The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance.
paper
Primary
Public
- Authors
- Kuo, Sally I-Chun; Poore, Holly E; Barr, Peter B; Chirico, Isabella S; Aliev, Fazil; Bucholz, Kathleen K; Chan, Grace; Kamarajan, Chella; Kramer, John R; McCutcheon, Vivia V; Plawecki, Martin H; Dick, Danielle M
- Year
- 2022
- Journal
- Development and psychopathology
- PMID
- 36200344
- DOI
- 10.1017/S0954579422000700
- PMCID
- PMC10076450
The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data to disentangle the genetic and environmental pathways contributing to adolescent externalizing behavior in a sample of 1,111 adolescents (50% female; 719 European and 392 African ancestry) and their parents from the Collaborative Study on the Genetics of Alcoholism. We found evidence for genetic nurture such that parental externalizing polygenic scores were associated with adolescent externalizing behavior, over and above the effect of adolescents' own externalizing polygenic scores. Mediation analysis indicated that parental externalizing psychopathology partly explained the effect of parental genotype on children's externalizing behavior. We also found evidence for evocative gene-environment correlation, whereby adolescent externalizing polygenic scores were associated with lower parent-child communication, less parent-child closeness, and lower parental knowledge, controlling for parental genotype. These effects were observed among participants of European ancestry but not African ancestry, likely due to the limited predictive power of polygenic scores across ancestral background. These results demonstrate that in addition to genetic transmission, genes influence offspring behavior through the influence of parental genotypes on their children's environmental experiences, and the role of children's genotypes in shaping parent-child relationships.
Conceptual model, adapted from Saunders et al. (2021), linking parental genotype and adolescent externalizing behavior. Solid lines represent direct genetic transmission. Dashed lines represent indirect effect of parental genotype on adolescent externalizing behavior through parental externalizing and parenting.
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| AchenbachTM (1966). The classification of children’s psychiatric symptoms: A factor-analytic study. Psychological Monographs: General and Applied, 80(7), 1–37. doi:10.1037/h00939065968338 | — | — | — |
| American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC: American Psychiatric Association. | — | — | — |
| Armstrong-CarterE, TrejoS, HillLJB, CrossleyKL, MasonD, & DomingueBW (2020). The Earliest Origins of Genetic Nurture: The Prenatal Environment Mediates the Association Between Maternal Genetics and Child Development. Psychological Science, 31(7), 781–791. doi:10.1177/095679762091720932484377 PMC7370247 | — | — | — |
| AvinunR, & KnafoA (2014). Parenting as a Reaction Evoked by Children’s Genotype: A Meta-Analysis of Children-as-Twins Studies. Personality and Social Psychology Review, 18(1), 87–102. doi:10.1177/108886831349830823940232 | — | — | — |
| BarrPB, & DickDM (2020). The Genetics of Externalizing Problems. In de WitH & JentschJD (Eds.), Recent Advances in Research on Impulsivity and Impulsive Behaviors (pp. 93–112). Cham: Springer International Publishing. | — | — | — |
