Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression.
paper
Cited
Public
- Authors
- Bowden, Jack; Davey Smith, George; Burgess, Stephen
- Year
- 2015
- Journal
- International journal of epidemiology
- PMID
- 26050253
- DOI
- 10.1093/ije/dyv080
- PMCID
- PMC4469799
BACKGROUND: The number of Mendelian randomization analyses including large numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome-wide association studies, and the desire to obtain more precise estimates of causal effects. However, some genetic variants may not be valid instrumental variables, in particular due to them having more than one proximal phenotypic correlate (pleiotropy). METHODS: We view Mendelian randomization with multiple instruments as a meta-analysis, and show that bias caused by pleiotropy can be regarded as analogous to small study bias. Causal estimates using each instrument can be displayed visually by a funnel plot to assess potential asymmetry. Egger regression, a tool to detect small study bias in meta-analysis, can be adapted to test for bias from pleiotropy, and the slope coefficient from Egger regression provides an estimate of the causal effect. Under the assumption that the association of each genetic variant with the exposure is independent of the pleiotropic effect of the variant (not via the exposure), Egger's test gives a valid test of the null causal hypothesis and a consistent causal effect estimate even when all the genetic variants are invalid instrumental variables. RESULTS: We illustrate the use of this approach by re-analysing two published Mendelian randomization studies of the causal effect of height on lung function, and the causal effect of blood pressure on coronary artery disease risk. The conservative nature of this approach is illustrated with these examples. CONCLUSIONS: An adaption of Egger regression (which we call MR-Egger) can detect some violations of the standard instrumental variable assumptions, and provide an effect estimate which is not subject to these violations. The approach provides a sensitivity analysis for the robustness of the findings from a Mendelian randomization investigation.
Illustrative diagram showing the standard instrumental variable assumptions for genetic variant Gj (solid lines) with potential violations of the assumptions shown by dotted lines (which are marked with a βcrossβ). The genetic effect on the exposure X is Ξ³j, the direct genetic effect on the outcome Y is Ξ±j and the causal effect of the exposure X on the outcome Y is Ξ².
Plot of the geneβoutcome (Ξ^) vs geneβexposure (Ξ³^) regression coefficients for a fictional Mendelian randomization analysis with 15 genetic variants. The true slope is shown by a dotted line, the inverse-variance weighted (IVW) estimate by a red line, and the MR-Egger regression estimate by a blue line. Refer to text for explanation of points (i) and (ii).
Genetic associations with height and lung function from 180 variants measured in the ALSPAC dataset. Left: scatter plot of genetic associations with forced vital capacity (Ξ^j) against associations with height (Ξ³^j), with causal estimate of height on lung function estimated by inverse-variance weighted method. Right: funnel plot of minor allele frequency corrected genetic associations with height (Ξ³^jC) against causal estimates based on each genetic variant individually (Ξ²^j).
Genetic associations with blood pressure and coronary artery disease risk from 29 variantsβfunnel plots of minor allele frequency corrected genetic associations with blood pressure (Ξ³^jC) against causal estimates of blood pressure on CAD based on each genetic variant individually (Ξ²^j). Left: funnel plot for systolic blood pressure. Right: funnel plot for diastolic blood pressure. The inverse-variance weighted (IVW) and MR-Egger causal effect estimates are also shown.
Funnel plots of minor allele frequency corrected genetic associations with exposure (Ξ³^jC) against causal estimates based on each genetic variant individually (Ξ²^j) for 50 IV estimates in four scenarios: (a) no pleiotropy; (b) balanced pleiotropy; (c) directional pleiotropy, InSIDE assumption satisfied; and (d) directional pleiotropy, InSIDE assumption not satisfied. The inverse-variance weighted (IVW, red) and MR-Egger (blue) causal effect estimates are also shown.
1β20 of 57
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| AngristJImbensG Two-stage least squares estimation of average causal effects in models with variable treatment intensity. J Am Stat Assoc 1995;90:431β42. | β | β | β |
| AngristJImbensGRubinD Identification of causal effects using instrumental variables. J Am Stat Assoc 1996;91:444β55. | β | β | β |
| AngristJPischkeJ-S Instrumental variables in action: sometimes you get whatyou need. In: Mostly Harmless Econometrics: An Empiricistβscompanion. Princeton, NJ: Princeton University Press, 2009. | β | β | β |
| BoefADekkersOLe CessieS Mendelian randomization studies: a review of the approaches used and the quality of reporting. Int J Epidemiol 2015;44:496β511.10.1093/ije/dyv07125953784 | β | β | β |
| BorensteinMHedgesLHigginsJRothsteinH Generality of the basic inverse-variance method .In: Introduction to Meta-analysis. Chichester, UK: Wiley, 2009. | β | β | β |
| Bowden ThompsonJBurtonP Using pseudo-data to correct for publication bias in meta-analysis. Stat Med 2006;25:3798β813.1638241810.1002/sim.2487 | β | β | β |
| BowdenJJacksonDThompsonS Modelling multiple sources of dissemination bias in meta-analysis. Stat Med 2010;29:945β55.2021370210.1002/sim.3813 | β | β | β |
| BoydAGoldingJMacleodJ Cohort Profile: The βChildren of the 90sββthe index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol 2013;42:111β27.2250774310.1093/ije/dys064PMC3600618 | β | β | β |
| BrionMJShakhbazovKVisscherPM Calculating statistical power in mendelian randomization studies. Int J Epidemiol 2013;42:1497β501.2415907810.1093/ije/dyt179PMC3807619 | β | β | β |
| BurgessSButterworthAMalarstigAThompsonS Use of Mendelian randomisation to assess potential benefit of clinical intervention. BMJ 2012;345:e7325.2313167110.1136/bmj.e7325 | β | β | β |
| BurgessSButterworthAThompsonS Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 2013;37:658β65.2411480210.1002/gepi.21758PMC4377079 | β | β | β |
| BurgessSScottRTimpsonNDavey SmithGThompsonS; EPIC-InterAct Consortium. Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 2015 PMID: 25773750. [Epub ahead of print.]10.1007/s10654-015-0011-zPMC451690825773750 | β | β | β |
| BurgessSThompsonS Use of allele scores as instrumental variables for Mendelian randomization. Int J Epidemiol 2013;42:1134β44.2406229910.1093/ije/dyt093PMC3780999 | β | β | β |
| BurgessSThompsonS; CRP CHD Genetics Collaboration. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 2011;40:755β64.2141499910.1093/ije/dyr036 | β | β | β |
| CopasJMalleyP A robust p-value for treatment effect in meta-analysis with publication bias. Stat Med 2008;27:4267β78.1838418510.1002/sim.3284 | β | β | β |
| Davey SmithG Random allocation in observational data: how small but robust effects could facilitate hypothesis-free causal inference. Epidemiology 2011; 22:460β63.2164277110.1097/EDE.0b013e31821d0426 | β | β | β |
| Davey SmithGEbrahimS Data dredging, bias, or confounding. BMJ 2002;325:1437β38.1249365410.1136/bmj.325.7378.1437PMC1124898 | β | β | β |
| Davey SmithGEbrahimS βMendelian randomizationβ: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1β22.1268999810.1093/ije/dyg070 | β | β | β |
| Davey SmithGHemaniG Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 2014;23:89β98.10.1093/hmg/ddu328PMC417072225064373 | β | β | β |
| DaviesNScholderSHKFarbmacherHBurgessSWindmeijerFDavey SmithG The many weak instrument problem and Mendelian randomization. Stat Med 2015;34:454β68.2538228010.1002/sim.6358PMC4305205 | β | β | β |
| DidelezVSheehanN Mendelian randomisation as an instrumental variable approach to causal inference. Stat Methods Med Res 2007;16:309β30.1771515910.1177/0962280206077743 | β | β | β |
| DuvalSTweedieR Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455β63.1087730410.1111/j.0006-341x.2000.00455.x | β | β | β |
| EggerMDavey SmithGSchneiderMMinderC Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629β34.931056310.1136/bmj.315.7109.629PMC2127453 | β | β | β |
| EhretGMunroePRiceK Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011;478:103β09.2190911510.1038/nature10405PMC3340926 | β | β | β |
| FreemanGCowlingBJSchoolingCM Power and sample size calculations for mendelian randomization studies using one genetic instrument. Int J Epidemiol 2013; 42:1157β63.2393431410.1093/ije/dyt110 | β | β | β |
| GalbraithR Some applications of radial plots. J Am Stat Assoc 1994;89:1232β42. | β | β | β |
| HanC Detecting invalid instruments using L1-GMM. Econ Lett 2008;101:285β87. | β | β | β |
| HigginsJThompsonSDeeksJAltmanD Measuring inconsistency in meta-analyse. BMJ 2003;327:557β60.1295812010.1136/bmj.327.7414.557PMC192859 | β | β | β |
| InoueASolonG Two-sample instrumental variables estimators. Rev Econ Stat 2010;92:557β61. | β | β | β |
| JohnsonT Efficient calculation for multi-SNP genetic risk scores. Technical report, The Comprehensive R Archive Network, 2013.http://cran.r-project.org/web/packages/gtx/vignettes/ashg2012.pdf [19 November 2014, date last accessed]. | β | β | β |
| KangHZhangACaiTSmallD Instrumental Variables Estimation With Some Invalid Instruments, and Its Application to Mendelian Randomisation. Technical report. Pennsylvania, PA: Department of Statistics, University of Pennsylvania, 2014. | β | β | β |
| KolesarMChettyRFriedmanJGlaeserEImbensG Identification and Inference With Many Invalid Instruments. NBER Working Paper 17519. Cambridge, MA: National Bureau of Economic Research, 2014. | β | β | β |
| Lango AllenHEstradaKLettreG Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010;467:832β38.2088196010.1038/nature09410PMC2955183 | β | β | β |
| LawlorDHarbordRSterneJTimpsonNDavey SmithG Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 2008; 27:1133β63.1788623310.1002/sim.3034 | β | β | β |
| LawMRMorrisJKWaldNJ Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ 2009;338:b1665.1945473710.1136/bmj.b1665PMC2684577 | β | β | β |
| NagarA The bias and moment matrix of the general k-class estimators of the parameters in simultaneous equations. Econometrica 1959;27:575β95. | β | β | β |
| PierceBBurgessS Efficient design for Mendelian randomization studies: subsample and two-sample instrumental variable estimators. Am J Epidemiol 2013;178:1177β84.2386376010.1093/aje/kwt084PMC3783091 | β | β | β |
| RΓΌckerGSchwarzerGCarpenterJBinderHSchumacherM Treatment-effect estimates adjusted for small study effects via a limit meta-analysis. Biostatistics 2011;12:122β42.2065669210.1093/biostatistics/kxq046 | β | β | β |
| SchunkertHKΓΆnigIKathiresanS Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011;43:333β38.2137899010.1038/ng.784PMC3119261 | β | β | β |
| SleimanPGrantS Mendelian randomization in the era of genomewide association studies. Clin Chem 2010;56:723β28.2022404510.1373/clinchem.2009.141564 | β | β | β |
| SmallD Sensitivity analysis for instrumental variables regression with overidentifying restrictions. J Am Stat Assoc 2007;102:1049β58. | β | β | β |
| StaigerDStockJ Instrumental variables regression with weak instruments. Econometrica 1997;65:557β86. | β | β | β |
| SterneJEggerM Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis. J Clin Epidemiol 2001;54:1046β55.1157681710.1016/s0895-4356(01)00377-8 | β | β | β |
| SterneJSuttonAIoannidisJ Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 2011;343:d4002.2178488010.1136/bmj.d4002 | β | β | β |
| TaylorADaviesNWareJVanderWeeleTDavey SmithGMunafΓ²M Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates. Econ Hum Biol 2014;13:99β106.2438812710.1016/j.ehb.2013.12.002PMC3989031 | β | β | β |
| ThompsonSSharpS Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med 1999;18:2693β708.1052186010.1002/(sici)1097-0258(19991030)18:20<2693::aid-sim235>3.0.co;2-v | β | β | β |
| TibshiraniR Regression shrinkage and selection via the lasso. J R Stat Soc B 1996;58:267β88. | β | β | β |
| VanderWeeleTTchetgenTchetgenECornelisMKraftP Methodological challenges in Mendelian randomization. Epidemiology 2014;25:427β35.2468157610.1097/EDE.0000000000000081PMC3981897 | β | β | β |
| WaldA The fitting of straight lines if both variables are subject to error. Ann Math Stat 1940;11:284β300. | β | β | β |
| WooldridgeJ Instrumental variables estimation and two stage least squares. In: Introductory Econometrics: A Modern Approach. Nashville, TN: South-Western, 2009. | β | β | β |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| 1400 plasma metabolites and SjΓΆgren's syndrome: a Mendelian randomization analysis. | Cui Q et al. | β | 2026 | β |
| A Bayesian Approach to Estimate Causal Average Treatment Effects Under Unmeasured Confounding. | Zeng J | β | 2026 | β |
| ABCC2 as a drug target for post-stroke recovery: Evidence from Mendelian randomization and colocalization analyses. | Gui J et al. | β | 2026 | β |
| A flexible semiparametric approach for robust causal inference with invalid instruments and unmeasured confounder. | Cao Y et al. | β | 2026 | β |
| A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. | Chechi K et al. | β | 2026 | β |
| Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study. | Wei S et al. | β | 2026 | β |
| A large-scale genome-wide association meta-analysis for nevus count provides direct insights into the genetics of melanoma. | Jayasinghe GJMSR et al. | β | 2026 | β |
| A Large-Scale Multi-omics Polygenic Risk Score Analysis Identified Candidate Biomarkers Associated with Heel Bone Mineral Density. | Yang X et al. | β | 2026 | β |
| Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses. | Chalitsios CV et al. | β | 2026 | β |
| Alterations of gut microbiome in chronic rhinosinusitis: insights from a mendelian randomization study. | Wang KS et al. | β | 2026 | β |
| A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders. | Jang B et al. | β | 2026 | β |
| Anxiety Disorder Types From a Metabolomics Perspective: A Mendelian Randomization Analysis Based on 1400 Plasma Metabolites. | Xiao Z et al. | β | 2026 | β |
| Assessing the bidirectional causal relationship between malnutrition, self-reported fatigue, and stroke: A 2-sample Mendelian randomization study. | Luo M et al. | β | 2026 | β |
| Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study. | Morales-Berstein F et al. | β | 2026 | β |
| Assessment of the Genetic Relationship Between Circulating Cytokines and Calcific Aortic Valvular Stenosis Using a Bidirectional Mendelian Randomization Analysis. | He J et al. | β | 2026 | β |
| Association between 1400 blood metabolites and the risk of ankylosing spondylitis: A 2-stage, 2-sample Mendelian randomization study. | Li F et al. | β | 2026 | β |
| Association between asthma and myopia: the NHANES database and Mendelian randomization analysis. | Zheng YJ et al. | β | 2026 | β |
| Association between chronic kidney disease and sarcopenia: a national cohort study and two-step Mendelian randomization analysis. | Wang H et al. | β | 2026 | β |
| Association between epigenetic age acceleration and psychiatric disorders: a bidirectional Mendelian randomization study. | Hong Y | β | 2026 | β |
| Association Between Folate Status and Risk of Cervical Cancer: A Systematic Review, Dose-Response Meta-analysis, and Mendelian Randomization Study. | Hua Y et al. | β | 2026 | β |
| Association between gut microbiota and spontaneous abortion: A two-sample Mendelian randomization study. | Tang C et al. | β | 2026 | β |
| Association between Helicobacter pylori infection and dyslipidemia: Evidence from observational studies and Mendelian randomization analysis. | Ren F et al. | β | 2026 | β |
| Association between immune cells and multiple cancers: Insights from Mendelian randomization and gene-based analysis. | Tang M et al. | β | 2026 | β |
| Association between type 2 diabetes and autoimmune liver disease: An integrated analysis of Mendelian randomization and clinical samples. | Wen L et al. | β | 2026 | β |
| Association of oral microbiota and digestive system cancers revealed by bidirectional two sample Mendelian randomization. | Zhang YJ et al. | β | 2026 | β |
| Association of triglyceride and cholesterol with vestibular vertigo: Evidence from univariable and multivariable mendelian randomization and mediation analysis. | Mu Y et al. | β | 2026 | β |
| Associations of blood cell indices with the severity of rheumatoid arthritis: a retrospective case-control and machine learning modeling study. | He R et al. | β | 2026 | β |
| Associations of lipid-lowering drugs with cardiovascular-kidney-metabolic syndrome: A drug-target Mendelian randomization study. | Hu M et al. | β | 2026 | β |
| Associations of loneliness and social isolation with the risk of suicide attempts: Insights from an observational and genetic analysis. | Hu W et al. | β | 2026 | β |
| A systematic exploration of gut microbiota-driven blood metabolites in sepsis: an integrated bioinformatics and genetic association study. | Zhang Y et al. | β | 2026 | β |
| A two-sample Mendelian randomization study of the causal relationship between respiratory diseases, gastric cancer risk, and Helicobacter pylori infection. | Kim Y et al. | β | 2026 | β |
| Bidirectional Mendelian Randomization and Colocalization Study of Memory B Cells and Major Depressive Disorder. | Si SM et al. | β | 2026 | β |
| Bidirectional Mendelian Randomization Study: Unraveling the Link Between Idiopathic Pulmonary Fibrosis and Cardiovascular Disease. | Hu L et al. | β | 2026 | β |
| Brain structures mediate the causal effects of socioeconomic status on mental disorders: A multi-stage Mendelian randomization study. | Pan S et al. | β | 2026 | β |
| Branched-chain amino acids and risk of major depressive disorder: a Mendelian randomization and colocalization study. | Li X et al. | β | 2026 | β |
| Cathepsin H as a causal risk factor and therapeutic target in proliferative diabetic retinopathy. | Zhou Q et al. | β | 2026 | β |
| Causal analysis of the impact of serum 25-hydroxyvitamin D levels on laryngeal cancer: A two-sample mendelian randomization study. | Li B et al. | β | 2026 | β |
| Causal association and potential mediators between obstructive sleep apnea and diabetic nephropathy: A Mendelian randomization study. | He Y et al. | β | 2026 | β |
| Causal association between benign anorectal disorders and mental disorders: A Mendelian randomization study. | Wu X et al. | β | 2026 | β |
| Causal association between dietary habits and aortic dissection and aortic aneurysm: Mendelian randomization study. | Gao J et al. | β | 2026 | β |
| Causal association between lipid profile and mental disorders: evidence from a bidirectional Mendelian randomization study. | Hu W et al. | β | 2026 | β |
| Causal Association Between Plasma Proteins and Pericarditis: A Mendelian Randomization Study With Therapeutic Target Identification. | Chen Z et al. | β | 2026 | β |
| Causal association between sleep disorders and delirium: A bidirectional mendelian randomization analysis for clinical practice. | Niu W et al. | β | 2026 | β |
| Causal Association Between Transferrin Saturation and Periodontitis: A Mendelian Randomization Study. | Gao J | β | 2026 | β |
| Causal associations between ankylosing spondylitis and cardiovascular disease: a mendelian randomization analysis. | Zhou L et al. | β | 2026 | β |
| Causal Associations Between Sleep Traits and Polycystic Ovary Syndrome: A Univariable, Bidirectional, and Multivariable Mendelian Randomization Study. | Chen X et al. | β | 2026 | β |
| Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population. | Zhang G et al. | β | 2026 | β |
| Causal effects of gut microbiota and blood metabolites on subtypes of perinatal depression classified based on depressive symptom trajectories: a mendelian randomization study. | Li H et al. | β | 2026 | β |
| Causal effects of inflammatory bowel disease on brain structure: A Mendelian randomization study. | He Y et al. | β | 2026 | β |
| Causal effects of lipid-lowering drug targets on psychiatric disorders: A drug-target Mendelian randomization study. | Wang Y et al. | β | 2026 | β |
| Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study. | Zhu J et al. | β | 2026 | β |
| Causal Inference and Prognostic Modeling in Colorectal Cancer through Integration of Computational Pathology and Mendelian Randomization. | Bao W et al. | β | 2026 | β |
| Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies. | Garcia-Argibay M et al. | β | 2026 | β |
| Causal interplay between trigeminal neuralgia and systemic inflammatory markers: A bidirectional Mendelian randomization study. | Hou L et al. | β | 2026 | β |
