Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors.
paper
Cited
Public
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- Authors
- Knopik, Valerie S; Heath, Andrew C; Madden, Pamela A F; Bucholz, Kathleen K; Slutske, Wendy S; Nelson, Elliot C; Statham, Dixie; Whitfield, John B; Martin, Nicholas G
- Year
- 2004
- Journal
- Psychological medicine
- PMID
- 15724882
- DOI
- 10.1017/s0033291704002922
BACKGROUND: Genetic influences have been shown to play a major role in determining the risk of alcohol dependence (AD) in both women and men; however, little attention has been directed to identifying the major sources of genetic variation in AD risk. METHOD: Diagnostic telephone interview data from young adult Australian twin pairs born between 1964 and 1971 were analyzed. Cox regression models were fitted to interview data from a total of 2708 complete twin pairs (690 MZ female, 485 MZ male, 500 DZ female, 384 DZ male, and 649 DZ female/male pairs). Structural equation models were fitted to determine the extent of residual genetic and environmental influences on AD risk while controlling for effects of sociodemographic and psychiatric predictors on risk. RESULTS: Risk of AD was increased in males, in Roman Catholics, in those reporting a history of major depression, social anxiety problems, and conduct disorder, or (in females only) a history of suicide attempt and childhood sexual abuse; but was decreased in those reporting Baptist, Methodist, or Orthodox religion, in those who reported weekly church attendance, and in university-educated males. After allowing for the effects of sociodemographic and psychiatric predictors, 47 % (95% CI 28-55) of the residual variance in alcoholism risk was attributable to additive genetic effects, 0% (95% CI 0-14) to shared environmental factors, and 53% (95% CI 45-63) to nonshared environmental influences. CONCLUSIONS: Controlling for other risk factors, substantial residual heritability of AD was observed, suggesting that psychiatric and other risk factors play a minor role in the inheritance of AD.
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|---|---|---|---|---|
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| Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes. | Bountress KE et al. | — | 2023 | → |
| Prevalence and heritability of alcohol use disorders in 18-year old Swedish twins. | Hildebrand Karlén M et al. | — | 2023 | → |
| Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach. | Bountress KE et al. | — | 2022 | → |
| Moderators of subjective response to alcohol in the human laboratory. | Nieto SJ et al. | — | 2022 | → |
| Patterns and predictors of high-intensity drinking and implications for intervention. | Patrick ME et al. | — | 2022 | → |
| Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. | Tielbeek JJ et al. | — | 2022 | → |
| Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study. | Bountress KE et al. | — | 2021 | → |
| Problems experienced by children from families with histories of substance misuse: An ABCD study®. | Lees B et al. | — | 2021 | → |
| Genetic aetiology of self-harm ideation and behaviour. | Campos AI et al. | — | 2020 | → |
| Pathways to post-traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults. | Subbie-Saenz de Viteri S et al. | — | 2020 | → |
| Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse. | Gendy MNS et al. | — | 2019 | → |
| Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors. | Richmond-Rakerd LS et al. | — | 2019 | → |
| Neurophysiological Correlates and Differential Drug Response in Subjects With a Family History of an Alcohol Use Disorder. | Comstock SM et al. | — | 2019 | → |
| A direct test of the diathesis-stress model for depression. | Colodro-Conde L et al. | — | 2018 | → |
| Association Between Population Density and Genetic Risk for Schizophrenia. | Colodro-Conde L et al. | — | 2018 | → |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | — | 2018 | → |
| Nineteen and Up study (19Up): understanding pathways to mental health disorders in young Australian twins. | Couvy-Duchesne B et al. | — | 2018 | → |
| No evidence of association of oxytocin polymorphisms with breastfeeding in 2 independent samples. | Colodro-Conde L et al. | — | 2018 | → |
| From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process. | Deutsch AR et al. | — | 2017 | → |
| Higher genetic risk for schizophrenia is associated with living in urban and populated areas | Colodro-Conde L et al. | — | 2017 | — |
| Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study. | Li JJ et al. | — | 2017 | → |
| Posttraumatic stress disorder and alcohol dependence: Epidemiology and order of onset. | Berenz EC et al. | — | 2017 | → |
| Relationships of Impulsivity and Subjective Response to Alcohol Use and Related Problems. | Berey BL et al. | — | 2017 | → |
| Review: Genetic research on alcohol use outcomes in African American populations: A review of the literature, associated challenges, and implications. | Dick DM et al. | — | 2017 | → |
| SNP by SNP by environment interaction network of alcoholism. | Zollanvari A et al. | — | 2017 | → |