| BatesTC, MaherBS, MedlandSE, McAloneyK, WrightMJ, HansellNK, … GillespieNA (2018). The Nature of Nurture: Using a Virtual-Parent Design to Test Parenting Effects on Children’s Educational Attainment in Genotyped Families. Twin Research and Human Genetics, 21(2), 73–83. doi:10.1017/thg.2018.1129530109 | — | — | — |
| BaurleyJW, EdlundCK, PardameanCI, ContiDV, & BergenAW (2016). Smokescreen: A targeted genotyping array for addiction research. BMC Genomics, 17, 145. doi:10.1186/s12864-016-2495-726921259 PMC4769529 | — | — | — |
| BegleiterH, ReichT, HesselbrockV, PorjeszB, LiT-K, SchuckitMA, … RiceJP (1995). The collaborative study on the genetics of alcoholism. Alcohol Health and Research World, 19, 228–228.31798102 PMC6875768 | — | — | — |
| BenjaminiY, & HochbergY (1995). Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society. Series B (Methodological), 57(1), 289–300. 10.1111/j.2517-6161.1995.tb02031.x | — | — | — |
| BogdanR, BarangerDAA, & AgrawalA (2018). Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences. Annual Review of Clinical Psychology, 14(1), 119–157. doi:10.1146/annurev-clinpsy-050817-084847PMC777293929579395 | — | — | — |
| BucholzKK, CadoretR, CloningerCR, DinwiddieSH, HesselbrockVM, NurnbergerJI, … SchuckitMA (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. Journal of Studies on Alcohol, 55(2), 149–158. doi:10.15288/jsa.1994.55.1498189735 | — | — | — |
| BucholzKK, McCutcheonVV, AgrawalA, DickDM, HesselbrockVM, KramerJR, … PorjeszB (2017). Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. Alcoholism, Clinical and Experimental Research, 41(2), 359–368. doi:10.1111/acer.1329328073157 PMC5272776 | — | — | — |
| CardonLR, & PalmerLJ (2003). Population stratification and spurious allelic association. The Lancet, 361(9357), 598–604. doi:10.1016/S0140-6736(03)12520-212598158 | — | — | — |
| CaseA, & DeatonA (2017). Mortality and morbidity in the 21(st) century. Brookings Papers on Eonomic Activity, 2017, 397–476. doi:10.1353/eca.2017.0005PMC564026729033460 | — | — | — |
| ChassinL, PillowDR, CurranPJ, MolinaBSG, & BarreraMJr. (1993). Relation of parental alcoholism to early adolescent substance use: A test of three mediating mechanisms. Journal of Abnormal Psychology, 102(1), 3–19. doi:10.1037/0021-843X.102.1.38436697 | — | — | — |
| DasS, ForerL, SchönherrS, SidoreC, LockeAE, KwongA, VriezeSI, ChewEY, LevyS, McGueM, SchlessingerD, StambolianD, LohP-R, IaconoWG, SwaroopA, ScottLJ, CuccaF, KronenbergF, BoehnkeM, … FuchsbergerC (2016). Next-generation genotype imputation service and methods. Nature Genetics, 48(10), 1284–1287. 10.1038/ng.365627571263 PMC5157836 | — | — | — |
| DavisLK (2021). Human genetics needs an antiracism plan. Scientific American. Retrieved from https://www.scientificamerican.com/article/human-genetics-needs-an-antiracism-plan/ | — | — | — |
| de ZeeuwEL, HottengaJ-J, OuwensKG, DolanCV, EhliEA, DaviesGE, … van BergenE (2020). Intergenerational Transmission of Education and ADHD: Effects of Parental Genotypes. Behavior Genetics, 50(4), 221–232. doi:10.1007/s10519-020-09992-w32026073 PMC7355279 | — | — | — |
| DelaneauO, HowieB, CoxAJ, ZaguryJ-F, & MarchiniJ (2013). Haplotype estimation using sequencing reads. American Journal of Human Genetics, 93(4), 687–696. 10.1016/j.ajhg.2013.09.00224094745 PMC3791270 | — | — | — |
| DickDM, ChoSB, LatendresseSJ, AlievF, NurnbergerJI, EdenbergHJ, … KupermanS (2014). Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. Addiction Biology, 19(6), 1055–1064. doi:10.1111/adb.1206623692184 PMC3783626 | — | — | — |