| Causality between appendiceal disease and cancers of the digestive system: A Mendelian randomization study. | Lin F et al. | β | 2026 | β |
| Causality of atrial fibrillation and left atrial traits: Genetic and epigenetic perspectives. | Cai D et al. | β | 2026 | β |
| Causal relationship between body mass index and risk of juvenile idiopathic arthritis: A 2-sample Mendelian randomization study. | Huang R et al. | β | 2026 | β |
| Causal relationship between consumption of different tea types and the risk of stroke: A two-sample Mendelian randomization analysis. | Jiang X et al. | β | 2026 | β |
| Causal relationship between fatty acid metabolism and allergic asthma: a mendelian randomization and multi-omics study. | Mo S et al. | β | 2026 | β |
| Causal Relationship Between Gut Microbiota and Pressure Ulcers: A Two-Sample Bidirectional Mendelian Randomisation Study. | Luo P et al. | β | 2026 | β |
| Causal relationship between mental illness and venous thromboembolism: a Mendelian randomization study. | Jin et al. | β | 2026 | β |
| Causal relationship between obesity, leptin, and brain structure and functional connectivity: evidence based on bidirectional and mediation mendelian randomisation analyses. | Wu Y et al. | β | 2026 | β |
| Causal relationship between serum metabolites and risk of psoriatic arthritis: A 2-way Mendelian randomization study. | Liao Y et al. | β | 2026 | β |
| Causal relationships between ADHD, ASD and brain structure: A mendelian randomization study. | Zhao Y et al. | β | 2026 | β |
| Causal relationships between antibody-induced immune responses and sepsis: Evidence from genetic studies. | Li L et al. | β | 2026 | β |
| Causal relationships between four types of sedentary behavior and insomnia: a two-sample Mendelian randomization study. | Qin Z et al. | β | 2026 | β |
| Causal Relationships Between High-Altitude Adaptation, Metabolic Traits, and Tumors: Insights from Mendelian Randomization. | Zhang X et al. | β | 2026 | β |
| Causal Relationships Between Major Depressive Disorder and Coronary Artery Disease Across Diverse Populations: A Bidirectional Mendelian Randomisation Study. | Silva S et al. | β | 2026 | β |
| Causal relationships between plasma lipidomics, trace elements, cerebrospinal fluid metabolites, and Parkinson's disease using Mendelian randomization. | Wang M et al. | β | 2026 | β |
| Causal relationships of lipid metabolism in diabetic nephropathy risk: A two-sample Mendelian randomization study. | Yu C et al. | β | 2026 | β |
| Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. | Zhou X et al. | β | 2026 | β |
| Causal roles of immune cells and plasma metabolites in esophageal cancer: A Mendelian randomization study with nutritional insights. | Liu X et al. | β | 2026 | β |
| Cell senescence-related pathogenic genes in sleep disorders: a multi-omics Mendelian randomization study. | Li J et al. | β | 2026 | β |
| Cerebrospinal fluid metabolites and multiple sclerosis: A two-sample Mendelian randomization study. | Zhang D et al. | β | 2026 | β |
| cfGWAS reveal genetic basis of cell-free DNA end motifs. | Zhu H et al. | β | 2026 | β |
| Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study. | Zhang Y et al. | β | 2026 | β |
| Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study. | Benavente Y et al. | β | 2026 | β |
| Circulating metabolites on dental caries risk: A Mendelian randomization study. | Shi P et al. | β | 2026 | β |
| Class-Specific Antihypertensives and Alzheimer's Disease: Genotype- and Hypertension-Stratified Analysis. | Yang D et al. | β | 2026 | β |
| Coffee and the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies. | Choi HB et al. | β | 2026 | β |
| Combining single-cell analysis and Mendelian randomization to elucidate the molecular mechanisms of fibronectin-related genes in multiple sclerosis. | Zhao N et al. | β | 2026 | β |
| Comparison of two-stage methods for count data in Mendelian randomization: a simulation study. | Appah M et al. | β | 2026 | β |
| Constructing a protein-protein interaction network for autoimmune liver diseases by integrating pQTL, rQTL, and mediation analyses. | Tian D et al. | β | 2026 | β |
| Cortical structural variations and scoliosis risk: insights from a large-scale Mendelian randomization analysis. | Ma H et al. | β | 2026 | β |
| Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases. | Peng B et al. | β | 2026 | β |
| Cross-trait genomic and sequential analyses of multiple omics datasets identified shared genetic components for the gut-eye axis. | Gao Y et al. | β | 2026 | β |
| Cumulative adverse childhood experiences increase migraine risk in later life in China: evidence from CHARLS with mediation and Mendelian randomization. | Duan L et al. | β | 2026 | β |
| Current evidence on TNX-102 SL (cyclobenzaprine HCl sublingual) for fibromyalgia: strengths, limitations, and emerging hypotheses. | Pontes-Silva A | β | 2026 | β |
| Deciphering the causal influence of BMI and related metabolic, inflammatory, and cardiovascular factors on brain structure: a Mendelian Randomization Study. | Painter JN et al. | β | 2026 | β |
| Decoding the triglyceride-glucose index in metabolic dysfunction-associated steatotic liver disease: integrative insights from Mendelian randomization, cross-tissue transcriptomics, and spatial multi-omics. | Wei S et al. | β | 2026 | β |
| Depressive disorder in middle-aged and elderly adults: Evidence from global burden of disease and genetic analysis. | Tang Y et al. | β | 2026 | β |
| Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2-NETs-Mediated Liver-Bile Barrier Damage. | Shi C et al. | β | 2026 | β |
| Diagnostic value of mitochondria-related genes in intervertebral disc degeneration associated with spinal metastasis: a Mendelian randomization study. | Liu L et al. | β | 2026 | β |
| Differential modulation of gestational immunity by fatty acids: tissue-specific immune remodeling and clinical implications. | Chen J et al. | β | 2026 | β |
| Discovery of circadian rhythm-related hub genes in acute myocardial infarction: A two-sample Mendelian randomization study. | Peng S et al. | β | 2026 | β |
| Disentangling the Effect of BMI on Hepatocellular Carcinoma From Cirrhosis With Multivariable Mendelian Randomization. | Gkatzionis A et al. | β | 2026 | β |
| Dissecting the genetic and proteomic risk factors for delirium. | Raptis V et al. | β | 2026 | β |
| Dissecting the Mediating Role of Cortical Structures in the Pathogenesis of Socioeconomic Status to ADHD: A Mendelian Randomization Study and Mediation Analysis. | Xie W et al. | β | 2026 | β |
| Dissecting the relationship between hypertensive disorders of pregnancy and branched-chain amino acids: An integrated investigation combining Mendelian randomization, transcriptomics, and machine learning. | Zheng Y et al. | β | 2026 | β |
| Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study. | Zhang Z et al. | β | 2026 | β |
| Elucidating Causal Associations Between Immune Cells, Circulating Inflammatory Proteins, and Chronic Inflammatory Demyelinating Polyneuropathy: A Two-Sample Two-Step Mendelian Randomization Study. | Wang AC et al. | β | 2026 | β |
| Elucidating the causal effects of plasma metabolites on breast cancer from multiple perspectives. | Fang K et al. | β | 2026 | β |
| Elucidating the Epigenetic Landscape of Type 2 Diabetes Mellitus: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic Traits. | Chung RH et al. | β | 2026 | β |
| Evidence for genetic correlation between appendix and inflammatory bowel disease: A bidirectional Mendelian randomization study. | Liu D et al. | β | 2026 | β |
| Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza. | Zhang Y et al. | β | 2026 | β |
| Exploration of the relationship between autoimmune neurologic diseases and mental disorders: evidence from Mendelian randomization study. | Shen Y et al. | β | 2026 | β |
| Exploring bidirectional causal relationships between ulcerative colitis and depression via the gut-brain axis: A Mendelian randomization study with plasma protein mediator analysis. | Lu C et al. | β | 2026 | β |
| Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. | Chang S et al. | β | 2026 | β |
| Exploring estrogen synthesis and metabolism related markers and immune dynamics in osteoporosis-insights from single-cell RNA sequencing and Mendelian randomization. | Hao X et al. | β | 2026 | β |
| Exploring Potential Associations Between HIV Acquisition and Biological Aging: Insights from a Bidirectional Mendelian Randomization Study. | Wang H et al. | β | 2026 | β |
| Exploring potential therapeutic targets for myopia: Causal analysis and biological annotation with gut microbiota. | Wang Z et al. | β | 2026 | β |
| Exploring the association of age at first sexual intercourse and lifetime number of sexual partners on neurological and psychiatric disorders: An observational and genetic study. | Dong Y et al. | β | 2026 | β |
| Exploring the causal association between body composition and primary ovarian insufficiency: A retrospective cohort study and Mendelian randomization analyses. | Zheng J et al. | β | 2026 | β |
| Exploring the causal effect of genetically predicted blood and cerebrospinal fluid metabolites and metabolic pathways on intracranial aneurysm. | Ding L et al. | β | 2026 | β |
| Exploring the Causal Links Between Toxoplasma gondii Infection and Risk of Brain Tumors: A Bidirectional Mendelian Randomization Analysis. | Shi P et al. | β | 2026 | β |
| Exploring the genetically predicted gut microbiota-reproductive axis: Impact on anti-MΓΌllerian hormone levels. | Liao CC et al. | β | 2026 | β |
| Female Reproductive Traits and Late-Life Hormone-Sensitive Cancer Risk: A Mendelian Randomization Study. | Li Z et al. | β | 2026 | β |
| From gut to glymphatic system: Causal pathways converge in midbrain glutamatergic neurons. | Li B et al. | β | 2026 | β |
| Gallbladder disease and colorectal cancer: a two-sample bidirectional Mendelian randomization study. | Hu Q et al. | β | 2026 | β |
| Genetic Adaptation to Tibetan High Altitude and Hepatocellular Cancer Risk: Integrative Bidirectional Mendelian Randomization and Single-Cell RNA Sequencing Analysis. | Nimadeji et al. | β | 2026 | β |
| Genetically predicted antiβrubella virus IgG levels and dermatitis risk: A twoβsample Mendelian randomization study. | Ouyang Z et al. | β | 2026 | β |
| Genetically predicted artificial sweeteners and stroke susceptibility: a multivariable Mendelian randomization study. | Song Z et al. | β | 2026 | β |
| Genetically predicted associations between blood cell perturbation responses and bronchiectasis through immune mediation: A Mendelian Randomization study. | Han J et al. | β | 2026 | β |
| Genetically Predicted Levels of Lipoprotein(a) and Risk of Cerebrovascular Disease. | Daghlas I et al. | β | 2026 | β |
| Genetically predicted susceptibility to dust-induced lung diseases and risk of autoimmune diseases: a two sample Mendelian randomization study. | Kim Y et al. | β | 2026 | β |
| Genetic assessment of the causal relationship between obstructive sleep apnea and pulmonary hypertension: Mendelian randomization and meta-analysis. | Pang L et al. | β | 2026 | β |
| Genetic Association Between Rheumatoid Arthritis and Preeclampsia: A Bidirectional Mendelian Randomization and Bioinformatics Study. | Li L et al. | β | 2026 | β |
| Genetic associations with placental and pregnancy proteins in maternal serum identify biomarkers for hypertension in pregnancy. | Yan Q et al. | β | 2026 | β |
| Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis. | Chen R et al. | β | 2026 | β |
| Genetic Evidence for Causal Effects of Blood Metabolites on Age-Related Macular Degeneration and its Subtypes. | Zhang K et al. | β | 2026 | β |
| Genetic evidence for causal effects of lifestyle factors, psychiatric factors, and socioeconomic status on various spinal disorders. | Shao J et al. | β | 2026 | β |
| Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia. | Li C et al. | β | 2026 | β |
| Genetic evidence for the causal relationship between metabolic diseases and primary aldosteronism: insights from Mendelian randomization analysis. | Zhang H et al. | β | 2026 | β |
| Genetic evidence on chemical communication between gut microbiota and neurological and psychiatric disorders: a Mendelian randomization study. | Yu S et al. | β | 2026 | β |
| Genetic insights into therapeutic targets for gestational diabetes mellitus: a multi-omics analysis. | Li Q et al. | β | 2026 | β |
| Genetic predisposition to smoking and the risk of Carpal Tunnel Syndrome: a mendelian randomization study. | Zeng Q et al. | β | 2026 | β |
| Genetic risk of chronic pain conditions associated with risk of suicide death through an integrative analysis of EHR and genomics data. | Han S et al. | β | 2026 | β |
| Genetic Susceptibility to Diabetes Subtypes and Risk of Developing Coronary Artery Disease. | Pan M et al. | β | 2026 | β |
| Genetic Variants Related to TGF-Ξ² Signaling Pathway Modulate Risk of Meniscus Injury: A Multiancestry Genome-wide Association Study. | Umesh A et al. | β | 2026 | β |
| Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. | ThΓ©riault S et al. | β | 2026 | β |
| Genome-wide cross-trait analyses reveal shared genetic architecture and causal links between attention-deficit/hyperactivity disorder and cardiovascular diseases. | Liu HY et al. | β | 2026 | β |
| Genomic and AI-driven discovery in chronic prostatitis: Causal role of ITPR3 and therapeutic repurposing of raloxifene. | Li Y et al. | β | 2026 | β |
| Genomic approach to investigate air pollution's causal impact on neurodevelopment and mental health: An extensive-scale 2-sample Mendelian randomization study. | Wu W et al. | β | 2026 | β |
| Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections. | Zou Y et al. | β | 2026 | β |
| Global, Population and Genetic Evidence on the Relationships Between Immune-Mediated Inflammatory Disease and Cancer Risk. | Dong X et al. | β | 2026 | β |
| Gut microbiota as potential mediator linking dietary preferences and aging phenotypes. | Li W et al. | β | 2026 | β |
| Gut microbiota, lipid metabolism, and PCOS: A Mendelian randomization and mediation analysis. | Li W et al. | β | 2026 | β |
| Gut microbiota's causal effect on physical activity: Insights from two-sample Mendelian randomization analysis. | Meng D et al. | β | 2026 | β |
| Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis: Results From A 2-Sample Mendelian Randomization Study. | KjΓ¦rsgaard Andersen R et al. | β | 2026 | β |
| Histone lactatation-related genes GPR19 and SLC22A16 are important diagnostic markers and drug treatment targets for prostate cancer. | Yan Y et al. | β | 2026 | β |
| Identification and Validation of the Prognostic Value of PTTG1-Related Genes in Hepatocellular Carcinoma by Mendelian Randomization and Single-Cell Transcriptome Analysis. | Wen Q et al. | β | 2026 | β |
| Identification of Biomarkers Associated With Copper Metabolism in Ischemic Stroke Through Bulk RNA Sequencing and Mendelian Randomization Analysis. | Yang R et al. | β | 2026 | β |
| Identification of Mediating Pathways Between Attention Deficit/Hyperactivity Disorder and Coronary Artery Disease and Heart Failure: A Two-Step Multivariable Mendelian Randomization Study. | Lin J et al. | β | 2026 | β |
| Identification of potential drug targets for Alzheimer's disease from genetic insights: A Mendelian randomization study. | Zhao YH et al. | β | 2026 | β |
| Identification of potential drug targets for delirium from genetic insights: A Mendelian randomization study. | Geng YN et al. | β | 2026 | β |
| Immune cells influence major depression through metabolites: A Mendelian randomization analysis of bidirectional causality and mediating effects. | Kong Z et al. | β | 2026 | β |
| Immune cells mediated the causal relationship between gut microbiota and carpal tunnel syndrome: A Mendelian randomization study. | Li JA et al. | β | 2026 | β |
| Impacts of host genetics on gut microbiome composition in Alzheimer's disease. | Liu J et al. | β | 2026 | β |
| Inflammation as a mediator of air pollution's role in Alzheimer's disease and related dementias. | Zhao B et al. | β | 2026 | β |
| Inflammatory cytokines mediate thoracic aortic aneurysm formation via plasma metabolites: A two-step Mendelian randomization and single cell sequencing-based investigation. | Liu Y et al. | β | 2026 | β |
| Insights into causal associations between type 2 diabetes and common human diseases: a phenotype-wide bi-directional Mendelian randomization analysis. | Sun W et al. | β | 2026 | β |
| Insulin resistance increases stroke risk: a cross-sectional study from NHANES 1999-2018 and a Mendelian randomization study. | Hu Y et al. | β | 2026 | β |
| Intake of coffee and blood pressure: A Mendelian randomized study. | Zhong J et al. | β | 2026 | β |
| Integrated multi-omics identifies macrophage ARG1-mediated deacetylation with causal and diagnostic implications in ischemic stroke. | Ruan HZ et al. | β | 2026 | β |
| Integrating genomic and exposomic data identifies endocrine disruptors potentially associated with chronic obstructive pulmonary disease. | Hong Y et al. | β | 2026 | β |
| Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes. | He Y et al. | β | 2026 | β |
| Integrative genomics establishes GNL3 as a pleiotropic hub and causal gene for osteoarthritis. | Qu T et al. | β | 2026 | β |
| Intracellular Osteopontin of Macrophages Promotes Carotid Plaques Formation by Inducing Foam Cells and Releasing Proinflammatory Cytokines. | Nie H et al. | β | 2026 | β |
| Investigating multidimensional associations between obesity-related traits and brain health, and identifying potential mechanisms. | Chen S et al. | β | 2026 | β |
| Investigating the association between uterine fibroids and weight-bearing joint osteoarthritis based on a bidirectional Mendelian randomization study. | Ma X et al. | β | 2026 | β |
| Investigating the relationship between dietary vitamin B12 and bone mineral density: Observational and genetic analyses. | Zhong Y et al. | β | 2026 | β |
| Investigating the relationship between taste perception of artificial sweeteners and cancer risk. | Crick DCP et al. | β | 2026 | β |
| Is ER-positive breast cancer a shield against myocardial infarction and its complications? A Mendelian randomization approach. | Zhao Z et al. | β | 2026 | β |
| Knowledge-graph embeddings for osteoarthritis candidate prediction. | Wang Z et al. | β | 2026 | β |
| Large-scale plasma proteomic analysis identifies pathophysiological mechanisms and predictive biomarkers for cardiac arrest. | Wang N et al. | β | 2026 | β |
| Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease. | Li YJ et al. | β | 2026 | β |
| Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity's influence on breast cancer risk. | Power GM et al. | β | 2026 | β |
| Lipoprotein(a) Is Associated With Increased Risk of Abdominal Aortic Aneurysm. | Sharma P et al. | β | 2026 | β |
| MACFIV: a novel framework for nonlinear causal inference in the body mass index-hypertension relationship with many weak and pleiotropic genetic instruments. | Chen D et al. | β | 2026 | β |
| Mapping the genetically predicted associations of plasma metabolites with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization and transcriptome analysis. | Wang Q et al. | β | 2026 | β |
| Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways. | Yu G et al. | β | 2026 | β |
| May obesity increase the risk of lymphoma? Insights from genetic evidence. | Liu J et al. | β | 2026 | β |
| MEF2A-mediated inhibition of ischemic stroke injury via the PI3K/AKT pathway: a comprehensive bioinformatics and in vitro study. | Zhang T et al. | β | 2026 | β |
| Memory B cells mediate the effect of gut microbiota glycolytic-glyoxylate pathway on lung cancer in never-smokers: A Mendelian randomization study. | Xiong W et al. | β | 2026 | β |
| Mendelian randomization analyses reveal relationships between white matter microstructure and risk of abdominal aortic aneurysm. | Duan L et al. | β | 2026 | β |
| Mendelian randomization analyses support causal relationships between COVID-19 and changes in brain structure and function. | Wang Q et al. | β | 2026 | β |
| Mendelian randomization analysis of the causal relationship between low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and androgenic alopecia. | Fu M et al. | β | 2026 | β |
| Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging-Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases. | Chen J et al. | β | 2026 | β |
| Mendelian Randomization and ScTranscriptomics Reveal a Lipid Low Malignant Cells Driving Immunosuppression and Matrix Remodeling in Oral squamous cell carcinoma. | Su K et al. | β | 2026 | β |
