Psychiatric comorbidity in methamphetamine dependence.
- Authors
- Salo, Ruth; Flower, Keith; Kielstein, Anousheh; Leamon, Martin H; Nordahl, Thomas E; Galloway, Gantt P
- Year
- 2011
- Journal
- Psychiatry research
- PMID
- 21055832
- DOI
- 10.1016/j.psychres.2010.09.014
- PMCID
- PMC3058719
The primary aim of the present study was to assess the prevalence of psychiatric comorbidity in a large sample of methamphetamine (MA)-dependent subjects using a validated structured clinical interview, without limitation to sexual orientation or participation in a treatment program. The secondary aim was to assess whether the prevalence of psychiatric comorbidities varied by gender. Structured clinical interviews (SCIDs) were administered to 189 MA-dependent subjects and lifetime prevalence of DSM-IV diagnoses was assessed. Across the sample, 28.6% had primary psychotic disorders, 23.8% of which were substance-induced; 13.2% had MA-induced delusional disorders and 11.1% had MA-induced hallucinations. A substantial number of lifetime mood disorders were identified that were not substance-induced (32.3%), whereas 14.8% had mood disorders induced by substances, and 10.6% had mood disorders induced by amphetamines. Of all participants, 26.5% had anxiety disorders and 3.7% had a substance-induced anxiety disorder, all of which were induced by MA. Male subjects reported a higher percentage of MA-induced delusions compared to female abusers. Given the impact of MA psychosis and other drug-induced symptoms on hospitals and mental health services, the description and characterization of comorbid psychiatric symptoms associated with MA use is of paramount importance.
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| Name | Type |
|---|---|
| addiction | phenotype |
| Adolescent methamphetamine abusers local | cohort |
| adolescents | cohort |
| alcohol | phenotype |
| amphetamine | drug |
| amphetamine-type stimulants | drug |
| Amphetamine use disorder | phenotype |
| anxiety | phenotype |
| Australian MA users local | cohort |
| axis I disorder | phenotype |
| bipolar disorder | phenotype |
| Brecht et al. 2004 cohort local | cohort |
| cannabis use | phenotype |
| Caucasian | cohort |
| Caucasians | cohort |
| Chen et al. 2003 cohort local | cohort |
| cocaine | phenotype |
| Cocaine-using persons local | cohort |
| Cohort_1580_arrestees_MA_dependence local | cohort |
| Cohort_31_non_users local | cohort |
| Cohort_46_MA_users local | cohort |
| Cohort_51_MA_users_minimal_contact local | cohort |
| Cohort_55_MA_users_mixed_population local | cohort |
| Co-occurring psychiatric disorder local | phenotype |
| Delusional disorder local | phenotype |
| delusions | phenotype |
| depression | phenotype |
| drug dependence | phenotype |
| drug-induced disorder local | phenotype |
| DSM-IV | phenotype |
| Early MA use local | phenotype |
| General drug-using population local | cohort |
| generalized anxiety disorder | phenotype |
| genetic factors | cohort |
| Hall et al. 1996 Australian study local | cohort |
| hallucinations | phenotype |
| Heterosexual local | phenotype |
| High MA consumption local | phenotype |
| Hospital readmission local | phenotype |
| Lin et al. 2004 cohort local | cohort |
| MA-abstinent local | cohort |
| MA abusers local | cohort |
| MA abusers cohort local | cohort |
| MA abusers cohort (Nakama 2008) local | cohort |
| MA abusers cohort (Sommers 2006) local | cohort |
| MA/Cocaine dependent cohort (Mahoney 2008) local | cohort |
| MA dependent cohort (Leamon 2010) local | cohort |
| MA-dependent individuals local | cohort |
| MA-dependent samples local | cohort |
| MA-dependent subjects local | cohort |
| MA-induced delusional disorder local | phenotype |
| MA-induced delusions local | phenotype |
| MA-induced disorder local | phenotype |
| MA-induced hallucinations local | phenotype |
