Recent research on impulsivity in individuals with drug use and mental health disorders: implications for alcoholism.
paper
Cited
Public
- Authors
- Rogers, Robert D; Moeller, Frederick G; Swann, Alan C; Clark, Luke
- Year
- 2010
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 20528825
- DOI
- 10.1111/j.1530-0277.2010.01216.x
- PMCID
- PMC4777895
Alcohol misuse and dependence, and many of its accompanying psychological problems, are associated with heightened levels of impulsivity that both accelerate the development of clinically significant illness and complicate clinical outcome. This article reviews recent developments in our understanding of impulsivity as they relate to brain circuitry that might underlie these comorbid factors, focusing upon the clinical features of substance use (and dependence), bipolar disorder, and pathological gambling. Individuals who are affected by these disorders exhibit problems in several domains of impulsive behavior including deficient response or "motor" control, and the tolerance of prolonged delays prior to larger rewards at the expense of smaller rewards ("delay-discounting"). These populations, like alcoholic dependents, also exhibit impairments in risky decision-making that may reflect dysfunction of monoamine and catecholamine pathways. However, several areas of uncertainty exist including the specificity of impairments across disorders and the relationship between impulse control problems and altered evaluation of reward outcomes underlying observed impairments in action selection.
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| Name | Type |
|---|---|
| 38 pathological gamblers local | cohort |
| Accelerated speech local | phenotype |
| action cancellation local | phenotype |
| action restraint local | phenotype |
| action set switching local | phenotype |
| addiction | phenotype |
| ADHD | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| Alcohol_dependence | phenotype |
| alcohol dependents local | cohort |
| alcoholism | phenotype |
| alcohol self-administration | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| alcohol use disorders | phenotype |
| Altered myelin local | phenotype |
| amygdala | anatomy |
| anhedonia | phenotype |
| anterior cingulate cortex | anatomy |
| anterior cingulate cortex (area 24) local | anatomy |
| anticipated aversive consequences local | phenotype |
| Anticipation of negative outcomes local | phenotype |
| Antisocial impulsive subtype local | phenotype |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| arousal | phenotype |
| atomoxetine | drug |
| behavioral control | phenotype |
| behavioral sensitization | phenotype |
| belief in imminent winning local | phenotype |
| bipolar disorder | phenotype |
| BIS | phenotype |
| BIS-11 score | phenotype |
| Campbell-Meiklejohn et al. 2008 local | cohort |
| catecholamine activity local | drug |
| Catecholamine activity local | drug |
| catecholamines | drug |
| chase-loss local | phenotype |
| chase-quit local | phenotype |
| chase-win local | phenotype |
| Clark et al. 2009 local | cohort |
| clearing losses local | phenotype |
| cocaine | phenotype |
| Cocaine-abusing individuals local | cohort |
| Cocaine-dependent individuals local | cohort |
| cocaine-treated rodents local | cohort |
| cocaine use disorder | phenotype |
| cognition | phenotype |
| cognitive distortions local | phenotype |
| Cognitive distortions local | phenotype |
| compulsivity | phenotype |
| conflict | phenotype |
| Continuous performance test | phenotype |
| control | cohort |
| control participants | cohort |
| controls | cohort |
| control subjects | cohort |
| corpus callosum | anatomy |
| correct inhibition local | phenotype |
| craving | phenotype |
| decision-making | phenotype |
| Decision-making deficit local | phenotype |
| Decision-making impairment local | phenotype |
| decisions to chase losses local | phenotype |
| decision to chase local | phenotype |
| decision to chase or quit local | phenotype |
| decision to gamble local | phenotype |
| decision to quit local | phenotype |
| delay discounting | phenotype |
| delay-discounting local | phenotype |
| Delayed discounting local | phenotype |
| Delay tolerance local | phenotype |
| depression | phenotype |
| depressive illness | phenotype |
| depressive symptoms | phenotype |
| Desipramine | drug |
| Disadvantageous choices on IGT local | phenotype |
| Disgust local | phenotype |
| dopamine | drug |
| dorsomedial-striatal circuitry local | anatomy |
| DRD2 | gene |
| drug | drug |
| Drug-dependent individuals local | cohort |
| Dysexecutive syndrome local | phenotype |
| dysphoria | phenotype |
