Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry.
paper
Cited
Public
Unavailable
- Authors
- Dalley, Jeffrey W; Mar, Adam C; Economidou, Daina; Robbins, Trevor W
- Year
- 2008
- Journal
- Pharmacology, biochemistry, and behavior
- PMID
- 18272211
- DOI
- 10.1016/j.pbb.2007.12.021
Impulsive acts and decisions are a part of everyday normal behavior. However, in its pathological forms, impulsivity can be a debilitating disorder often associated with a number of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD). This article reviews recent progress in our understanding of the neurobiology of impulsivity using examples from recent investigations in experimental animals. Evidence is reviewed from several well-established paradigms with putative utility in assessing distinct forms of impulsive behavior in rodents, including the 5-choice serial reaction time (5CSRT) task and the delay discounting paradigm. We discuss, in particular, recent psychopharmacological and in-vivo neurochemical data in task-performing rats showing functional heterogeneity of the forebrain dopamine (DA), noradrenaline (NA), serotonin (5-HT) and acetylcholine (ACh) systems and identify how these systems normally function to facilitate flexible goal-directed behavior in situations that tax basic attentional functions and inhibitory response control mechanisms. We also discuss future research needs in terms of understanding the functional diversity of different sub-regions of prefrontal cortex (PFC) and how these systems normally interact with the striatum and main nuclei of origin of DA and NA neurons. Finally, we argue in line with others that animal paradigms are unlikely to model all aspects of complex psychiatric conditions such as ADHD but components of such syndromes may be amenable to investigation using sophisticated animal models based on highly-defined psychiatric endophenotypes.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Behavioral consequences of organophosphorus poisoning: Insights from human exposures and rodent models. | Bel R et al. | β | 2026 | β |
| Eight weeks of high-intensity interval training increases peripheral serotonin transporter expression independently of promoter methylation changes. | Javelle F et al. | β | 2026 | β |
| Neuroanatomy reflects individual variability in impulsivity in youth. | Dhamala E et al. | β | 2026 | β |
| Cocaine Self-Administration Increases Impulsive Decision-Making in Low-Impulsive Rats Associated with Impaired Functional Connectivity in the Mesocorticolimbic System. | Shen H et al. | β | 2025 | β |
| Impulsivity Drives Adolescents to Smoke and Drink: Gender Differences in the Mediating Effects of Resilience and Depression. | Yan K et al. | β | 2025 | β |
| Predictive coding in neuropsychiatric disorders: A systematic transdiagnostic review. | Qela B et al. | β | 2025 | β |
| Proteomic Findings in ADHD: A Systematic Review. | Karabulut OB et al. | β | 2025 | β |
| Disentangling the neurobiological bases of temporal impulsivity in Huntington's disease. | Pardina-Torner H et al. | β | 2024 | β |
| Exercise recovers weight gain, but not increased impulsive choice, caused by a high-fat diet. | Wilson KF et al. | β | 2024 | β |
| From Nutritional Patterns to Behavior: High-Fat Diet Influences on Inhibitory Control, Brain Gene Expression, and Metabolomics in Rats. | Ruiz-Sobremazas D et al. | β | 2024 | β |
| Serotonergic neuromodulation of synaptic plasticity. | Higa GSV et al. | β | 2024 | β |
| The contributions of neonatal inhalation of copper to air pollution-induced neurodevelopmental outcomes in mice. | Cubello J et al. | β | 2024 | β |
| The Relationship Between Impulsivity Traits and In Vivo Cerebral Serotonin Transporter and Serotonin 2A Receptor Binding in Healthy Individuals: A Double-Tracer PET Study with C-11 DASB and C-11 MDL100907. | Kim JH et al. | β | 2024 | β |
| A behavioral timing intervention upregulates striatal serotonergic markers and reduces impulsive action in adult male mice. | Eckard ML et al. | β | 2023 | β |
| Annual Research Review: Perspectives on progress in ADHD science - from characterization to cause. | Sonuga-Barke EJS et al. | β | 2023 | β |
| Augmented impulsive behavior in febrile seizure-induced mice. | Remonde CG et al. | β | 2023 | β |
| Concurrent measures of impulsive action and choice are partially related and differentially modulated by dopamine D<sub>1</sub>- and D<sub>2</sub>-like receptors in a rat model of impulsivity. | BellΓ©s L et al. | β | 2023 | β |
| Deleting Snord115 genes in mice remodels monoaminergic systems activity in the brain toward cortico-subcortical imbalances. | Marty V et al. | β | 2023 | β |
| Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets. | Biro L et al. | β | 2023 | β |
| Repeated Cocaine Intake Differentially Impacts Striatal D<sub>2/3</sub> Receptor Availability, Psychostimulant-Induced Dopamine Release, and Trait Behavioral Markers of Drug Abuse. | UrueΓ±a-MΓ©ndez G et al. | β | 2023 | β |
| ADHD co-morbidities: A review of implication of gene Γ environment effects with dopamine-related genes. | Kanarik M et al. | β | 2022 | β |
