Hemispatial PCA dissociates temporal from parietal ERP generator patterns: CSD components in healthy adults and depressed patients during a dichotic oddball task.
- Authors
- Tenke, Craig E; Kayser, JΓΌrgen; Shankman, Stewart A; Griggs, Carlye B; Leite, Paul; Stewart, Jonathan W; Bruder, Gerard E
- Year
- 2008
- Journal
- International journal of psychophysiology : official journal of the International Organization of Psychophysiology
- PMID
- 17963912
- DOI
- 10.1016/j.ijpsycho.2007.09.001
- PMCID
- PMC2271144
Event-related potentials (31-channel ERPs) were recorded from 38 depressed, unmedicated outpatients and 26 healthy adults (all right-handed) in tonal and phonetic oddball tasks developed to exploit the perceptual challenge of a dichotic stimulation. Tonal nontargets were pairs of complex tones (corresponding to musical notes G and B above middle C) presented simultaneously to each ear (L/R) in an alternating series (G/B or B/G; 2-s fixed SOA). A target tone (note A) replaced one of the pair on 20% of the trials (A/B, G/A, B/A, A/G). Phonetic nontargets were L/R pairs of syllables (/ba/, /da/) with a short voice onset time (VOT), and targets contained a syllable (/ta/) with a long VOT. Subjects responded with a left or right button press to targets (counterbalanced across blocks). Target detection was poorer in patients than controls and for tones than syllables. Reference-free current source densities (CSDs; spherical spline Laplacian) derived from ERP waveforms were simplified and measured using temporal, covariance-based PCA followed by unrestricted Varimax rotation. Target-related N2 sinks and mid-parietal P3 sources were represented by CSD factors peaking at 245 and 440 ms. The P3 source topography included a secondary, left-lateralized temporal lobe maximum for both targets and nontargets. However, a subsequent hemispheric spatiotemporal PCA disentangled temporal lobe N1 and P3 sources as distinct factors. P3 sources were reduced in patients compared with controls, even after using performance as a covariate. Results are consistent with prior reports of P3 reduction in depression and implicate distinct parietal and temporal generators of P3 when using a dichotic oddball paradigm.
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| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| Controlling for experimental effects in event-related potentials by means of principal component rotation. | Beauducel A et al. | β | 2015 | β |
| Issues and considerations for using the scalp surface Laplacian in EEG/ERP research: A tutorial review. | Kayser J et al. | β | 2015 | β |
| The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. | Kamarajan C et al. | β | 2015 | β |
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| Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions. | Tenke CE et al. | β | 2012 | β |
| Cognitive inefficiency in depressive undergraduates: stroop processing and ERPs. | Krompinger JW et al. | β | 2011 | β |
| Current source density (CSD) old/new effects during recognition memory for words and faces in schizophrenia and in healthy adults. | Kayser J et al. | β | 2010 | β |
| ERP generator patterns in schizophrenia during tonal and phonetic oddball tasks: effects of response hand and silent count. | Kayser J et al. | β | 2010 | β |
| Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia. | Kayser J et al. | β | 2010 | β |
| Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms. | Tenke CE et al. | β | 2010 | β |
| Stimulus- and response-locked neuronal generator patterns of auditory and visual word recognition memory in schizophrenia. | Kayser J et al. | β | 2009 | β |
| Reference-independent ERP old/new effects of auditory and visual word recognition memory: Joint extraction of stimulus- and response-locked neuronal generator patterns. | Kayser J et al. | β | 2007 | β |