| Early onset of illness local | phenotype |
| elevated wagers local | phenotype |
| endophenotype | phenotype |
| errors of commission | phenotype |
| Euthymic bipolar subjects local | cohort |
| Euthymic state local | phenotype |
| FA reduction | phenotype |
| Faster reaction times local | phenotype |
| First-degree relatives of alcoholics local | cohort |
| First-degree relatives of bipolar disorder patients local | cohort |
| fractional anisotropy | phenotype |
| frontal-striatal circuits local | anatomy |
| full-miss local | phenotype |
| Gambler's fallacy local | phenotype |
| Gamblers with co-morbid ADHD local | cohort |
| Go-no go performance local | phenotype |
| Go reaction time local | phenotype |
| Head of the caudate local | anatomy |
| healthy adult volunteers local | cohort |
| healthy controls | cohort |
| Hedonic thrill local | phenotype |
| heightened mood local | phenotype |
| hope local | phenotype |
| hopelessness | phenotype |
| hunger | phenotype |
| hyperactivity | phenotype |
| hypomania | phenotype |
| Illusion of control local | phenotype |
| Impaired decision-making local | phenotype |
| Impulse Control Disorder local | phenotype |
| Impulsive attempters local | phenotype |
| Impulsive disorders local | phenotype |
| Impulsive suicide attempts local | phenotype |
| impulsivity | phenotype |
| Impulsivity (BIS-11 score) local | phenotype |
| Impulsivity-related measures local | phenotype |
| increased commission errors local | phenotype |
| Increased energy local | phenotype |
| inferior frontal gyrus | anatomy |
| insula | anatomy |
| internal capsule | anatomy |
| Intolerance of longer delays to larger rewards local | phenotype |
| lateral orbitofrontal cortex | anatomy |
| left anterior insula local | anatomy |
| left inferior frontal gyrus | anatomy |
| lifetime alcohol use | phenotype |
| longer deliberation times local | phenotype |
| loss-chasing local | phenotype |
| Loss-chasing local | phenotype |
| loss-chasing behavior local | phenotype |
| lower socialization scores local | phenotype |
| low mood | phenotype |
| mania | phenotype |
| Manic episode | phenotype |
| manic or depressive episodes local | phenotype |
| manic patients local | cohort |
| Many depressive episodes local | phenotype |
| Many manic episodes local | phenotype |
| medial prefrontal cortex | anatomy |
| medial superior frontal gyrus | anatomy |
| mesolimbic circuits local | anatomy |
| mesolimbic pathways local | anatomy |
| methamphetamine | drug |
| methamphetamine dependence | phenotype |
| middle frontal gyrus | anatomy |
| mixed manic-depressive group local | cohort |
| monetary win local | phenotype |
| mood disorders | phenotype |
| motivation | phenotype |
| myelin basic protein local | phenotype |
| near-miss local | phenotype |
| Negative reinforcement model local | phenotype |
| Negative states local | phenotype |
| neurofilaments local | phenotype |
| neuromodulators local | drug |
| Neuronal changes local | phenotype |
| nonplanning impulsiveness | phenotype |
| Nonusing controls local | cohort |
| noradrenaline | drug |
| Noradrenaline metabolite local | drug |
| Noradrenergic function local | phenotype |
| novelty seeking | phenotype |
| obsessive-compulsive disorder | phenotype |
| outcome | phenotype |
| pain | phenotype |
| paracingulate cortex (area 32) local | anatomy |
| parietal cortex | anatomy |
| paroxetine | drug |
| participants | cohort |
| pathological gamblers | cohort |
| pathological gambling | phenotype |
| patients with bipolar disorder | phenotype |
| Patients with bipolar disorder with highly recurrent illness or history of alcohol- or substance-use disorders local | cohort |
| Patients with bipolar disorder without these features local | cohort |
| Poorer IGT performance local | phenotype |
| posterior cingulate cortex | anatomy |
| Posterior mesofrontal cortex local | anatomy |
| prefrontal cortex | anatomy |
| Presupplementary motor area local | anatomy |
| propensity to chase local | phenotype |
| quit chasing losses local | phenotype |
| radial diffusivity | phenotype |
| rapid responding local | phenotype |
| Rapid-response impulsivity local | phenotype |
| rats | cohort |
| Recreational gamblers local | cohort |
| Reduced accuracy | phenotype |
| Reduced attention local | phenotype |
| relapse | phenotype |
| response inhibition | phenotype |
| reward | phenotype |
| reward expectancy local | phenotype |
| reward expectancy pathway local | anatomy |
| reward expectation local | phenotype |
| reward processing | phenotype |
| right medial frontal gyrus | anatomy |
| right prefrontal cortex | anatomy |
| Risk decision-making local | phenotype |