| Mendelian randomization applied to migraine research: Opportunities and challenges. | Daghlas I et al. | β | 2026 | β |
| Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis. | Huang G et al. | β | 2026 | β |
| Mendelian randomization implicates circulating plasma proteins in gout risk and identifies candidate therapeutic targets. | Zhang H et al. | β | 2026 | β |
| Mendelian Randomization Methods for Causal Inference: Estimands, Identification and Inference. | Yao M et al. | β | 2026 | β |
| Mendelian randomization study: investigating the causal impact of Covid-19 on adverse pregnancy outcomes. | Tang R et al. | β | 2026 | β |
| Mendelian Randomization Study of Age-Related Macular Degeneration and Inflammatory Bowel Disease. | Hua Z et al. | β | 2026 | β |
| Mendelian Randomization Study on Serum Metabolites and Diabetic Nephropathy Risk: Identifying Potential Biomarkers for Early Intervention. | Song S et al. | β | 2026 | β |
| Metabolome Wide Mendelian Randomization Assessing the Causal Relationship Between Serum Metabolites, Cerebrospinal Metabolites, and Aneurysmal Subarachnoid Hemorrhage. | Song B et al. | β | 2026 | β |
| Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis. | Li ZY et al. | β | 2026 | β |
| Metabolomic Profile of Genetic Liability to Type 2 Diabetes Among 125,000 Mexican Adults: A Mendelian Randomization Study. | Bragg F et al. | β | 2026 | β |
| Metformin treatment and reduction of gastrointestinal cancer risk: A 2-sample Mendelian randomization study. | Huang D et al. | β | 2026 | β |
| Mining Potential Therapeutic Targets for T Cell Exhaustion in Osteoarthritis by Integrating Mendelian Randomization and Single-Cell Sequencing. | Li J et al. | β | 2026 | β |
| Multi-omics analysis reveals the neuroprotective effects of phosphatidylcholine (18:1/18:2) on ischemic stroke by inhibiting plasma IL-18 levels. | Wang S et al. | β | 2026 | β |
| Multi-omics and causal inference reveal lactylation-based osteoblast regulatory networks and drug candidates. | Chen R et al. | β | 2026 | β |
| Multiomics Mendelian Randomization Reveals Causal Oxidative Stress Genes in Androgenetic Alopecia. | Zhu Y et al. | β | 2026 | β |
| Multivariable Mendelian randomization analysis reveals the protective effect of restless legs syndrome against lower limb venous diseases and pulmonary embolism. | Zhang RY et al. | β | 2026 | β |
| Novel insights into the causal effects of triglycerides to high density lipoprotein cholesterol ratio on blood pressure. | Wan A et al. | β | 2026 | β |
| Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. | Tang W et al. | β | 2026 | β |
| Observational and Mendelian randomization studies of plasma sclerostin levels do not provide evidence of cardiovascular adverse effects of sclerostin inhibition. | Thorolfsdottir RB et al. | β | 2026 | β |
| Obstructive sleep apnea and metabolic-associated fatty liver disease risk: Insights from National Health and Nutrition Examination Survey and Mendelian randomization analysis. | Beibei C et al. | β | 2026 | β |
| Osteochondrosis and osteomalacia are distinguished by inflammatory factors and metabolites. | Chen J et al. | β | 2026 | β |
| Oxidative Stress-Related Genome-Wide Mendelian Randomization Identifies Causal Genes for Coronary Artery Disease. | Zhang H et al. | β | 2026 | β |
| Peak expiratory flow causally affects brain neuronal activity: A Mendelian randomization study. | Mao Y et al. | β | 2026 | β |
| Personality disorders and cardiometabolic diseases: A Mendelian randomization study. | Yang W et al. | β | 2026 | β |
| Plasma Proteome Signature for Leukocyte Telomere Length and Its Link to Abdominal Aortic Aneurysm. | Li A et al. | β | 2026 | β |
| Platelet indices as prognostic biomarkers in lung cancer: A meta-analysis and Mendelian randomization study. | Yuan M et al. | β | 2026 | β |
| Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders. | Antonyan L et al. | β | 2026 | β |
| Positive effect of physical activity for depression and major depression: a Mendelian randomization study. | Du Z et al. | β | 2026 | β |
| Postcholecystectomy cholangiocarcinoma risk alert: evidence from Mendelian randomization study and bioinformatics analysis. | Chen S et al. | β | 2026 | β |
| Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders. | Xue H et al. | β | 2026 | β |
| PRISM-xQTL: Pleiotropic Relationships Integrated with System-level Multiomic QTL analysis for causal genes and molecular mediators in Alzheimer's disease. | Enduru N et al. | β | 2026 | β |
| Protective role of PCED1B -expressing naive CD4 + T cells in sepsis. | Shang W et al. | β | 2026 | β |
| Proteome-wide Mendelian randomization and colocalization analyses identify novel protein targets for cardiac conduction disorders. | Song ZQ et al. | β | 2026 | β |
| Relationship between genetically determined telomere length and childhood glioma risk. | Zhou N et al. | β | 2026 | β |
| Relationship between the microbiome and obesity-associated cancer risk using Mendelian randomisation. | Yates T et al. | β | 2026 | β |
| Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization. | Taylor-Bateman V et al. | β | 2026 | β |
| Role of CD127 on CD28<sup>+</sup> CD45RA<sup>+</sup> CD8<sup>br</sup> Treg Cells in Mediating the Association Between GDF-15 and Sarcopenia. | Pan Y et al. | β | 2026 | β |
| Role of CD25 on resting Treg immune cell in mediating the effect of stearate biosynthesis microbiome pathway on lung adenocarcinoma. | Yang L et al. | β | 2026 | β |
| Role of TRAIL in mediating the effect of lipidome on breast cancer: a Mendelian randomization study. | Wang X et al. | β | 2026 | β |
| Screen Time and Chronic Pain Health: Mendelian Randomization Study. | Jiang J et al. | β | 2026 | β |
| Sedentary behaviour, muscle diseases, fractures: Mendelian randomisation study. | Qin H et al. | β | 2026 | β |
| Serum Minerals and Male Age-related Hypogonadism: Multimodal Evidence Decoding Associations and Intervention Strategies. | Xie J et al. | β | 2026 | β |
| Shared Genetic Basis Between Systemic Lupus Erythematosus and Inflammatory Bowel Disease in East Asian Ancestry: A Genome-Wide Cross-trait Analysis. | Mo X et al. | β | 2026 | β |
| Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers. | Buyukkurt A et al. | β | 2026 | β |
| Shared latent genetic liability across fibromyalgia and psychiatric traits: Novel insights from genomic structural equation modeling. | Lin L et al. | β | 2026 | β |
| Smoking behaviour, altered DNA methylation, and heart failure risk: evidence from a prospective cohort and epigenetic Mendelian randomization study. | Song ZQ et al. | β | 2026 | β |
| Social isolation and 59 common health conditions: insights from observational and genetics analyses. | Ai S et al. | β | 2026 | β |
| Study on the bidirectional causal relationship between visceral adipose tissue and heart failure: Multivariate Mendelian randomization and mediation analysis. | Liao J et al. | β | 2026 | β |
| Systematic prioritization of potential therapeutic targets for glomerulonephritis using multi-omics Mendelian randomization. | Li G et al. | β | 2026 | β |
| Systematic review and meta-analysis of Mendelian randomization in delirium studies: Key findings and methodological issues. | Tao H et al. | β | 2026 | β |
| Systemic interleukin signaling and Alzheimer's disease risk: A two-sample cross-replication Mendelian randomization study. | Ahmed HM et al. | β | 2026 | β |
| Taste Preferences Shape Disease Susceptibility via Heritable Nutrient Predispositions: A Behavior-Gene Coevolution Framework. | Yan X et al. | β | 2026 | β |
| Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study. | Fang Y et al. | β | 2026 | β |
| The Association Between Autoimmune Rheumatic Diseases and Depression: A Two-Sample Bidirectional Mendelian Randomization. | Wang H et al. | β | 2026 | β |
| The association between interatrial shunt and subtypes of migraine: a Mendelian randomization study. | Che X et al. | β | 2026 | β |
| The association between steatotic liver disease and chronic kidney disease: a meta-analysis and Mendelian randomization study highlighting metabolic comorbidities. | Ji X et al. | β | 2026 | β |
| The association of tobacco use on gastrointestinal cancers: A secondary dataset analysis of the Global Burden of Disease Study 2021 and Mendelian randomization. | Liu Y et al. | β | 2026 | β |
| The causal association between plasma amino acid levels and abdominal aortic aneurysm: insights from Mendelian randomization and an experimental validation. | Li M et al. | β | 2026 | β |
| The causal effect of cytokine cycling levels on the risk of cervical cancer: A bidirectional 2-sample Mendelian randomization study. | Ge Z et al. | β | 2026 | β |
| The causal effects of dementia on systemic sclerosis: a two-sample bidirectional Mendelian randomization study. | Xiao J et al. | β | 2026 | β |
| The causal relationship between cathepsins and ankylosing spondylitis: a two-sample Mendelian randomization study. | Wu B et al. | β | 2026 | β |
| The causal relationship between multiple cardiovascular diseases and glioblastoma: A Mendelian randomization study. | Lin K et al. | β | 2026 | β |
| The causal relationship between Omega-3 fatty acids and Achilles Tendinitis risk: A two-sample Mendelian randomization study in European populations. | Wang B et al. | β | 2026 | β |
| The causal relationship in hypertensive encephalopathy: mechanistic analysis of five specific circulating cytokines. | Zhang P et al. | β | 2026 | β |
| The correlation between exercise and atherosclerotic cardiovascular disease: a combined analysis using NHANES data (2007-2018) and Mendelian randomization. | Zhao Z et al. | β | 2026 | β |
| The Cortical Structural Mediators of Cognitive Enhancement in Computer Game Players: Evidence From Mendelian Randomization. | Sun Y et al. | β | 2026 | β |
| The effectiveness of digital cognitive behavioral therapy in reducing loneliness among older adults: A systematic review and meta-analysis. | Fu JY et al. | β | 2026 | β |
| The Genetic Link Between Primary Immune Thrombocytopenia and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study. | Jiang L et al. | β | 2026 | β |
| The genetic relationships between post-traumatic stress disorder and its corresponding neural circuit structures. | Gong Q et al. | β | 2026 | β |
| The Growing Burden of Early-Onset Lung Cancer in Young Women in China: Analysis for the Global Burden of Disease Study 2021. | Song J et al. | β | 2026 | β |
| The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition. | Moksnes MR et al. | β | 2026 | β |
| The impact of different intensities of physical activity on aging: A Mendelian randomization study. | Li H et al. | β | 2026 | β |
| The relationship between high-sensitivity C-reactive protein and coronary slow flow: a systematic review and meta-analysis. | Zare S et al. | β | 2026 | β |
| The role of lipids in mediating the effects of immune cells on Alzheimer's disease risk: A network Mendelian randomization study. | Yang X et al. | β | 2026 | β |
| Transcriptomics reveals new therapeutic targets for ovarian cancer. | Feng Y et al. | β | 2026 | β |
| Transfer learning-based two-sample Mendelian randomization method for heterogeneous population. | Wei Y et al. | β | 2026 | β |
| Type 2 diabetes mellitus and liver diseases: a phenome-wide Mendelian randomization atlas and genome-wide genetic correlation study. | Ding R et al. | β | 2026 | β |
| Uncovering and validating biomarkers associated with RNA methylation modifications in keloids: Insights from transcriptomic and Mendelian randomization analyses. | Han P et al. | β | 2026 | β |
| Uncovering novel protein pathways regulating bioavailable testosterone through sex hormone-binding globulin. | Hong Y | β | 2026 | β |
| Uncovering plasma protein biomarkers linked to depression: A differential abundance analysis and Mendelian randomization using large-scale data. | Abebe E et al. | β | 2026 | β |
| Unraveling COPD pathogenesis: a multi-omics approach to identify metabolites and genetic links. | Zeng M et al. | β | 2026 | β |
| Unraveling the causal link between inflammatory cytokines and hypertensive renal disease: a Mendelian randomization analysis. | Gong X et al. | β | 2026 | β |
| Unraveling the neural underpinnings of major depressive disorder and pain: A mendelian randomization study and mediation analysis. | Jiang J et al. | β | 2026 | β |
| Unravelling genetic susceptibility and causal factors in liver health using MRI quantification of inflammation, fat and iron in the liver. | Meena D et al. | β | 2026 | β |
| Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues. | Bocher O et al. | β | 2026 | β |
| Using human genetics to understand the epidemiological association between child obesity at different ages and MASLD. | Ge Q et al. | β | 2026 | β |
| Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance. | Qiu S et al. | β | 2026 | β |
| Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders. | Qiu S et al. | β | 2026 | β |
| A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity. | Tong D et al. | β | 2025 | β |
| A Blood Metabolic Signature of a Healthy Lifestyle and Colorectal Cancer Risk: Results from Cohort and Mendelian Randomization Studies. | Yuan F et al. | β | 2025 | β |
| Absence of bidirectional causality between primary biliary cholangitis and major depression: A two-sample Mendelian randomization study. | Du Q et al. | β | 2025 | β |
| A Causal Association Between Drug Use and Cognitive Impairment: A Two-Sample Mendelian Randomization Study. | Yan B et al. | β | 2025 | β |
| Accelerometer-Derived Rest-Activity Rhythm Amplitude, Genetic Predisposition, and the Risk of Ischemic Heart Disease: Observational and Mendelian Randomization Study. | Wang L et al. | β | 2025 | β |
| Acetylcarnitine in cerebrospinal fluid and blood as a protective factor for neuromyelitis optica spectrum disorders: a mendelian randomization study. | Xie Z et al. | β | 2025 | β |
| ADHD and Differences in Brain Function as Measured by EEG: Cause or Effect? | Ahn K et al. | β | 2025 | β |
| Adiposity, metabolites and endometrial cancer risk: inference from combinations of Mendelian randomization and observational analyses. | Lee MA et al. | β | 2025 | β |
| Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms. | Lu X et al. | β | 2025 | β |
| A genetic data-based causal exploration of the relationship between docosahexaenoic acid levels and the risk of acute pancreatitis. | Yu J et al. | β | 2025 | β |
| A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study. | Gao Z et al. | β | 2025 | β |
| A Genome-wide study on the genetic and causal effects of smoking in neurodegeneration. | Chen C et al. | β | 2025 | β |
| Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases. | Liu L et al. | β | 2025 | β |
| A Mendelian randomization analysis reveals the role of the skin microbiota in systemic lupus erythematosus. | Yin Y et al. | β | 2025 | β |
| A Mendelian randomization-based risk model using aging-related genes for prognosis in lung adenocarcinoma. | Feng S et al. | β | 2025 | β |
| A Mendelian randomization study between air pollutants and benign prostatic hyperplasia. | Xia L et al. | β | 2025 | β |
| A Mendelian Randomization Study of the Association Between Loud Music Exposure Frequency and Anxiety Disorders in European Populations. | Meng F et al. | β | 2025 | β |
| A Mendelian randomization study of the gut microbiota and risk of knee osteoarthritis and the mediating role of immune cells. | Zhang J et al. | β | 2025 | β |
| Analysis of spermidine's effect on coronary heart disease risk using bidirectional Mendelian randomization and LC-MS/MS. | Wang T et al. | β | 2025 | β |
| Analysis of the causal association between systemic lupus erythematosus and osteonecrosis: A bidirectional 2-sample Mendelian randomization study. | Zhang L et al. | β | 2025 | β |
| Analyzing the causal relationship between gut microbiota, metabolites, and constipation: A Mendelian randomization study. | He M et al. | β | 2025 | β |
| Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study. | Zhang X et al. | β | 2025 | β |
| An Integrated Multi-Omics Analysis Identifies Oxeiptosis-Related Biomarkers in Diabetic Retinopathy. | Deng J et al. | β | 2025 | β |
| Anorexia nervosa and gastrointestinal diseases: A multivariable Mendelian randomization study. | Pu C | β | 2025 | β |
| A Novel Depression Risk Prediction Model Using NHANES Data With Mendelian Randomization Validation. | Lin L et al. | β | 2025 | β |
| Application of Mendelian randomization in the discovery of risk factors for cancer from 2014 to 2024: a bibliometric review. | Yang J et al. | β | 2025 | β |
| Application of Mendelian randomization to explore metabolic pathways in colorectal cancer. | Hoang T et al. | β | 2025 | β |
| A prognostic model for breast cancer survival based on PCD and m6A gene interactions. | Li W et al. | β | 2025 | β |
| Are lipid-lowering drugs harmful to cognitive performance?: A Mendelian randomization study. | Han L et al. | β | 2025 | β |
| A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies. | Huang YJ et al. | β | 2025 | β |
| Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes. | Prince C et al. | β | 2025 | β |
| Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study. | Fu J et al. | β | 2025 | β |
| Assessing the relationship between gut microbiota and hyperprolactinemia: A bidirectional two-sample Mendelian randomization study. | Qi T et al. | β | 2025 | β |
| Assessment of the causal effect of lifestyle factors on postoperative infections based on Mendelian randomization. | Fu WJ et al. | β | 2025 | β |
| Association between anemia and stroke with its subtypes in adults: Insights from NHANES 2005-2016 and Mendelian randomization analyses. | Li Q et al. | β | 2025 | β |
| Association between antibody-mediated immune responses and gastroesophageal reflux disease: Evidence from genetic studies. | Li L et al. | β | 2025 | β |
| Association between Anti-Helicobacter pylori IgG seropositivity on coronary heart disease and potential pathogenesis: a Mendelian randomization study. | Wang J et al. | β | 2025 | β |
| Association between chronic kidney disease and depression: evidence from the NHANES 2015-2018 and Mendelian randomization analysis. | Cheng X et al. | β | 2025 | β |
| Association between diabetes mellitus and adhesive capsulitis of shoulder: A 2-sample Mendelian randomization study. | Li W et al. | β | 2025 | β |
| Association Between Dysmenorrhea and Endometrial Cancer: A Mendelian Randomization Study. | Huang Q et al. | β | 2025 | β |
| Association between folate intake and suicidal ideation: NHANES 2005-2018 and Mendelian randomization. | Feng L et al. | β | 2025 | β |
| Association between frailty and chest pain: Insights from the 2009 to 2018 NHANES cross-sectional analysis and Mendelian randomization. | Zhang Z et al. | β | 2025 | β |
| Association between frailty and gout in middle-aged and older adults: A nationwide cross-sectional and Mendelian randomization study. | Sun Y et al. | β | 2025 | β |
| Association Between Gastroesophageal Reflux Disease, Barrett's Esophagus and Ear Disorders: A Mendelian Randomization Study. | Zhao W et al. | β | 2025 | β |
| Association between gut microbiota and disorders of lipoprotein metabolism: a two sample Mendelian randomization study. | Du Q et al. | β | 2025 | β |
| Association between gut microbiota and lymphomas: A bidirectional multivariable Mendelian randomization study. | Lan D et al. | β | 2025 | β |
| Association between metabolites and hepatocellular carcinoma: findings from a two-sample Mendelian randomization study. | Hoang T et al. | β | 2025 | β |
| Association between mitochondrial DNA copy number and the risk of Parkinson's disease: a meta-analysis and Mendelian randomization study. | Zheng H et al. | β | 2025 | β |
| Association between mitochondria-related genes and systemic lupus erythematosus: Findings from Mendelian randomization study. | Huang X et al. | β | 2025 | β |
| Association between neutrophil to lymphocyte ratio and Alzheimer's disease in large biobank cohorts. | Drzymalla E et al. | β | 2025 | β |
| Association between nitrogen oxides and COVID-19 risk: A Mendelian randomization study. | Cao J et al. | β | 2025 | β |
| Association Between Preoperative Cognitive Performance and Postoperative Delirium in Older Patients: Results From a Multicenter, Prospective Cohort Study, and a Mendelian Randomization Study. | Sun R et al. | β | 2025 | β |
| Association between rheumatoid arthritis and blood lipid levels: An integrated epidemiological observational analysis and Mendelian randomization study. | Yi J et al. | β | 2025 | β |
| Association between specific neuroticism symptoms and cardiovascular disease: insights from genetic analysis. | Zhang H et al. | β | 2025 | β |