| Amygdala reactivity and ventromedial prefrontal cortex coupling in the processing of emotional face stimuli in attention-deficit/hyperactivity disorder. | Viering T et al. | β | 2022 | β |
| Analyses of microstructural variation in the human striatum using non-negative matrix factorization. | Robert C et al. | β | 2022 | β |
| Behavioral phenotypes revealed during reversal learning are linked with novel genetic loci in diversity outbred mice. | Bagley JR et al. | β | 2022 | β |
| Concurrent measures of impulsive action and choice are partially related and differentially modulated by dopamine D<sub>1</sub>- and D<sub>2</sub>-like receptors in a rat model of impulsivity | BellΓ©s L et al. | β | 2022 | β |
| Frontostriatal circuitry as a target for fMRI-based neurofeedback interventions: A systematic review. | Orth L et al. | β | 2022 | β |
| The effects of early life stress on impulsivity. | Sanchez EO et al. | β | 2022 | β |
| The Link Between Cannabis Use and Violent Behavior in the Early Phase of Psychosis: The Potential Role of Impulsivity. | Moulin V et al. | β | 2022 | β |
| Unraveling the Contribution of Serotonergic Polymorphisms, Prefrontal Alpha Asymmetry, and Individual Alpha Peak Frequency to the Emotion-Related Impulsivity Endophenotype. | Javelle F et al. | β | 2022 | β |
| Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors. | Valentina S et al. | β | 2021 | β |
| Dopamine D2/3 Receptor Availabilities and Evoked Dopamine Release in Striatum Differentially Predict Impulsivity and Novelty Preference in Roman High- and Low-Avoidance Rats. | BellΓ©s L et al. | β | 2021 | β |
| Impulsivity in heroin-dependent individuals: structural and functional abnormalities within frontostriatal circuits. | Wang S et al. | β | 2021 | β |
| Serotonergic control of the glutamatergic neurons of the subthalamic nucleus. | Ugedo L et al. | β | 2021 | β |
| Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence. | De DeurwaerdΓ¨re P et al. | β | 2021 | β |
| Sign tracking predicts suboptimal behavior in a rodent gambling task. | Swintosky M et al. | β | 2021 | β |
| Temporally Specific Roles of Ventral Tegmental Area Projections to the Nucleus Accumbens and Prefrontal Cortex in Attention and Impulse Control. | Flores-Dourojeanni JP et al. | β | 2021 | β |
| The Human Connectome Project: A retrospective. | Elam JS et al. | β | 2021 | β |
| The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics. | Boswell RG et al. | β | 2021 | β |
| The role of oxytocin in delay of gratification and flexibility in non-social decision making. | Kapetaniou GE et al. | β | 2021 | β |
| Translational Research in Nicotine Addiction. | Fisher ML et al. | β | 2021 | β |
| Alterations of cerebral perfusion and functional brain connectivity in medication-naΓ―ve male adults with attention-deficit/hyperactivity disorder. | Tan YW et al. | β | 2020 | β |
| Brain Network Underlying Executive Functions in Gambling and Alcohol Use Disorders: An Activation Likelihood Estimation Meta-Analysis of fMRI Studies. | Quaglieri A et al. | β | 2020 | β |
| Buspirone-associated Movement Disorder: A Literature Review. | Rissardo JP et al. | β | 2020 | β |
| Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways. | Bari A et al. | β | 2020 | β |
| Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis. | Javelle F et al. | β | 2020 | β |
| Mirtazapine-associated movement disorders: A literature review. | Rissardo JP et al. | β | 2020 | β |
| Network failures: When incentives trigger impulsive responses. | Zhukovsky P et al. | β | 2020 | β |
| Serotonin in Animal Cognition and Behavior. | BacquΓ©-Cazenave J et al. | β | 2020 | β |
| Sex differences in impulsivity in adult rats are mediated by organizational actions of neonatal gonadal hormones and not by hormones acting at puberty or in adulthood. | Darling JS et al. | β | 2020 | β |
| The relationship between monoaminergic gene expression, learning, and optimism in red junglefowl chicks. | Boddington R et al. | β | 2020 | β |
| The role of dopamine pharmacotherapy and addiction-like behaviors in Parkinson's disease. | Napier TC et al. | β | 2020 | β |
| Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine. | McCarthy DM et al. | β | 2020 | β |
| Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[<sup>11</sup>C]methylreboxetine positron emission tomography study. | Ulke C et al. | β | 2019 | β |
| Deep brain stimulation targets for treating depression. | Drobisz D et al. | β | 2019 | β |
| Impulsive Action and Impulsive Choice Are Differentially Associated With Gene Expression Variations of the GABA<sub>A</sub> Receptor Alfa 1 Subunit and the CB<sub>1</sub> Receptor in the Lateral and Medial Orbitofrontal Cortices. | Ucha M et al. | β | 2019 | β |
| Pharmacological insights into impulsive-compulsive spectrum disorders associated with dopaminergic therapy. | Napier TC et al. | β | 2019 | β |
| Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats. | Hyatt WS et al. | β | 2019 | β |
| Stress, sensitive periods, and substance abuse. | Andersen SL | β | 2019 | β |
| The Arctic/Swedish APP mutation alters the impact of chronic stress on cognition in mice. | Cortese A et al. | β | 2019 | β |