| Risk-free choices local | phenotype |
| risky choice local | phenotype |
| Risky choice local | phenotype |
| risky decision-making | phenotype |
| sadness local | phenotype |
| saline-treated rodents local | cohort |
| self-control | phenotype |
| sense of dread local | phenotype |
| serotonin | drug |
| severe bipolar disorder local | phenotype |
| severity of drug use | phenotype |
| Severity of past attempt local | phenotype |
| slower reaction times | phenotype |
| Socialization scores local | phenotype |
| state negative affect local | phenotype |
| Steeper delay-discounting local | phenotype |
| stimulants | drug |
| Stop-signal reaction time (SSRT) local | phenotype |
| stressors | phenotype |
| subjective aversive rating local | phenotype |
| subjective sensitivity to reward gradients local | phenotype |
| Subjective sensitivity to reward gradients local | phenotype |
| substance use | phenotype |
| Substance-use disorder local | phenotype |
| suicide | phenotype |
| Sustained attention deficit local | phenotype |
| tolerance | phenotype |
| Trait harm avoidance local | phenotype |
| treatment response | phenotype |
| Treatment-seeking pathological gamblers local | cohort |
| value-based choices local | phenotype |
| ventral striatum | anatomy |
| ventromedial prefrontal cortex | anatomy |
| ventromedial prefrontal lesions local | anatomy |
| Violent methods local | phenotype |
| visceral arousal circuit local | anatomy |
| white matter | anatomy |
| withdrawal | phenotype |
| Worse treatment response local | phenotype |
| yohimbine | drug |
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| Title | Year | PMID |
|---|---|---|
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | 2015 | 26388585 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A multimethod examination of impulsivity and its association with gamma-aminobutyric acid (GABA), glutamate, and other neurometabolite levels in youth who do and do not use alcohol. | Porter AM et al. | — | 2025 | → |
| Health Measures and Willingness to Pay for Internet Services. | Rabbani M et al. | — | 2025 | → |
| Uncovering urgency in daily life: Testing a novel method for assessing emotion-impulsivity co-occurrence in momentary data. | Mostajabi J et al. | — | 2025 | → |
| Environmental uncertainty and the advantage of impulsive choice strategies. | Burk DC et al. | — | 2023 | → |
| The factor structure of the Barratt Impulsiveness Scale (BIS-11) and correlates of impulsivity among outpatients with schizophrenia and other psychotic disorders in Singapore. | Lau JH et al. | — | 2022 | → |
| Effects of transcranial direct current stimulation of prefrontal cortex on risk-taking behavior. | Khaleghi A et al. | — | 2020 | → |
| The Neurobiology of Impulsive Decision-Making and Reinforcement Learning in Nonhuman Animals. | Groman SM | — | 2020 | → |
| A comparison of implicit and explicit reward learning in low risk alcohol users versus people who binge drink and people with alcohol dependence. | Paelecke-Habermann Y et al. | — | 2019 | → |
| Does degree completion improve non-cognitive skills during early adulthood and adulthood? | Oi K | — | 2019 | → |
| The role of the dorsal striatum in choice impulsivity. | Kim B et al. | — | 2019 | → |
| Child Maltreatment, Delayed Reward Discounting, and Alcohol and Other Drug Use Problems: The Moderating Role of Heart Rate Variability. | Oshri A et al. | — | 2018 | → |
| Higher Impulsivity and HIV-Risk Taking Behaviour in Males with Alcohol Dependence Compared to Bipolar Mania: A Pilot Study. | Rai S et al. | — | 2018 | → |
| Measuring self-efficacy, executive function, and temporal discounting in Kenya. | Esopo K et al. | — | 2018 | → |
| Personality as an intermediate phenotype for genetic dissection of alcohol use disorder. | Oreland L et al. | — | 2018 | → |
| The putative lithium-mimetic ebselen reduces impulsivity in rodent models. | Barkus C et al. | — | 2018 | → |
| Impulsivity in rodents with a genetic predisposition for excessive alcohol consumption is associated with a lack of a prospective strategy. | Linsenbardt DN et al. | — | 2017 | → |
| Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity. | Wang J et al. | — | 2016 | → |
| Attentional Bias Predicts Increased Reward Salience and Risk Taking in Bipolar Disorder. | Mason L et al. | — | 2016 | → |
| Altered performance in a rat gambling task after acute and repeated alcohol exposure. | Spoelder M et al. | — | 2015 | → |
| Categories of alcohol outcome expectancies and their relationships to alcohol related consequences. | Blume AW et al. | — | 2015 | → |
| Choice impulsivity: Definitions, measurement issues, and clinical implications. | Hamilton KR et al. | — | 2015 | → |
