Event-related oscillations versus event-related potentials in a P300 task as biomarkers for alcoholism.
- Authors
- Andrew, Colin; Fein, George
- Year
- 2010
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 20102573
- DOI
- 10.1111/j.1530-0277.2009.01136.x
- PMCID
- PMC3246424
OBJECTIVE: It has been proposed that event-related oscillation (ERO) measures of EEG activity recorded in P300 tasks provide more powerful biomarkers of alcoholism than event-related potential (ERP) measures. This study examines this question in a group of long-term abstinent alcoholics (LTAAs). METHODS: EEGs were recorded on 48 LTAAs and 48 age and gender-matched nonalcoholic controls (NACs) during the performance of a 3-condition visual target detection task. The event-related data were analyzed to extract ERP amplitude measures and total and evoked ERO power measures. Data were analyzed using multivariate analysis of covariance to determine the contributions of ERO versus ERP measures to discriminate between the LTAA versus NAC groups. RESULTS: The LTAA group showed significantly lower evoked delta ERO power and total delta and theta ERO power compared to the control group. The evoked and total ERO power measures provide an alternative (but not more powerful) representation of the group difference than does P3b amplitude. There was a weak suggestion that nonphase-locked theta ERO power (which contributes to total ERO power) might provide independent discriminatory information. CONCLUSIONS: Reduced evoked ERO power in the response to target stimuli provided an alternative and comparable representation of the reduced P3b amplitude in LTAA. This is not surprising as the evoked ERO power measures are derived from time-frequency representations of the ERP waveform. Induced theta oscillations might provide independent discriminatory information beyond ERP amplitude measures, but separate analysis of the event-related nonphase-locked activity is required to investigate this further.
Comparison of ERP and ERO measures derived from the event-related data for the target condition for the NACs. (a) The grand average ERP waveform for electrode site Cz is displayed, along with the grand average topographical maps for each of the major ERP components, namely the N100, P200, N200, P300 (P3b) and N300. (b) The grand average EROEVK TFR for the Cz electrode site is shown, together with the grand average topographical maps for the TFROIs given in Table 2.
| Name | Type |
|---|---|
| 32-channel cohort local | cohort |
| 40-channel cohort local | cohort |
| 64-channel cohort local | cohort |
| Adult male alcoholics local | cohort |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| alcoholic group | cohort |
| alcoholism | phenotype |
| alpha band | phenotype |
| bipolar electrode site pair local | anatomy |
| central-parietal regions local | anatomy |
| central region | anatomy |
| central site local | anatomy |
| centro-parietal region | anatomy |
| chronic alcoholism | phenotype |
| control group | cohort |
| control participants | cohort |
| controls | cohort |
| CPz | anatomy |
| current study | cohort |
| Cz | anatomy |
| delta band | phenotype |
| EEG | phenotype |
| ERO | phenotype |
| EROEVK TFR | phenotype |
| ERO power | phenotype |
| ERO power measures local | phenotype |
| EROTOT power local | phenotype |
| EROTOT power measures local | phenotype |
| EROTOT TFR | phenotype |
| EROVK power measures local | phenotype |
| ERP | phenotype |
| ERP1 local | phenotype |
| ERP amplitude measures local | phenotype |
| event-related desynchronization | phenotype |
| Event-related oscillation | phenotype |
| event-related potential | phenotype |
| Event-Related Synchronization local | phenotype |
| FCz | anatomy |
| Fein and Chang 2006 local | cohort |
| Frequency-Specific Oscillations local | phenotype |
| frontal cortex | anatomy |
| frontal site local | anatomy |
| fronto-central region | anatomy |
| Fz | anatomy |
| ground electrode local | anatomy |
| group | cohort |
| High-risk adolescents | cohort |
| High risk individuals local | cohort |
| individuals at high risk of alcoholism local | cohort |
| Induced Oscillation local | phenotype |
| induced theta activity local | phenotype |
| Jones et al 2006 local | cohort |
| Jones et al. (2006) local | cohort |
| Jones et al., 2006 local | cohort |
| Light/non-drinkers local | phenotype |
| lower δ band local | phenotype |
| Low-risk adolescents local | cohort |
| LTAA | cohort |
| LTAA group local | cohort |
| MESOIs | anatomy |
| N100 local | phenotype |
| N100 amplitude local | phenotype |
| N200 local | phenotype |
| N200 amplitude local | phenotype |
| N300 local | phenotype |
| N300 amplitude local | phenotype |
| NAc | anatomy |
| Non-Phase-Locked Frequency-Specific Activity Increase local | phenotype |
| non-phase-locked induced oscillations local | phenotype |
| occipital cortex | anatomy |
| P200 local | phenotype |
| P200 amplitude local | phenotype |
| P300 measures | phenotype |
| P3a amplitude | phenotype |
| P3b amplitude | phenotype |
| P3b dynamics local | phenotype |
| P3b ERP component local | phenotype |
| parietal cortex | anatomy |
| parieto-occipital local | anatomy |
| phase-locked oscillations local | phenotype |
| Power Decrease local | phenotype |
| Power Increase local | phenotype |
| predisposition to alcoholism local | phenotype |
| Pz | anatomy |
| Rangaswamy et al 2007 local | cohort |
| Rangaswamy et al. (2007) local | cohort |
| Rangaswamy et al., 2007 local | cohort |
| recovery from alcoholism | phenotype |
| Reduced P3b amplitude local | phenotype |
| right ear reference electrode local | anatomy |
| TFROIs local | anatomy |
| theta band | phenotype |
| theta oscillations | phenotype |
| vertical electro-oculogram (EOG) local | anatomy |
| α local | anatomy |
| α power (EROEVK) local | phenotype |
| α power (EROTOT) local | phenotype |
| δ1 local | anatomy |
| δ1 local | phenotype |
| δ1 EROEVK power local | phenotype |
| δ1 EROTOT power local | phenotype |
| δ1 power (EROEVK) local | phenotype |
| δ1 power (EROTOT) local | phenotype |
| δ2 local | anatomy |
| δ2 power (EROEVK) local | phenotype |
| δ2 power (EROTOT) local | phenotype |
| δ EROEVK power local | phenotype |
| δ EROTOT power local | phenotype |
| δ evoked power local | phenotype |
| θ1 local | anatomy |
| θ1 local | phenotype |
| θ1 EROEVK power local | phenotype |
| θ1 EROTOT power local | phenotype |
| θ1 power (EROEVK) local | phenotype |
| θ1 power (EROTOT) local | phenotype |
| θ2 local | anatomy |
| θ2 local | phenotype |
| θ2 EROEVK power local | phenotype |
| θ2 EROTOT power local | phenotype |
| θ2 power (EROEVK) local | phenotype |
| θ2 power (EROTOT) local | phenotype |
| θ band | phenotype |
| θ EROTOT power local | phenotype |
| θ total power local | phenotype |
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