| MA-induced paranoia local | phenotype |
| MA-induced psychosis local | phenotype |
| MA-induced psychotic disorder | phenotype |
| major depressive disorder | phenotype |
| MA treatment cohort local | cohort |
| MA users local | cohort |
| men | cohort |
| methamphetamine | drug |
| Methamphetamine Abuse local | phenotype |
| methamphetamine dependence | phenotype |
| Methamphetamine-dependent users local | cohort |
| methamphetamine-induced psychosis local | phenotype |
| Methamphetamine Treatment Program local | cohort |
| Methamphetamine Treatment Project cohort local | cohort |
| mood disorders | phenotype |
| MTP follow-up study local | cohort |
| National Epidemiologic Survey on Alcohol and Related Conditions | cohort |
| NESARC | cohort |
| nicotine | drug |
| Non-clinical MA-dependent cohort local | cohort |
| non-drug-induced psychotic disorder local | phenotype |
| Non-heterosexual individuals local | cohort |
| Non-substance-induced psychiatric disorders local | phenotype |
| opiates | drug |
| Other disorder local | phenotype |
| other drugs | drug |
| other substances | phenotype |
| panic disorder | phenotype |
| paranoia | phenotype |
| People worldwide (2007) local | cohort |
| Post-Traumatic Stress Disorder | phenotype |
| psychiatric disorders | phenotype |
| Psychiatric hospital admission local | phenotype |
| psychiatric hospitalization local | phenotype |
| psychiatric symptoms | phenotype |
| psychosis | phenotype |
| Publically-funded substance abuse treatment programs (US) local | cohort |
| relapse | phenotype |
| Schizoid/schizotypal personality traits local | phenotype |
| schizophrenia | phenotype |
| Separated/divorced local | phenotype |
| severe anxiety local | phenotype |
| sex | phenotype |
| sex differences | phenotype |
| Shoptaw study local | cohort |
| Single and never married local | phenotype |
| social dysfunction | phenotype |
| study cohort | cohort |
| Study of 146 heterosexual female MA users local | cohort |
| substance-induced anxiety disorders local | phenotype |
| substance-induced disorder local | phenotype |
| Substance-induced disorder local | phenotype |
| substance-induced disorders local | phenotype |
| Substance-induced mood disorders local | phenotype |
| Substance-induced psychiatric disorders local | phenotype |
| substance use | phenotype |
| suicide | phenotype |
| Taiwanese MA users cohort local | cohort |
| Thailand MA cohort local | cohort |
| treatment response | phenotype |
| United States | cohort |
| women | cohort |
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alexithymia in Chinese methamphetamine dependent males: prevalence, demographic, clinical correlates, and relationship with craving. | Kiyani ART et al. | β | 2026 | β |
| Methamphetamine Use, Post-Traumatic Stress, and Substance Use Consequences Among American Indians with a Substance Use Problem. | Skewes MC et al. | β | 2026 | β |
| Prevalence and clinical characteristics of cognitive impairment in male patients of methamphetamine dependence: The moderating role of childhood trauma. | Ding M et al. | β | 2026 | β |
| Chemsex: Quiet revolution with loud risks. | Joseph AJ et al. | β | 2025 | β |
| Childhood Sexual Abuse Moderates the Long-Term Effect of an HIV Prevention Intervention Among Men Who Have Sex With Men With Crystal Methamphetamine Use Disorder. | Elliott RJ et al. | β | 2025 | β |
| How does methamphetamine affect the brain? A systematic review of magnetic resonance imaging studies. | Liu GXH et al. | β | 2025 | β |
| Methamphetamine-related psychiatric emergencies in TΓΌrkiye: clinical features, risk factors, and follow-up results from a tertiary mental health center. | Ergelen YalΓ§Δ±n M et al. | β | 2025 | β |
| Methamphetamine use and suicide risk: a comprehensive case-control study. | Aljadani AH et al. | β | 2025 | β |