| The Correlation between the Frontostriatal Network and Impulsivity in Internet Gaming Disorder. | Kim JY et al. | β | 2019 | β |
| The role of the dorsal striatum in choice impulsivity. | Kim B et al. | β | 2019 | β |
| The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats. | Meda S et al. | β | 2019 | β |
| Top-down control of the medial orbitofrontal cortex to nucleus accumbens core pathway in decisional impulsivity. | Wang Z et al. | β | 2019 | β |
| Volume of motor area predicts motor impulsivity. | Ai H et al. | β | 2019 | β |
| Anterior cingulate cortex glutamate and its association with striatal functioning during cognitive control. | Naaijen J et al. | β | 2018 | β |
| Association of 24βh maternal deprivation with a saline injection in the neonatal period alters adult stress response and brain monoamines in a sex-dependent fashion. | Cabbia R et al. | β | 2018 | β |
| Attention-deficit/hyperactivity disorder symptoms and psychological comorbidity in eating disorder patients. | Sala L et al. | β | 2018 | β |
| Circuits regulating pleasure and happiness: evolution and role in mental disorders. | Loonen AJM et al. | β | 2018 | β |
| Dietary influences on cognition. | Reichelt AC et al. | β | 2018 | β |
| Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds. | Yates JR | β | 2018 | β |
| Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior. | Kim B et al. | β | 2018 | β |
| Dopamine effects on stress-induced working memory deficits. | Bahari Z et al. | β | 2018 | β |
| Effects of Suvorexant, a Dual Orexin/Hypocretin Receptor Antagonist, on Impulsive Behavior Associated with Cocaine. | Gentile TA et al. | β | 2018 | β |
| Equivalence of mother and father ratings of ADHD in children. | Mayfield AR et al. | β | 2018 | β |
| Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. | Davis GL et al. | β | 2018 | β |
| Inter-individual differences in the impulsive/compulsive dimension: deciphering related dopaminergic and serotonergic metabolisms at rest. | Dellu-Hagedorn F et al. | β | 2018 | β |
| Neural Correlates of Outcome Anticipation in Multiple Sclerosis. | Spirou A et al. | β | 2018 | β |
| Online effects of transcranial direct current stimulation on prefrontal metabolites in gambling disorder. | Dickler M et al. | β | 2018 | β |
| Psychopathic traits are differentially associated with efficiency of neural communication. | Tillem S et al. | β | 2018 | β |
| Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. | Miller ML et al. | β | 2018 | β |
| Vigilance demand and the effects of stimulant drugs in a five-choice reaction-time procedure in mice. | Katz JL et al. | β | 2018 | β |
| ACC GABA levels are associated with functional activation and connectivity in the fronto-striatal network during interference inhibition in patients with borderline personality disorder. | Wang GY et al. | β | 2017 | β |
| Altered experiential, but not hypothetical, delay discounting in schizophrenia. | Horan WP et al. | β | 2017 | β |
| A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice. | Remmelink E et al. | β | 2017 | β |
| Associating resting-state connectivity with trait impulsivity. | Angelides NH et al. | β | 2017 | β |
| Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field. | Ide JS et al. | β | 2017 | β |
| Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior. | Mackey S et al. | β | 2017 | β |
| Chemogenetic Activation of Midbrain Dopamine Neurons Affects Attention, but not Impulsivity, in the Five-Choice Serial Reaction Time Task in Rats. | Boekhoudt L et al. | β | 2017 | β |
| Circuits Regulating Pleasure and Happiness in Bipolar Disorder. | Loonen AJM et al. | β | 2017 | β |
| Cocaine self-administration in male and female rats perinatally exposed to PCBs: Evaluating drug use in an animal model of environmental contaminant exposure. | Miller MM et al. | β | 2017 | β |
| Commentary on "A non-reward attractor theory of depression": A proposal to include the habenula connection. | Loonen AJM et al. | β | 2017 | β |
| Difference in Perseverative Errors during a Visual Attention Task with Auditory Distractors in Alpha-9 Nicotinic Receptor Subunit Wild Type and Knock-Out Mice. | Jorratt P et al. | β | 2017 | β |
| Distinct Roles of Dopamine Receptors in the Lateral Thalamus in a Rat Model of Decisional Impulsivity. | Wang Z et al. | β | 2017 | β |
| Reward Processing, Neuroeconomics, and Psychopathology. | Zald DH et al. | β | 2017 | β |
| Toward a multiscale modeling framework for understanding serotonergic function. | Wong-Lin K et al. | β | 2017 | β |
| Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice. | Reverte I et al. | β | 2016 | β |
| Attention-Deficit/Hyperactivity Disorder and Monetary Delay Discounting: A Meta-Analysis of Case-Control Studies. | Jackson JN et al. | β | 2016 | β |
| Behavioral, pharmacological and neuroanatomical analysis of serotonin 2C receptor agonism on maternal behavior in rats. | Wu R et al. | β | 2016 | β |
| Chronic methamphetamine self-administration disrupts cortical control of cognition. | Bernheim A et al. | β | 2016 | β |
| Circuits regulating pleasure and happiness in major depression. | Loonen AJ et al. | β | 2016 | β |