| GeT, ChenC-Y, NiY, FengY-CA, & SmollerJW (2019). Polygenic prediction via Bayesian regression and continuous shrinkage priors. Nature Communications, 10(1), 1776. doi:10.1038/s41467-019-09718-5PMC646799830992449 | — | — | — |
| HambrickDZ, & Tucker-DrobEM (2015). The genetics of music accomplishment: Evidence for gene–environment correlation and interaction. Psychonomic Bulletin & Review, 22(1), 112–120. doi:10.3758/s13423-014-0671-924957535 | — | — | — |
| HamdiNR, & IaconoWG (2014). Lifetime prevalence and co-morbidity of externalizing disorders and depression in prospective assessment. Psychological Medicine, 44(2), 315–324. doi:10.1017/S003329171300062723590946 PMC3797261 | — | — | — |
| HesselbrockM, EastonC, BucholzKK, SchuckitM, & HesselbrockV (1999). A validity study of the SSAGA-a comparison with the SCAN. Addiction, 94(9), 1361–1370. doi:10.1046/j.1360-0443.1999.94913618.x10615721 | — | — | — |
| HindorffLA, BonhamVL, BrodyLC, GinozaM, HutterCM, ManolioTA, & GreenED (2018). Prioritizing diversity in human genomics research. Nature Reviews Genetics, 19(3), 175–185. 10.1038/nrg.2017.89PMC653266829151588 | — | — | — |
| JaffeeSR, & PriceTS (2007). Gene–environment correlations: a review of the evidence and implications for prevention of mental illness. Molecular Psychiatry, 12(5), 432–442. doi:10.1038/sj.mp.400195017453060 PMC3703541 | — | — | — |
| JangKL, VernonPA, LivesleyWJ, SteinMB, & WolfH (2001). Intra- and extra-familial influences on alcohol and drug misuse: a twin study of gene–environment correlation. Addiction, 96(9), 1307–1318. doi:10.1046/j.1360-0443.2001.969130710.x11672495 | — | — | — |
| Karlsson LinnérR, MallardTT, BarrPB, Sanchez-RoigeS, MadoleJW, DriverMN, … DickDM (2021). Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience, 24(10), 1367–1376. doi:10.1038/s41593-021-00908-334446935 PMC8484054 | — | — | — |
| KendlerKS, & BakerJH (2007). Genetic influences on measures of the environment: a systematic review. Psychological Medicine, 37(5), 615–626. doi:10.1017/S003329170600952417176502 | — | — | — |
| KendlerKS, JiJ, EdwardsAC, OhlssonH, SundquistJ, & SundquistK (2015). An Extended Swedish National Adoption Study of Alcohol Use Disorder. JAMA Psychiatry, 72(3), 211–218. doi:10.1001/jamapsychiatry.2014.213825565339 PMC4351126 | — | — | — |
| KendlerKS, PrescottCA, MyersJ, & NealeMC (2003). The Structure of Genetic and Environmental Risk Factors for Common Psychiatric and Substance Use Disorders in Men and Women. Archives of General Psychiatry, 60(9), 929–937. doi:10.1001/archpsyc.60.9.92912963675 | — | — | — |
| KendlerKS, SundquistK, OhlssonH, PalmérK, MaesH, WinklebyMA, & SundquistJ (2012). Genetic and Familial Environmental Influences on the Risk for Drug Abuse: A National Swedish Adoption Study. Archives of General Psychiatry, 69(7), 690–697. doi:10.1001/archgenpsychiatry.2011.211222393206 PMC3556483 | — | — | — |
| KeyesM, LegrandLN, IaconoWG, & McGueM (2008). Parental Smoking and Adolescent Problem Behavior: An Adoption Study of General and Specific Effects. American Journal of Psychiatry, 165(10), 1338–1344. doi:10.1176/appi.ajp.2008.0801012518676589 PMC2597022 | — | — | — |
| KlahrAM, & BurtSA (2014). Elucidating the etiology of individual differences in parenting: A meta-analysis of behavioral genetic research. Psychological Bulletin, 140(2), 544–586. doi:10.1037/a003420524016230 | — | — | — |
