Heritability of delay discounting in adolescence: a longitudinal twin study.
- Authors
- Anokhin, Andrey P; Golosheykin, Simon; Grant, Julia D; Heath, Andrew C
- Year
- 2011
- Journal
- Behavior genetics
- PMID
- 20700643
- DOI
- 10.1007/s10519-010-9384-7
- PMCID
- PMC3036802
Delay discounting (DD) refers to the preference for smaller immediate rewards over larger but delayed rewards, and is considered to be a distinct component of a broader "impulsivity" construct. Although greater propensity for discounting the value of delayed gratification has been associated with a range of problem behaviors and substance abuse, particularly in adolescents, the origins of individual differences in DD remain unclear. We examined genetic and environmental influences on a real-life behavioral measure of DD using a longitudinal twin design. Adolescent participants were asked to choose between a smaller ($7) reward available immediately and a larger ($10) reward to be received in 7Β days. Biometrical genetic analysis using linear structural equation modeling showed significant heritability of DD at ages 12 and 14 (30 and 51%, respectively) and suggested that the same genetic factors influenced the trait at both ages. DD was significantly associated with symptoms of conduct disorder, attention deficit hyperactivity disorder, substance use, and with higher novelty seeking and poor self-regulation. This study provides the first evidence for heritability of DD in humans and suggests that DD can be a promising endophenotype for genetic studies of addiction and externalizing disorders.
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| Name | Type |
|---|---|
| 12-14 years local | cohort |
| 12-year-old participants local | cohort |
| 14-year-old participants local | cohort |
| addiction | phenotype |
| additive genetic influences | cohort |
| ADHD | phenotype |
| ADHD Hyperactive Symptoms local | phenotype |
| ADHD Impulsive Symptoms local | phenotype |
| ADHD inattentive symptoms | phenotype |
| adolescents | cohort |
| Adolescent Twin Cohort local | cohort |
| African American | cohort |
| age 12 | cohort |
| age 14 | cohort |
| age 14 local | phenotype |
| alcohol | phenotype |
| alcohol preference | phenotype |
| Alcohol Use | phenotype |
| any substance use | phenotype |
| behavior | phenotype |
| Birth-year Cohort local | cohort |
| brain function | phenotype |
| broad-sense heritability local | phenotype |
| choice behavior | phenotype |
| cocaine | phenotype |
| cocaine self-administration | phenotype |
| conduct disorder | phenotype |
| Cortical fronto-parietal system local | anatomy |
| DD | phenotype |
| DD phenotype local | phenotype |
| decision making | phenotype |
| Delay aversion local | phenotype |
| delay discounting | phenotype |
| Delay discounting behavior local | phenotype |
| Delay Discounting (DD) local | phenotype |
| Delayed reward choice local | phenotype |
| Delay of Gratification Procedure local | phenotype |
| dependence | phenotype |
| dopamine-related genes | gene |
| DZO pairs local | cohort |
| externalizing disorders | phenotype |
| Family socioeconomic status | phenotype |
| Frontally mediated cognitive control system local | anatomy |
| genetic factors | cohort |
| Head injury | phenotype |
| Higher socioeconomic status | phenotype |
| High School Children local | cohort |
| Hypothetical Reward local | drug |
| Immediate reward choice local | phenotype |
| Impulse control disorders | phenotype |
| impulsive choice | phenotype |
| impulsive decision making style local | phenotype |
| Impulsive decision making style local | phenotype |
| impulsive system local | anatomy |
| impulsivity | phenotype |
| inter-temporal choice local | phenotype |
| Intertemporal Choice local | phenotype |
| inter-temporal decision style local | phenotype |
| investing local | phenotype |
| lateral prefrontal cortex | anatomy |
| limbic system | anatomy |
| marijuana | phenotype |
| medial prefrontal cortex | anatomy |
| mental retardation | phenotype |
| mice | cohort |
| mid-adolescence | cohort |
| non-additive genetic influence local | phenotype |
| non-additive genetic influences local | phenotype |
| novelty seeking | phenotype |
| nucleus accumbens core | anatomy |
| occupational status local | phenotype |
| older adults | cohort |
| ongoing longitudinal study local | cohort |
| orbitofrontal cortex | anatomy |
| Paralimbic system local | anatomy |
| Parental Occupation Data local | phenotype |
| parietal cortex | anatomy |
| pathological gambling | phenotype |
| personality traits | phenotype |
| posterior cingulate cortex | anatomy |
| prefrontal cortex | anatomy |
| problem behavior | phenotype |
| psychiatric symptoms | phenotype |
| purchasing decisions local | phenotype |
| rate of discounting local | phenotype |
| rats | cohort |
| Real Reward local | drug |
| real-world economic behavior local | phenotype |
| reflective system local | anatomy |
| response inhibition | phenotype |
| reward | phenotype |
| Reward valuation network local | anatomy |
| saving local | phenotype |
| SD | phenotype |
| self-reported impulsivity | phenotype |
| SES | phenotype |
| Severe visual impairment local | phenotype |
| shared environmental influence | phenotype |
| Social status | phenotype |
| socioeconomic status | phenotype |
| Sub-cortical reward system local | anatomy |
| substance use | phenotype |
| Temporal discounting local | phenotype |
| temporal discounting preferences local | phenotype |
| tobacco use | phenotype |
| Twin cohort | cohort |
| unique environmental influences | phenotype |
| ventral striatum | anatomy |
| young adults | cohort |
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