| Peripheral Blood Exosomal miR-184-3p in Methamphetamine Use Disorder: Biomarker Potential and CRTC1-Mediated Neuroadaptation. | Zhao Y et al. | β | 2025 | β |
| An improved Simon reaction method to discriminate between methamphetamine and false-positive substances. | Saito K et al. | β | 2024 | β |
| A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders. | Nardi WR et al. | β | 2024 | β |
| Crystal methamphetamine and its effects on mental and oral health: A narrative review. | Alqarni H et al. | β | 2024 | β |
| Evaluation of Complete Blood Cell Count Parameters and Their Role in Inflammation in Patients with Methamphetamine and Synthetic Cannabis Use Disorder. | SehlikoΔlu Ε et al. | β | 2024 | β |
| Measuring Objective and Subjective Sleep during Lisdexamfetamine Treatment of Acute Methamphetamine Withdrawal: A Feasibility Study. | Acheson LS et al. | β | 2024 | β |
| U.S. trends in methamphetamine-involved psychiatric hospitalizations in the United States, 2015-2019. | Calcaterra SL et al. | β | 2024 | β |
| Anxiety treatment of methamphetamine-dependent patients with buprenorphine: A randomized, double-blind, clinical trial. | Ahmadi J et al. | β | 2023 | β |
| A systematic review and meta-analysis of health, functional, and cognitive outcomes in young people who use methamphetamine. | Guerin AA et al. | β | 2023 | β |
| Biennial Changes in the Characteristics of Patients with Methamphetamine Use Disorder in Japan from 2000 to 2020. | Yamamoto T et al. | β | 2023 | β |
| Comorbidities of Major Depressive Disorder and Bipolar Disorders in Patients with Substance Use Disorder in Iran Psychiatric Hospital: A Cross-sectional Study. | Oladikalarijani M et al. | β | 2023 | β |
| Corpus-Based Discourse Analysis of a Reddit Community of Users of Crystal Methamphetamine: Mixed Methods Study. | Lustig A et al. | β | 2023 | β |
| Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder. | He L et al. | β | 2023 | β |
| Evaluation of the BEAT Meth Intervention for Emergency Department Patients with Methamphetamine Psychosis. | Simpson SA et al. | β | 2023 | β |
| Methamphetamine exposure and depression-A systematic review and meta-analysis. | Leung J et al. | β | 2023 | β |
| Sociodemographic profiles and determinants of relapse risks among people with substance use disorders in the Philippines: A survey in community and residential care settings. | Harada T et al. | β | 2023 | β |
| Amphetamine-type stimulant use and self-harm: protocol for a systematic review of observational studies. | Cumming C et al. | β | 2022 | β |
| Applying the Addictions Neuroclinical Assessment to derive neurofunctional domains in individuals who use methamphetamine. | Nieto SJ et al. | β | 2022 | β |
| Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence. | Kim B et al. | β | 2022 | β |
| Exercise modulates central and peripheral inflammatory responses and ameliorates methamphetamine-induced anxiety-like symptoms in mice. | Re GF et al. | β | 2022 | β |
| Frequency of reported methamphetamine use linked to prevalence of clinical conditions, sexual risk behaviors, and social adversity in diverse men who have sex with men in Los Angeles. | Shoptaw S et al. | β | 2022 | β |
| Healthcare utilization and psychiatric and physical comorbidities before suicide mortality in patients with methamphetamine use disorder: A nationwide case-control study. | Lee WC et al. | β | 2022 | β |
| Substances use disorders and liver injury: a concise review. | Testino G et al. | β | 2022 | β |
| The Effects of Oxytocin on Craving, Mental Health Parameters, and Stress Hormones in Methamphetamine-Dependent Patients Undergoing Matrix Treatment Model: A Randomized, Double-Blind Clinical Trial. | Azadbakht A et al. | β | 2022 | β |