| KongA, ThorleifssonG, FriggeML, VilhjalmssonBJ, YoungAI, ThorgeirssonTE, … StefanssonK (2018). The nature of nurture: Effects of parental genotypes. Science, 359(6374), 424–428. doi:10.1126/science.aan687729371463 | — | — | — |
| KruegerRF, HicksBM, PatrickCJ, CarlsonSR, IaconoWG, & McGueM (2002). Etiologic connections among substance dependence, antisocial behavior and personality: Modeling the externalizing spectrum. Journal of Abnormal Psychology, 111(3), 411–424. doi:10.1037/0021-843X.111.3.41112150417 | — | — | — |
| KupermanS, ChanG, KramerJR, WetherillL, BucholzKK, DickD, … SchuckitM (2013). A Model to Determine the Likely Age of an Adolescent’s First Drink of Alcohol. Pediatrics, 131(2), 242. doi:10.1542/peds.2012-088023296431 PMC3557403 | — | — | — |
| LaheyBB, RathouzPJ, Van HulleC, UrbanoRC, KruegerRF, ApplegateB, … WaldmanID (2008). Testing Structural Models of DSM-IV Symptoms of Common Forms of Child and Adolescent Psychopathology. Journal of Abnormal Child Psychology, 36(2), 187–206. doi:10.1007/s10802-007-9169-517912624 | — | — | — |
| LaiD, JohnsonEC, ColbertS, PandeyG, ChanG, BauerL, … & ForoudT (2022). Evaluating risk for alcohol use disorder: Polygenic risk scores and family history. Alcoholism: Clinical and Experimental Research, 46(3), 374–383. 10.1111/acer.1477235267208 PMC8928056 | — | — | — |
| LaiD, WetherillL, BertelsenS, CareyCE, KamarajanC, KapoorM, … ForoudT (2019). Genome‐wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria. Genes, Brain & Behavior, 18(6). doi:10.1111/gbb.12579PMC661257331090166 | — | — | — |
| LansfordJE, RothenbergWA, JensenTM, LippoldMA, BacchiniD, BornsteinMH, … Al-HassanSM (2018). Bidirectional Relations Between Parenting and Behavior Problems From Age 8 to 13 in Nine Countries. Journal of Research on Adolescence, 28(3), 571–590. doi:10.1111/jora.1238130515947 PMC6282841 | — | — | — |
| Lemery-ChalfantK, KaoK, SwannG, & GoldsmithHH (2013). Childhood temperament: passive gene-environment correlation, gene-environment interaction, and the hidden importance of the family environment. Development and Psychopathology, 25(1), 51–63. doi:10.1017/S095457941200089223398752 PMC3581153 | — | — | — |
| LiangY, PividoriM, ManichaikulA, PalmerAA, CoxNJ, WheelerHE, & ImHK (2022). Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries. Genome Biology, 23(1), 1–18. 10.1186/s13059-021-02591-w35027082 PMC8759285 | — | — | — |
| MarceauK, HorwitzBN, NarusyteJ, GanibanJM, SpottsEL, ReissD, & NeiderhiserJM (2013). Gene-Environment Correlation Underlying the Association Between Parental Negativity and Adolescent Externalizing Problems. Child Development, 84(6), 2031–2046. doi:10.1111/cdev.1209423573986 PMC3928634 | — | — | — |
| MartinAR, GignouxCR, WaltersRK, WojcikGL, NealeBM, GravelS, … KennyEE (2017). Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations. The American Journal of Human Genetics, 100(4), 635–649. doi:10.1016/j.ajhg.2017.03.00428366442 PMC5384097 | — | — | — |
| MartinAR, KanaiM, KamataniY, OkadaY, NealeBM, & DalyMJ (2019). Clinical use of current polygenic risk scores may exacerbate health disparities. Nature Genetics, 51(4), 584–591. doi:10.1038/s41588-019-0379-x30926966 PMC6563838 | — | — | — |
| McGueM, ElkinsI, WaldenB, & IaconoWG (2005). Perceptions of the Parent-Adolescent Relationship: A Longitudinal Investigation. Developmental Psychology, 41(6), 971–984. doi:10.1037/0012-1649.41.6.97116351340 | — | — | — |