| Circuits Regulating Pleasure and Happiness-Mechanisms of Depression. | Loonen AJ et al. | β | 2016 | β |
| Circuits Regulating Pleasure and Happiness: The Evolution of the Amygdalar-Hippocampal-Habenular Connectivity in Vertebrates. | Loonen AJ et al. | β | 2016 | β |
| Cognitive Translation Using the Rodent Touchscreen Testing Approach. | Hvoslef-Eide M et al. | β | 2016 | β |
| COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment. | Myrga JM et al. | β | 2016 | β |
| Coping Styles and Alcohol Dependence among Homeless People. | Opalach C et al. | β | 2016 | β |
| Dopamine Modulation of Intertemporal Decision-making: Evidence from Parkinson Disease. | Foerde K et al. | β | 2016 | β |
| Effect of a human serotonin 5-HT<sub>2A</sub> receptor gene polymorphism on impulsivity: Dependence on cholesterol levels. | Tomson K et al. | β | 2016 | β |
| Emotion regulation as a transdiagnostic factor in the development of internalizing and externalizing psychopathology: Current and future directions. | Aldao A et al. | β | 2016 | β |
| Endocannabinoid CB1 receptor activation upon global ischemia adversely impact recovery of reward and stress signaling molecules, neuronal survival and behavioral impulsivity. | Knowles MD et al. | β | 2016 | β |
| General Habit Propensity Relates to the Sensation Seeking Subdomain of Impulsivity But Not Obesity. | Dietrich A et al. | β | 2016 | β |
| Impulsivity, Stimulant Abuse, and Dopamine Receptor Signaling. | London ED | β | 2016 | β |
| Mifepristone Treatment during Early Adolescence Fails to Restore Maternal Deprivation-Induced Deficits in Behavioral Inhibition of Adult Male Rats. | Kentrop J et al. | β | 2016 | β |
| Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults. | Smith CT et al. | β | 2016 | β |
| Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy. | Engeln M et al. | β | 2016 | β |
| Neural substrates of trait impulsivity, anhedonia, and irritability: Mechanisms of heterotypic comorbidity between externalizing disorders and unipolar depression. | Zisner A et al. | β | 2016 | β |
| Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress. | Tzanoulinou S et al. | β | 2016 | β |
| Prenatal cocaine exposure and its impact on cognitive functions of offspring: a pathophysiological insight. | Gkioka E et al. | β | 2016 | β |
| Reduced brain activation during inhibitory control in children with <i>COMT</i> Val/Val genotype. | Cope LM et al. | β | 2016 | β |
| The influence of early maternal care on perceptual attentional set shifting and stress reactivity in adult rats. | Sakhai SA et al. | β | 2016 | β |
| Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent Processes. | Voon V et al. | β | 2016 | β |
| Accumbal Ξ±-adrenoceptors, but not Ξ²-adrenoceptors, regulate behaviour that is mediated by reserpine-sensitive storage vesicles. | Verheij MM et al. | β | 2015 | β |
| A comparison of brain volume and cortical thickness in excoriation (skin picking) disorder and trichotillomania (hair pulling disorder) in women. | Roos A et al. | β | 2015 | β |
| Circuits regulating pleasure and happiness: the evolution of reward-seeking and misery-fleeing behavioral mechanisms in vertebrates. | Loonen AJ et al. | β | 2015 | β |
| Complex Living Conditions Impair Behavioral Inhibition but Improve Attention in Rats. | van der Veen R et al. | β | 2015 | β |
| Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. | Liang J et al. | β | 2015 | β |
| Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats. | Barrus MM et al. | β | 2015 | β |
| Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency. | Yates JR et al. | β | 2015 | β |
| Dopa therapy and action impulsivity: subthreshold error activation and suppression in Parkinson's disease. | FluchΓ¨re F et al. | β | 2015 | β |
| Effects of the selective 5-HT7 receptor antagonist SB-269970 on premature responding in the five-choice serial reaction time test in rats. | Nikiforuk A et al. | β | 2015 | β |
| Frontostriatal systems comprising connections between ventral medial prefrontal cortex and nucleus accumbens subregions differentially regulate motor impulse control in rats. | Feja M et al. | β | 2015 | β |
| High levels of impulsivity in rats are not accompanied by sensorimotor gating deficits and locomotor hyperactivity. | Feja M et al. | β | 2015 | β |
| Identifying the Basal Ganglia network model markers for medication-induced impulsivity in Parkinson's disease patients. | Balasubramani PP et al. | β | 2015 | β |
| Impaired Energy Metabolism and Disturbed Dopamine and Glutamate Signalling in the Striatum and Prefrontal Cortex of the Spontaneously Hypertensive Rat Model of Attention-Deficit Hyperactivity Disorder. | Dimatelis JJ et al. | β | 2015 | β |
| Impairment of Oligodendroglia Maturation Leads to Aberrantly Increased Cortical Glutamate and Anxiety-Like Behaviors in Juvenile Mice. | Chen X et al. | β | 2015 | β |
| Individual differences in novelty-seeking behavior in spontaneously hypertensive rats: Enhanced sensitivity to the reinforcing effect of methylphenidate in the high novelty-preferring subpopulation. | dela PeΓ±a I et al. | β | 2015 | β |
