Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use.
- Authors
- Trucco, Elisa M; Hicks, Brian M; Villafuerte, Sandra; Nigg, Joel T; Burmeister, Margit; Zucker, Robert A
- Year
- 2016
- Journal
- Journal of abnormal psychology
- PMID
- 26845260
- DOI
- 10.1037/abn0000143
- PMCID
- PMC4850114
Understanding how specific genes contribute to risk for addiction remains challenging. This study tests whether childhood temperament and externalizing behavior in early adolescence account for a portion of the association between specific genetic variants and substance use problems in late adolescence. The sample consisted of 487 adolescents from the Michigan Longitudinal Study, a high-risk sample (70.2% male, 81.7% European American ancestry). Polymorphisms across serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems. The temperament traits behavioral control and resiliency were assessed using interviewer ratings (ages 9-11), and externalizing behavior (ages 12-14) was assessed using teacher ratings. Self-reported substance use outcomes (ages 15-17) included maximum alcoholic beverages consumed in 24 hours, and frequency of past year cigarette and marijuana use. Behavioral control, resiliency, and externalizing behavior accounted for the associations between polymorphisms in noradrenergic and GABAergic genes and substance use in late adolescence. Individual differences in emotional coping and behavioral regulation represent nonspecific neurobiological underpinnings for an externalizing pathway to addiction. (PsycINFO Database Record
Conceptual multiple mediator model. Note. Covariances between each exogenous variable and between temperament constructs were estimated but not depicted.
Model for maximum number of drinks. Values represent standardized path coefficients. Only significant paths (* = p < .05, *** = p < .001) are presented. Covariates and covariances are not depicted. Model fit = χ2 = 8.92 (10), p = 0.54, RMSEA = 0.00, CFI = 1.00.
Model for cigarette use. Values represent standardized path coefficients. Only significant paths (* = p < .05, ** = p < .01, *** = p < .001) are presented. Covariates and covariances are not depicted. Model fit = χ2 = 8.92 (10), p = 0.54, RMSEA = 0.00, CFI = 1.00.
Model for marijuana use. Values represent standardized path coefficients. Only significant paths (* = p < .05, ** = p < .01, *** = p < .001) are presented. Covariates and covariances are not depicted. Model fit = χ2 = 8.92 (10), p = 0.54, RMSEA = 0.00, CFI = 1.00.
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| Developmental Cascades from Polygenic and Prenatal Substance Use to Adolescent Substance Use: Leveraging Severity and Directionality of Externalizing and Internalizing Problems to Understand Pubertal and Harsh Discipline-Related Risk. | Marceau K et al. | — | 2021 | → |
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| Substance Use Outcomes from Two Formats of a Cognitive-Behavioral Intervention for Aggressive Children: Moderating Roles of Inhibitory Control and Intervention Engagement. | Lochman JE et al. | — | 2021 | → |
| Temperament and character traits in substance use disorder in Iran: a case control study. | Shahini N et al. | — | 2021 | → |
| The externalizing and internalizing pathways to marijuana use initiation: Examining the synergistic effects of impulsiveness and sensation seeking. | Wasserman AM et al. | — | 2021 | → |
| Developmental Pathways from Genetic, Prenatal, Parenting and Emotional/Behavioral Risk to Cortisol Reactivity and Adolescent Substance Use: A TRAILS Study. | Marceau K et al. | — | 2020 | → |
| Exploring pathways to substance use: A longitudinal examination of adolescent sport involvement, aggression, and peer substance use. | Cristello JV et al. | — | 2020 | → |
| The link between bipolarity and substance use: A controlled clinic based study. | Gupta AK et al. | — | 2020 | → |
| Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors. | Fava NM et al. | — | 2019 | → |
| Predicting Behavior Problems in Korean Preschoolers: Interactions of the <i>SLC6A4</i> Gene and Maternal Negative Affectivity. | Ha J et al. | — | 2019 | → |
| The Impact of Genes on Adolescent Substance Use: A Developmental Perspective. | Trucco EM et al. | — | 2019 | → |
| Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use. | Trucco EM et al. | — | 2018 | → |
| [Internalizing and externalizing behavior problems and substance use in adolescence]. | Poton WL et al. | — | 2018 | → |
| Pathways to Youth Behavior: The Role of Genetic, Neural, and Behavioral Markers. | Trucco EM et al. | — | 2018 | → |
| Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk. | Wang FL et al. | — | 2018 | → |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | — | 2017 | → |
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | Meyers JL et al. | — | 2017 | → |
| GABA<sub>A</sub> receptor subtype involvement in addictive behaviour. | Stephens DN et al. | — | 2017 | → |
| National Trends in Substance Use and Use Disorders Among Youth. | Han B et al. | — | 2017 | → |
| Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. | Mathies LD et al. | — | 2017 | → |