| Does impulsiveness moderate response to financial incentives for smoking cessation among pregnant and newly postpartum women? | Lopez AA et al. | — | 2015 | → |
| Examination of a recommended algorithm for eliminating nonsystematic delay discounting response sets. | White TJ et al. | — | 2015 | → |
| Predicting treatment failure in pathological gambling: the role of personality traits. | Ramos-Grille I et al. | — | 2015 | → |
| Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. | Kamarajan C et al. | — | 2015 | → |
| Risk Factors in Arrest of Rural and Urban Female Victims of Intimate Partner Violence. | Lynch KR et al. | — | 2015 | → |
| The genetics of impulsivity: evidence for the heritability of delay discounting. | Anokhin AP et al. | — | 2015 | → |
| Can transcranial direct current stimulation (tDCS) alleviate symptoms and improve cognition in psychiatric disorders? | Mondino M et al. | — | 2014 | → |
| Cognitive control in alcohol use disorder: deficits and clinical relevance. | Wilcox CE et al. | — | 2014 | → |
| Decision-making and trait impulsivity in bipolar disorder are associated with reduced prefrontal regulation of striatal reward valuation. | Mason L et al. | — | 2014 | → |
| Delay discounting differentiates pre-adolescents at high and low risk for substance use disorders based on family history. | Dougherty DM et al. | — | 2014 | → |
| Effects of amphetamine exposure in adolescence or young adulthood on inhibitory control in adult male and female rats. | Hammerslag LR et al. | — | 2014 | → |
| Examining educational attainment, prepregnancy smoking rate, and delay discounting as predictors of spontaneous quitting among pregnant smokers. | White TJ et al. | — | 2014 | → |
| Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol. | Smith CT et al. | — | 2014 | → |
| A retrospective study of gender differences in depressive symptoms and risk of relapse in patients with alcohol dependence. | Abulseoud OA et al. | — | 2013 | → |
| Cigarette smoking and measures of impulsivity in a college sample. | Balevich EC et al. | — | 2013 | → |
| Inhibition and impulsivity: behavioral and neural basis of response control. | Bari A et al. | — | 2013 | → |
| Neural correlates of impulsivity in healthy males and females with family histories of alcoholism. | DeVito EE et al. | — | 2013 | → |
| Pre-attentive information processing and impulsivity in bipolar disorder. | Swann AC et al. | — | 2013 | → |
| Test-retest reliability of behavioral measures of impulsive choice, impulsive action, and inattention. | Weafer J et al. | — | 2013 | → |
| The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior. | Gulley JM et al. | — | 2013 | → |
| Acute inflammatory bowel disease complicating chronic alcoholism and mimicking carcinoid syndrome. | Ballo P et al. | — | 2012 | → |
| Age and sex differences in impulsive action in rats: the role of dopamine and glutamate. | Burton CL et al. | — | 2012 | → |
| Disordered gambling among higher-frequency gamblers: who is at risk? | Hodgins DC et al. | — | 2012 | → |
| Exercise and mental illness: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). | Dakwar E et al. | — | 2012 | → |
| GABRA2 genotype, impulsivity, and body mass. | Bauer LO et al. | — | 2012 | → |
| Impulsivity in the general population: a national study. | Chamorro J et al. | — | 2012 | → |
| I want it now! Neural correlates of hypersensitivity to immediate reward in hypomania. | Mason L et al. | — | 2012 | → |
| Relationships of impulsiveness and depressive symptoms in alcohol dependence. | Jakubczyk A et al. | — | 2012 | → |
| Translational application of neuromodulation of decision-making. | Levasseur-Moreau J et al. | — | 2012 | → |
| Delay-discounting among homeless, out-of-treatment, substance-dependent men who have sex with men. | Dierst-Davies R et al. | — | 2011 | → |
| Interacting mechanisms of impulsivity in bipolar disorder and antisocial personality disorder. | Swann AC et al. | — | 2011 | → |
| Neuronal-immune interactions in mediating stress effects in the etiology and course of schizophrenia: role of the amygdala in developmental co-ordination. | Anderson G | — | 2011 | → |
| Schizophrenia and serious violence: a clinical-profile analysis incorporating impulsivity and substance-use disorders. | Dumais A et al. | — | 2011 | → |
| Serotonin and dopamine play complementary roles in gambling to recover losses. | Campbell-Meiklejohn D et al. | — | 2011 | → |
| Shift in the intrinsic excitability of medial prefrontal cortex neurons following training in impulse control and cued-responding tasks. | Hayton SJ et al. | — | 2011 | → |