| Infection of male rats with Toxoplasma gondii results in enhanced delay aversion and neural changes in the nucleus accumbens core. | Tan D et al. | β | 2015 | β |
| Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism. | Chantiluke K et al. | β | 2015 | β |
| Irrational beliefs, biases and gambling: exploring the role of animal models in elucidating vulnerabilities for the development of pathological gambling. | Cocker PJ et al. | β | 2015 | β |
| Long-term test-retest reliability of delayed reward discounting in adolescents. | Anokhin AP et al. | β | 2015 | β |
| Mouse Models of Huntington's Disease. | Brooks SP et al. | β | 2015 | β |
| Persistent effects of chronic Ξ9-THC exposure on motor impulsivity in rats. | Irimia C et al. | β | 2015 | β |
| Possible alteration of catecholaminergic transporters in specific brain areas of iron deficit rats. | Mohamed W | β | 2015 | β |
| Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: implications for inhibitory control. | Bayless DW et al. | β | 2015 | β |
| Spatial discrimination reversal and incremental repeated acquisition in adolescent and adult BALB/c mice. | Shen AN et al. | β | 2015 | β |
| Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects. | Robertson CL et al. | β | 2015 | β |
| The genetics of impulsivity: evidence for the heritability of delay discounting. | Anokhin AP et al. | β | 2015 | β |
| Understanding opioid reward. | Fields HL et al. | β | 2015 | β |
| Validation of a method to assess ADHD-related impulsivity in animal models. | Watterson E et al. | β | 2015 | β |
| 5-HT(2A) and mGlu2 receptor binding levels are related to differences in impulsive behavior in the Roman Low- (RLA) and High- (RHA) avoidance rat strains. | Klein AB et al. | β | 2014 | β |
| Atomoxetine decreases vulnerability to develop compulsivity in high impulsive rats. | Ansquer S et al. | β | 2014 | β |
| Baseline impulsive choice predicts the effects of nicotine and nicotine withdrawal on impulsivity in rats. | Kayir H et al. | β | 2014 | β |
| Behavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies. | Jupp B et al. | β | 2014 | β |
| Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. | Kozlenkov A et al. | β | 2014 | β |
| Dissecting impulsivity and its relationships to drug addictions. | Jentsch JD et al. | β | 2014 | β |
| Distinguishing borderline personality disorder from adult attention deficit/hyperactivity disorder: a clinical and dimensional perspective. | Prada P et al. | β | 2014 | β |
| Dopamine D(2/3) receptor availability and human cognitive impulsivity: a high-resolution positron emission tomography imaging study with [ΒΉΒΉC]raclopride. | Kim JH et al. | β | 2014 | β |
| Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior. | Caprioli D et al. | β | 2014 | β |
| High trait impulsivity predicts food addiction-like behavior in the rat. | VelΓ‘zquez-SΓ‘nchez C et al. | β | 2014 | β |
| Impulsive action and impulsive choice across substance and behavioral addictions: cause or consequence? | Grant JE et al. | β | 2014 | β |
| Impulsive actions and choices in laboratory animals and humans: effects of high vs. low dopamine states produced by systemic treatments given to neurologically intact subjects. | D'Amour-Horvat V et al. | β | 2014 | β |
| Impulsivity, risk-taking, and distractibility in rats exhibiting robust conditioned orienting behaviors. | Olshavsky ME et al. | β | 2014 | β |
| Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. | Tsutsui-Kimura I et al. | β | 2014 | β |
| Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. | Loos M et al. | β | 2014 | β |
| Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol. | Smith CT et al. | β | 2014 | β |
| Reducing substance use during adolescence: a translational framework for prevention. | Stanis JJ et al. | β | 2014 | β |
| Reward pathway dysfunction in gambling disorder: A meta-analysis of functional magnetic resonance imaging studies. | Meng YJ et al. | β | 2014 | β |
| Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure. | Yates JR et al. | β | 2014 | β |
| Self-reported impulsivity and inhibitory control in problem gamblers. | Lorains FK et al. | β | 2014 | β |
| Sex-dependent impacts of low-level lead exposure and prenatal stress on impulsive choice behavior and associated biochemical and neurochemical manifestations. | Weston HI et al. | β | 2014 | β |
| Sex differences in response to amphetamine in adult Long-Evans rats performing a delay-discounting task. | Eubig PA et al. | β | 2014 | β |
| The 5-choice serial reaction time task: a task of attention and impulse control for rodents. | Asinof SK et al. | β | 2014 | β |
| Ventral medial prefrontal cortex inactivation impairs impulse control but does not affect delay-discounting in rats. | Feja M et al. | β | 2014 | β |
| ADHD symptomatology in eating disorders: a secondary psychopathological measure of severity? | FernΓ‘ndez-Aranda F et al. | β | 2013 | β |
| Antagonizing 5-HTβA receptors with M100907 and stimulating 5-HTβC receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats. | Burton CL et al. | β | 2013 | β |
| Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome. | Caprioli D et al. | β | 2013 | β |
| Behavioral deficits induced by lead exposure are accompanied by serotonergic and cholinergic alterations in the prefrontal cortex. | Mansouri MT et al. | β | 2013 | β |
| Common and distinct neural targets of treatment: changing brain function in substance addiction. | Konova AB et al. | β | 2013 | β |
| Delay discounting and frontostriatal fiber tracts: a combined DTI and MTR study on impulsive choices in healthy young adults. | Peper JS et al. | β | 2013 | β |
| Delay discounting task in pigs reveals response strategies related to dopamine metabolite. | Melotti L et al. | β | 2013 | β |
| Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice. | Ash JA et al. | β | 2013 | β |
| Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex. | Jupp B et al. | β | 2013 | β |
| From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists. | Higgins GA et al. | β | 2013 | β |
| Function in the human connectome: task-fMRI and individual differences in behavior. | Barch DM et al. | β | 2013 | β |
| Impaired cliff avoidance reaction in dopamine transporter knockout mice. | Yamashita M et al. | β | 2013 | β |
| Impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus. | Zoratto F et al. | β | 2013 | β |
| Impulsivity and the modular organization of resting-state neural networks. | Davis FC et al. | β | 2013 | β |
| Individual differences in discount rate are associated with demand for self-administered cocaine, but not sucrose. | Koffarnus MN et al. | β | 2013 | β |
| Individual differences in the proneness to have flow experiences are linked to dopamine D2-receptor availability in the dorsal striatum. | de Manzano Γ et al. | β | 2013 | β |
| Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task. | Humpston CS et al. | β | 2013 | β |
| Long term compulsivity on the 5-choice serial reaction time task after acute Chlorpyrifos exposure. | Montes de Oca L et al. | β | 2013 | β |
| Mechanisms by which neonatal testosterone exposure mediates sex differences in impulsivity in prepubertal rats. | Bayless DW et al. | β | 2013 | β |
| Milnacipran enhances the control of impulsive action by activating Dβ-like receptors in the infralimbic cortex. | Tsutsui-Kimura I et al. | β | 2013 | β |
| Pattern of distribution of serotonergic fibers to the orbitomedial and insular cortex in the rat. | Linley SB et al. | β | 2013 | β |
| Postreward delays and systematic biases in measures of animal temporal discounting. | Blanchard TC et al. | β | 2013 | β |
| Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity. | Simon NW et al. | β | 2013 | β |
| Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: a pilot study of six candidate genes. | Carpentier PJ et al. | β | 2013 | β |
| Temporally distinct cognitive effects following acute administration of ketamine and phencyclidine in the rat. | Gastambide F et al. | β | 2013 | β |
| The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function. | Parker MO et al. | β | 2013 | β |
| The thalamostriatal pathway and cholinergic control of goal-directed action: interlacing new with existing learning in the striatum. | Bradfield LA et al. | β | 2013 | β |
| Age and sex differences in impulsive action in rats: the role of dopamine and glutamate. | Burton CL et al. | β | 2012 | β |
| A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HTβA/C and 5-HTβA receptor agonists. | Blasio A et al. | β | 2012 | β |
| Characterizing cognitive aging of working memory and executive function in animal models. | Bizon JL et al. | β | 2012 | β |
| Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex. | Sun H et al. | β | 2012 | β |
| Don'T let me do that! - models of precommitment. | Kurth-Nelson Z et al. | β | 2012 | β |
| Impulsivity and aggressive behavior in Roman high and low avoidance rats: baseline differences and adolescent social stress induced changes. | Coppens CM et al. | β | 2012 | β |
| Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators. | Reeves SJ et al. | β | 2012 | β |
| Linking ADHD, impulsivity, and drug abuse: a neuropsychological perspective. | Urcelay GP et al. | β | 2012 | β |
| Long-term effects of chronic oral Ritalin administration on cognitive and neural development in adolescent wistar kyoto rats. | Pardey MC et al. | β | 2012 | β |
| Measuring impulsivity in mice: the five-choice serial reaction time task. | Sanchez-Roige S et al. | β | 2012 | β |
| Muscarinic mechanisms in psychotic disorders. | McKinzie DL et al. | β | 2012 | β |
| Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens. | Economidou D et al. | β | 2012 | β |
| Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice. | Valencia-Torres L et al. | β | 2012 | β |
| Pregabalin- and topiramate-mediated regulation of cognitive and motor impulsivity in DBA/2 mice. | Navarrete F et al. | β | 2012 | β |
| Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness. | Buckholtz JW et al. | β | 2012 | β |
| Reversal learning as a measure of impulsive and compulsive behavior in addictions. | Izquierdo A et al. | β | 2012 | β |
| Serotonin and decision making processes. | Homberg JR | β | 2012 | β |