| Association between Streptococcus and chronic obstructive pulmonary disease: A two-sample Mendelian randomization study. | Ding Z et al. | β | 2025 | β |
| Association between thyroid function and type 2 diabetes mellitus based on the NHANES and Mendelian randomization study. | Su C et al. | β | 2025 | β |
| Association of antipsychotic drug target genes and risk of lung cancer: a Mendelian randomization study. | Xiang J et al. | β | 2025 | β |
| Association of blood urea nitrogen with gout: Observational and Mendelian randomization analyses. | Hong KD et al. | β | 2025 | β |
| Association of chaperone-mediated autophagy with the mechanisms of vascular calcification in diabetic nephropathy. | Zhang Y et al. | β | 2025 | β |
| Association of circulating fatty acids with metabolic dysfunction-associated steatotic liver disease: A cross-sectional analysis and Mendelian randomization study. | Liu Z et al. | β | 2025 | β |
| Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study. | Liu J et al. | β | 2025 | β |
| Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses. | Lou C et al. | β | 2025 | β |
| Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization. | Xiao S et al. | β | 2025 | β |
| Association of SGLT2 inhibition with psychiatric disorders: A Mendelian randomization study. | Liu L et al. | β | 2025 | β |
| Association of sleep traits with risk of adverse pregnancy outcomes: a Mendelian randomisation analysis. | Shao S et al. | β | 2025 | β |
| Associations between allergic diseases and autoimmune thyroid diseases: A meta-analysis of Mendelian randomization studies. | Li J et al. | β | 2025 | β |
| Associations between artificial sweeteners and cardiovascular disease, stroke, and diabetes: A Mendelian randomization study. | Fan J et al. | β | 2025 | β |
| Associations Between Dietary Factors, Metabolic Factors, Sleep Disorders, Physical Activity, and the Risk of Multiple Sclerosis: A Univariable and Multivariable Mendelian Randomization Study. | Liu H et al. | β | 2025 | β |
| Associations Between Gastroenteropancreatic Neuroendocrine Neoplasms and Inflammatory Factors: Insights From a Two-Sample Mendelian Randomization Analysis. | Guo H et al. | β | 2025 | β |
| Associations between gut microbiota and multiple system atrophy: a Mendelian randomization study. | Wang D et al. | β | 2025 | β |
| Associations Between Obstructive Sleep Apnea and Metabolic Dysfunction-Associated Fatty Liver Disease: Insights from Comprehensive Mendelian Randomization and Gene Expression Analysis. | Ma T et al. | β | 2025 | β |
| Associations of 35 Serum and Urine Biomarkers With Vascular Dementia-A Mendelian Randomization Study. | Zhu X et al. | β | 2025 | β |
| Associations of genetic proxies for non-steroidal anti-inflammatory drugs with increased kidney stone risk: a Mendelian randomization study. | Liu J et al. | β | 2025 | β |
| Associations of gestational diabetes mellitus with the risk of cardiometabolic diseases: results from NHANES and mendelian randomization analyses. | Zhang L et al. | β | 2025 | β |
| A study revealed the impact of gut microbiota on acne vulgaris: Evidence based on Mendelian randomization. | Tang Y et al. | β | 2025 | β |
| A Trace Element-Ulcer Map: Decoding Micronutrient-Ulcer Relationships Through Genetic Architecture and Pleiotropy-Aware Inference. | Cai X et al. | β | 2025 | β |
| Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis. | Xiong Z et al. | β | 2025 | β |
| A two-sample Mendelian randomization analysis of the impact of GABA receptor subtypes on human height. | Chen L et al. | β | 2025 | β |
| Bayesian-weighted Mendelian randomization reveals sleep apnea syndrome mediates the BMI-chronic pain link. | Shi W et al. | β | 2025 | β |
| Bidirectional causal association and shared anti-inflammatory target of asthma and atopic dermatitis: a Mendelian randomization and colocalisation study. | Bi J et al. | β | 2025 | β |
| Bidirectional Causal Associations Between Plasma Metabolites and Parkinson's Disease. | Zhao M et al. | β | 2025 | β |
| Bidirectional causality between liver dysfunction and migraine: A mediating Mendelian randomization study. | Yi S et al. | β | 2025 | β |
| Bidirectional causal links between diabetes mellitus and autoimmune liver diseases: Insights from Mendelian randomization. | Kuang H et al. | β | 2025 | β |
| Bidirectional causal relationship between depression and Type 2 diabetes: a multi-ancestry and sex stratified Mendelian Randomization analysis. | Liu HY et al. | β | 2025 | β |
| Bidirectional Causal Relationship Between Gut Microbiota and Thyroid Cancer Genetic Susceptibility: A Two-Sample Mendelian Randomization Study | MA Z et al. | β | 2025 | β |
| Bidirectional Mendelian Randomization Analysis of Mood Disorders and Risk of Preeclampsia-Eclampsia. | Zhao C et al. | β | 2025 | β |
| Bidirectional Mendelian randomization analysis of the causal relationship between inflammatory bowel disease and Hashimoto thyroiditis. | Ding X et al. | β | 2025 | β |
| Bidirectional Mendelian Randomization Analysis of the Causal Relationship Between Uterine Fibroids and Breast Cancer in East Asian Women. | Lee Y et al. | β | 2025 | β |
| Bidirectional Mendelian randomization and immune cell mediation analysis: A STROBE-MR study unveiling the causal link between non-small cell and small cell lung cancers. | Gao Y et al. | β | 2025 | β |
| Bidirectional Mendelian Randomization and Multi-Omics Uncover Causal Serum Metabolites and Neuro-Related Mechanistic Pathways in Acute Myeloid Leukemia. | Ye H et al. | β | 2025 | β |
| Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation. | Liao W et al. | β | 2025 | β |
| Bioavailable testosterone and thyroid cancer: A 2-sample Mendelian randomization study. | Xu Q et al. | β | 2025 | β |
| Biological aging phenotypes mediate gut microbiota effects on age-related macular degeneration subtype progression: genetic causality by mendelian randomization and mediation analysis. | Zhou Y et al. | β | 2025 | β |
| Blood metabolites and gastric cancer risk: A bidirectional 2-sample Mendelian randomization study. | Chen S et al. | β | 2025 | β |
| Blood Pressure and Mortality in Mexico City: A Mendelian Randomization Study. | Turner M et al. | β | 2025 | β |
| Body Composition and Kidney Outcomes: A Cohort Study of Rapid Kidney Function Decline and a Mendelian Randomization Analysis of CKD Incidence. | Li K et al. | β | 2025 | β |
| Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics. | MULTI Consortium et al. | β | 2025 | β |
| Brain network connectivity and dementia risk: a bidirectional Mendelian randomisation perspective. | Zhu S et al. | β | 2025 | β |
| Breakfast Skipping Increases the Risk of Coronary Heart Disease and Myocardial Infarction: Evidence From the Mendelian Randomization Study. | Cao S et al. | β | 2025 | β |
| Burden and risk factors of autism spectrum disorder: global study and analysis. | Lin L et al. | β | 2025 | β |
| Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization. | Jin M et al. | β | 2025 | β |
| Can coronavirus disease 2019 affect male fertility or cause spontaneous abortion? A two-sample Mendelian randomization analysis. | Liang Y et al. | β | 2025 | β |
| Can Omega-3 polyunsaturated fatty acids improve bone mineral density?: Evidence from a Mendelian randomization study. | Gou X et al. | β | 2025 | β |
| Cathepsin Levels and Atrial Fibrillation Risk: Insights From Bidirectional and Multivariable Mendelian Randomization Analyses. | Ye F et al. | β | 2025 | β |
| Cathepsins effect on diffuse large B cell lymphoma risk: A Mendelian randomization study. | Lu C et al. | β | 2025 | β |
| Causal association between 91 circulating inflammatory proteins and primary open-angle glaucoma: a bidirectional Mendelian randomization study. | Liu C et al. | β | 2025 | β |
| Causal association between chronic obstructive pulmonary disease and brain cortical structure: A Mendelian randomization study. | Wang HQ et al. | β | 2025 | β |
| Causal association between circulating Klotho levels and B-cell lymphoma: A 2-sample Mendelian randomization study. | Wang Z et al. | β | 2025 | β |
| Causal association between dietary factors and Primary Biliary Cholangitis: A Mendelian randomization study. | Luo H et al. | β | 2025 | β |
| Causal association between different types of ametropia and risk of diabetic retinopathy: a two-sample Mendelian randomization study. | Ma Q et al. | β | 2025 | β |
| Causal association between gut microbiota and neonatal digestive system diseases: A Mendelian randomization study. | Pang J et al. | β | 2025 | β |
| Causal association between gut microbiota composition and the risk of atrial fibrillation. | Tan J et al. | β | 2025 | β |
| Causal Association Between Immune Cell Traits and Risk of Multiple Malignant and Nonmalignant CNS Diseases: A Mendelian Randomization and Single-Cell Transcriptomic Analysis. | Ke S et al. | β | 2025 | β |
| CAUSAL ASSOCIATION BETWEEN MEDICATION USE AND SEPSIS: A TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY. | Sun M et al. | β | 2025 | β |
| Causal association between neutrophil extracellular traps and rheumatoid arthritis: A 2-sample bidirectional Mendelian randomization study. | Luo J et al. | β | 2025 | β |
| Causal association between plasma inflammatory proteins and longitudinal brain atrophy: a bidirectional Mendelian randomisation study. | Cui W et al. | β | 2025 | β |
| Causal Association Between Psoriasis and Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study. | Lee Y et al. | β | 2025 | β |
| Causal association between sarcopenia-related traits and osteoarthritis: A bidirectional 2-sample Mendelian randomization Study. | Zhang C et al. | β | 2025 | β |
| Causal association between sleep traits and diabetic nephropathy. | Ji C et al. | β | 2025 | β |
| Causal Association of Alzheimer's Disease with Low Back Pain: A Mendelian Randomization Study. | Li Y et al. | β | 2025 | β |
| Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study. | Liang G et al. | β | 2025 | β |
| Causal association of education, smoking, sedentary lifestyle and body mass index with disc degeneration: Mendelian randomization. | Cui H et al. | β | 2025 | β |
| Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two-Sample Mendelian Randomization Study Based on European Ancestry. | Cheng H et al. | β | 2025 | β |
| Causal Associations Between Body Composition and Cerebral Small Vessel Disease. | Wang M et al. | β | 2025 | β |
| Causal associations between cognitive impairments and retinal diseases: A two-sample Mendelian randomization study. | Shi Q et al. | β | 2025 | β |
| Causal associations between diet and thromboembolism: A 2-sample Mendelian randomization study. | Hu S et al. | β | 2025 | β |
| Causal Associations Between Immune Cell Phenotypes and Oral Lichen Planus: A Large-Scale Mendelian Randomization Study. | Meng Z et al. | β | 2025 | β |
| Causal associations between inflammatory cytokines and hypertensive disorders. | Li X et al. | β | 2025 | β |
| Causal associations between insulin-like growth factor binding protein-1 to -7 and osteoporosis: A two-sample Mendelian randomization study. | Du P et al. | β | 2025 | β |
| Causal Associations Between Obstructive Sleep Apnea and Hypertension: Evidence From a Bidirectional and Multivariable Mendelian Randomization Analysis. | Tang S et al. | β | 2025 | β |
| Causal associations between psoriasis and atopic dermatitis: A bidirectional Mendelian randomization study. | Wang Z et al. | β | 2025 | β |
| Causal associations between schizophrenia and other psychiatric disorders: A Mendelian randomization study. | Zhou Y et al. | β | 2025 | β |
| Causal associations between sleep disorders and endometriosis: A Mendelian randomization analysis. | Yang X et al. | β | 2025 | β |
| Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization. | Kaisaier W et al. | β | 2025 | β |
| Causal Associations of Iron Status With the Renal Function and Diabetic Nephropathy in Patients With Diabetes Mellitus: A Two-Sample Mendelian Randomization Study. | Zhang Y et al. | β | 2025 | β |
| Causal Associations of the Alterations in Peripheral Blood Immune Cell Characteristics on the Incidence of Osteoporosis: A Bidirectional Mendelian Randomization Study. | Yin Q et al. | β | 2025 | β |
| Causal effect between systemic inflammatory cytokines and osteoporotic pathological fractures: A bidirectional Mendelian randomization study. | Wang H et al. | β | 2025 | β |
| Causal effect of gut microbiota and its metabolites on cerebral small vessel disease: A multivariable Mendelian randomization analysis. | Xue H et al. | β | 2025 | β |
| Causal effect of kimchi intake on HDL-cholesterol levels in middle aged Korean men: a two-sample Mendelian randomization analysis. | Cha J et al. | β | 2025 | β |
| Causal Effect of Plasma Fatty Acid Profiles on Psoriasis Risk: Genetic Evidence from a Mendelian Randomization Study. | Yao L et al. | β | 2025 | β |
| Causal effect of potential risk factors on obstructive sleep apnea: a Mendelian randomization study. | Chen J et al. | β | 2025 | β |
| Causal effects and immune cells mediators between gut microbiota and sicca syndrome: A Mendelian randomization study. | Yue J et al. | β | 2025 | β |
| Causal effects and metabolite mediation of immune cells in preterm birth: a Mendelian randomization study. | Zhou T et al. | β | 2025 | β |
| Causal effects between gut microbiota and coronary heart disease: A Mendelian randomization study. | Chen H et al. | β | 2025 | β |
| Causal effects of breastfeeding on childhood health outcomes: A Mendelian randomization analysis of mental and physical health. | Lu Y et al. | β | 2025 | β |
| Causal effects of cholecystectomy on the lipidome: cross-sectional and mendelian randomization studies. | Liang Y et al. | β | 2025 | β |
| Causal effects of circulating inflammatory proteins on colorectal cancer: a Mendelian randomization and Spatial transcriptomic study. | Bai M et al. | β | 2025 | β |
| Causal effects of dietary antioxidants on epigenetic age: A two-sample Mendelian randomization study. | Huang C et al. | β | 2025 | β |
| Causal Effects of Gut Microbiome on Tinnitus: A Mendelian Randomization Study. | Zeng Q et al. | β | 2025 | β |
| Causal effects of gut microbiota on IgG levels after Helicobacter pylori (H pylori) infection: Insights from genome-wide Mendelian randomization. | Chen J et al. | β | 2025 | β |
| Causal effects of immune cell populations on biological aging: a Mendelian randomization study. | Fu J et al. | β | 2025 | β |
| Causal Effects of Immune Cell Populations on Cognitive Performance: A Mendelian Randomization Study. | Fu J et al. | β | 2025 | β |
| Causal Effects of Inflammatory Arthritis Subtypes on Fibromyalgia: A Comprehensive Mendelian Randomization Study. | Wang F et al. | β | 2025 | β |
| Causal Effects of Metabolic Syndrome on Gastric Disorders: Univariable and Multivariable Mendelian Randomization. | Li B et al. | β | 2025 | β |
| Causal effects of physical activity and screen time on childhood intelligence via Mendelian randomization: The mediating role of intracranial volume. | Feng J et al. | β | 2025 | β |
| Causal effects of serum nutrients and macronutrient intake on periodontitis: A Mendelian randomization study. | Lin J et al. | β | 2025 | β |
| Causal effects of the gut microbiota, circulating metabolites, and cardiometabolic diseases: A Mendelian randomization study. | Ye C et al. | β | 2025 | β |
| Causal Gene Identification and Biomarker Prioritization in Periodontitis via Integrative Multiomics and Mendelian Randomization. | Mo H et al. | β | 2025 | β |
| Causal impact of obesity class stratification and endometrial cancer subtypes: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis. | Tong Y et al. | β | 2025 | β |
| Causal inference of modifiable lifestyle and birth traits on osteonecrosis risk: A bidirectional 2-sample Mendelian randomization study. | Xu B et al. | β | 2025 | β |
| Causal insights into multiple myeloma: The impact of circulating inflammatory proteins and metabolites. | Zhang P et al. | β | 2025 | β |
| Causality between aging and interstitial lung disease: A bidirectional two-sample Mendelian randomization study. | Luo W et al. | β | 2025 | β |
| Causality between periodontitis and schizophrenia, bipolar disorder, and major depressive disorder: A mendelian randomization study. | Zhang S et al. | β | 2025 | β |
| Causality between rheumatic diseases and iron-deficiency anemia: A 2-sample, 2-step mediation Mendelian randomization investigation. | Huang W et al. | β | 2025 | β |
| Causality between thyroid disease and psoriasis: Bidirectional Mendelian randomization analysis. | Cong X et al. | β | 2025 | β |
| Causality of blood metabolites and narcolepsy type 1: A Mendelian randomization study. | Shen B et al. | β | 2025 | β |
| Causality of circulating vitamins on infectious diseases: integrating Mendelian randomization and <i>in vivo</i> evidence. | Tang A et al. | β | 2025 | β |
| Causality of genetically determined gut microbiota on lung cancer: a Mendelian randomization study. | Yu H et al. | β | 2025 | β |
| Causal link between ankylosing spondylitis and thyroid dysfunction: A Mendelian randomization study. | Ye Q et al. | β | 2025 | β |
| Causal Link Between Thyroid Function and Female-Specific Cancers: A Bidirectional Two-Sample and Mediation Mendelian Randomization Study. | Gao B et al. | β | 2025 | β |
| Causal Link of Distinct Mental Disorders with Androgenetic Alopecia and Alopecia Areata: A Bidirectional Two-Sample Mendelian Randomization Study. | Hu C et al. | β | 2025 | β |
| Causal links and mediating effects of lipid metabolism, immune cells, and inflammatory proteins in endometriosis: Evidence from Mendelian randomization. | Guo P et al. | β | 2025 | β |
| Causal mediation analysis for time-varying heritable risk factors with Mendelian randomization. | Wu Z et al. | β | 2025 | β |
| Causal proteomic insights into drug target discovery for tension-type headache. | Gao R et al. | β | 2025 | β |
| Causal relationship and shared genetic pathways between diabetic kidney disease and cognitive impairment: a Mendelian randomization study. | Yu K et al. | β | 2025 | β |
| Causal relationship between 179 plasma lipids and intracranial aneurysm: A 2-sample Mendelian randomization study. | Ding L et al. | β | 2025 | β |
| Causal relationship between albumin, total protein, and colorectal cancer risk: A 2-sample Mendelian randomization study. | Chen J et al. | β | 2025 | β |
| Causal relationship between asthma and chronic rhinosinusitis: A Mendelian randomization study. | Li J et al. | β | 2025 | β |
| Causal relationship between blood metal levels and breast cancer risk: a Mendelian randomization study in East Asian populations. | Zhang J et al. | β | 2025 | β |
| Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study. | Lin W et al. | β | 2025 | β |
| Causal Relationship Between Butyrate and Dyspepsia: Evidence From Two-Sample Mendelian Randomization Analysis of CSF Metabolites. | Cai Y et al. | β | 2025 | β |
| Causal relationship between chronic hepatitis B infection and gastric ulcer: A Mendelian randomization study. | Wang Y et al. | β | 2025 | β |
| Causal relationship between circulating immune cells and diabetic nephropathy: A Mendelian randomization study. | Wang T et al. | β | 2025 | β |
| Causal relationship between circulating micronutrient levels and bipolar disorder: A Mendelian randomization study. | You T et al. | β | 2025 | β |
| Causal relationship between COVID-19, vaccination, and 20 digestive diseases: a comprehensive two-sample Mendelian randomization study. | Zeng X et al. | β | 2025 | β |
| Causal relationship between diet and common female diseases: a comprehensive Mendelian randomization study. | Fu M et al. | β | 2025 | β |
| Causal relationship between dietary factors and oral mucosal lesions: Two-sample Mendelian randomization analysis. | Jiang S et al. | β | 2025 | β |
| Causal relationship between dietary patterns and the risk of developing chronic renal failure: a Mendelian randomization study. | Li Y et al. | β | 2025 | β |
| Causal relationship between frailty and diabetes subtypes: A bidirectional Mendelian randomization study. | Pan Z et al. | β | 2025 | β |
| Causal relationship between gastroesophageal reflux disease and 7 types of hernias: A bidirectional Mendelian randomization study. | Chen X et al. | β | 2025 | β |
| Causal Relationship Between Genetically Determined Free Fatty Acids and Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study. | Li K et al. | β | 2025 | β |
| Causal Relationship between Gut Microbiota and Endometrial Cancer: A Two-Sample Mendelian Randomization Study. | Yao X et al. | β | 2025 | β |
| Causal relationship between gut microbiota and pituitary neuroendocrine tumors: a bidirectional Mendelian randomization. | Wang W et al. | β | 2025 | β |