| Beyond the tip of the iceberg: A narrative review to identify research gaps on comorbid psychiatric disorders in adolescents with methamphetamine use disorder or chronic methamphetamine use. | Kuitunen-Paul S et al. | β | 2021 | β |
| Direction of the relationship between methamphetamine use and positive psychotic symptoms in regular methamphetamine users: evidence from a prospective cohort study. | Hides L et al. | β | 2021 | β |
| Genome-wide association study of stimulant dependence. | Cox J et al. | β | 2021 | β |
| Methamphetamine exposure and its cessation alter gut microbiota and induce depressive-like behavioral effects on rats. | Forouzan S et al. | β | 2021 | β |
| Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap? | Hersey M et al. | β | 2021 | β |
| Targeting mGlu<sub>5</sub> for Methamphetamine Use Disorder. | Petzold J et al. | β | 2021 | β |
| The prevalence of mental health disorders among young adults who use amphetamine-type stimulants, compared to young adults who do not. | Thoradeniya MR et al. | β | 2021 | β |
| A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. | Tschumi CW et al. | β | 2020 | β |
| Attempted Suicide with Intravenous Methamphetamine and Chemsex. | Garcia-Fuentes D et al. | β | 2020 | β |
| Daily heroin injection and psychiatric disorders: A cross-sectional survey among People Who Inject Drugs (PWID) in Haiphong, Vietnam. | Le SM et al. | β | 2020 | β |
| Multiscale neurobiological correlates of human neuroticism. | Xu Q et al. | β | 2020 | β |
| Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder: A Review. | Paulus MP et al. | β | 2020 | β |
| The effect of chronic oxytocin treatment during abstinence from methamphetamine self-administration on incubation of craving, reinstatement, and anxiety. | Everett NA et al. | β | 2020 | β |
| Towards Targeted Interventions in Low- and Middle-Income Countries: Risk Profiles of People Who Inject Drugs in Haiphong (Vietnam). | Riondel A et al. | β | 2020 | β |
| Methamphetamine (MA) Use Induces Specific Changes in LINE-1 Partial Methylation Patterns, Which Are Associated with MA-Induced Paranoia: a Multivariate and Neuronal Network Study. | Kalayasiri R et al. | β | 2019 | β |
| Understanding the reasons for using methamphetamine by sexual minority people in Dhaka, Bangladesh. | Khan SI et al. | β | 2019 | β |
| Co-occurring Mental Disorders in Substance Abuse Treatment: the Current Health Care Situation in Germany. | Dauber H et al. | β | 2018 | β |
| Ecological momentary assessments for self-monitoring and counseling to optimize methamphetamine treatment and sexual risk reduction outcomes among gay and bisexual men. | Reback CJ et al. | β | 2018 | β |
| Profile of psychiatric symptoms in methamphetamine users in China: Greater risk of psychiatric symptoms with a longer duration of use. | Ma J et al. | β | 2018 | β |
| Psychiatric Comorbidities among People Who Inject Drugs in Hai Phong, Vietnam: The Need for Screening and Innovative Interventions. | Pham Minh K et al. | β | 2018 | β |
| Relationship between the duration of methamphetamine use and psychotic symptoms: A two-year prospective cohort study. | Ma J et al. | β | 2018 | β |
| The prevalence of substance-induced psychotic disorder in methamphetamine misusers: A meta-analysis. | Lecomte T et al. | β | 2018 | β |
| Comparison of demographic characteristics and psychiatric comorbidity among methamphetamine-, heroin- and methamphetamine-heroin co- dependent males in Hunan, China. | Dong H et al. | β | 2017 | β |
| [Methamphetamine : Epidemiology, clinical importance and sequelae of abuse]. | Arnaud N et al. | β | 2017 | β |
| Pharmacological treatments for methamphetamine addiction: current status and future directions. | Ballester J et al. | β | 2017 | β |
| Sigma Receptors and Substance Use Disorders. | Sabino V et al. | β | 2017 | β |
| Two Case Studies Illustrating a Shared Decision-Making Approach to Illicit Methamphetamine Use and Breastfeeding. | Blandthorn J et al. | β | 2017 | β |