| The extended fronto-striatal model of obsessive compulsive disorder: convergence from event-related potentials, neuropsychology and neuroimaging. | Melloni M et al. | β | 2012 | β |
| The influence of sex-linked genetic mechanisms on attention and impulsivity. | Trent S et al. | β | 2012 | β |
| The relationship between impulsive choice and impulsive action: a cross-species translational study. | Broos N et al. | β | 2012 | β |
| ADHD in adolescents with borderline personality disorder. | Speranza M et al. | β | 2011 | β |
| A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex? | Fitzgerald PJ | β | 2011 | β |
| Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention? | Andersen SL et al. | β | 2011 | β |
| Contributions of serotonin in addiction vulnerability. | Kirby LG et al. | β | 2011 | β |
| Deficits in inhibitory executive functions in Klinefelter (47, XXY) syndrome. | Kompus K et al. | β | 2011 | β |
| Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems. | Rutherford HJ et al. | β | 2011 | β |
| Dorsolateral prefrontal Ξ³-aminobutyric acid in men predicts individual differences in rash impulsivity. | Boy F et al. | β | 2011 | β |
| Effects of selective dopaminergic compounds on a delay-discounting task. | Koffarnus MN et al. | β | 2011 | β |
| Fetal alcohol-induced hyperactivity is reversed by treatment with the PPARΞ± agonist fenofibrate in a rat model. | Marche K et al. | β | 2011 | β |
| Heritability of delay discounting in adolescence: a longitudinal twin study. | Anokhin AP et al. | β | 2011 | β |
| High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. | Molander AC et al. | β | 2011 | β |
| Impact of size and delay on neural activity in the rat limbic corticostriatal system. | Roesch MR et al. | β | 2011 | β |
| Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT(2C) receptor stimulation and 5-HT(2A) receptor blockade. | Fletcher PJ et al. | β | 2011 | β |
| Individual differences in impulsivity predict anticipatory eye movements. | Cirilli L et al. | β | 2011 | β |
| Insulin modulates cocaine-sensitive monoamine transporter function and impulsive behavior. | Schoffelmeer AN et al. | β | 2011 | β |
| Inverted-U-shaped dopamine actions on human working memory and cognitive control. | Cools R et al. | β | 2011 | β |
| Learning not to be impulsive: disruption by experience of alcohol withdrawal. | Walker SE et al. | β | 2011 | β |
| Maturation of limbic corticostriatal activation and connectivity associated with developmental changes in temporal discounting. | Christakou A et al. | β | 2011 | β |
| Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders. | Gamo NJ et al. | β | 2011 | β |
| Motivational state and reward content determine choice behavior under risk in mice. | Leblond M et al. | β | 2011 | β |
| Opponency revisited: competition and cooperation between dopamine and serotonin. | Boureau YL et al. | β | 2011 | β |
| Perfluorochemical (PFC) exposure in children: associations with impaired response inhibition. | Gump BB et al. | β | 2011 | β |
| Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure. | Williams SK et al. | β | 2011 | β |
| Response requirement and increases in accuracy produced by stimulant drugs in a 5-choice serial reaction-time task in rats. | Koffarnus MN et al. | β | 2011 | β |
| Selective norepinephrine reuptake inhibition by atomoxetine prevents cue-induced heroin and cocaine seeking. | Economidou D et al. | β | 2011 | β |
| Serotonin and dopamine: unifying affective, activational, and decision functions. | Cools R et al. | β | 2011 | β |
| Shift in the intrinsic excitability of medial prefrontal cortex neurons following training in impulse control and cued-responding tasks. | Hayton SJ et al. | β | 2011 | β |
| Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats. | GarcΓa-Lecumberri C et al. | β | 2011 | β |
| Stress responses: the contribution of prostaglandin E(2) and its receptors. | Furuyashiki T et al. | β | 2011 | β |
| Suicidality in temporal lobe epilepsy: measuring the weight of impulsivity and depression. | de Oliveira GN et al. | β | 2011 | β |
| What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? | Cumming P et al. | β | 2011 | β |
| Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task. | Jentsch JD et al. | β | 2010 | β |
| Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core. | da Costa AraΓΊjo S et al. | β | 2010 | β |
| Cognitive enhancement as a pharmacotherapy target for stimulant addiction. | Sofuoglu M | β | 2010 | β |
| Context-dependent dynamic processes in attention deficit/hyperactivity disorder: differentiating common and unique effects of state regulation deficits and delay aversion. | Sonuga-Barke EJ et al. | β | 2010 | β |
| Coping styles and behavioural flexibility: towards underlying mechanisms. | Coppens CM et al. | β | 2010 | β |
| Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) mice. | Pothakos K et al. | β | 2010 | β |
| Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens. | Besson M et al. | β | 2010 | β |
| Dissociable roles of the medial prefrontal cortex and nucleus accumbens core in goal-directed actions for differential reward magnitude. | Gill TM et al. | β | 2010 | β |
