Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.
paper
Cited
Public
- Authors
- Sovio, Ulla; Bennett, Amanda J; Millwood, Iona Y; Molitor, John; O'Reilly, Paul F; Timpson, Nicholas J; Kaakinen, Marika; Laitinen, Jaana; Haukka, Jari; Pillas, Demetris; Tzoulaki, Ioanna; Molitor, Jassy; Hoggart, Clive; Coin, Lachlan J M; Whittaker, John; Pouta, Anneli; Hartikainen, Anna-Liisa; Freimer, Nelson B; Widen, Elisabeth; Peltonen, Leena; Elliott, Paul; McCarthy, Mark I; Jarvelin, Marjo-Riitta
- Year
- 2009
- Journal
- PLoS genetics
- PMID
- 19266077
- DOI
- 10.1371/journal.pgen.1000409
- PMCID
- PMC2646138
Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0-20 years. Twenty-six of the 48 variants tested associated with adult height (p<0.05, adjusted for sex and principal components) in this sample, all in the same direction as in previous GWA scans. Seven SNPs in or near the genes HHIP, DLEU7, UQCC, SF3B4/SV2A, LCORL, and HIST1H1D associated with PHV1 and five SNPs in or near SOCS2, SF3B4/SV2A, C17orf67, CABLES1, and DOT1L with PHV2 (p<0.05). We formally tested variants for interaction with age (infancy versus puberty) and found biologically meaningful evidence for an age-dependent effect for the SNP in SOCS2 (p = 0.0030) and for the SNP in HHIP (p = 0.045). We did not have similar prior evidence for the association between height variants and timing of pubertal height growth spurt as we had for PHVs, and none of the associations were statistically significant after correction for multiple testing. The fact that in this sample, less than half of the variants associated with adult height had a measurable effect on PHV1 or PHV2 is likely to reflect limited power to detect these associations in this dataset. Our study is the first genetic association analysis on longitudinal height growth in a prospective cohort from birth to adulthood and gives grounding for future research on the genetic regulation of human height during different periods of growth.
Mean-constant curves for height growth velocity between ages 8–16 y, estimated from the JPA-2 model (see Materials and Methods: Statistical Analyses), by sex and rs11107116 genotype (SOCS2 gene, Table S2).Adult height increasing allele (T) is associated with higher PHV2 and earlier timing of pubertal height growth spurt.
Flow chart of genotyping strategy for the genetic association study on height growth in the NFBC1966.The left arm shows genotyping done separately for 19 SNPs from Weedon et al, 2008 [4]; the right arm shows the GWA route to identify further 29 SNPs [5],[6]. The maximum number in final analyses was 3,538 with both growth and genotype information.
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| How do changes in body mass index in infancy and childhood associate with cardiometabolic profile in adulthood? Findings from the Northern Finland Birth Cohort 1966 Study. | Sovio U et al. | — | 2014 | → |
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| Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. | Kou I et al. | — | 2013 | → |
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| Osteoarthritis year 2013 in review: genetics and genomics. | Gonzalez A | — | 2013 | → |
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| Four loci explain 83% of size variation in the horse. | Makvandi-Nejad S et al. | — | 2012 | → |
| Functional mapping of ontogeny in flowering plants. | Zhao X et al. | — | 2012 | → |
| Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. | Castaño Betancourt MC et al. | — | 2012 | → |
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| Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. | Zhou X et al. | — | 2012 | → |
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| Role of mtDNA haplogroups in COPD susceptibility in a southwestern Han Chinese population. | Zheng S et al. | — | 2012 | → |
| Adult height variants affect birth length and growth rate in children. | Paternoster L et al. | — | 2011 | → |
| Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle. | Lindholm-Perry AK et al. | — | 2011 | → |
| Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows. | Clempson AM et al. | — | 2011 | → |
| Fetal and infant growth and the risk of obesity during early childhood: the Generation R Study. | Mook-Kanamori DO et al. | — | 2011 | → |
| High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort. | Hyppönen E et al. | — | 2011 | → |
| Recent progress in the study of the genetics of height. | Lettre G | — | 2011 | → |
| The SNP c.1326T>G in the non-SMC condensin I complex, subunit G (NCAPG) gene encoding a p.Ile442Met variant is associated with an increase in body frame size at puberty in cattle. | Setoguchi K et al. | — | 2011 | → |
| The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels. | Vesterlund M et al. | — | 2011 | → |
| Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families. | Kim HN et al. | — | 2010 | → |
| Joint identification of multiple genetic variants via elastic-net variable selection in a genome-wide association analysis. | Cho S et al. | — | 2010 | → |
| Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. | Kaminen-Ahola N et al. | — | 2010 | → |
| Molecular cloning, expression and characterization of bovine UQCC and its association with body measurement traits. | Liu Y et al. | — | 2010 | → |
| Postnatal growth restriction and gene expression changes in a mouse model of fetal alcohol syndrome. | Kaminen-Ahola N et al. | — | 2010 | → |
| Functional mapping of human growth trajectories. | Li N et al. | — | 2009 | → |
| Genetics of reproductive lifespan. | Hartge P | — | 2009 | → |
| Human genetics: Hit or miss? | Chi KR | — | 2009 | → |
| Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy. | Burwell RG et al. | — | 2009 | → |