Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder - Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study).
- Authors
- Baune, Bernhard T; Air, Tracy
- Year
- 2016
- Journal
- Frontiers in psychiatry
- PMID
- 27616997
- DOI
- 10.3389/fpsyt.2016.00150
- PMCID
- PMC4999943
Cross-sectional and longitudinal studies exploring clinical, functional, and biological correlates of major depressive disorder are frequent. In this type of research, depression is most commonly defined as a categorical diagnosis based on studies using diagnostic instruments. Given the phenotypic and biological heterogeneity of depression, we chose to focus the phenotypic assessments on three cognitive dimensions of depression including (a) cognitive performance, (b) emotion processing, and (c) social cognitive functioning. Hence, the overall aim of the study is to investigate the long-term clinical course of these cognitive dimensions in depression and its functional (psychosocial) correlates. We also aim to identify biological "genomic" correlates of these three cognitive dimensions of depression. To address the above overall aim, we created the Cognition and Mood Study (CoFaMS) with the key objective to investigate the clinical, functional, and biological correlates of cognitive dimensions of depression by employing a prospective study design and including a healthy control group. The study commenced in April 2015, including patients with a primary diagnosis of a major depressive episode of major depressive disorder or bipolar disorder according to DSM-IV-TR criteria. The assessments cover the three cognitive dimensions of depression (cognitive performance, emotion processing, and social cognition), cognitive function screening instrument, plus functional scales to assess general, work place, and psychosocial function, depression symptom scales, and clinical course of illness. Blood is collected for comprehensive genomic discovery analyses of biological correlates of cognitive dimensions of depression. The CoFaM-Study represents an innovative approach focusing on cognitive dimensions of depression and its functional and biological "genomic" correlates. The CoFaMS team welcomes collaborations with both national and international researchers.
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| 20 | Clinical, Self-Report, and Cognitive Assessments β Work Productivity | A self-made employment questionnaire is administered to the participants. This questionnaire wasβ¦ |
| 21 | Clinical, Self-Report, and Cognitive Assessments β General Functioning | Participants are rated on their symptom severity using the Clinical Global Impression Severity Scaleβ¦ |
| 22 | Clinical, Self-Report, and Cognitive Assessments β Treatment Response to Psychotropic Medication | The Lifetime Psychotropic Treatment Response scale (LPTR) is a modified scale from the Lithiumβ¦ |
| 23 | Clinical, Self-Report, and Cognitive Assessments β Assessments of Additional Clinical Characteristics | Participants will complete a battery of self-report questionnaires using standardized scalesβ¦ |
| 24 | Clinical, Self-Report, and Cognitive Assessments β Assessments of Additional Clinical Characteristics | Some participants that will be recruited to the study will have a history of, or are suffering fromβ¦ |
| 25 | Clinical, Self-Report, and Cognitive Assessments β Assessments of Additional Clinical Characteristics β The Parenting Scale | The Parenting Scale (80) is a 30-item self-report questionnaire that measures three dysfunctionalβ¦ |
| 26 | Clinical, Self-Report, and Cognitive Assessments β Assessments of Additional Clinical Characteristics β The Parenting Tasks Checklist | The Parenting Tasks Checklist (82) consists of 28 items (self-report) designed to assessβ¦ |
| 27 | Clinical, Self-Report, and Cognitive Assessments β Assessments of Additional Clinical Characteristics β The Edinburgh Postnatal Depression Scale | The Edinburgh Postnatal Depression Scale (EPDS) is a self-report 10-item questionnaire that wasβ¦ |
| 28 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments | Participants are administered series of computer-based game-like activities using the Psychologyβ¦ |
| 29 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β The Psychology Experiment Building Language | The PEBL is a free, open-source software system that allows researchers and clinicians to design,β¦ |
| 30 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β The Psychology Experiment Building Language β Tower of London Test | Tower of London Test (89) is a well-known test used in applied clinical neuropsychology for theβ¦ |
| 31 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β The Psychology Experiment Building Language β Wisconsin Card Sort Test | Wisconsin Card Sort Test (WCST) (90) is a neuropsychological test of βset-shifting,β i.e., theβ¦ |
| 32 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β The Psychology Experiment Building Language β Corsi Block Tapping Test | Corsi Block Tapping Test (91) assesses visuo-spatial short term working memory. It involves clickingβ¦ |
| 33 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β The Psychology Experiment Building Language β Stroop Test β Stroop β Color-Word Interference | The Stroop test is a neuropsychological measure assessing processing speed and attentionβ¦ |
| 34 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β The Psychology Experiment Building Language β Repeatable Battery for the Assessment of Neuropsychological Status | The RBANS is a brief, individually administered screening instrument that aids in determining theβ¦ |
| 35 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β THINC-It Tool | The THINC-it tool has been developed in response to the need for a brief screening instrument forβ¦ |
| 36 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β THINC-It Tool β Digit Coding | This is a measure of attention, perceptual speed, motor speed, visual scanning, and memory. The testβ¦ |
| 37 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β THINC-It Tool β Choice Reaction Time | This test is used to assess psychomotor speed and choice reaction time. In this test, participantsβ¦ |