| Dopamine, time, and impulsivity in humans. | Pine A et al. | β | 2010 | β |
| Evaluating the relationship between inattention and impulsivity-related falls in hospitalized older adults. | Harrison BE et al. | β | 2010 | β |
| Impulsivity characterization in the Roman high- and low-avoidance rat strains: behavioral and neurochemical differences. | Moreno M et al. | β | 2010 | β |
| Impulsivity: current and future trends in pharmacological treatment. | Braquehais MD et al. | β | 2010 | β |
| Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5-choice serial reaction time task and strain-specific responsivity to amphetamine. | Loos M et al. | β | 2010 | β |
| Insight into the relationship between impulsivity and substance abuse from studies using animal models. | Winstanley CA et al. | β | 2010 | β |
| Involvement of high plasma corticosterone status and activation of brain regional serotonin metabolism in long-term erythrosine-induced rearing motor hyper activity in young adult male rats. | Dalal A et al. | β | 2010 | β |
| Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. | Eagle DM et al. | β | 2010 | β |
| Methylphenidate and atomoxetine enhance prefrontal function through Ξ±2-adrenergic and dopamine D1 receptors. | Gamo NJ et al. | β | 2010 | β |
| Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex. | Tsutsui-Kimura I et al. | β | 2010 | β |
| Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. | Brigman JL et al. | β | 2010 | β |
| Recent research on impulsivity in individuals with drug use and mental health disorders: implications for alcoholism. | Rogers RD et al. | β | 2010 | β |
| Reversal-specific learning impairments after a binge regimen of methamphetamine in rats: possible involvement of striatal dopamine. | Izquierdo A et al. | β | 2010 | β |
| Serotonergic modulation of response inhibition and re-engagement? Results of a study in healthy human volunteers. | Drueke B et al. | β | 2010 | β |
| Target-specific encoding of response inhibition: increased contribution of AMPA to NMDA receptors at excitatory synapses in the prefrontal cortex. | Hayton SJ et al. | β | 2010 | β |
| The effect of a functional NOS1 promoter polymorphism on impulsivity is moderated by platelet MAO activity. | Laas K et al. | β | 2010 | β |
| The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. | Schumann G et al. | β | 2010 | β |
| Understanding the construct of impulsivity and its relationship to alcohol use disorders. | Dick DM et al. | β | 2010 | β |
| When desire collides with reason: functional interactions between anteroventral prefrontal cortex and nucleus accumbens underlie the human ability to resist impulsive desires. | Diekhof EK et al. | β | 2010 | β |
| Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. | Bortolato M et al. | β | 2009 | β |
| Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'. | Robinson ES et al. | β | 2009 | β |
| Cognitive impulsivity in Parkinson's disease patients: assessment and pathophysiology. | Robert G et al. | β | 2009 | β |
| Developmental exposure to PCBs and/or MeHg: effects on a differential reinforcement of low rates (DRL) operant task before and after amphetamine drug challenge. | Sable HJ et al. | β | 2009 | β |
| Dopamine receptors in the learning, memory and drug reward circuitry. | Dalley JW et al. | β | 2009 | β |
| Effects of acute intra-cerebral administration of the 5-HT(2A/C) receptor ligands DOI and ketanserin on impulse control in rats. | Hadamitzky M et al. | β | 2009 | β |
| Effects of chronic administration of drugs of abuse on impulsive choice (delay discounting) in animal models. | Setlow B et al. | β | 2009 | β |
| Effects of lesions of the nucleus accumbens core on inter-temporal choice: further observations with an adjusting-delay procedure. | da Costa AraΓΊjo S et al. | β | 2009 | β |
| Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder. | Maurex L et al. | β | 2009 | β |
| Ethanol effects on impulsivity in two mouse strains: similarities to diazepam and ketamine. | Oliver YP et al. | β | 2009 | β |
| Impulsivity predicts the escalation of cocaine self-administration in rats. | Anker JJ et al. | β | 2009 | β |
| Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys. | Seu E et al. | β | 2009 | β |
| Long-lasting cognitive deficits resulting from adolescent nicotine exposure in rats. | Counotte DS et al. | β | 2009 | β |
| Modelling human drug abuse and addiction with dedicated small animal positron emission tomography. | Dalley JW et al. | β | 2009 | β |
| Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder. | Minton GO et al. | β | 2009 | β |
| Serotonin depletion impairs waiting but not stop-signal reaction time in rats: implications for theories of the role of 5-HT in behavioral inhibition. | Eagle DM et al. | β | 2009 | β |
| Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. | Lee B et al. | β | 2009 | β |
| Initial nicotine sensitivity in humans as a function of impulsivity. | Perkins KA et al. | β | 2008 | β |
| NeurobiologΓa de la impulsividad y los trastornos de la conducta alimentaria. | Orozco-Cabal LF et al. | β | 2008 | β |