| MuthénK, & MuthénBO (1998–2017). Mplus User’s Guide (8th ed.). Los Angeles, CA: Authors. | — | — | — |
| NeiderhiserJM, ReissD, LichtensteinP, SpottsEL, & GanibanJ (2007). Father-adolescent relationships and the role of genotype-environment correlation. Journal of Family Psychology, 21(4), 560–571. doi:10.1037/0893-3200.21.4.56018179328 | — | — | — |
| NeiderhiserJM, ReissD, PedersenNL, LichtensteinP, SpottsEL, HanssonK, … EllhammerO (2004). Genetic and environmental influences on mothering of adolescents: a comparison of two samples. Developmental Psychology, 40(3), 335–351. doi:10.1037/0012-1649.40.3.33515122961 PMC1226934 | — | — | — |
| PetersonRE, KuchenbaeckerK, WaltersRK, ChenC-Y, PopejoyAB, PeriyasamyS, … DuncanLE (2019). Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations. Cell, 179(3), 589–603. doi:10.1016/j.cell.2019.08.05131607513 PMC6939869 | — | — | — |
| PinquartM (2017). Associations of parenting dimensions and styles with externalizing problems of children and adolescents: An updated meta-analysis. Developmental Psychology, 53(5), 873–932. doi:10.1037/dev000029528459276 | — | — | — |
| PopejoyAB, & FullertonSM (2016). Genomics is failing on diversity. Nature, 538(7624), 161–164. doi:10.1038/538161a27734877 PMC5089703 | — | — | — |
| PriceAL, PattersonNJ, PlengeRM, WeinblattME, ShadickNA, & ReichD (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, 38(8), 904–909. doi:10.1038/ng184716862161 | — | — | — |
| R Development Core Team. (2019). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Retrieved from https://www.R-project.org/ | — | — | — |
| ReichW, & EarlsFJ (1982). The Home Environment Interview for Children, child and parent versions. Washington University. St. Louis. | — | — | — |
| ReichW, EarlsF, & PowellJ (1988). A Comparison of the Home and Social Environments of Children of Alcoholic and Non-alcoholic Parents. British Journal of Addiction, 83(7), 831–839. doi:10.1111/j.1360-0443.1988.tb00518.x3207941 | — | — | — |
| ReubenJD, ShawDS, NeiderhiserJM, NatsuakiMN, ReissD, & LeveLD (2016). Warm Parenting and Effortful Control in Toddlerhood: Independent and Interactive Predictors of School-Age Externalizing Behavior. Journal of Abnormal Child Psychology, 44(6), 1083–1096. doi:10.1007/s10802-015-0096-626496906 PMC5097859 | — | — | — |
| Richmond-RakerdLS, D’SouzaS, AndersenSH, HoganS, HoutsRM, PoultonR, … MoffittTE (2020). Clustering of health, crime and social-welfare inequality in 4 million citizens from two nations. Nature Human Behaviour, 4(3), 255–264. doi:10.1038/s41562-019-0810-4PMC708219631959926 | — | — | — |
| RothbaumF, & WeiszJR (1994). Parental caregiving and child externalizing behavior in nonclinical samples: A meta-analysis. Psychological Bulletin, 116(1), 55–74. doi:10.1037/0033-2909.116.1.558078975 | — | — | — |
| RuanY, LinY-F, FengY-CA, ChenC-Y, LamM, GuoZ, Stanley Global Asia Initiatives, HeL, SawaA, MartinAR, QinS, HuangH, & GeT (2022). Improving polygenic prediction in ancestrally diverse populations. Nature Genetics. 10.1038/s41588-022-01054-7PMC911745535513724 | — | — | — |
| RutterM, & SilbergJ (2002). Gene-environment interplay in relation to emotional and behavioral disturbance. Annual Review of Psychology, 53(1), 463. doi:10.1146/annurev.psych.53.100901.13522311752493 | — | — | — |
