The effects of alcoholism on the human basolateral amygdala.
paper
Cited
Public
Unavailable
- Authors
- Kryger, R; Wilce, P A
- Year
- 2010
- Journal
- Neuroscience
- PMID
- 20153402
- DOI
- 10.1016/j.neuroscience.2010.01.061
Alcohol affects gene expression in several brain regions. The amygdala is a key structure in the brain's emotional system and in recent years the crucial importance of the amygdala in drug-seeking and relapse has been increasingly recognized. In this study gene expression screening was used to identify genes involved in alcoholism in the human basolateral amygdala of male patients. The results show that alcoholism affects a broad range of genes and many systems including genes involved in synaptic transmission, neurotransmitter transport, structural plasticity, metabolism, energy production, transcription and RNA processing and the circadian cycle. In particular, genes involved in the glutamate system were affected in the alcoholic patients. In the amygdala the glutamate system is involved in the acquisition, consolidation, expression and extinction of associative learning, which is a vital part of addiction, and in alcohol abusers it is associated with withdrawal anxiety and neurodegeneration. Downregulation of the excitatory amino acid transporters GLAST, GLT-1 and the AMPA glutamate receptor 2 (GluR2) revealed by the microarray were confirmed by Western blots. The decreased expression of GLAST, GLT-1 and GluR2 in the alcoholic patients may increase glutamate tone and activity in the basolateral amygdala and this may contribute to neurodegeneration as well as the expression of associative memories and anxiety which underlie continued drug-seeking and chronic relapse.
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| Astrocytic transcriptional and epigenetic mechanisms of drug addiction. | Holt LM et al. | β | 2024 | β |
| Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders. | Nicosia N et al. | β | 2024 | β |
| Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice. | Plasil SL et al. | β | 2024 | β |
| Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction. | Peng Z et al. | β | 2024 | β |
| Astrocyte expression in the extended amygdala of C57BL/6J mice is sex-dependently affected by chronic intermittent and binge-like ethanol exposure. | Brewton HW et al. | β | 2023 | β |
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| Astroglia in the Vulnerability and Maintenance of Alcohol Use Disorders. | Miguel-Hidalgo JJ | β | 2021 | β |
| Alcohol Use Disorder, Neurodegeneration, Alzheimer's and Parkinson's Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity. | Kamal H et al. | β | 2020 | β |
| Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. | Fructuoso M et al. | β | 2020 | β |
| The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders. | Shor C et al. | β | 2020 | β |
| Alteration in AMPA receptor subunit expression and receptor binding among patients with addictive disorders: A systematic review of human postmortem studies. | Ueno F et al. | β | 2019 | β |
| Association between Sedative-hypnotics and Subsequent Cancer in Patients with and without Insomnia: A 14-year Follow-up Study in Taiwan. | Fang HF et al. | β | 2019 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Molecular windows into the human brain for psychiatric disorders. | Egervari G et al. | β | 2019 | β |
| Serial exposure to ethanol drinking and methamphetamine enhances glutamate excitotoxicity. | Blaker AL et al. | β | 2019 | β |
| Exposure of Rat Neural Stem Cells to Ethanol Affects Cell Numbers and Alters Expression of 28 Proteins. | Kashem MA et al. | β | 2018 | β |
| Glucocorticoid receptors in the basolateral amygdala mediated the restraint stress-induced reinstatement of methamphetamine-seeking behaviors in rats. | Taslimi Z et al. | β | 2018 | β |
| Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence. | Alasmari F et al. | β | 2018 | β |
| Adolescent Alcohol Drinking Renders Adult Drinking BLA-Dependent: BLA Hyper-Activity as Contributor to Comorbid Alcohol Use Disorder and Anxiety Disorders. | Moaddab M et al. | β | 2017 | β |
| Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice. | Baker JA et al. | β | 2017 | β |
| Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats. | Li J et al. | β | 2017 | β |
| Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner. | Cannady R et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Astrocyte plasticity induced by emotional stress: A new partner in psychiatric physiopathology? | Bender CL et al. | β | 2016 | β |
| CB1 Cannabinoid Agonist (WIN55,212-2) Within the Basolateral Amygdala Induced Sensitization to Morphine and Increased the Level of ΞΌ-Opioid Receptor and c-fos in the Nucleus Accumbens. | Molaei M et al. | β | 2016 | β |
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | Bell RL et al. | β | 2016 | β |
| Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking. | McClintick JN et al. | β | 2015 | β |
| Targeting glutamate uptake to treat alcohol use disorders. | Rao PS et al. | β | 2015 | β |
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| Cannabinoid receptors in the basolateral amygdala are involved in the potentiation of morphine rewarding properties in the acquisition, but not expression of conditioned place preference in rats. | Haghparast A et al. | β | 2014 | β |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics. | Jin Z et al. | β | 2014 | β |
| Microinjection of WIN55,212-2 as A Cannabinoid Agonist into The Basolateral Amygdala Induces Sensitization to Morphine in Rats. | Molaei M et al. | β | 2014 | β |
| Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. | You C et al. | β | 2014 | β |
| The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization. | Gao Y et al. | β | 2014 | β |
| Using autopsy brain tissue to study alcohol-related brain damage in the genomic age. | Sutherland GT et al. | β | 2014 | β |
| Advances in genetic studies of substance abuse in China. | Sun Y et al. | β | 2013 | β |
| Glutamatergic targets for new alcohol medications. | Holmes A et al. | β | 2013 | β |
| Modeling the diagnostic criteria for alcohol dependence with genetic animal models. | Crabbe JC et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| Assessing the genetic risk for alcohol use disorders. | Foroud T et al. | β | 2012 | β |
| Blockade of D1/D2 dopamine receptors within the nucleus accumbens attenuated the antinociceptive effect of cannabinoid receptor agonist in the basolateral amygdala. | Haghparast A et al. | β | 2012 | β |
| Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression. | Duncan JR | β | 2012 | β |
| Glutamate transporter 1: target for the treatment of alcohol dependence. | Rao PS et al. | β | 2012 | β |