| The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. | Maciejewski DF et al. | — | 2017 | → |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | — | 2017 | → |
| Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis. | Richmond-Rakerd LS et al. | — | 2016 | → |
| A National Swedish Twin-Sibling Study of Alcohol Use Disorders. | Kendler KS et al. | — | 2016 | → |
| Genetic overlap between impulsivity and alcohol dependence: a large-scale national twin study. | Khemiri L et al. | — | 2016 | → |
| Neurobiological phenotypes associated with a family history of alcoholism. | Cservenka A | — | 2016 | → |
| Test for association of common variants in GRM7 with alcohol consumption. | Melroy-Greif WE et al. | — | 2016 | → |
| Alcohol preferring (P) rats as a model for examining sex differences in alcohol use disorder and its treatment. | Moore CF et al. | — | 2015 | → |
| Association between ADH1C and ALDH2 polymorphisms and alcoholism in a Turkish sample. | Ayhan Y et al. | — | 2015 | → |
| A twin study of breastfeeding with a preliminary genome-wide association scan. | Colodro-Conde L et al. | — | 2015 | → |
| Progression in substance use initiation: A multilevel discordant monozygotic twin design. | Richmond-Rakerd LS et al. | — | 2015 | → |
| The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies. | Verhulst B et al. | — | 2015 | → |
| The role of conduct disorder in the relationship between alcohol, nicotine and cannabis use disorders. | Grant JD et al. | — | 2015 | → |
| Alcohol cues, approach bias, and inhibitory control: applying a dual process model of addiction to alcohol sensitivity. | Fleming KA et al. | — | 2014 | → |
| Alcohol dependence and reproductive timing in African and European ancestry women: findings in a midwestern twin cohort. | Waldron M et al. | — | 2014 | → |
| Cognitive impairments in alcohol-dependent subjects. | Bernardin F et al. | — | 2014 | → |
| Genetic and environmental influences on the ages of drinking and gambling initiation: evidence for distinct aetiologies and sex differences. | Richmond-Rakerd LS et al. | — | 2014 | → |
| Genetic predisposition to schizophrenia associated with increased use of cannabis. | Power RA et al. | — | 2014 | → |
| Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders. | Few LR et al. | — | 2014 | → |
| Human mate selection and addiction: a conceptual critique. | Heath AC et al. | — | 2014 | → |
| Influence of sensation seeking on response to alcohol versus placebo: implications for the acquired preparedness model. | Scott C et al. | — | 2014 | → |
| Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. | Kos MZ et al. | — | 2014 | → |
| Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology? | Maciejewski DF et al. | — | 2014 | → |
| Substance use and sexual intercourse onsets in adolescence: a genetically informative discordant twin design. | Deutsch AR et al. | — | 2014 | → |
| Are there differences between young African-American and European-American women in the relative influences of genetics versus environment on age at first drink and problem alcohol use? | Sartor CE et al. | — | 2013 | → |
| Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. | Seneviratne C et al. | — | 2013 | → |
| A twin study of alcohol dependence, binge eating, and compensatory behaviors. | Munn-Chernoff MA et al. | — | 2013 | → |
| Causal influence of age at first drink on alcohol involvement in adulthood and its moderation by familial context. | Deutsch AR et al. | — | 2013 | → |
| Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. | Kos MZ et al. | — | 2013 | → |
| Determining the heritability of ethanol-induced locomotor sensitization in mice using short-term behavioral selection. | Linsenbardt DN et al. | — | 2013 | → |
| Early subjective response and acquired tolerance as predictors of alcohol use and related problems in a clinical sample. | Corbin WR et al. | — | 2013 | → |
| Effects of sibship size and composition on younger brothers' and sisters' alcohol use initiation: findings from an Australian twin sample. | Richmond-Rakerd LS et al. | — | 2013 | → |
| An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology. | Lynskey MT et al. | — | 2012 | → |
| Convergence of genome-wide association and candidate gene studies for alcoholism. | Olfson E et al. | — | 2012 | → |
| Copy number variations in 6q14.1 and 5q13.2 are associated with alcohol dependence. | Lin P et al. | — | 2012 | → |
| Do shared etiological factors contribute to the relationship between sexual orientation and depression? | Zietsch BP et al. | — | 2012 | → |
| Environmental influences predominate in remission from alcohol use disorder in young adult twins. | McCutcheon VV et al. | — | 2012 | → |
| Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. | Zhang H et al. | — | 2012 | → |
| Sex hormone activity in alcohol addiction: integrating organizational and activational effects. | Lenz B et al. | — | 2012 | → |
| Stable genetic effects on symptoms of alcohol abuse and dependence from adolescence into early adulthood. | van Beek JH et al. | — | 2012 | → |
| The genetics of alcohol dependence: advancing towards systems-based approaches. | Palmer RH et al. | — | 2012 | → |