| SalvatoreJE, AlievF, BucholzK, AgrawalA, HesselbrockV, HesselbrockM, … DickDM (2015). Polygenic Risk for Externalizing Disorders: Gene-by-Development and Gene-by-Environment Effects in Adolescents and Young Adults. Clinical Psychological Science, 3(2), 189–201. doi:10.1177/216770261453421125821660 PMC4371857 | — | — | — |
| SaundersGRB, LiuM, VriezeS, McGueM, & IaconoWG (2021). Mechanisms of parent–child transmission of tobacco and alcohol use with polygenic risk scores: Evidence for a genetic nurture effect. Developmental Psychology, 57(5), 796–804. doi:10.1037/dev000102834166022 PMC8238311 | — | — | — |
| ScarrS, & McCartneyK (1983). How People Make Their Own Environments: A Theory of Genotype → Environment Effects. Child Development, 54(2), 424–435. doi:10.2307/11297036683622 | — | — | — |
| SuJ, KuoSI, AlievF, GuyMC, DerlanCL, EdenbergHJ, … DickDM (2018). Influence of Parental Alcohol Dependence Symptoms and Parenting on Adolescent Risky Drinking and Conduct Problems: A Family Systems Perspective. Alcoholism, Clinical and Experimental Research, 42(9), 1783–1794. doi:10.1111/acer.1382729969154 PMC6120770 | — | — | — |
| TingleyD, YamamotoT, HiroseK, KeeleL, & ImaiK (2020). mediation: Causal Mediation Analysis (Version 4.5.0) Retrieved from https://cran.r-project.org/web/packages/mediation/ | — | — | — |
| TullyLA, & HuntC (2016). Brief Parenting Interventions for Children at Risk of Externalizing Behavior Problems: A Systematic Review. Journal of Child and Family Studies, 25(3), 705–719. doi:10.1007/s10826-015-0284-6 | — | — | — |
| WangB, BaldwinJR, SchoelerT, CheesmanR, BarkhuizenW, DudbridgeF, … PingaultJ-B (2021). Robust genetic nurture effects on education: A systematic review and meta-analysis based on 38,654 families across 8 cohorts. The American Journal of Human Genetics, 108(9), 1780–1791. doi:10.1016/j.ajhg.2021.07.01034416156 PMC8456157 | — | — | — |
| WangY, TsuoK, KanaiM, NealeBM, & MartinAR (2022). Challenges and opportunities for developing more generalizable polygenic risk scores. Annual Review of Biomedical Data Science, 5. 10.1146/annurev-biodatasci-111721-074830PMC982829035576555 | — | — | — |
| WertzJ, BelskyJ, MoffittTE, BelskyDW, HarringtonH, AvinunR, … CaspiA (2019). Genetics of nurture: A test of the hypothesis that parents’ genetics predict their observed caregiving. Developmental Psychology, 55(7), 1461–1472. doi:10.1037/dev000070930920238 PMC6586484 | — | — | — |
| WertzJ, MoffittTE, Agnew‐BlaisJ, ArseneaultL, BelskyDW, CorcoranDL, … Richmond-RakerdLS (2020). Using DNA From mothers and children to study parental investment in children’s educational attainment. Child Development, 91(5), 1745–1761. doi:10.1111/cdev.1332931657015 PMC7183873 | — | — | — |
| WilloughbyEA, McGueM, IaconoWG, RustichiniA, & LeeJJ (2021). The role of parental genotype in predicting offspring years of education: evidence for genetic nurture. Molecular Psychiatry, 26(8), 3896–3904. doi:10.1038/s41380-019-0494-131444472 PMC7061492 | — | — | — |
| WrayNR, LeeSH, MehtaD, VinkhuyzenAAE, DudbridgeF, & MiddeldorpCM (2014). Research Review: Polygenic methods and their application to psychiatric traits. Journal of Child Psychology and Psychiatry, 55(10), 1068–1087. 10.1111/jcpp.1229525132410 | — | — | — |
| YoungSE, StallingsMC, CorleyRP, KrauterKS, & HewittJK (2000). Genetic and environmental influences on behavioral disinhibition. American Journal of Medical Genetics, 96(5), 684–695. 10.1002/1096-8628(20001009)96:5<684::AID-AJMG16>3.0.CO;2-G11054778 | — | — | — |
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