| 38 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β THINC-It Tool β N-Back | The N-Back test is measures executive control of the updating of information in working memory. Theβ¦ |
| 39 | Clinical, Self-Report, and Cognitive Assessments β Cognitive Assessments β THINC-It Tool β Trail-Making Test B | Trail-Making Test B is a neuropsychological test of visual attention and task switching.β¦ |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | 2018 | 28373689 |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Analysis of BoDV-1 status, EEG resting-state alpha activity and pro-inflammatory cytokines in adults with and without major depressive disorder. | Torner AJ et al. | β | 2024 | β |
| Use of transcranial magnetic stimulation (TMS) for studying cognitive control in depressed patients: A systematic review. | HernΓ‘ndez-Sauret A et al. | β | 2024 | β |
| Factors associated with objective and subjective cognitive impairment in Chinese patients with acute major depressive disorder. | Zhu N et al. | β | 2023 | β |
| If you feel you can't, you won't: the role of subjective and objective cognitive competence on psychosocial functioning in depression. | Vicent-Gil M et al. | β | 2023 | β |
| Spontaneous Changes in Attentional Capabilities and Reasoning After an Alcohol Rehabilitation Treatment: Evidence About the Role of Age and Alcohol Use. | Fiabane E et al. | β | 2023 | β |
| Corrigendum: Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score analysis. | Melhuish Beaupre LM et al. | β | 2022 | β |
| The pattern glare and visual memory are disrupted in patients with major depressive disorder. | Wang M et al. | β | 2022 | β |
| White Matter Alterations in Depressive Disorder. | He E et al. | β | 2022 | β |
| Difference Between Young and Old Adults' Performance on the Psychology Experiment Building Language (PEBL) Test Battery: What Is the Role of Familiarity With Technology in Cognitive Performance? | Scarpina F et al. | β | 2021 | β |
| Patient and Physician Perspectives of Depressive Symptoms and Expectations for Treatment Outcome: Results from a Web-Based Survey. | Ishigooka J et al. | β | 2021 | β |
| Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis. | Melhuish Beaupre LM et al. | β | 2021 | β |
| The Assessment of Cognitive Dysfunction in Major Depressive Disorder: A 16-Week Prospective Case-Control Study. | ΓΓΆkmΓΌΕ FP et al. | β | 2021 | β |
| The Effects of Ketamine on Cognition in Treatment-Resistant Depression: A Systematic Review and Priority Avenues for Future Research. | Gill H et al. | β | 2021 | β |
| The potential pro-cognitive effects with intravenous subanesthetic ketamine in adults with treatment-resistant major depressive or bipolar disorders and suicidality. | Zhou Y et al. | β | 2021 | β |
| Alterations of Cognition and Cerebral Ventricle Volume in Manic and Euthymic Pediatric Bipolar Disorder. | Kuang L et al. | β | 2020 | β |
| Amyloid Plaques and Symptoms of Depression Links to Medical Help-Seeking due to Subjective Cognitive Decline. | Espenes R et al. | β | 2020 | β |
| Depressive symptoms as predictors of visual memory deficits in middle-age. | Taivalantti M et al. | β | 2020 | β |
| Symptoms of Major Depressive Disorder and Their Impact on Psychosocial Functioning in the Different Phases of the Disease: Do the Perspectives of Patients and Healthcare Providers Differ? | Christensen MC et al. | β | 2020 | β |
| Conducting clinical studies targeting cognition in psychiatry: guiding principles and design. | Van Rheenen TE et al. | β | 2019 | β |
| Differences in Perceptions of Major Depressive Disorder Symptoms and Treatment Priorities Between Patients and Health Care Providers Across the Acute, Post-Acute, and Remission Phases of Depression. | Baune BT et al. | β | 2019 | β |
| Risk factors for further sick leave among Japanese workers returning to work after an episode of major depressive disorder: a prospective follow-up study over 1 year. | Hori H et al. | β | 2019 | β |
| Social cognitive abilities predict psychosocial dysfunction in major depressive disorder. | Knight MJ et al. | β | 2019 | β |
| The Direct and Indirect Relationship Between Social Cognition and Psychosocial Dysfunction in Major Depressive Disorder. | Knight MJ et al. | β | 2019 | β |
| Anti-inflammatory treatment of depression: study protocol for a randomised controlled trial of vortioxetine augmented with celecoxib or placebo. | Fourrier C et al. | β | 2018 | β |
| Cognitive and Functional Assessment of Psychosis Stratification Study (CoFAPSS): Rationale, Design, and Characteristics. | Clark SR et al. | β | 2018 | β |
| Cognitive dysfunction in major depressive disorder. | Knight MJ et al. | β | 2018 | β |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | β | 2018 | β |
| Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. | Peyrot WJ et al. | β | 2018 | β |
| Executive Function and Spatial Cognition Mediate Psychosocial Dysfunction in Major Depressive Disorder. | Knight MJ et al. | β | 2018 | β |
| Executive Subdomains Are Differentially Associated With Psychosocial Outcomes in Major Depressive Disorder. | Knight MJ et al. | β | 2018 | β |
| Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD. | Van der Auwera S et al. | β | 2018 | β |
| Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder. | Yu C et al. | β | 2018 | β |
| Psychosocial and Neurocognitive Factors Associated With Hepatitis C - Implications for Future Health and Wellbeing. | Barreira DP et al. | β | 2018 | β |
| The effects of vortioxetine on cognitive performance in working patients with major depressive disorder: A short-term, randomized, double-blind, exploratory study. | Baune BT et al. | β | 2018 | β |
| The role of cognitive impairment in psychosocial functioning in remitted depression. | Knight MJ et al. | β | 2018 | β |
| Investigation of copy number variation in subjects with major depression based on whole-genome sequencing data. | Yu C et al. | β | 2017 | β |
| Psychosocial Dysfunction in Major Depressive Disorder-Rationale, Design, and Characteristics of the Cognitive and Emotional Recovery Training Program for Depression (CERT-D). | Knight MJ et al. | β | 2017 | β |
| Whole-genome single nucleotide variant distribution on genomic regions and its relationship to major depression. | Yu C et al. | β | 2017 | β |