| Affective disorders, anxiety disorders and the risk of alcohol dependence and misuse. | Liang W et al. | — | 2011 | → |
| A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. | Heath AC et al. | — | 2011 | → |
| arouser reveals a role for synapse number in the regulation of ethanol sensitivity. | Eddison M et al. | — | 2011 | → |
| Could a continuous measure of individual transmissible risk be useful in clinical assessment of substance use disorder? Findings from the National Epidemiological Survey on Alcohol and Related Conditions. | Ridenour TA et al. | — | 2011 | → |
| Drinking motives in female smokers: factor structure, alcohol dependence, and genetic influences. | Kristjansson SD et al. | — | 2011 | → |
| Heritabilities of Alcohol Use Disorders Identification Test (AUDIT) scores and alcohol biomarkers in Koreans: the KoGES (Korean Genome Epi Study) and Healthy Twin Study. | Sung J et al. | — | 2011 | → |
| Identifying neurobiological phenotypes associated with alcohol use disorder severity. | Claus ED et al. | — | 2011 | → |
| A cognitive model for the intergenerational transference of alcohol use behavior. | Campbell JM et al. | — | 2010 | → |
| A genome-wide association study of alcohol dependence. | Bierut LJ et al. | — | 2010 | → |
| A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. | Lind PA et al. | — | 2010 | → |
| Associations between ADH gene variants and alcohol phenotypes in Dutch adults. | van Beek JH et al. | — | 2010 | → |
| Common genetic contributions to alcohol and cannabis use and dependence symptomatology. | Sartor CE et al. | — | 2010 | → |
| H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. | Nelson EC et al. | — | 2010 | → |
| Low novelty seeking and high self directedness scores in alcohol-dependent patients without comorbid psychiatric disorders homozygous for the A10 allele of the dopamine transporter gene. | Anghelescu I et al. | — | 2010 | → |
| Neural circuitry associated with risk for alcohol use disorders. | Tessner KD et al. | — | 2010 | → |
| Nicotine withdrawal symptoms in adolescent and adult twins. | Pergadia ML et al. | — | 2010 | → |
| Subjective response to alcohol: a critical review of the literature. | Morean ME et al. | — | 2010 | → |
| Alcohol consumption indices of genetic risk for alcohol dependence. | Grant JD et al. | — | 2009 | → |
| Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | — | 2009 | → |
| Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms. | Agrawal A et al. | — | 2009 | → |
| Genetic and environmental influences on externalizing behavior and alcohol problems in adolescence: a female twin study. | Knopik VS et al. | — | 2009 | → |
| Mood-related drinking motives mediate the familial association between major depression and alcohol dependence. | Young-Wolff KC et al. | — | 2009 | → |
| Parental alcoholism and offspring behavior problems: findings in Australian children of twins. | Waldron M et al. | — | 2009 | → |
| Parental history of anxiety and alcohol-use disorders and alcohol expectancies as predictors of alcohol-related problems. | Morean ME et al. | — | 2009 | → |
| Paternal alcoholism and offspring ADHD problems: a children of twins design. | Knopik VS et al. | — | 2009 | → |
| Timing of first alcohol use and alcohol dependence: evidence of common genetic influences. | Sartor CE et al. | — | 2009 | → |
| Adult transition from at-risk drinking to alcohol dependence: the relationship of family history and drinking motives. | Beseler CL et al. | — | 2008 | → |
| Alcohol consumption and health among elders. | Balsa AI et al. | — | 2008 | → |
| Disentangling the complex association between childhood sexual abuse and alcohol-related problems: a review of methodological issues and approaches. | Sartor CE et al. | — | 2008 | → |
| Gender, victimization, and psychiatric outcomes. | Gershon A et al. | — | 2008 | → |
| Genetic and environmental influences on the rate of progression to alcohol dependence in young women. | Sartor CE et al. | — | 2008 | → |
| Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence. | Hansell NK et al. | — | 2008 | → |
| Measuring carbohydrate-deficient transferrin by direct immunoassay: factors affecting diagnostic sensitivity for excessive alcohol intake. | Whitfield JB et al. | — | 2008 | → |
| Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. | Ishiguro H et al. | — | 2007 | → |
| Puberty, hormones, and sex differences in alcohol abuse and dependence. | Witt ED | — | 2007 | → |
| Duration of cannabis use--a novel phenotype? | Lynskey MT et al. | — | 2006 | → |
| Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates--2006. | Mehra MR et al. | — | 2006 | → |
| The implications of simultaneous smoking initiation for inferences about the genetics of smoking behavior from twin data. | Pergadia ML et al. | — | 2006 | → |
| Women's mental health research: the emergence of a biomedical field. | Blehar MC | — | 2006 | → |
| Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins. | Lynskey MT et al. | — | 2005 | → |
| Similarities and differences of longitudinal phenotypes across alternate indices of alcohol involvement: a methodologic comparison of trajectory approaches. | Jackson KM et al. | — | 2005 | → |