P300 amplitudes vary inversely with continuum of risk in first degree male relatives of alcoholics.
paper
Cited
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- Authors
- Benegal, V; Jain, S; Subbukrishna, D K; Channabasavanna, S M
- Year
- 1995
- Journal
- Psychiatric genetics
- PMID
- 8750356
- DOI
- 10.1097/00041444-199524000-00001
First degree relatives of alcoholics show significantly reduced P300 amplitudes. This phenomenon is though to be a vulnerability marker of alcoholism. Relatives of alcoholics with higher family loading and early onset alcoholism are at greater risk for developing alcoholism. The high risk population may comprise subtypes differentiated by family history and/or age at onset of alcoholism, with differing risks, measurable in terms of the expression of the vulnerability marker. Four groups of alcohol-naive sons/male siblings of alcoholics (n = 64) were studied. The groups were constructed on the permutation of two defining characteristics: high family loading (two or more first degree alcoholic relatives) and early onset alcohol dependence (before 25 years) in the relatives. Comparison of P300 amplitude in an auditory paradigm showed significant inter-group differences as well as progressive increase/normalization of amplitudes from the high loading-early onset group (HR1) to the low loading-late onset group (HR4), with the latter being indistinguishable from a separate group of (control) normals. There were no significant differences of P300 latency among the groups. We conclude that P300 amplitudes vary inversely with the presumed continuum of risk in those at high risk for developing alcoholism.
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|---|---|---|---|---|
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| The collaborative study on the genetics of alcoholism: Brain function. | Meyers JL et al. | — | 2023 | → |
| Estimating the familial risk of psychiatric illnesses: A review of family history scores. | Ali F et al. | — | 2021 | → |
| Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol. | Sharma E et al. | — | 2020 | → |
| Density and Dichotomous Family History Measures of Alcohol Use Disorder as Predictors of Behavioral and Neural Phenotypes: A Comparative Study Across Gender and Race/Ethnicity. | Pandey G et al. | — | 2020 | → |
| Situating adult attention-deficit/hyperactivity disorder in the externalizing spectrum: Etiological, diagnostic, and treatment considerations. | Mahadevan J et al. | — | 2019 | → |
| Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. | Viswanath B et al. | — | 2018 | → |
| Trait Impulsivity in Alcohol-naïve Offspring at High Risk for Alcoholism. | Kumar R et al. | — | 2018 | → |
| Age of onset of alcoholism: Improving samples & design to inform policy. | Mysore VA | — | 2017 | → |
| Disrupted resting brain graph measures in individuals at high risk for alcoholism. | Holla B et al. | — | 2017 | → |
| Need for power in genetic explorations of alcoholism in India. | Mysore VA | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. | Kamarajan C et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Speech-evoked auditory brainstem responses reflect familial and cognitive influences. | Hornickel J et al. | — | 2013 | → |
| Early-onset alcohol dependence increases the acoustic startle reflex. | Schellekens AF et al. | — | 2012 | → |
| Event-related oscillations versus event-related potentials in a P300 task as biomarkers for alcoholism. | Andrew C et al. | — | 2010 | → |
| Severity of alcoholism in Indian males: Correlation with age of onset and family history of alcoholism. | Johnson PR et al. | — | 2010 | → |
| Genome-wide association study of alcohol dependence. | Treutlein J et al. | — | 2009 | → |
| The P300 event-related potential and its possible role as an endophenotype for studying substance use disorders: a review. | Singh SM et al. | — | 2009 | → |
| The relationship of N2 and P3 to inhibitory processing of social drinkers in a Go/NoGo task. | Oddy BW et al. | — | 2009 | → |
| The association between attention-deficit/hyperactivity disorder and early-onset alcohol dependence: A retrospective study. | Sringeri SK et al. | — | 2008 | → |
| Cognitive deficits in children of alcoholics: At risk before the first sip! | Silva MC et al. | — | 2007 | → |
| Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence. | Venkatasubramanian G et al. | — | 2007 | → |
| Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. | Rangaswamy M et al. | — | 2007 | → |
| Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence. | Benegal V et al. | — | 2007 | → |
| Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task. | Padmanabhapillai A et al. | — | 2006 | → |
| Spatial-anatomical mapping of NoGo-P3 in the offspring of alcoholics: evidence of cognitive and neural disinhibition as a risk for alcoholism. | Kamarajan C et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Alcoholism risk, tobacco smoking, and P300 event-related potential. | Polich J et al. | — | 2004 | → |
| Electrodermal reactivity and its association to substance use disorders. | Taylor J | — | 2004 | → |
| Auditory P3 in female alcoholics. | Suresh S et al. | — | 2003 | → |
| Alcohol-related ERP changes recorded from different modalities: a topographic analysis. | Cohen HL et al. | — | 2002 | → |
| Polymorphisms at the DRD2 locus in early-onset alcohol dependence in the Indian population. | Shaikh KJ et al. | — | 2001 | → |
| Visual P300 and the self-directedness scale of the Temperament and Character Inventory. | Vedeniapin AB et al. | — | 2001 | → |
| A genome screen of maximum number of drinks as an alcoholism phenotype. | Saccone NL et al. | — | 2000 | → |
| P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development. | Bauer LO et al. | — | 1999 | → |
| Psychopathology and achievement in children at high risk for developing alcoholism. | Hill SY et al. | — | 1999 | → |
| Visual P3a in male subjects at high risk for alcoholism. | Rodríguez Holguín S et al. | — | 1999 | → |
| Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: preliminary results from the COGA Project. Collaborative Study on the Genetics of Alcoholism. | Porjesz B et al. | — | 1998 | → |
| P3 scalp topography to target and novel visual stimuli in children of alcoholics. | Van der Stelt O et al. | — | 1998 | → |
| Quantitative trait loci analysis of human event-related brain potentials: P3 voltage. | Begleiter H et al. | — | 1998 | → |
| Visual and auditory event-related potentials in young children of alcoholics from high- and low-density families. | Rodríguez Holguín S et al. | — | 1998 | → |
| No electrocortical evidence of automatic mismatch dysfunction in children of alcoholics. | van der Stelt O et al. | — | 1997 | → |
| A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA). | Reich T | — | 1996 | → |
| NIAAA 25th anniversary: advances in the neuroscience of alcohol. | Gordis E | — | 1996 | → |
| No association of PROP taster status and paternal history of alcohol dependence. | Kranzler HR et al. | — | 1996 | → |