The Universal Protein Resource (UniProt) in 2010.
- Authors
- UniProt Consortium
- Year
- 2010
- Journal
- Nucleic acids research
- PMID
- 19843607
- DOI
- 10.1093/nar/gkp846
- PMCID
- PMC2808944
The primary mission of UniProt is to support biological research by maintaining a stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase, with extensive cross-references and querying interfaces freely accessible to the scientific community. UniProt is produced by the UniProt Consortium which consists of groups from the European Bioinformatics Institute (EBI), the Swiss Institute of Bioinformatics (SIB) and the Protein Information Resource (PIR). UniProt is comprised of four major components, each optimized for different uses: the UniProt Archive, the UniProt Knowledgebase, the UniProt Reference Clusters and the UniProt Metagenomic and Environmental Sequence Database. UniProt is updated and distributed every 3 weeks and can be accessed online for searches or download at http://www.uniprot.org.
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| # | Section | Preview |
|---|---|---|
| 20 | PROGRESS REPORT — UniProtKB annotation — Integration with other databases | Integration between the three types of sequence-related databases (nucleic acid sequences, protein… |
| 21 | PROGRESS REPORT — Controlled vocabularies | Controlled vocabularies (CVs) (http://www.uniprot.org/docs/#vocabulary) are used to describe various… |
| 22 | PROGRESS REPORT — Controlled vocabularies — Plastid annotation controlled vocabulary | In the OG (OrGanelle) line (Encoded on subsection of the ‘Names and origin’ section,… |
| 23 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | The metabolism of living organisms can be understood as a network of biochemical reactions,… |
| 24 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | We have followed this classical approach in the UniPathway project (a collaborative project with the… |
| 25 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | The role of a protein in metabolism is described in the 'Pathway' subsection of the 'General… |
| 26 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | Examples: |
| 27 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | P49367: S. cerevisiae homoacotinase (EC 4.2.1.36) catalyzes the second step of the sub-pathway… |
| 28 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA |
| 29 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | CCpathway; L-alpha-aminoadipate from 2-oxoglutarate: step 2/4. |
| 30 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | Q980X0: S. solfataricus acetylglutamate/acetylaminoadipate kinase (EC 2.7.2.8 & EC 2.7.2.-)… |
| 31 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)- |
| 32 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | CC acetyl-L-ornithine from L-glutamate: step 2/4. |
| 33 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA |
| 34 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | CC pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step |
| 35 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | CC 2/5. |
| 36 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | The UniProt web site supplies direct links to UniPathway… |
| 37 | PROGRESS REPORT — Controlled vocabularies — Structuring of the metabolic pathway topic using UniPathway | UniProtKB/Swiss-Prot release 57.6 contains more than 105 000 distinct proteins (∼155 000 PATHWAY… |
| 38 | PROGRESS REPORT — Controlled vocabularies — Enzyme nomenclature in UniProt | EC numbers are used to describe enzyme reactions and are based on the recommendations of the… |
| 39 | PROGRESS REPORT — Controlled vocabularies — Enzyme nomenclature in UniProt | Examples: |
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. | 2010 | 20529875 |