-Małecka K et al. | — | 2016 | → |
| Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen Species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. | Estrago-Franco MF et al. | — | 2016 | → |
| Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine. | Hall MA et al. | — | 2016 | → |
| Evaluation of CC-cytokine ligand 2 and complementary factor H Y402H polymorphisms and their interactional association with age-related macular degeneration. | Bonyadi M et al. | — | 2016 | → |
| Genetic basis of atrial fibrillation. | Campuzano O et al. | — | 2016 | → |
| Genetics and age-related macular degeneration: a practical review for the clinician. | Schwartz SG et al. | — | 2016 | → |
| Genome-Wide Association Studies in Obstructive Sleep Apnea. Will We Catch a Black Cat in a Dark Room? | Pham LV et al. | — | 2016 | → |
| Glaucoma Genetics: Recent Advances and Future Directions. | Aung T et al. | — | 2016 | → |
| Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. | Andriessen EM et al. | — | 2016 | → |
| If genetic variation could talk: What genomic data may teach us about the importance of gene expression regulation in the genetics of autism. | Yeh E et al. | — | 2016 | → |
| In silico Mapping of Protein Unfolding Mutations for Inherited Disease. | McCafferty CL et al. | — | 2016 | → |
| Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD. | Wagner EK et al. | — | 2016 | → |
| miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. | Tian B et al. | — | 2016 | → |
| Molecular Genomics of Eye Diseases. | Pang CP | — | 2016 | → |
| Monomeric C-reactive protein and inflammation in age-related macular degeneration. | Chirco KR et al. | — | 2016 | → |
| Multi-strategy genome-wide association studies identify the DCAF16-NCAPG region as a susceptibility locus for average daily gain in cattle. | Zhang W et al. | — | 2016 | → |
| Next generation sequencing technology and genomewide data analysis: Perspectives for retinal research. | Chaitankar V et al. | — | 2016 | → |
| Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. | Wang L et al. | — | 2016 | → |
| Pentraxins in the activation and regulation of innate immunity. | Daigo K et al. | — | 2016 | → |
| Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. | Mohan RR et al. | — | 2016 | → |
| Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus. | Sardell RJ et al. | — | 2016 | → |
| Protection of host cells by complement regulators. | Schmidt CQ et al. | — | 2016 | → |
| Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†. | Yu Y et al. | — | 2016 | → |
| Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina. | Williams JA et al. | — | 2016 | → |
| RISK OF AGE-RELATED MACULAR DEGENERATION IN END-STAGE RENAL DISEASE PATIENTS RECEIVING LONG-TERM DIALYSIS. | Wang IK et al. | — | 2016 | → |
| Self-nonself discrimination by the complement system. | Meri S | — | 2016 | → |
| SHEDDING LIGHT ON FUNDUS DRUSEN ASSOCIATED WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS: BREAKING STEREOTYPES OF TYPES I, II, AND III. | Dalvin LA et al. | — | 2016 | → |
| Small leucine-rich repeat proteoglycans in corneal inflammation and wound healing. | Frikeche J et al. | — | 2016 | → |
| The continuum of causality in human genetic disorders. | Katsanis N | — | 2016 | → |
| The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem. | Maadooliat M et al. | — | 2016 | → |
| Whole exome sequencing of extreme age-related macular degeneration phenotypes. | Sardell RJ et al. | — | 2016 | → |