| Causal relationship between gut microbiota and pneumonia: a Mendelian randomization and retrospective case-control study. | Huang P et al. | β | 2025 | β |
| [Causal relationship between gut microbiota and T cell subsets in the development of colorectal cancer: a Mendelian randomization analysis]. | Yu Z et al. | β | 2025 | β |
| Causal relationship between immune cells and myocardial infarction: A Mendelian randomization study. | Xu Y et al. | β | 2025 | β |
| Causal Relationship between Immune Cells and Postpartum Depression: A Bidirectional Two-Sample Mendelian Randomization Study. | Zhu Y et al. | β | 2025 | β |
| Causal relationship between immune cells and venous thromboembolism: a bidirectional two-sample Mendelian randomization study. | Xiao W et al. | β | 2025 | β |
| Causal relationship between immune mediators and parkinson's disease: A Mendelian randomization analysis. | Qiu R et al. | β | 2025 | β |
| Causal Relationship Between Inflammatory Bowel Disease and Neuropsychiatric Disorders: A Bidirectional Mendelian Randomization Study. | Lei J et al. | β | 2025 | β |
| Causal relationship between interleukin-6 levels and the risk of synovitis and tenosynovitis: A two-sample Mendelian randomization study. | Wang B et al. | β | 2025 | β |
| Causal Relationship Between Metabolic Traits and Risk of NSCLC: A Two-Sample Mendelian Randomization Analysis. | Li X et al. | β | 2025 | β |
| Causal relationship between primary biliary cholangitis on osteoporosis: A two-sample Mendelian randomization study. | Liu W et al. | β | 2025 | β |
| Causal relationship between sarcopenia and cognitive performance: A bidirectional Mendelian randomization study. | Zhou Y et al. | β | 2025 | β |
| Causal relationship between schizophrenia and tachyarrhythmia: A Mendelian randomization study based on a European population. | Li P et al. | β | 2025 | β |
| Causal relationship between serum bilirubin, cholelithiasis and hepatobiliary and pancreatic malignancy: A bidirectional and 2-sample Mendelian randomization study. | Luo T et al. | β | 2025 | β |
| Causal relationship between serum metabolites and chronic myeloid leukemia: A bidirectional Mendelian randomization study. | Ye H et al. | β | 2025 | β |
| Causal Relationship Between Serum Uric Acid and Atherosclerotic Disease: A Mendelian Randomization and Transcriptomic Analysis. | Wang S et al. | β | 2025 | β |
| Causal relationship between statins and hemorrhagic stroke: A drug-target Mendelian randomization analysis. | Xia M et al. | β | 2025 | β |
| Causal relationship between varicose veins and hydrocele: A bidirectional two-sample Mendelian randomization study. | Guo C et al. | β | 2025 | β |
| Causal relationship of body mass index with autoimmune liver diseases mediated by circulating cytokines: A Mendelian randomization study. | Lu Y et al. | β | 2025 | β |
| Causal relationships between 25-hydroxyvitamin D levels and laryngeal cancer risk: A two-sample Mendelian randomization study. | Wang D et al. | β | 2025 | β |
| Causal relationships between antibody-mediated immune responses and acute pancreatitis: Evidence from a genetic study. | Xie M et al. | β | 2025 | β |
| Causal relationships between cerebrospinal fluid metabolites, immune cell traits, and head and neck cancers. | Liu F et al. | β | 2025 | β |
| Causal relationships between immune cells and common urinary system tumors: A bidirectional analysis of Mendelian randomization. | Liu Z et al. | β | 2025 | β |
| Causal relationships between immune-related adverse events, immune cell characteristics, and plasma metabolites: insights from Mendelian randomization study. | Shi Z et al. | β | 2025 | β |
| Causal relationships between monocyte chemoattractant protein-1 levels and neuropsychiatric disorders: Evidence from large-scale genetic data. | He Y et al. | β | 2025 | β |
| Causal Relationships Between Neuropathic Pain and Alzheimer's Disease: A Multi-Omics Mendelian Randomization Study with Exploratory Evidence of a Potential Protective Role of Diabetic Neuropathy. | Li X et al. | β | 2025 | β |
| Causal relationships between plasma proteins and Alzheimer's disease using bidirectional Mendelian randomization. | Li Y et al. | β | 2025 | β |
| Causal relationships of serum iron metabolites with sepsis and cardiomyopathy: a Mendelian randomization analysis. | Zhang J et al. | β | 2025 | β |
| Causal relations of trace elements and nutrients with insomnia: A Mendelian randomization study. | Luo L et al. | β | 2025 | β |
| Causal role of immunophenotypes in HIV-1 acquisition: insights from Mendelian randomization analysis. | Li N et al. | β | 2025 | β |
| Causal role of oxidative stress in age-related macular degeneration: a bidirectional Mendelian randomization study. | Yuan LY et al. | β | 2025 | β |
| Causal role of phenylalanine and cholesterol metabolism in bladder cancer Chemoresistance: Insights from mendelian randomization and targeted molecular docking. | Li J et al. | β | 2025 | β |
| CD14<sup>-</sup> CD16<sup>+</sup> monocyte PD-L1 prevents early tuberculosis progression and constrains reactivation under immune checkpoint therapy. | Wang W et al. | β | 2025 | β |
| CD45 on CD33br HLA-DR+ immune cells promote cholecystitis via glycine-mediated pathways: A Mendelian randomization study. | Zeng X et al. | β | 2025 | β |
| CD5 mediates the link between CD4+ CD39+ activated Treg cells and gastric cancer: A Mendelian randomization study. | Zhang Q et al. | β | 2025 | β |
| Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization. | Kayode GA et al. | β | 2025 | β |
| Characterizing aging-related genetic and physiological determinants of spinal curvature. | Wang FM et al. | β | 2025 | β |
| Cholecystitis and cholangiocarcinoma: a two-sample Mendelian randomization study. | Gao X et al. | β | 2025 | β |
| Circulating Inflammatory Cytokines, Lipoprotein Particles, and Gestational Diabetes Risk: A Mendelian Randomization Study. | Xu J et al. | β | 2025 | β |
| Circulating inflammatory proteins as causal drivers and therapeutic targets in asthma: insights from genetic and pathway-based analyses. | Miao Y et al. | β | 2025 | β |
| Circulating inflammatory proteins associated with risks of schizophrenia, bipolar disorder, and major depressive disorder: a mendelian randomization study. | Dong Z et al. | β | 2025 | β |
| CIRCULATING INFLAMMATORY PROTEINS IN DRUG-INDUCED ANAPHYLACTIC SHOCK: EVIDENCE FROM MULTIVARIABLE MENDELIAN RANDOMIZATION AND MULTIOMICS INTEGRATION. | Dai J et al. | β | 2025 | β |
| Clinical and genetic determinants of worse sexual experience in male patients with radiographic axial spondyloarthritis: a multimodal study. | Hu L et al. | β | 2025 | β |
| Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank. | Xu W et al. | β | 2025 | β |
| Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma. | Li Y et al. | β | 2025 | β |
| Clonal hematopoiesis of indeterminate potential as a risk factor for atrial fibrillation: Evidence of a causal relationship by Mendelian randomization study. | Zhang Q et al. | β | 2025 | β |
| Co-expression-wide association studies link genetically regulated interactions with complex traits. | Malakhov MM et al. | β | 2025 | β |
| Combined Analysis of Transcriptome and Mendelian Randomization Reveals <i>AKT1</i> and <i>PPARG</i> as Biomarkers Related to Glucose Metabolism in Sepsis. | Ma J et al. | β | 2025 | β |
| Community-based causal evidence that high habitual caffeine consumption alters distinct polysomnography-derived sleep variables. | Stucky B et al. | β | 2025 | β |
| Complex causal association between immune cells and psoriatic arthritis: A bidirectional Mendelian randomization study. | Jia Y et al. | β | 2025 | β |
| Comprehensive Analysis Reveals Biomarkers Related to Diabetic Peripheral Neuropathy and Its Molecular Mechanism. | Zhu Q et al. | β | 2025 | β |
| Comprehensive Genome-Wide Analysis of Shared Genetic Factors in Gastrointestinal and Neurodegenerative Diseases. | Jiang Y et al. | β | 2025 | β |
| Comprehensive multi-omics analysis identifies transferrin receptor as a therapeutic target in esophageal cancer. | Sun X et al. | β | 2025 | β |
| Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis. | Qiao J et al. | β | 2025 | β |
| C-reactive protein and prospective cardiometabolic risk: observational and Mendelian randomization study of ischemic stroke and all-cause death. | Rolver MG et al. | β | 2025 | β |
| Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation. | Yuan S et al. | β | 2025 | β |
| Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates. | Liu Y et al. | β | 2025 | β |
| Deciphering cross-cohort metabolic signatures of immune responses and their implications for disease pathogenesis. | Fu J et al. | β | 2025 | β |
| Deciphering the causal relationships between plasma metabolites, peripheral cells, inflammatory factors and DLBCL for discovering novel therapeutic targets. | Xu M et al. | β | 2025 | β |
| Deciphering the immunometabolic axis: a mendelian randomization study of a causal cascade network from immune cell phenotypes to metabolites in esophageal cancer. | Gui D et al. | β | 2025 | β |
| Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study. | Guo B et al. | β | 2025 | β |
| Decoding rheumatoid arthritis: Biomarker identification and immune profiling via bioinformatics and Mendelian randomization. | Shao S et al. | β | 2025 | β |
| Delineating unique MASH-endothelial cells in metabolic dysfunction-associated steatotic liver disease using single-cell lensing. | Liu L et al. | β | 2025 | β |
| Denosumab for Primary Osteoporosis and Its Impact on Sarcopenia in the Chinese Population: Insights from Clinical Evidence and RANKL Pathway Mendelian Randomization. | Li S et al. | β | 2025 | β |
| Depression, ovarian cysts and infertility in women: A mediated Mendelian randomization analysis. | Yuan D et al. | β | 2025 | β |
| Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization. | Yang M et al. | β | 2025 | β |
| Diabetes and benign paroxysmal positional vertigo: A 2-sample Mendelian randomization study. | Liu S et al. | β | 2025 | β |
| Diabetes is associated with a decreased risk of meningiomas: a mendelian randomization study. | Wang R et al. | β | 2025 | β |
| Dietary factors causally affect the risk of kidney cancer: a two-sample Mendelian randomization study. | Zhu C et al. | β | 2025 | β |
| Dietary patterns, physical activity, and risk of urinary tract diseases: a two sample Mendelian randomization analysis. | Zhao C et al. | β | 2025 | β |
| Dietary Sodium-Potassium Imbalance and Hypertension: Causal Pathways Involving Gut Microbiota Dysbiosis, Inflammation, and Metabolic Disorders. | Lu C et al. | β | 2025 | β |
| Differential association of platelet indices in NAFLD/NASH: a Mendelian randomized study. | Huang H et al. | β | 2025 | β |
| Differential Causal Effects of Common Analgesics on Breast Cancer Risk and Survival: Evidence from Mendelian Randomization. | Peng Z et al. | β | 2025 | β |
| Disentangling horizontal and vertical Pleiotropy in genetic correlation estimation: introducing the HVP model. | Amente LD et al. | β | 2025 | β |
| Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization. | Chatterjee A et al. | β | 2025 | β |
| Disentangling the inverse relationship between cancer and Alzheimer's or Parkinson's disease: A systematic review on Mendelian randomization studies. | Aung KZ et al. | β | 2025 | β |
| Dissecting causal networks of inflammatory factors and metabolites in heart failure: A mediation Mendelian randomization study. | Guan X et al. | β | 2025 | β |
| Dissecting causal relationships between dietary factors and intracerebral hemorrhage: A Mendelian randomization study. | Wang P et al. | β | 2025 | β |
| Dissecting Causal Relationships Between Gut Microbiota Imbalance, Inflammatory Cytokines, and Structural Connectivity in the Brain: A Mendelian Randomization Study. | Guo Q et al. | β | 2025 | β |
| Dissecting Causal Relationships Between Gut Microbiota, Immunocyte Phenotype, and Migraine: A Mendelian Randomization Study. | Lai Y et al. | β | 2025 | β |
| Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study. | Che K et al. | β | 2025 | β |
| Dissecting the pathogenic effects of ambient air pollution exposure and its blood DNA methylation markers on cardiovascular disease risk. | Li W et al. | β | 2025 | β |
| Dissecting the role of plasma and urinary metabolites in bone mineral density: Evidence from a bidirectional univariable Mendelian randomization study. | Xie T et al. | β | 2025 | β |
| Distinct gut microbiota profiles in acute vs. chronic sinusitis: potential biomarkers. | Cao H et al. | β | 2025 | β |
| DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target. | Qin J et al. | β | 2025 | β |
| DNA methylation-mediated ADA overexpression drives pancreatic cancer progression. | Zeng J et al. | β | 2025 | β |
| DNA methylation regulates TREM1 expression to modulate immune responses and drive progression in colorectal neuroendocrine neoplasm as a potential therapeutic target. | Guo H et al. | β | 2025 | β |
| Does uveitis increase the risk of age-related wet macular degeneration? A Mendelian randomization study. | Jing RH et al. | β | 2025 | β |
| Dorzagliatin shows potential in preventing cognitive impairment in diabetes: evidence from Mendelian randomization analysis and animal study. | Ni J et al. | β | 2025 | β |
| Druggable Genome Mendelian Randomization and GWAS-sceQTLs MR Analysis Reveal Genetic Associations Between Open-Angle Glaucoma and Immune Cells, and Identify Potential Drugs. | Ke K et al. | β | 2025 | β |
| Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences. | Beeche C et al. | β | 2025 | β |
| Educational Attainment as the Primary Socioeconomic Determinant of Heart Failure: A Multivariable Mendelian Randomization Study. | Ye M et al. | β | 2025 | β |
| Education, socioeconomic status, leisure sedentary behaviors and female infertility: mendelian randomization study. | Qu Y et al. | β | 2025 | β |
| Effects of thyroid-stimulating hormone and sensitivity to thyroid hormones on the risk of hyperuricemia in euthyroid adults. | Ding H et al. | β | 2025 | β |
| Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects. | Zhang L et al. | β | 2025 | β |
| Elevated interleukin-12B is associated with increased seizure susceptibility: insights from two-sample Mendelian randomization and <i>in vivo</i> experiment. | Lu Y et al. | β | 2025 | β |
| Elucidating causal relationships between circulating inflammatory factors and aging traits: Transcriptomics and Mendelian randomization analyses. | Cao D et al. | β | 2025 | β |
| Elucidating the causal role of age of menarche, adiposity, lipid fractions, and blood pressure upon cardiovascular disease: a multivariable Mendelian randomization study. | Jee Y et al. | β | 2025 | β |
| Elucidating the causal triad of cardiovascular disease, cancer, and lipid traits: a bidirectional Mendelian randomization study with genetic mediation analysis. | Wu W et al. | β | 2025 | β |
| Employing plasma proteins in proteomic Mendelian randomization analysis to identify therapeutic targets for duodenal ulcer. | Luo X et al. | β | 2025 | β |
| Endometriosis and Ovarian Cancer: Insights from NHANES and Mendelian Randomization Analysis. | Liu D et al. | β | 2025 | β |
| Endoscopic Treatment of Staple-Line Leaks After Sleeve Gastrectomy in Patients with Obesity: Which One is the Best Option, if Any? A Systematic Review with Meta-Analysis and Meta-regression. | Galloro G et al. | β | 2025 | β |
| Entertainment activities and the risk of multiple sclerosis: A Mendelian randomization analysis. | Wang Z et al. | β | 2025 | β |
| Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization. | Pan Y et al. | β | 2025 | β |
| Epigenetic Mediating Mechanisms in Parkinson's Disease: The Impact of Educational Attainment on SETD1A Expression. | Yin KF et al. | β | 2025 | β |
| Epilepsy and migraine: A bidirectional mendelian randomization study. | Chen F et al. | β | 2025 | β |
| Epstein-Barr virus and the origin of frailty and fatigue: A two-sample multivariable bidirectional Mendelian randomization study. | Li J et al. | β | 2025 | β |
| Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian randomization study. | Lu T et al. | β | 2025 | β |
| Evaluating Causal Effects of Gut Microbiome on Bipolar Disorder. | Zhao Q et al. | β | 2025 | β |
| Evaluating the relationship between educational attainment, obesity-related indicators, and prostate diseases: A univariable and multivariable Mendelian randomization study. | Ji WT et al. | β | 2025 | β |
| Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data. | Howe LJ et al. | β | 2025 | β |
| Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study. | Bala R et al. | β | 2025 | β |
| Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis. | Mei Y et al. | β | 2025 | β |
| Exploration of causal relationship between transplant rejection and immune cells: A two-sample Mendelian randomization study. | Xue F et al. | β | 2025 | β |
| Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening. | Ma Z et al. | β | 2025 | β |
| Exploration of potential therapeutic target genes for preeclampsia through genetic analysis. | Wang H et al. | β | 2025 | β |
| Exploring 1400 Plasma Metabolites and Polycystic Ovary Syndrome: A Bidirectional Mendelian Randomization Study. | Lei X et al. | β | 2025 | β |
| Exploring causal associations between nuclear magnetic resonance biomarkers and colorectal cancer risk. | Zhou Q et al. | β | 2025 | β |
| Exploring causal link of 25-hydroxyvitamin D with eating disorder risk via bidirectional Mendelian randomization. | Zhang H et al. | β | 2025 | β |
| Exploring causal relationships between epigenetic age acceleration and Alzheimer's disease: a bidirectional Mendelian randomization study. | Liu H et al. | β | 2025 | β |
| Exploring Causal Relationships Between Kidney Function and the Risk of Senile Cataract and Primary Open-Angle Glaucoma: A Mendelian Randomization Study and Bioinformatics Analyses. | Li P et al. | β | 2025 | β |
| Exploring genetic association of chronic kidney disease with sarcopenia among European population: a bidirectional Mendelian randomization study. | Zhu X et al. | β | 2025 | β |
| Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study. | Lu C et al. | β | 2025 | β |
| Exploring Potential Causal Links: How Parkinson's Disease Brain Damage Impacts Liver Health-A Mendelian Randomization and Transcriptomic Study. | Liu T et al. | β | 2025 | β |
| Exploring the association and mediation between educational attainment and intracerebral hemorrhage: an integrated Mendelian randomization and global burden of disease analysis. | Li Q et al. | β | 2025 | β |
| Exploring the association between DNA methylation and pancreatic cancer susceptibility through epigenome-wide Mendelian randomization and multi-omics data integration. | Wang P et al. | β | 2025 | β |
| Exploring the Association Between Multidimensional Dietary Patterns and Non-Scarring Hair Loss Using Mendelian Randomization. | Pan L et al. | β | 2025 | β |
| Exploring the causal effects of epilepsy and its subtypes on anthropometric traits: A 2-sample Mendelian randomization study. | Chen L et al. | β | 2025 | β |
| Exploring the causal genetic relationship between 41 inflammatory cytokines and osteoporosis: a bidirectional Mendelian randomization analysis. | Zhang K et al. | β | 2025 | β |
| Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease. | Zhang H et al. | β | 2025 | β |
| Exploring the causal relationship between 25-hydroxyvitamin D and asthma: A bidirectional Mendelian randomization study. | Wu X et al. | β | 2025 | β |
| Exploring the causal relationship between acute respiratory distress syndrome and gut microbiota: Unveiling the gut-lung axis through a large-scale Mendelian randomization study. | Li C et al. | β | 2025 | β |
| Exploring the Causal Relationship Between Antidepressant Use and Lung Cancer Risk: A Mendelian Randomization Analysis. | Yang C et al. | β | 2025 | β |
| Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization. | Li W et al. | β | 2025 | β |
| Exploring the causal relationship between gut microbiota, circulating inflammatory proteins, and colorectal neuroendocrine tumors: a Mendelian randomization study. | Cui J et al. | β | 2025 | β |
| Exploring the causal relationship between plasma proteins and postherpetic neuralgia: a Mendelian randomization study. | Wei Q et al. | β | 2025 | β |
| Exploring the causal relationship between sedentary behavior and cardiovascular disease: A two-sample Mendelian randomization analysis. | Cao Y et al. | β | 2025 | β |
| Exploring the causal role of plasma metabolites in pediatric asthma: a Mendelian randomization study. | Ma S et al. | β | 2025 | β |