| A Review of Methamphetamine Dependence and Withdrawal Treatment: A Focus on Anxiety Outcomes. | Hellem TL | β | 2016 | β |
| Cognitive Function as a Transdiagnostic Treatment Target in Stimulant Use Disorders. | Sofuoglu M et al. | β | 2016 | β |
| Demographic and clinical characteristics of current comorbid psychiatric disorders in a randomized clinical trial for adults with stimulant use disorders. | Warden D et al. | β | 2016 | β |
| Drugs of abuse and addiction: A slippery slope toward liver injury. | Roy DN et al. | β | 2016 | β |
| Sex Differences in the Association Between Internalizing Symptoms and Craving in Methamphetamine Users. | Hartwell EE et al. | β | 2016 | β |
| Use of novel psychoactive substances by inpatients on general adult psychiatric wards. | Stanley JL et al. | β | 2016 | β |
| Acute exercise ameliorates craving and inhibitory deficits in methamphetamine: An ERP study. | Wang D et al. | β | 2015 | β |
| Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study. | Hellem TL et al. | β | 2015 | β |
| Neuropsychiatric Adverse Effects of Amphetamine and Methamphetamine. | Harro J | β | 2015 | β |
| Primary and substance-induced psychotic disorders in methamphetamine users. | Hides L et al. | β | 2015 | β |
| Sustained-release methylphenidate in methamphetamine dependence treatment: a double-blind and placebo-controlled trial. | Rezaei F et al. | β | 2015 | β |
| The effects of adolescent methamphetamine exposure. | Buck JM et al. | β | 2015 | β |
| Treatment of co-occurring anxiety disorders and substance use disorders. | McHugh RK | β | 2015 | β |
| Childhood maltreatment and amygdala connectivity in methamphetamine dependence: a pilot study. | Dean AC et al. | β | 2014 | β |
| Comparison of health service use among veterans with methamphetamine versus alcohol use disorders. | Morasco BJ et al. | β | 2014 | β |
| Intensive motivational interviewing for women with concurrent alcohol problems and methamphetamine dependence. | Korcha RA et al. | β | 2014 | β |
| Psychiatric disorders in individuals with methamphetamine dependence: prevalence and risk factors. | Akindipe T et al. | β | 2014 | β |
| Stimulant dependence and stimulant-associated psychosis: clinical characteristics and age of onset in a native American community sample. | Gilder DA et al. | β | 2014 | β |
| You are the danger: attenuated insula response in methamphetamine users during aversive interoceptive decision-making. | Stewart JL et al. | β | 2014 | β |
| A cognitive behavioral therapy-based text messaging intervention for methamphetamine dependence. | Keoleian V et al. | β | 2013 | β |
| A stress steroid triggers anxiety via increased expression of Ξ±4Ξ²Ξ΄ GABAA receptors in methamphetamine dependence. | Shen H et al. | β | 2013 | β |
| Differences in associations between cannabis and stimulant disorders in first admission psychosis. | Sara G et al. | β | 2013 | β |
| Efficacy of psychostimulant drugs for amphetamine abuse or dependence. | PΓ©rez-MaΓ±Γ‘ C et al. | β | 2013 | β |
| Liver abnormalities in drug and substance abusers. | Pateria P et al. | β | 2013 | β |
| National trends in psychostimulant-related deaths: 1999-2009. | Calcaterra S et al. | β | 2013 | β |
| Predictors of persistent psychotic symptoms in persons with methamphetamine abuse receiving psychiatric treatment. | Lecomte T et al. | β | 2013 | β |
| The prevalence of substance use disorders and psychiatric disorders as a function of psychotic symptoms. | Lechner WV et al. | β | 2013 | β |
| Psychostimulant-related deaths among former inmates. | Calcaterra S et al. | β | 2012 | β |
| Drug assertiveness and sexual risk-taking behavior in a sample of HIV-positive, methamphetamine-using men who have sex with men. | Semple SJ et al. | β | 2011 | β |