| Exploring the complex relationship between systemic lupus erythematosus and coronavirus disease 2019: genetic insights and potential protective mechanisms. | Xu X et al. | β | 2025 | β |
| Exploring the genetic causality of childhood maltreatment on multiple risk-related outcomes using Mendelian randomization: evidence from European-Ancestry GWAS. | Zhang Z et al. | β | 2025 | β |
| Exploring the genetic determinants of the oral microbiome's role in gastrointestinal cancer risk: Mendelian randomization and genetic correlation analysis in an East Asian population. | Jin W et al. | β | 2025 | β |
| Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study. | Li F et al. | β | 2025 | β |
| Exploring the link between dietary inflammatory index and sleep disorders: Insights from NHANES and Mendelian randomization approach. | Jiang J et al. | β | 2025 | β |
| Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers. | Zhu Q et al. | β | 2025 | β |
| Exploring the Protein-Metabolite Interplay to Discover Novel Drug Targets for Alzheimer's Disease. | Yin KF et al. | β | 2025 | β |
| Exploring therapeutic targets for hepatocellular carcinoma through druggable genes. | Tang C et al. | β | 2025 | β |
| Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning, and SHAP methods for comprehensive analysis. | Li J et al. | β | 2025 | β |
| Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study. | He H et al. | β | 2025 | β |
| Exploring the Role of B-Cell Biotherapy in Myasthenia Gravis from a Genetic Perspective: A Mendelian Randomization Study. | Zhang M et al. | β | 2025 | β |
| Exploring the role of inflammation, immunity, and metabolism in colorectal cancer via mendelian randomization approach. | Zhou L et al. | β | 2025 | β |
| Exploring the Shared Genetic Architectures Between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain. | Aman AM et al. | β | 2025 | β |
| Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study. | Song ZQ et al. | β | 2025 | β |
| Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes. | Baranova A et al. | β | 2025 | β |
| Ferritinophagy-related prognostic genes UBE2Q1, NEDD4L, and TCP11L2 for prognosis prediction in sepsis. | Xiong W et al. | β | 2025 | β |
| From genetic causality to druggable targets: A multiomics framework identifies ZSCAN16 in gout pathogenesis. | Chen C et al. | β | 2025 | β |
| From Hypothyroidism to Coronary Heart Disease: Unraveling the Lipid Profile Link: A Mendelian Randomization Study. | Li J et al. | β | 2025 | β |
| From Mind to Liver: Exploring the Causal Relationship Between Anxiety Disorders and Non-Alcoholic Fatty Liver Disease Through Mendelian Randomization and UK Biobank Validation. | Song H et al. | β | 2025 | β |
| From trigeminal ganglion to cortex: ATG7 emerges as a key integrator of migraine pathways via multi-omics profiling. | Zhang C et al. | β | 2025 | β |
| Gastroesophageal reflux disease and risk of atrial fibrillation/flutter: Implications for heart failure progression. | Hu W et al. | β | 2025 | β |
| Genetically Elevated Neutrophil Count Is Associated with Poor Outcome Following Ischemic Stroke: A Mendelian Randomization Study. | Wang M et al. | β | 2025 | β |
| Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation. | Guan PL et al. | β | 2025 | β |
| Genetically Predict Diet-derived Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study. | Duan QQ et al. | β | 2025 | β |
| Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study. | Liu C et al. | β | 2025 | β |
| Genetically predicted CD28 on CD4+ CD45RA+ T cells mediate the association between rheumatoid arthritis and blood leukocytes mitochondrial DNA copy number: A mediation Mendelian randomization study. | Song X et al. | β | 2025 | β |
| Genetically predicted effects of COVID-19 on 2272 traits: exploring through a phenome-wide Mendelian randomization study. | Zhou J et al. | β | 2025 | β |
| Genetically Predicted Gut Microbiota and Host Metabolites Mediate the Causal Link Between Dietary Factors and Acute Myeloid Leukemia. | Qin J et al. | β | 2025 | β |
| Genetically predicted immune cell-mediated causal associations between 473 gut microbiome species and neurodevelopmental disorders. | Yang H et al. | β | 2025 | β |
| Genetically predicted immune cell mediate the association between plasma lipidomics and osteomyelitis. | Wu X et al. | β | 2025 | β |
| Genetically predicted immune cells and metabolites mediate the causal relationship between inflammatory factors and rheumatoid arthritis. | Li T et al. | β | 2025 | β |
| Genetically Predicted Sarcopenia Traits and the Risk of Barrett's Esophagus. | Zhou J et al. | β | 2025 | β |
| Genetically Predicted Serum 25-Hydroxyvitamin D Concentrations in Related to Type 2 Diabetes Mellitus: A Mendelian Randomization Study. | Yang J | β | 2025 | β |
| Genetically predicted the causal relationship between blood metal levels and ischemic stroke risk based on Asian ethnicity. | Jing Z et al. | β | 2025 | β |
| Genetically predicted the causal relationship between gut-brain axis and chronic pain: a Mendelian randomization study. | Shi S et al. | β | 2025 | β |
| Genetically proxied blood pressure, vascular brain injury, and Alzheimer's disease pathology. | Daghlas I et al. | β | 2025 | β |
| Genetically proxied glucagon-like peptide-1 receptor agonist is associated with risk of tubulo-interstitial nephritis: A network Mendelian randomization study. | Xu XC et al. | β | 2025 | β |
| Genetic analysis the causal associations between metal elements and thyroid cancer: a bidirectional Mendelian randomization. | Yan S et al. | β | 2025 | β |
| Genetic and Multi-Omics Insights Into Monocyte Pantothenate-Mediated Protection in Acute Respiratory Distress Syndrome. | Wang Y et al. | β | 2025 | β |
| Genetic and transcriptional insights reveal hepatitis C virus as a driver of kidney cancer. | Wang Q et al. | β | 2025 | β |
| Genetic association analysis between LDL-c lowering drugs and portal hypertension using Mendelian randomization analysis. | Xiao QA et al. | β | 2025 | β |
| Genetic association of lipid-lowering drug target genes with cholecystitis: A summary-data-based Mendelian randomization analysis. | Zhao K et al. | β | 2025 | β |
| Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Atopic Dermatitis: A Drug Target Mendelian Randomization Study. | Luo M et al. | β | 2025 | β |
| Genetic Associations of Clonal Hematopoiesis With Cardioembolic Stroke: Insights From Genome-Wide Mendelian Randomization, Bulk RNA, Single-Cell RNA Sequencing. | Tan H et al. | β | 2025 | β |
| Genetic associations of plasma proteomics with dementia subtypes and neuroimaging markers. | Salih AM et al. | β | 2025 | β |
| Genetic correlation and causation of craniofacial microsomia with 33 diseases in Asian populations: insights from large-scale genome-wide cross-trait analysis. | Luo P et al. | β | 2025 | β |
| Genetic Determinants of Leukocyte Count in Nonsyndromic Cleft Lip With or Without Cleft Palate Among Asians. | Xing C et al. | β | 2025 | β |
| Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis. | Tchuisseu-Kwangoua LA et al. | β | 2025 | β |
| Genetic Downregulation of Interleukin-6 Signaling, Coagulation Function, and Risk of Thromboembolic Disease. | Daghlas I et al. | β | 2025 | β |
| Genetic evidence for a causal relationship between 179 lipid species and cognitive function and alzheimer's disease: a bidirectional Mendelian randomization study. | Sun Y et al. | β | 2025 | β |
| Genetic evidence for causal effects of inflammatory protein factors on breast cancer. | Liu X et al. | β | 2025 | β |
| Genetic evidence for causal links between type 1 diabetes and autoimmune liver diseases. | Liang C et al. | β | 2025 | β |
| Genetic Evidence for Causal Relationships Between Circulating Cathepsin Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study. | Duan C et al. | β | 2025 | β |
| Genetic evidence for causal relationships between vegetarian biomarkers and esophageal cancer risk. | Liu X et al. | β | 2025 | β |
| Genetic evidence for repurposing GLP-1 receptor agonists in chronic kidney disease and IgA nephropathy: Metabolic and anti-inflammatory pathways beyond glycaemic control. | Yang X et al. | β | 2025 | β |
| Genetic Evidence Linking Lactylation-Related Gene Expression To Dementia Risk. | Zhang H et al. | β | 2025 | β |
| Genetic Evidence Linking Lipoprotein(a) to Cardiovascular Disease and the Potential Role of Aspirin: A Mendelian Randomization Study. | Tan J et al. | β | 2025 | β |
| Genetic evidence of association between family factors and the risk of stroke: A 2-sample Mendelian randomization analysis. | Wang B et al. | β | 2025 | β |
| Genetic evidence supports primary biliary cholangitis as a risk factor for lacunar stroke. | Wang M et al. | β | 2025 | β |
| Genetic imputation of transcriptome and proteome illuminates novel therapeutic targets of cutaneous melanoma. | Xu Y et al. | β | 2025 | β |
| Genetic Insights Into Skin Diseases and Depression: Evidence From East Asian Mendelian Randomization Analysis. | Lin S et al. | β | 2025 | β |
| Genetic insights into the interaction between chronic hepatitis B virus infection and metabolic syndrome. | Zou J et al. | β | 2025 | β |
| Genetic insights into the mediating role of cardiac function in hypertension-induced brain cortical changes: a Mendelian randomization study with cardiac magnetic resonance imaging. | Wen J et al. | β | 2025 | β |
| Genetic insights into visceral obesity with health conditions, from disease susceptibility to therapeutic intervention. | Zhang G et al. | β | 2025 | β |
| Genetic liability to atrial fibrillation, aortic valve disease, and mitral valve disease: a two-sample Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| Genetic Liability to Bone Mineral Density and Functional Outcome After Ischemic Stroke. | Fan D et al. | β | 2025 | β |
| Genetic liability to depression and cerebral small vessel disease: A mendelian randomization study. | Wang M et al. | β | 2025 | β |
| Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis. | Zhang M et al. | β | 2025 | β |
| Genetic prediction of the effect of gut microbiota on retinal vein occlusion via blood metabolites. | Xie X et al. | β | 2025 | β |
| Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study. | Wang Z et al. | β | 2025 | β |
| Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk. | Emanuelsson F et al. | β | 2025 | β |
| Genetic Variants Specific to Critical COVID-19: Insights From Genome-Wide Association Studies and Structural Analysis. | Chen H et al. | β | 2025 | β |
| Genome- and Exome-Wide Identification of Common-to-Rare Variants Associated with Middle Ear Cholesteatoma. | Qiu K et al. | β | 2025 | β |
| Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression. | Shorter JR et al. | β | 2025 | β |
| Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants. | FΓΆrster F et al. | β | 2025 | β |
| Genome-Wide Association Studies Data and Transcriptomics Data Link Herpes Simplex Virus 1 Infection and Parkinson's Disease. | Lu C et al. | β | 2025 | β |
| Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density. | Lei B et al. | β | 2025 | β |
| Genome-wide lipidomic profiling reveals causal lipid species as targets for inguinal hernia risk. | Xu X et al. | β | 2025 | β |
| Getting to GRIPS with MR-Egger: Modelling directional pleiotropy independently of allele coding. | Dudbridge F et al. | β | 2025 | β |
| Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study. | Wang X et al. | β | 2025 | β |
| Glutamine and allergic rhinitis: A bidirectional two-sample Mendelian randomization study. | Fan S et al. | β | 2025 | β |
| Glutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels. | Liu X et al. | β | 2025 | β |
| Gut microbiome and diabetic kidney disease: Insights from Mendelian randomization and genetic correlations. | Yang K et al. | β | 2025 | β |
| Gut microbiome and peritoneal inflammation: a new perspective on peritoneal dialysis-associated peritonitis. | Xu P et al. | β | 2025 | β |
| Gut microbiota and breast cancer risk: a Mendelian randomization study stratified by ER status. | Yue J et al. | β | 2025 | β |
| Gut microbiota and insomnia: Mendelian randomization and network pharmacology to predict potential intervention with traditional Chinese medicine. | Wang X et al. | β | 2025 | β |
| Gut microbiota and perianal abscess and anal fistula: A bidirectional Mendelian randomization study. | He RC et al. | β | 2025 | β |
| Gut microbiota as a causal mediator linking inflammatory cytokines and ageing phenotypes. | Liu Q et al. | β | 2025 | β |
| Gut microbiota-mediated targeting of EHMT2 in individuals of European ancestry: A novel therapeutic approach for Alzheimer's disease. | Yan Y et al. | β | 2025 | β |
| Gut microbiota mediates the relationship between smoking and fall risk: A 2-step Mendelian randomization study. | Zhang J et al. | β | 2025 | β |
| Gut microbiota, plasma metabolites, and venous thromboembolism: a Mendelian randomization study. | Cheng PF et al. | β | 2025 | β |
| GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology. | Luben RN et al. | β | 2025 | β |
| Helicobacter pylori Infection and Eradication in Relation to Gastroesophageal Reflux Disease. | Wang H et al. | β | 2025 | β |
| Helicobacter Pylori Infection is Not Causally Associated with Colorectal Cancer: A Two-Sample Mendelian Randomization Study. | Wang S et al. | β | 2025 | β |
| Higher levels of plasma phosphatidylcholine (17:0_18:1) raise the risk of developing Parkinson's disease. | Su D et al. | β | 2025 | β |
| High humidity environment increases FBG by impairing the intestinal barrier. | Wang Y et al. | β | 2025 | β |
| Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells. | Huang J et al. | β | 2025 | β |
| Human herpes virus infection and vestibular neuritis: A Mendelian randomization study. | Luo L et al. | β | 2025 | β |
| Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases. | Bhak Y et al. | β | 2025 | β |
| Identification and Validation of Novel Lipids Linked to Bone Mineral Density Change and Fracture Risk. | Ma C et al. | β | 2025 | β |
| Identification of Biomarkers for Oxidative Stress in Age-Related Macular Degeneration: Combining Transcriptomics and Mendelian Randomization Analysis. | Chen W et al. | β | 2025 | β |
| Identification of cancer-associated fibroblast signature genes for potential biomarkers in cholangiocarcinoma: a Mendelian randomization study. | Hu S et al. | β | 2025 | β |
| Identification of Cathepsin H and Metabolic Traits as Potential Biomarkers for Lung Cancer by Mendelian Randomization and Single-Cell Transcriptomics. | Song C et al. | β | 2025 | β |
| Identification of exosome-related genes in Alzheimer's disease: Evidence from transcriptomic and Mendelian randomization analyses. | Jiang X et al. | β | 2025 | β |
| Identification of hub genes involved in the pathogenesis of diabetic nephropathy: A multi-omics study integrating machine learning, mendelian randomization and mediation analysis. | Li K et al. | β | 2025 | β |
| Identification of <i>TMEM106B</i> as a Shared Potential Drug Target for Depression and Stroke Through Comprehensive Genetic Analyses. | Zhang W et al. | β | 2025 | β |
| Identification of Novel Biomarkers and Potential Therapeutic Targets for Systemic Sclerosis: An Integrated Analysis of Plasma Proteome-Wide Mendelian Randomization and Transcriptome. | Li H et al. | β | 2025 | β |
| Identification of novel therapeutic targets for cognitive performance and associations with brain health. | Zhang LY et al. | β | 2025 | β |
| Identification of potential bladder cancer drug targets through Mendelian randomization and molecular docking. | Bi C et al. | β | 2025 | β |
| Identification of potential therapeutic targets for problematic alcohol use using multi-omics data. | Lee DJ et al. | β | 2025 | β |
| Identification of prognostic genes associated with mitochondria and macrophage polarization in prostate adenocarcinoma based on transcriptome and Mendelian randomization analysis. | Heng L et al. | β | 2025 | β |
| Identification of protein targets for dyslipidaemia and cardiovascular diseases among people with South Asian ancestry: a mendelian randomisation study. | Wu S et al. | β | 2025 | β |
| Identification of SARS2, PKN1, and IL11RA as causally-associated genes for patients with gastric cancer via immune cell activity: A multi-omics Mendelian randomization study integrating GWAS, eQTL, and pQTL data. | Tang C et al. | β | 2025 | β |
| Identifying CTSF and GSTM3 as chemoresistance therapeutic targets in breast cancer through multi-omics MR analysis. | Liu R et al. | β | 2025 | β |
| Identifying diagnostic biomarkers for glaucoma based on transcriptome combined with Mendelian randomization. | Lin X et al. | β | 2025 | β |
| Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease. | Zhang Z et al. | β | 2025 | β |
| Identifying novel risk targets in inflammatory skin diseases by comprehensive proteome-wide Mendelian randomization study. | Li Y et al. | β | 2025 | β |
| Identifying therapeutic targets for erectile dysfunction in the European population using genome-wide Mendelian randomization. | Guo P et al. | β | 2025 | β |
| IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk. | Zhang L et al. | β | 2025 | β |
| Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer's disease. | Li J et al. | β | 2025 | β |
| Immune cells and the risk of acne vulgaris: A Mendelian randomization study. | Yang X et al. | β | 2025 | β |
| Immune cells, inflammatory proteins, and sepsis: A mediation Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| Immune Inflammation at the Crossroads of Atherosclerosis and Ischemic Stroke: Mechanisms, Trends, and Translational Perspectives. | Hao H et al. | β | 2025 | β |
| Immune-mediated bone loss: A Mendelian randomization and NHANES-based study of viral infections and osteoporosis. | Xiong L et al. | β | 2025 | β |
| Immune-metabolic perspective on the association of seven psychiatric disorders and five common auditory diseases: a bidirectional two-sample Mendelian randomization study and mediation analysis. | Yang J et al. | β | 2025 | β |
| Impact of birth weight on cardiovascular disease and mediating role of metabolic traits: a Mendelian randomisation study. | Zhuang J et al. | β | 2025 | β |
| Impact of Immune Cells on IgA Vasculitis via Metabolites and Inflammatory Cytokines. | Xie M et al. | β | 2025 | β |
| Impact of mild cortisol excess on osteoporosis and the mediating role of sarcopenia-related traits: A Mendelian randomization study. | Zhu J et al. | β | 2025 | β |
| Implications of childhood subcortical volumes on psychiatric disorders: A mendelian randomization study. | Ran Q et al. | β | 2025 | β |
| Independent Effects of Hypothyroidism and Obesity on Endometrial Cancer Risk Revealed by Mendelian Randomisation. | Glubb DM et al. | β | 2025 | β |
| Inferring multi-organ genetic connections using imaging and clinical data through Mendelian randomization. | Shu J et al. | β | 2025 | β |
| Inflammation-metabolite crosstalk in multiple sclerosis: A mediation Mendelian randomization study of plasma inflammatory proteins, iron, and serum/cerebrospinal fluid metabolites. | Yan W et al. | β | 2025 | β |
| Inflammatory cytokines, metabolites, and pre-eclampsia: a two-sample Mendelian randomization study. | Liang Y et al. | β | 2025 | β |
| Inflammatory index-based nomogram for risk stratification of erectile dysfunction: a cross-sectional study with dual-cohort validation and mendelian randomization analysis. | Shi Z et al. | β | 2025 | β |
| Insights into the impact of neuropsychiatric disorders on prostate diseases: A 2-sample Mendelian randomization study. | Xie H et al. | β | 2025 | β |
| Integrated genetic and epigenetic analysis identifies that rs939408 affects non-smoking lung adenocarcinoma risk by modulating the DNA methylation of LRRC2. | Zhang L et al. | β | 2025 | β |
| Integrated machine learning and causal inference reveal CHRDL1 as a diagnostic and functional biomarker in NSCLC. | Shen C et al. | β | 2025 | β |
| Integrating Genetic and Single-Cell Genomic Data to Reveal Brain Cell-Specific Regulation of Attention-Deficit/Hyperactivity Disorder Risk in the Prefrontal Cortex. | Gui J et al. | β | 2025 | β |
| Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia. | Fu W et al. | β | 2025 | β |
| Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart disease. | de Ruiter SC et al. | β | 2025 | β |
| Integrating multi-omics to reveal the causal effect of gut microbiota on post-traumatic stress disorder and potential drug target analysis. | Huang H et al. | β | 2025 | β |
| Integrating plasma proteomics and genome-wide association data to identify therapeutic targets for retinal neurodegenerative diseases in Europeans. | Guo YJ et al. | β | 2025 | β |
| Integration of summary data from GWAS and eQTLs studies predicts causality of S1PR1 and breast cancer. | Shi H et al. | β | 2025 | β |
| Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics. | Feng S et al. | β | 2025 | β |
| Integrative GEO and Mendelian randomization analysis reveals transcriptomic and lipidomic features of esophageal adenocarcinoma. | Wang Y et al. | β | 2025 | β |
| Integrative machine learning and Mendelian randomization identify causal laboratory biomarkers for coronary artery lesions in Kawasaki disease: a prospective study. | Yang H et al. | β | 2025 | β |
| Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics. | Xu K et al. | β | 2025 | β |
| Integrative multi-omics and Mendelian randomization identify WWOX and THBS2 as potential therapeutic targets in mature T/NK-cell lymphoma. | Qin Y et al. | β | 2025 | β |
| Integrative multi-omics and single-cell transcriptomics reveal ARHGEF12 driving chemoresistance in bladder cancer. | Zhu K et al. | β | 2025 | β |
| Interaction between sleep disorder and depression on early onset hypertension: a machine learning modelling approach. | Liu F et al. | β | 2025 | β |
| Investigating bidirectional causality between prostate cancer and inflammatory factors: A 2-sample Mendelian randomization analysis. | Wang J et al. | β | 2025 | β |
| Investigating bidirectional causal relationships between gut microbiota and insomnia. | Shi S et al. | β | 2025 | β |
| Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs. | Shakeshaft A et al. | β | 2025 | β |
| Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization andΒ transcriptomic analysis. | Wang Y et al. | β | 2025 | β |
| Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases. | Sun F et al. | β | 2025 | β |
| Investigating the causal relationship between multimodal brain imaging-derived phenotypes and insomnia: A Mendelian randomization study. | Gu H et al. | β | 2025 | β |
| Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis. | Zhu H et al. | β | 2025 | β |
| Investigating the contribution of circulating inflammatory cytokines on the link between obesity and COVID-19. | Khamis ZJ et al. | β | 2025 | β |
| Investigating the genetic causality between periodontitis and intracranial aneurysms: A 2-sample Mendelian randomization study. | Chen Y et al. | β | 2025 | β |
| Investigating the potential impact of gut microbiota and immune cells on ankylosing spondylitis based on single-cell sequencing and genetic variation analysis. | Xue J et al. | β | 2025 | β |
| Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence. | Bouras E et al. | β | 2025 | β |
| Investigating the role of homocysteine and B vitamins in gestational diabetes mellitus: Mendelian randomization study. | Zhan X et al. | β | 2025 | β |
| Investigating the shared genetic architecture between adiposity measures and obesity-related cancers. | Wang S et al. | β | 2025 | β |
| Investigation of the Causal Association Between Treg Cells and Actinic Keratosis Through Two-Sample Mendelian Randomization Analysis. | Li H et al. | β | 2025 | β |
| Investigation of the causal relationship of saturated fat acids on heart stroke: evidence from two-sample Mendelian randomization. | Habibi D et al. | β | 2025 | β |
| Iron Homeostasis as a Mediator Linking Central Obesity with MASLD and Primary Liver Cancer: A Two-Step Mendelian Randomization Study. | Zeng Y et al. | β | 2025 | β |
| KAZN methylation as a potential diagnostic and prognostic marker in non-small cell lung cancer. | Zhu S et al. | β | 2025 | β |
| Key genes and pathogenesis related to type 2 diabetes and cardiogenic stroke. | Deng Z et al. | β | 2025 | β |
| Key genes associated with the comorbidity of allergic rhinitis and chronic rhinosinusitis with nasal polyps: Identification, experimental validation, and an observational study using transcriptomic profiling and Mendelian randomization analysis in humans. | Hu X et al. | β | 2025 | β |
| Kidney stone disease increases the risk of cardiovascular events. | Chen Y et al. | β | 2025 | β |
| L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validation. | Wang H et al. | β | 2025 | β |
| Lack of evidence for obesity paradox in patients with cardiovascular disease: A UK BioBank cohort study. | Yu W et al. | β | 2025 | β |
| Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation. | Zhu Z et al. | β | 2025 | β |
| Length of mobile phone use mediating the effect of major depression on low back pain/sciatica: a mendelian randomization study. | Liu W et al. | β | 2025 | β |
| Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing. | Balbona JV et al. | β | 2025 | β |
| Lipid-lowering drug targets influence inflammatory bowel disease through gut microbiota and inflammatory cytokines. | Huang X et al. | β | 2025 | β |
| Lipids, Lipid-Lowering Drug Target Genes, and COPD Risk: A Mendelian Randomization Study. | Jia G et al. | β | 2025 | β |
| Local Genetic Correlations and Pleiotropy Reveal Shared Genetic Architecture Between COVID-19 Phenotypes and Prostate Cancer in European Populations. | Xiang R et al. | β | 2025 | β |
| Longitudinal study reveals plasma glycans associations with prediabetes/type 2 diabetes in KORA study. | Niu J et al. | β | 2025 | β |
| Lung cancer and COVID-19 susceptibility and severity: a Mendelian randomization analysis. | Bai M et al. | β | 2025 | β |
| Luteolin attenuates inflammation and apoptosis in LPS-induced ALI mice by activating the HGF/c-Met pathway. | Bi J et al. | β | 2025 | β |
| Male infertility and the risk of developing prostate cancer: a bidirectional two-sample Mendelian randomization study. | Shao J et al. | β | 2025 | β |
| M-CSF Protects Against Ulcerative Colitis via Aconitate: Mendelian Randomization and Experimental Evidence. | Zhang Y et al. | β | 2025 | β |
| Measurement Error and Power in Family-Based Extensions to Mendelian Randomization. | Castro-de-Araujo LFS et al. | β | 2025 | β |
| Mediators linking gut microbiota and sporadic Creutzfeldt-Jakob disease: a Mendelian randomization study. | Shao J et al. | β | 2025 | β |
| Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk. | Yates T et al. | β | 2025 | β |
| Mendelian randomization analyses explore the causal relationship between fibroblast growth factor receptors and hypertrophic scar. | Ma HF et al. | β | 2025 | β |
| Mendelian Randomization Analyses Reveal the Causal Effect of Cathepsin Z on the Risk of Different Subtypes of Thyroid Cancer. | Sun SK et al. | β | 2025 | β |
| Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain. | Xie XY et al. | β | 2025 | β |
| Mendelian Randomization Analyses Support Causal Relationships Between Psychiatric Disorders and Risk of Urinary Tract Infections. | Ke M et al. | β | 2025 | β |
| Mendelian randomization analysis of C-reactive protein on septic arthritis risk. | Lei H et al. | β | 2025 | β |
| Mendelian randomization analysis of lipidomic profiles and thyroid cancer risk in European populations. | Li S et al. | β | 2025 | β |
| Mendelian randomization analysis of lipids traits and lipid-lowering drug-targets in relation to cognitive status. | Fu J et al. | β | 2025 | β |
| Mendelian randomization analysis of the causal relationship between COPD and type 1 and type 2 diabetes mellitus. | Wu Y et al. | β | 2025 | β |
| Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer's Disease. | Huang DH et al. | β | 2025 | β |
| Mendelian randomization analysis unveiling the genetic connection: How psychiatric disorders heighten cancer risk. | Wang J et al. | β | 2025 | β |
| Mendelian randomization and AlphaFold3 analysis suggest putative causal plasma proteins in graves' disease. | Deng B et al. | β | 2025 | β |
| Mendelian randomization and bioinformatics analysis identify the association between plasma proteins and cataract. | Han X et al. | β | 2025 | β |
| Mendelian randomization and genetic analyses reveal causal roles of immune cells and inflammatory proteins in keratoconus. | Chen J et al. | β | 2025 | β |
| Mendelian randomization and mediation analysis reveal the role of immune cells in the pathways between inflammatory factors and glioblastoma. | Xu R et al. | β | 2025 | β |
| Mendelian randomization and nomogram-based prediction of hepatocellular carcinoma risk in patients with hepatitis B cirrhosis. | Zheng X et al. | β | 2025 | β |
| Mendelian Randomization and Transcriptome Analyses Reveal Important Roles for CEBPB and CX3CR1 in Osteoarthritis. | Gao H et al. | β | 2025 | β |
| Mendelian randomization and transcriptomic data analysis reveals the causal association between gout and breast cancer. | Zhang H et al. | β | 2025 | β |
| Mendelian randomization combined with single-cell sequencing analysis revealed prognostic genes related to myeloid cell differentiation in prostate cancer and experimental verification. | Chen J et al. | β | 2025 | β |
| Mendelian Randomization Evidence for Relationship and Mediation of Educational Attainment on Chronic Obstructive Pulmonary Disease. | Yang X et al. | β | 2025 | β |
| Mendelian Randomization Identifies CD25+ CD4+ Tregs and Plasma Proteins in Androgenetic Alopecia Pathogenesis. | Du Y et al. | β | 2025 | β |
| Mendelian Randomization Identifies IL-4, IL-6, CCL19, and DNER as Potential Causal Inflammatory Proteins in Allergic Rhinitis: Evidence Partially Supported by Transcriptomics and Protein Interaction Analysis. | Quan S et al. | β | 2025 | β |
| Mendelian randomization, lipids, and coronary artery disease: trade-offs between study designs and assumptions. | Shi J et al. | β | 2025 | β |
| Mendelian randomization of autoimmune hepatitis and cardiovascular diseases. | Tang F et al. | β | 2025 | β |
| Mendelian Randomization Reveals Unidirectional Links Between Amyloid-Ξ² and Tau in Alzheimer's Disease. | Kim JP et al. | β | 2025 | β |
| Mendelian randomization studies of gastric cancer reveal potential risk factors, promising biomarkers and therapeutic targets. | He M et al. | β | 2025 | β |
| Mendelian randomization study explores the peripheral immunological characteristics of colorectal cancer. | Yuan C et al. | β | 2025 | β |
| Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity. | Villaplana-Velasco A et al. | β | 2025 | β |
| Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function. | Guo Y | β | 2025 | β |
| Mendelian Randomization Study of Sex Hormone Binding Globulin and Its Influence on Adverse Pregnancy Outcomes. | Wu H et al. | β | 2025 | β |
| Mendelian randomization study of the causal relationship between autoimmune diseases and anemia using proteomic and genetic data. | Zhuang X et al. | β | 2025 | β |
| Mendelian randomization study reveals causal association between skin microbiome and skin cancers. | He Y et al. | β | 2025 | β |
| Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis. | Zuo GS et al. | β | 2025 | β |
| Mendelian randomization study: The association between pain, analgesics, and frailty. | Wu Z | β | 2025 | β |
| Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases. | Daria T et al. | β | 2025 | β |
| Mendelian randomization suggests a causal relationship between cerebrospinal fluid metabolites and intracranial aneurysms. | Yuan H et al. | β | 2025 | β |
| Mendelian randomization underscores the importance of clinical nursing in mitigating anxiety and panic attack risks among low-educated populations. | Li H et al. | β | 2025 | β |
| Metabolic biomarkers mediate allergic rhinitis via circulating inflammatory proteins: Evidence from a Mendelian randomization study. | Cao X et al. | β | 2025 | β |
| Metabolic signatures for gastric cancer diagnosis and mechanistic insights: a multicenter study. | Zhu J et al. | β | 2025 | β |
| Metabolome-Wide Mendelian Randomization Identifies Maleate as a Mediator of the Effect of Obesity on the Risk of Small Cell Lung Cancer. | Li K et al. | β | 2025 | β |
| Metformin reduces the risk of frailty: evidence from a Mendelian randomization study. | Chen T et al. | β | 2025 | β |
| Mitochondrial DNA copy number as a genetic determinant of renal function: insights from bidirectional Mendelian randomization. | Wang S et al. | β | 2025 | β |
| Mitochondrial proteins contribute to the pathogenesis of myasthenia gravis. | Cao F et al. | β | 2025 | β |
| Mobile phone usage duration and male fertility: A two-sample Mendelian randomization analysis. | Xiang Y et al. | β | 2025 | β |
| Molecular characterization and functional prioritization of CD46, IL6R, KLRC1, LEAP2 and SMOX as candidate targets in acute kidney injury. | Liu J et al. | β | 2025 | β |
| MR analysis reveals no causal association between mitochondrial DNA copy number and osteoporosis. | Xiao M et al. | β | 2025 | β |
| MR-EILLS: an invariance-based Mendelian randomization method integrating multiple heterogeneous GWAS summary datasets. | Hou L et al. | β | 2025 | β |
| MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality. | van der Graaf A et al. | β | 2025 | β |
| Multidimensional Analysis of Frailty and Its Influencing Factors in Hospitalized Elderly Stroke Patients. | Zhou H et al. | β | 2025 | β |
| Multi-Omics Analyses Reveal Relationships Between Gut Microbiota and Frailty. | Hou X et al. | β | 2025 | β |
| Multi-Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of NAFLD. | Fu Q et al. | β | 2025 | β |
| Multi-omics analysis reveals the prognostic value and immunomodulatory role of CTSW in breast cancer. | Liu X et al. | β | 2025 | β |
| Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy. | Song X et al. | β | 2025 | β |
| Multi-omics integration reveals Chr1 associated QTL mediating backfat thickness in pigs. | Yu N et al. | β | 2025 | β |
| Multi-Omics Mendelian Randomization Identifies Therapeutic Targets for SjΓΆgren's Disease with Clinical and Bayesian Validation. | He J et al. | β | 2025 | β |
| Multi-omic underpinnings of heterogeneous aging across multiple organ systems. | Xiong J et al. | β | 2025 | β |
| Multi-Target Synergy Against Acute Lung Injury: Systems Pharmacology Decoding Dahuang-Huangqin Herb Pair's Therapeutic Mechanism. | Zhang J et al. | β | 2025 | β |
| Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health. | Ye C et al. | β | 2025 | β |
| Natural active ingredients targeted inflammatory cytokines and major blinding eye diseases: a two-sample Mendelian randomization and molecular docking analysis. | Shao Y et al. | β | 2025 | β |
| Neuroticism, omega-3 fatty acids, and risk of incident dementia. | Gao Y et al. | β | 2025 | β |
| New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein. | Hong Y et al. | β | 2025 | β |
| No causal links between estradiol and female's brain and mental health using Mendelian randomization. | Oppenheimer H et al. | β | 2025 | β |
| No Evidence for a Causal Association Between Depression and Herpes Zoster or Post-Herpetic Neuralgia: A Mendelian Randomization Study. | Zhang X et al. | β | 2025 | β |
| Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index. | Park K et al. | β | 2025 | β |
| Novel Insights Into the Causal Association Between Dietary Factors and Risk of Urinary Calculus: A Multivariate and Two-Step Mendelian Randomization Analysis. | Tang X et al. | β | 2025 | β |
| Novel insights into the relationship between glaucoma and brain diseases from the genetic to diseases levels: A cross-sectional study. | Chen X et al. | β | 2025 | β |
| Obesity impact on leukocyte telomere shortening and immune aging assessed by Mendelian randomization and transcriptomics analysis. | Feng Z et al. | β | 2025 | β |
| Observational and Genetic Evidence Reveals the Effect of Serum Lipid Levels on COPD Risk. | Jia G et al. | β | 2025 | β |
| Omics-driven strategy develops a tumor biomarker-derived signature to forecast the occurrence and progression of heart failure. | Zhu Y et al. | β | 2025 | β |
| Oncostatin M mediates the causal relationship between obesity and chronic kidney disease: evidence from Mendelian randomization and experimental validation. | Zhang X et al. | β | 2025 | β |
| One-carbon metabolism and risk of PCOS: insights from Mendelian randomization. | Zhao Y et al. | β | 2025 | β |
| Outlier Detection in Mendelian Randomization. | Mandl MM et al. | β | 2025 | β |
| Personal history of irradiation and risk of osteomyelitis: A Mendelian randomization study. | Yun X et al. | β | 2025 | β |
| Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study. | Chalitsios CV et al. | β | 2025 | β |
| Physical activity lowers hypertension risk: A 2-sample Mendelian randomization study. | Zhang C et al. | β | 2025 | β |
| Placental Gene Expression Associated With Early Childhood Growth Trajectories and Obesity Risk. | Choi HY et al. | β | 2025 | β |
| Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization analysis. | Xu YP et al. | β | 2025 | β |
| Plasma glial fibrillary acidic protein and neurological diseases: A bidirectional Mendelian randomization study. | Jiang D et al. | β | 2025 | β |
| Plasma metabolic landscape unveils key regulators of leukemia subtype progression. | Liang C et al. | β | 2025 | β |
| Plasma metabolites mediate the effects of circulating immune cell phenotypes on prostate cancer: A 2-step Mendelian randomization study. | Zhou W et al. | β | 2025 | β |
| Plasma proteins and onset of atherosclerosis: integrating human plasma proteogenomics, transcriptomics and in vivo evidence. | Chen K et al. | β | 2025 | β |
| Polyunsaturated Fatty Acids and Skin Cancer: Two-Sample Mendelian Randomization Study. | Kim G et al. | β | 2025 | β |
| Potential causal effect of SLE on osteoporosis, and the mediation effect: a Mendelian randomisation study. | Wang Z et al. | β | 2025 | β |
| Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis. | Chen L et al. | β | 2025 | β |
| Potential Risk of Cutaneous Melanoma Attributable to Medication Use: A Mendelian Randomization Approach. | Wan H et al. | β | 2025 | β |
| pQTL Mendelian randomization analysis combined with single-cell sequencing to identify biomarkers and drug targets for bladder cancer. | Gao W et al. | β | 2025 | β |
| Prenatal and childhood exposure to mixtures of environmental chemicals and adolescence attentional problems: a triangulation study. | Fabbri L et al. | β | 2025 | β |
| Prognostic model for pediatric brain tumors based on tumor microenvironment-specific gene signatures. | Liu Y et al. | β | 2025 | β |
| Protective Role of High-Density Lipoprotein Cholesterol in Stress Urinary Incontinence with Special Emphasis on Overweight/Obese Individuals. | Huang J et al. | β | 2025 | β |
| Protein markers of ovarian cancer and its subtypes: insights from proteome-wide Mendelian randomisation analysis. | Mulugeta A et al. | β | 2025 | β |
| Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention. | Yarmolinsky J et al. | β | 2025 | β |
| Proteogenomic signature of Alzheimer's disease and related dementia risk in individuals with major depressive disorder. | Diniz BS et al. | β | 2025 | β |
| Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease. | Caro I et al. | β | 2025 | β |
| Proteome-wide and network pharmacology integration identifies sunitinib as a potential therapeutic for type 2 diabetes targets. | Kong Y et al. | β | 2025 | β |
| Proteome-Wide Mendelian Randomisation Study of Adverse Perinatal Outcomes. | Daubney ER et al. | β | 2025 | β |
| Proteome-wide Mendelian randomization identifies drug targets for atrial fibrillation/flutter. | Jia Q et al. | β | 2025 | β |
| Proteome-wide mendelian randomization identifies FCRL3 and LY9 as potential therapeutic targets for lymphoma. | Guo Q et al. | β | 2025 | β |
| Proteome-wide Mendelian randomization identifies Ξ²-nerve growth factor as a target for endometriosis. | Gao C et al. | β | 2025 | β |
| Proteome-wide mendelian randomization reveals circulating proteins causally associated with childhood body mass index. | Avocegamou R et al. | β | 2025 | β |
| Proteomic insights into chronic pancreatitis: Proteome-wide mendelian randomization to identify potential therapeutic targets. | Li Q et al. | β | 2025 | β |
| Proteomic landscape of multidimensional aging phenotypes. | Cao Z et al. | β | 2025 | β |
| Proteomic ratio reveals subtype-specific genetic mechanisms and therapeutic targets in osteoarthritis. | Wang Y et al. | β | 2025 | β |
| Proton pump inhibitors and the risk of urolithiasis: A Mendelian randomization study. | Guo J et al. | β | 2025 | β |
| Real-world data and Mendelian randomization analysis in assessing adverse reactions of rilonacept. | Liu L et al. | β | 2025 | β |
| Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study. | Morales Berstein F et al. | β | 2025 | β |
| Reassessing the relationship between major depressive disorder and blood lipids: a comprehensive Mendelian randomisation study. | Sun G et al. | β | 2025 | β |
| [Reduced intestinal abundance of <i>Gordonibacter</i> increases risk of kidney stones: a Mendelian randomization study and evidence from rat models]. | Pan X et al. | β | 2025 | β |
| Reevaluating the standard: A bidirectional Mendelian randomization study of autoimmune thyroiditis and thyroid function. | Sun X et al. | β | 2025 | β |
| Relationship between metabolic syndrome and overactive bladder: insights from the NHANES and Mendelian randomization study. | Liu Z et al. | β | 2025 | β |
| Repurposing piroxicam as an SLC7A5 antagonist to ameliorate prothrombotic state in Diane-35-treated polycystic ovary syndrome patients. | Jiang S et al. | β | 2025 | β |
| Revealing the causal association among clonal hematopoiesis (CH), stroke and circulating inflammatory factors: A Mendelian randomization study. | Yu H et al. | β | 2025 | β |
| Revealing the causal relationship between cathepsin and inflammatory disease of wrist through Mendelian randomization. | Qu Y et al. | β | 2025 | β |
| Revealing the genetic architectures underlying organ-specific aging based on proteomic data. | Zhu RJ et al. | β | 2025 | β |
| Risk-based screening and prognostic analysis for second primary malignancies in kidney cancer patients: a retrospective cohort study based on large-scale population and Mendelian randomization analysis. | Zou M et al. | β | 2025 | β |
| Risk factors for sacrococcygeal pilonidal sinus: a systematic review and meta-analysis supplemented by genetic causal assessment. | Xu X et al. | β | 2025 | β |
| RMR-ICP: robust Mendelian randomization method accounting for idiosyncratic and correlated pleiotropy with applications to stroke outcomes. | Cheng Q et al. | β | 2025 | β |
| Role of Dendritic Cells in Mediating the Effect of Growth Differentiation Factor 15 on Nonalcoholic Fatty Liver Disease: Insights From Causal Inference and Single-Cell Profiling. | Yao T et al. | β | 2025 | β |
| Role of ferroptosis-related IREB2 in the shared genetic etiology between smoking and facial aging: Insights from large-scale genome-wide cross-trait analysis. | Cai X et al. | β | 2025 | β |
| Role of Lung Function, Chronic Obstructive Pulmonary Disease on Hearing Impairment: Evidence for Causal Effects and Clinical Implications. | Yuan L et al. | β | 2025 | β |
| Roles of Gut Microbiota and Associated Metabolites in <i>Clostridioides difficile</i> Infection. | Gao Y et al. | β | 2025 | β |
| Sarcopenia and cognitive impairment: a multidimensional study of clinical associations, shared genetics, and causal links. | Zhang K et al. | β | 2025 | β |
| Sedentary lifestyle, physical activity, and aging: evidence from genetic correlation and mendelian randomization. | Jiang C et al. | β | 2025 | β |
| Serum iron levels as a risk factor for Osteoporosis-Related pathological fractures. | Lin S et al. | β | 2025 | β |
| Serum urate and pancreatitis: A bidirectional Mendelian randomization study. | Li Y et al. | β | 2025 | β |
| Serum Vitamin D Levels Over Time and the Incidence of Atrial Fibrillation in the HUNT Study. | Jiang L et al. | β | 2025 | β |
| Shared genetic architecture between stroke and blood lipids: a large-scale genome-wide cross-trait analysis. | Bai W et al. | β | 2025 | β |
| sIL-6R impact on aortic aneurysm: Genetic evidence from FinnGen and GWAS. | Wang M et al. | β | 2025 | β |
| SIRT3 mitigates osteoarthritis by suppressing ferroptosis through activating AMPK signaling pathway. | Tian W et al. | β | 2025 | β |
| SjΓΆgren's syndrome is associated with a reduction in the surface area of the right caudal anterior cingulate gyrus. | Wang P et al. | β | 2025 | β |
| Sleep disorders and aging: Mendelian randomization analysis of epigenetic and frailty markers. | Zhang Z et al. | β | 2025 | β |
| Sleep Traits and Risk of Epilepsy: A Bidirectional and Multivariable Two-Sample Mendelian Randomization Study. | Zhu Y et al. | β | 2025 | β |
| Smoking can increase the risk of osteoarthritis in European women. | Mao B et al. | β | 2025 | β |
| Smoking elevating osteoarthritis risk: Insights from genetics, blood DNA methylations and proteome profiles. | Ling D et al. | β | 2025 | β |
| Socioeconomic status, individual behaviors and the risk of aneurysmal subarachnoid hemorrhage: a Mendelian randomization study. | Luo S et al. | β | 2025 | β |
| Species-level enterosignatures predict clinical phenotypes in chronic hepatitis B and causal triangulation of gut-metabolite-CHB interactions. | Yuan T et al. | β | 2025 | β |
| Statins as a risk factor for anaemia: Evidence from genetic and epidemiological data. | Liu Z et al. | β | 2025 | β |
| Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration. | Skrivankova VW et al. | β | 2025 | β |
| Sugar consumption and its role in dental caries: Insights from a 2-sample Mendelian randomization study. | Lim SW et al. | β | 2025 | β |
| Synergistic Effects of Dietary Protein and Vitamin E Intake on Reducing Metabolic-Associated Fatty Liver Disease Risk: Insights From NHANES [2017-2023] and Mendelian Randomization Study. | Wu W et al. | β | 2025 | β |
| Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for calcium pyrophosphate deposition disease. | Zhang RP et al. | β | 2025 | β |
| Systematic Exploration of Potential Druggable Genes for Ischemic Stroke Employing Genome-Wide Mendelian Randomization Analysis. | Zhang P et al. | β | 2025 | β |
| Systematic genetic investigation on relative macronutrient intake, circulating metabolic biomarkers and the risk of autoimmune diseases. | Zheng S et al. | β | 2025 | β |
| Systematic Review of Mendelian Randomization Studies on <i>Helicobacter pylori</i>-Associated Health Outcomes. | Kato I et al. | β | 2025 | β |
| Systemic evaluation of the effects of monomeric GLP-1R-based agonists on MASLD and its complications. | Cai Y et al. | β | 2025 | β |
| Systolic and diastolic blood pressure, abdominal obesity, and alcohol consumption contribute to the risk of hypertrophic and dilated cardiomyopathies in European and East Asian populations. | Zhang W et al. | β | 2025 | β |
| The association between arachidonic acid and gallstone risk: cross-sectional study and Mendelian randomization analysis. | Gao Z et al. | β | 2025 | β |
| The association between diet and bladder cancer risk: a two-sample mendelian randomization. | Dai YN et al. | β | 2025 | β |
| The association between maternal smoking and the risk of kidney diseases in offspring: A Mendelian randomization analysis based on large-scale GWAS. | Kang S et al. | β | 2025 | β |
| The association between sedentary behavior and infertility: a population-based cross-sectional observational studyβand Mendelian randomization analysis. | Wang Y et al. | β | 2025 | β |
| The association between Sjogren's disease and sex hormones: A case-control and Mendelian randomization study. | Zhang J et al. | β | 2025 | β |
| The association between white blood cell count and relative risk of non-small cell lung cancer. | Yang X et al. | β | 2025 | β |
| The Associations of General, Central, Visceral Obesity, and Body Fat Percentage with Cognitive Impairment in the Elderly: Meta-analysis and Mendelian Randomization Study. | Lu D et al. | β | 2025 | β |
| [The causal association between circulating zinc, magnesium, and other minerals with autism spectrum disorder: a Mendelian randomization study]. | Zhu BQ et al. | β | 2025 | β |
| The causal association between insomnia and cognitive decline: A 2-sample, 2-step multivariable Mendelian randomization study. | Wang Z et al. | β | 2025 | β |
| The causal association between liver diseases and vascular dementia: A two-sample Mendelian randomization study. | Zhang X et al. | β | 2025 | β |
| The causal associations of 25(OH)D and its metabolites with oropharyngeal cancer risk: a Mendelian randomization study. | Yu Y et al. | β | 2025 | β |
| The Causal Correlation Between Gastroesophageal Reflux Disease and Chronic Widespread Pain: A Bidirectional Mendelian Randomization Study. | Chen M et al. | β | 2025 | β |
| The Causal Effects Between Circulating Inflammatory Proteins and Osteoarthritis: A Mendelian Randomization and Transcriptomic Analysis. | Lin S et al. | β | 2025 | β |
| The causal links between gut microbiota and both acute and chronic renal failure: A two-sample mendelian randomization study. | Yang W | β | 2025 | β |
| The causal relationship between body mass index and perianal abscess: a Mendelian randomization study. | Wu L et al. | β | 2025 | β |
| The causal relationship between childhood obesity and adult oral health: A 2-sample Mendelian randomization study. | Zhang H et al. | β | 2025 | β |
| The Causal Relationship Between Chronic Pain and Frailty: A Two-Sample Mendelian Randomization Study. | Wang S et al. | β | 2025 | β |
| The causal relationship between circulating inflammatory proteins, gut microbiotas, immune cells and leukemia: a bidirectional Mendelian randomization study. | Zhu L et al. | β | 2025 | β |
| The causal relationship between inflammatory bowel disease and primary biliary cholangitis: A bidirectional two-sample Mendelian randomization study. | Chen Z et al. | β | 2025 | β |
| The causal relationship between obstructive sleep apnea and otitis media: a bidirectional Mendelian randomization study. | Guo R et al. | β | 2025 | β |
| The Causal Relationship Between Palmitoylation Genes and Parkinson's Disease: A Mendelian Randomization Study. | Qiu J et al. | β | 2025 | β |
| The causal relationship between rheumatoid arthritis and the risk of leg ulcers: A mendelian randomization study. | Xiao P et al. | β | 2025 | β |
| The Causal Relationship of Multiple Sclerosis on Serum Uric Acid Levels: A Mendelian Randomization Study. | Kang H et al. | β | 2025 | β |
| The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis. | Zhao L et al. | β | 2025 | β |
| The Causal Role of the Gut Microbiota-Plasma Metabolome Axis in Myeloproliferative Neoplasm Pathogenesis: A Mendelian Randomization and Mediation Analysis. | Kan H et al. | β | 2025 | β |
| The "double-edged sword" effect of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of endometriosis (EMS). | Shi Z et al. | β | 2025 | β |
| The Effect of Epigenetic Age Acceleration on Atopic Dermatitis: A Mendelian Randomization Study. | Xin Y et al. | β | 2025 | β |
| The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities. | Arruda AL et al. | β | 2025 | β |
| The Effects of Different Exercises on Insulin Resistance and Testosterone Changes in Women with Polycystic Ovarian Syndrome: A Network Meta-Analysis Study. | Tan Y et al. | β | 2025 | β |
| The Genetic Association Between Prescription Pain Medication Use and the Risk for Fibromyalgia: A Bidirectional and Multivariable Mendelian Randomization Analysis. | Zhou G et al. | β | 2025 | β |
| The gut microbiome and ovarian cysts: a mendelian randomization study. | Qu J et al. | β | 2025 | β |
| The gut microbiota, circulating metabolites, immune cells, and pancreatitis risk: Evidence from a bidirectional two-sample Mendelian randomization study and mediation analysis. | Zeng YZ et al. | β | 2025 | β |
| The impact of beverage consumption on chronic renal failure risk and the mediation of serum metabolites: based on Mendelian randomization study. | Wei Z et al. | β | 2025 | β |
| The Impact of Childhood Obesity on Adult Dental Caries: A Mendelian Randomization Study. | Kim YW et al. | β | 2025 | β |
| The Impact of the Trajectory of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio on the Incidence of Metabolic Dysfunction-Associated Fatty Liver Disease: Random Forest Anaylsis, Trajectory Anaylsis, and Mendelian Randomization Study. | Zhang W et al. | β | 2025 | β |
| The Inflammatory-Immune Axis in Thyroid Disease: A Mendelian Randomization Study. | Pan T et al. | β | 2025 | β |
| The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia. | Xiang Y et al. | β | 2025 | β |
| The Linkage Among Gut Microbiota, Inflammatory Cytokines, and Immune Cell Dynamics in Osteoporosis: A Mendelian Randomization Study. | Guo Y et al. | β | 2025 | β |
| The mechanisms of kidney-lung interactions in chronic kidney disease-associated pulmonary diseases: A two-sample Mendelian randomization study. | Yang S et al. | β | 2025 | β |
| The mediation of circulating inflammatory proteins in the causal pathway from immune cells to osteoarthritis. | Yuan Y et al. | β | 2025 | β |
| The Negative Feedback of the Glutamine/Prostatitis Loop Identified Among 1400 Metabolites and Prostatitis via Mendelian Randomization. | Wang Y et al. | β | 2025 | β |
| Theoretical Framework and Methodological Approach for Investigating Potential Associations Between Long COVID and Autism Spectrum Disorder Prevalence. | Rudroff T | β | 2025 | β |
| The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese Cohort Data. | Wang J et al. | β | 2025 | β |
| The potential causal relationship between fat mass in different body areas and low back pain: Findings from NHANES and Mendelian randomization studies. | Yang J et al. | β | 2025 | β |
| The ratio of omega-6 fatty acids to omega-3 fatty acids mediating the effect of gastroesophageal reflux disease on pancreatic cancer risk: a two-step mediation Mendelian randomisation study. | Ouyang J et al. | β | 2025 | β |
| The Relationship Between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures. | Hao Y et al. | β | 2025 | β |
| The relationship between insomnia and multiple gastrointestinal disorders: a Mendelian randomization study. | Yu J et al. | β | 2025 | β |
| The relationship between vitamin D levels and depression: a genetically informed study. | Lyu H et al. | β | 2025 | β |
| The Role of Energy Homeostasis in Depression Pathophysiology and Its Heterogeneity. | Pistis G et al. | β | 2025 | β |
| The role of inflammatory cytokines and blood metabolites in osteoporosis: A Mendelian randomization study on pathways and therapeutic targets. | Liu Y et al. | β | 2025 | β |
| The Role of Inflammatory Cytokines in the Causal Pathway From Gut Microbiota to SjΓΆgren's Syndrome: Evidence From Mendelian Randomization. | Zhao J et al. | β | 2025 | β |
| The Role of Mitochondrial DNA Copy Number in Neurodevelopmental Disorders: A Bidirectional Two-Sample Mendelian Randomization Study. | Qiu X et al. | β | 2025 | β |
| The role of phosphatidylinositol (18:1_18:1) in benign prostatic hyperplasia: an integrated study of Mendelian randomization and network pharmacology. | Chen B et al. | β | 2025 | β |
| The role of sleep traits in prostate, endometrial, and epithelial ovarian cancers: An observational and Mendelian randomisation study. | Chalitsios CV et al. | β | 2025 | β |
| The use of statins can reduce the risk of osteoarthritis and osteoporosis. | Zeng X et al. | β | 2025 | β |
| Thyroid disease and breast cancer, benign breast neoplasm: a two-sample Mendelian randomization study. | Wang B et al. | β | 2025 | β |
| Thyroid disorders and pregnancy loss: a bidirectional mendelian randomization exploration. | Chen P et al. | β | 2025 | β |
| Thyroiditis and human blood metabolites: A mendelian randomization study. | Shao L et al. | β | 2025 | β |
| To explore the association between the neutrophil percentage to albumin ratio and low bone mineral density/osteoporosis based on NHANES 2011-2018. | Liu T et al. | β | 2025 | β |
| Toxic effect of carbon monoxide and 41 inflammatory cytokines: A bidirectional 2-sample Mendelian randomization study. | Yang H et al. | β | 2025 | β |
| Treatment outcomes for patients with newly diagnosed or relapsed/refractory TP53-mutated mantle cell lymphoma: a systematic review and meta-analysis. | Zhang N et al. | β | 2025 | β |
| Triangulation evidence for the causal effect of monocytes on pulmonary artery hypertension: a Mendelian randomization study and results from NHANES. | Liu Z et al. | β | 2025 | β |
| Triglyceride glucose index as a causal risk factor for metabolic dysfunction-associated fatty liver disease: evidence from the National Health and Nutrition Examination Survey 2017-2020 and Mendelian randomization. | Su Z et al. | β | 2025 | β |
| Two Birds With One Stone: The Protective Role of the Antidiabetic Drug Sodium-Glucose Cotransporter-2 Inhibitor in Neurodegenerative Diseases. | Zhang L et al. | β | 2025 | β |
| Two-step Mendelian randomization reveals a lipid-driven protective effect of type 2 diabetes on ALS. | Kong M et al. | β | 2025 | β |
| Type 1 diabetes and its complications affect preeclampsia: A Mendelian randomization analysis. | Li Z et al. | β | 2025 | β |
| Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis. | Nurzat Y et al. | β | 2025 | β |
| Uncovering new MicroRNAs linked to acute pancreatitis: zeroing in on the protective effect. | Zhao C et al. | β | 2025 | β |
| Uncovering novel metabolic and inflammatory pathways in gout using Mendelian randomization. | Li Q et al. | β | 2025 | β |
| Understanding the alcohol harm paradox: A multivariable mendelian randomization approach. | Sawyer G et al. | β | 2025 | β |
| Unique association of COVID-19 with increased risk of aplastic anemia among various viruses: insights from a two-sample Mendelian randomization study. | Zou J et al. | β | 2025 | β |
| Unlocking the Secrets: Causal Associations Between Blood Metabolites and Aspergillosis. | Ma Y et al. | β | 2025 | β |
| Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits. | Zeng B et al. | β | 2025 | β |
| Unraveling the causal link between immune cells and temporomandibular disorders: A Mendelian randomization analysis. | Zhang X et al. | β | 2025 | β |
| Unraveling the causal link between lipidomes and unstable angina pectoris: A Mendelian randomization analysis. | Pan W et al. | β | 2025 | β |
| Unraveling the connection between obesity, metabolic syndrome and osteoarthritis risk: a large-observational study. | Wang J et al. | β | 2025 | β |
| Unraveling the Gut-Oral Axis: A Mendelian Randomization Analysis of Gut Microbiota Impact on Periodontitis via Circulating Inflammatory Proteins. | Tang Y et al. | β | 2025 | β |
| Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study. | Zhu H et al. | β | 2025 | β |
| Unraveling the relationship between metabolic syndrome and epigenetic aging: evidence from NHANES 1999-2002 and Mendelian randomization study. | Zhang Y et al. | β | 2025 | β |
| Unraveling the Role of PTGIR in Atrial Fibrillation: Insights From Single-Cell Sequencing and Mendelian Randomization. | Lin Z et al. | β | 2025 | β |
| Unravelling the causal link between gut microbiota and acne risk using a genetic approach. | Cao F et al. | β | 2025 | β |
| Unveiling causal links between serum amino acid levels and risk of hepatobiliary neoplasms by Mendelian randomization study. | Zhai A et al. | β | 2025 | β |
| Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease association proteins: a comprehensive Mendelian randomization study. | Zhou C et al. | β | 2025 | β |
| Unveiling novel potential drug targets for lung cancer through Mendelian randomization analysis. | Huang Y et al. | β | 2025 | β |
| Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective. | Wan P et al. | β | 2025 | β |
| Unveiling the causal relationships between circulating metabolites and intelligence: A bidirectional Mendelian randomization study. | Liu J et al. | β | 2025 | β |
| Unveiling the diagnostic and causal role of hyperlipidemia- and lipophagy-associated genes PLAUR, IVNS1ABP, and QKI in acute myocardial infarction. | Zou JH et al. | β | 2025 | β |
| Unveiling the Relationship Between Oral Microbiota and Alzheimer's Disease: A Genetic Instrumental Variable Analysis via Mendelian Randomization. | Li Z et al. | β | 2025 | β |
| Unveiling the role of angiogenesis-related biomarkers in diabetic nephropathy via transcriptomics. | Zhao S et al. | β | 2025 | β |
| Use of bidirectional Mendelian randomization to unveil the association between antibody-mediated immune responses to infectious agents and allergic rhinitis. | Cao W et al. | β | 2025 | β |
| Utilising genomic association data for causal inference in anorexia nervosa. | Adams DM et al. | β | 2025 | β |
| Visceral obesity, partly mediated by a reduction in HDL-C, increases the risk of asthma: Insights from NHANES and Mendelian randomization studies. | Chen L et al. | β | 2025 | β |
| Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis. | Huang L et al. | β | 2025 | β |
| What comes first: Heart rate variability changes or insomnia? A causal investigation using Mendelian randomization. | Yan B et al. | β | 2025 | β |
| Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders. | Xu H et al. | β | 2025 | β |
| XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries. | Siddiqui MK et al. | β | 2025 | β |
| YBX1 regulation of alveolar type II epithelial cells in idiopathic pulmonary fibrosis: mechanistic insights and small-molecule drug screening. | He Y et al. | β | 2025 | β |
| Zinc alleviates stroke development through autophagy-mediated modulation of immune microenvironment. | Qiu Z et al. | β | 2025 | β |